DE3766472D1 - Tetrahydroisochinolin-2-yl-derivate von carbonsaeuren als thromboxan a2-antagonisten. - Google Patents
Tetrahydroisochinolin-2-yl-derivate von carbonsaeuren als thromboxan a2-antagonisten.Info
- Publication number
- DE3766472D1 DE3766472D1 DE8787309454T DE3766472T DE3766472D1 DE 3766472 D1 DE3766472 D1 DE 3766472D1 DE 8787309454 T DE8787309454 T DE 8787309454T DE 3766472 T DE3766472 T DE 3766472T DE 3766472 D1 DE3766472 D1 DE 3766472D1
- Authority
- DE
- Germany
- Prior art keywords
- tetrahydroisochinolin
- thromboxane
- antagonists
- derivatives
- carbonic acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- -1 TETRAHYDROISOCHINOLIN-2-YL Chemical class 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 150000004653 carbonic acids Chemical class 0.000 title 1
- DSNBHJFQCNUKMA-SCKDECHMSA-N thromboxane A2 Chemical compound OC(=O)CCC\C=C/C[C@@H]1[C@@H](/C=C/[C@@H](O)CCCCC)O[C@@H]2O[C@H]1C2 DSNBHJFQCNUKMA-SCKDECHMSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB868625739A GB8625739D0 (en) | 1986-10-28 | 1986-10-28 | Pharmaceutically active compounds |
GB878715274A GB8715274D0 (en) | 1987-06-30 | 1987-06-30 | Pharmaceutically active compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3766472D1 true DE3766472D1 (de) | 1991-01-10 |
Family
ID=26291459
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8787309454T Expired - Lifetime DE3766472D1 (de) | 1986-10-28 | 1987-10-26 | Tetrahydroisochinolin-2-yl-derivate von carbonsaeuren als thromboxan a2-antagonisten. |
Country Status (11)
Country | Link |
---|---|
US (1) | US4812573A (de) |
EP (1) | EP0266949B1 (de) |
JP (1) | JPH01503233A (de) |
AU (1) | AU600992B2 (de) |
CA (1) | CA1296011C (de) |
DE (1) | DE3766472D1 (de) |
DK (1) | DK160550C (de) |
ES (1) | ES2036213T3 (de) |
GR (1) | GR3001267T3 (de) |
PT (1) | PT86000B (de) |
WO (1) | WO1988003137A1 (de) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2613222B1 (fr) * | 1987-04-03 | 1991-06-14 | Guigon Nadine | Composition pour les soins locaux de l'epiderme, notamment du cuir chevelu |
GB8717374D0 (en) * | 1987-07-22 | 1987-08-26 | Smith Kline French Lab | Pharmaceutically active compounds |
HU198458B (en) * | 1987-12-30 | 1989-10-30 | Chinoin Gyogyszer Es Vegyeszet | Process for producing 2-aminoisoquinoline derivatives and pharmaceutical compositions comprising these compounds |
US6137002A (en) * | 1993-07-22 | 2000-10-24 | Eli Lilly And Company | Glycoprotein IIb/IIIa antagonists |
DZ2446A1 (fr) * | 1997-03-18 | 2003-01-11 | Smithkline Beecham Plc | Nouveaux composés |
WO1999016752A1 (en) * | 1997-09-30 | 1999-04-08 | Molecular Designs International, Inc. | β3-ADRENORECEPTOR AGONISTS, AGONIST COMPOSITIONS AND METHODS OF USING |
DE19934272A1 (de) * | 1999-07-21 | 2001-01-25 | Bayer Ag | Neue antivirale Mittel |
CN1217936C (zh) * | 1999-12-28 | 2005-09-07 | 卫材株式会社 | 含有磺酰胺的杂环化合物 |
US6593341B2 (en) | 2001-03-29 | 2003-07-15 | Molecular Design International, Inc. | β3-adrenoreceptor agonists, agonist compositions and methods of making and using the same |
DE60325025D1 (de) | 2002-02-15 | 2009-01-15 | Glaxo Group Ltd | Modulatoren des vanilloidrezeptors |
AR040126A1 (es) | 2002-05-29 | 2005-03-16 | Glaxo Group Ltd | Compuesto de fenilsulfonilo, composicion farmaceutica que lo comprende y su uso para la elaboracion de un medicamento |
US6596734B1 (en) | 2002-10-11 | 2003-07-22 | Molecular Design International, Inc. | Tetrahydroisoquinoline compounds for use as β3-adrenoreceptor agonists |
ES2576477T3 (es) * | 2006-08-07 | 2016-07-07 | Janssen Pharmaceutica Nv | Proceso para la preparación de derivados de 1,2,3,4-tetrahidroisoquinolina sustituidos |
ES2617868T3 (es) | 2008-08-22 | 2017-06-20 | Baxalta GmbH | Derivados de carbonato de bencilo poliméricos |
JP2012525386A (ja) | 2009-05-01 | 2012-10-22 | アエリエ・ファーマシューティカルズ・インコーポレーテッド | 疾患の治療のための二重機構阻害剤 |
KR102568079B1 (ko) | 2016-08-31 | 2023-08-17 | 에어리 파마슈티컬즈, 인코포레이티드 | 안과용 조성물 |
US9840468B1 (en) * | 2016-12-30 | 2017-12-12 | Aerie Pharmaceuticals, Inc. | Methods for the preparation of 6-aminoisoquinoline |
AU2019337703B2 (en) | 2018-09-14 | 2023-02-02 | Aerie Pharmaceuticals, Inc. | Aryl cyclopropyl-amino-isoquinolinyl amide compounds |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE28034E (en) * | 1972-12-14 | 1974-06-04 | Alkylsulfinylalkyl- and sulfonyl- alkyl-i,z,j,x.tetrahydroisoqijinolines | |
DE3000377A1 (de) * | 1980-01-07 | 1981-07-09 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue sulfonamide, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel |
US4321254A (en) * | 1980-09-26 | 1982-03-23 | Smithkline Corporation | Antiallergic imidodisulfamides |
US4350698A (en) * | 1981-09-25 | 1982-09-21 | Smithkline Corporation | Antiallergic imidosulfamides |
US4536510A (en) * | 1983-07-22 | 1985-08-20 | Smith Kline Beckman Corporation | Method of antagonizing the effects of thromboxane |
-
1987
- 1987-10-26 EP EP87309454A patent/EP0266949B1/de not_active Expired - Lifetime
- 1987-10-26 WO PCT/GB1987/000757 patent/WO1988003137A1/en unknown
- 1987-10-26 AU AU81081/87A patent/AU600992B2/en not_active Ceased
- 1987-10-26 DE DE8787309454T patent/DE3766472D1/de not_active Expired - Lifetime
- 1987-10-26 ES ES198787309454T patent/ES2036213T3/es not_active Expired - Lifetime
- 1987-10-26 JP JP62501623A patent/JPH01503233A/ja active Pending
- 1987-10-27 PT PT86000A patent/PT86000B/pt not_active IP Right Cessation
- 1987-10-27 CA CA000550294A patent/CA1296011C/en not_active Expired - Fee Related
-
1988
- 1988-06-24 DK DK351788A patent/DK160550C/da not_active IP Right Cessation
- 1988-06-27 US US07/212,095 patent/US4812573A/en not_active Expired - Fee Related
-
1990
- 1990-12-31 GR GR90401225T patent/GR3001267T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
US4812573A (en) | 1989-03-14 |
PT86000A (en) | 1987-11-01 |
JPH01503233A (ja) | 1989-11-02 |
WO1988003137A1 (en) | 1988-05-05 |
EP0266949B1 (de) | 1990-11-28 |
DK160550C (da) | 1991-09-09 |
ES2036213T3 (es) | 1993-05-16 |
DK160550B (da) | 1991-03-25 |
CA1296011C (en) | 1992-02-18 |
PT86000B (pt) | 1990-08-31 |
AU600992B2 (en) | 1990-08-30 |
AU8108187A (en) | 1988-05-25 |
EP0266949A1 (de) | 1988-05-11 |
GR3001267T3 (en) | 1992-08-25 |
DK351788D0 (da) | 1988-06-24 |
DK351788A (da) | 1988-06-24 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE3766472D1 (de) | Tetrahydroisochinolin-2-yl-derivate von carbonsaeuren als thromboxan a2-antagonisten. | |
DE3785808T2 (de) | Mischungen von dicyanatestern von dihydroxyphenolen. | |
ATE113610T1 (de) | Ester von alginsäure. | |
DE3783802D1 (de) | Laufflaeche von luftreifen. | |
DE3780933T2 (de) | Herstellung von aminoalanen. | |
DE3685384D1 (de) | Vorbereitung von emulsionen. | |
DE3486138T2 (de) | Analogen von wachstum befreiendem faktor. | |
DE3856076D1 (de) | Nachweis von flüssigkeitsströmungen | |
DE3773964D1 (de) | Nachweis von magnetischen unstetigkeiten. | |
DE3786928D1 (de) | Verpackung von schleifmitteln. | |
ATE112172T1 (de) | Targetformer von antitumor-methyltrithioagenzien. | |
DE68906938T2 (de) | Einstellung des chargenverhaeltnisses von fluessigkeitsgemischen. | |
DE68921340D1 (de) | Herstellung von epoxinitraten. | |
DE3874011T2 (de) | Ueberempfindlichmachung von silberhalogenid enthaltender emulsion. | |
DE3761048D1 (de) | Umsetzungsprodukte von bis-glycidylthioethern. | |
ATE58725T1 (de) | Tetrahydroisochinolin-2-yl-derivate von carbonsaeuren als thromboxan a2-antagonisten. | |
DE68911503D1 (de) | Wiedergewinnung von urokinaseverbindungen. | |
DE3775861D1 (de) | Erstarrung von fluessigkeitenfilmen. | |
DE360604T1 (de) | Umlauf von fluessigen proben. | |
DE69002136D1 (de) | Saccharidderivate von protocatechualdehyd. | |
DE3587341D1 (de) | Epoxidation von propylen. | |
DE3767799D1 (de) | Herstellungsverfahren von dichlorohydrin. | |
DE3766873D1 (de) | Herstellung von substituierten dichlormethylpyridinen. | |
DE3884014D1 (de) | Mono- und Diepoxidderivate von 23-Deoxy-LL-F28249-Verbindungen. | |
DE3765295D1 (de) | Synthese von hochreinem 5-chlorisophthaloylchlorid. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |