JP2001518468A5 - - Google Patents

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Publication number
JP2001518468A5
JP2001518468A5 JP2000513838A JP2000513838A JP2001518468A5 JP 2001518468 A5 JP2001518468 A5 JP 2001518468A5 JP 2000513838 A JP2000513838 A JP 2000513838A JP 2000513838 A JP2000513838 A JP 2000513838A JP 2001518468 A5 JP2001518468 A5 JP 2001518468A5
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JP
Japan
Prior art keywords
halogen
hydrogen
och
compound
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2000513838A
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English (en)
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JP2001518468A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US1998/020427 external-priority patent/WO1999016752A1/en
Publication of JP2001518468A publication Critical patent/JP2001518468A/ja
Publication of JP2001518468A5 publication Critical patent/JP2001518468A5/ja
Pending legal-status Critical Current

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Description

【特許請求の範囲】
【請求項１】
以下の構造式を有する化合物または薬学的に受容可能なその塩。
【化１】
Figure 2001518468
｛式中、
Ｒ1およびＲ3は、水素、ハロゲン、アルキル、アリールアルキル、ＣＦ3およびＯＣＨ3からなる群から相互に独立に選択され、
Ｒ2は、水素、ハロゲン、ＯＨ、ＯＣＨ3、ＯＣＨ2ＣＯＯＨ、Ｃ（Ｏ）−アリール、ＮＣＳ、ＮＨ2、Ｎ3、ＮＨＲ8、ＮＨＣＨ2ＣＯＯＨ、ＮＨＣＯＲ13、ＮＨＣＯＮＨＲ13およびＮＨＣＯＳＲ13からなる群から選択され、
Ｒ4およびＲ5は、水素、ＯＨおよびハロゲンからなる群から相互に独立に選択され、
Ｒ6およびＲ7は、水素およびハロゲンからなる群から相互に独立に選択され、
Ｒ8は、水素、炭素数１〜約８の低級アルキル、ハロゲン、ＯＣＨ3およびＣＦ3からなる群から選択され、
Ｒ13は、水素、炭素数１〜約８の低級アルキル、フェニル、ハロゲン、ＯＣＨ3、ＣＦ3および−ＣＨ2Ｒ’（式中、Ｒ’はハロゲンである。）からなる群から選択され、
Ｒ1、Ｒ2およびＲ3の１つのみが、ＯＣＨ3または水素であり、Ｒ4およびＲ5の一方のみが、ＯＨである。｝
【請求項２】
Ｒ4がＯＨであり、Ｒ5が水素またはハロゲンである、請求項１に記載の化合物。
【請求項３】
Ｒ5がＯＨであり、Ｒ4が水素またはハロゲンである、請求項１に記載の化合物。
【請求項４】
Ｒ6およびＲ7が、それぞれハロゲンである、請求項１に記載の化合物。
【請求項５】
Ｒ6およびＲ7が、それぞれ水素である、請求項１に記載の化合物。
【請求項６】
Ｒ2がＯＣＨ3、ＮＨ2またはＮＨＣＯＲ13である、請求項１に記載の化合物。
【請求項７】
Ｒ1およびＲ3がハロゲンである、請求項１に記載の化合物。
【請求項８】
Ｒ1がハロゲンであり、Ｒ2がＯＣＲ3またはＮＨ2であり、Ｒ3が水素である、請求項１に記載の化合物。
【請求項９】
Ｒ5がＯＨであり、Ｒ4が水素またはハロゲンであり、Ｒ2がＯＣＨ3、ＮＨ2またはＮＨＣＯＲ13であり、Ｒ1およびＲ3がハロゲンである、請求項１に記載の化合物。
【請求項１０】
薬学的に受容可能なキャリアと、請求項１〜９のいずれかに記載の化合物の少なくとも１つとを含む医薬組成物。
JP2000513838A 1997-09-30 1998-09-30 β３アドレナリン受容体拮抗薬、拮抗薬合成物およびこれらの応用方法 Pending JP2001518468A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6115297P 1997-09-30 1997-09-30
US60/061,152 1997-09-30
PCT/US1998/020427 WO1999016752A1 (en) 1997-09-30 1998-09-30 β3-ADRENORECEPTOR AGONISTS, AGONIST COMPOSITIONS AND METHODS OF USING

Publications (2)

Publication Number Publication Date
JP2001518468A JP2001518468A (ja) 2001-10-16
JP2001518468A5 true JP2001518468A5 (ja) 2006-01-05

Family

ID=22033968

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000513838A Pending JP2001518468A (ja) 1997-09-30 1998-09-30 β３アドレナリン受容体拮抗薬、拮抗薬合成物およびこれらの応用方法

Country Status (5)

Country Link
US (2) US6825213B2 (ja)
EP (1) EP1023269A4 (ja)
JP (1) JP2001518468A (ja)
AU (1) AU9512298A (ja)
WO (1) WO1999016752A1 (ja)

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