DK160550C - Tetrahydroisoquinolin-2-ylderivater af carboxylsyrer som thromboxan-a2-antagonister, deres anvendelse i et medicinsk praeparat og farmaceutisk middel indeholdende dem - Google Patents

Tetrahydroisoquinolin-2-ylderivater af carboxylsyrer som thromboxan-a2-antagonister, deres anvendelse i et medicinsk praeparat og farmaceutisk middel indeholdende dem

Info

Publication number
DK160550C
DK160550C DK351788A DK351788A DK160550C DK 160550 C DK160550 C DK 160550C DK 351788 A DK351788 A DK 351788A DK 351788 A DK351788 A DK 351788A DK 160550 C DK160550 C DK 160550C
Authority
DK
Denmark
Prior art keywords
thromboxan
yld
tetrahydroisoquinolin
antagonists
derivatives
Prior art date
Application number
DK351788A
Other languages
English (en)
Other versions
DK160550B (da
DK351788D0 (da
DK351788A (da
Inventor
John Graham Durant
Andrew Derrick Gribble
Robert Anthony Slater
Original Assignee
Smith Kline French Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB868625739A external-priority patent/GB8625739D0/en
Priority claimed from GB878715274A external-priority patent/GB8715274D0/en
Application filed by Smith Kline French Lab filed Critical Smith Kline French Lab
Publication of DK351788D0 publication Critical patent/DK351788D0/da
Publication of DK351788A publication Critical patent/DK351788A/da
Publication of DK160550B publication Critical patent/DK160550B/da
Application granted granted Critical
Publication of DK160550C publication Critical patent/DK160550C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK351788A 1986-10-28 1988-06-24 Tetrahydroisoquinolin-2-ylderivater af carboxylsyrer som thromboxan-a2-antagonister, deres anvendelse i et medicinsk praeparat og farmaceutisk middel indeholdende dem DK160550C (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB868625739A GB8625739D0 (en) 1986-10-28 1986-10-28 Pharmaceutically active compounds
GB8625739 1986-10-28
GB878715274A GB8715274D0 (en) 1987-06-30 1987-06-30 Pharmaceutically active compounds
GB8715274 1987-06-30
PCT/GB1987/000757 WO1988003137A1 (en) 1986-10-28 1987-10-26 Tetrahydroisoquinolin-2-yl derivatives of carboxylic acids as thromboxane a2 antagonists
GB8700757 1987-10-26

Publications (4)

Publication Number Publication Date
DK351788D0 DK351788D0 (da) 1988-06-24
DK351788A DK351788A (da) 1988-06-24
DK160550B DK160550B (da) 1991-03-25
DK160550C true DK160550C (da) 1991-09-09

Family

ID=26291459

Family Applications (1)

Application Number Title Priority Date Filing Date
DK351788A DK160550C (da) 1986-10-28 1988-06-24 Tetrahydroisoquinolin-2-ylderivater af carboxylsyrer som thromboxan-a2-antagonister, deres anvendelse i et medicinsk praeparat og farmaceutisk middel indeholdende dem

Country Status (11)

Country Link
US (1) US4812573A (da)
EP (1) EP0266949B1 (da)
JP (1) JPH01503233A (da)
AU (1) AU600992B2 (da)
CA (1) CA1296011C (da)
DE (1) DE3766472D1 (da)
DK (1) DK160550C (da)
ES (1) ES2036213T3 (da)
GR (1) GR3001267T3 (da)
PT (1) PT86000B (da)
WO (1) WO1988003137A1 (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2613222B1 (fr) * 1987-04-03 1991-06-14 Guigon Nadine Composition pour les soins locaux de l'epiderme, notamment du cuir chevelu
GB8717374D0 (en) * 1987-07-22 1987-08-26 Smith Kline French Lab Pharmaceutically active compounds
HU198458B (en) * 1987-12-30 1989-10-30 Chinoin Gyogyszer Es Vegyeszet Process for producing 2-aminoisoquinoline derivatives and pharmaceutical compositions comprising these compounds
US6137002A (en) * 1993-07-22 2000-10-24 Eli Lilly And Company Glycoprotein IIb/IIIa antagonists
DZ2446A1 (fr) * 1997-03-18 2003-01-11 Smithkline Beecham Plc Nouveaux composés
JP2001518468A (ja) * 1997-09-30 2001-10-16 モレキュラー デザインズ インターナショナル，インコーポレイテッド β３アドレナリン受容体拮抗薬、拮抗薬合成物およびこれらの応用方法
DE19934272A1 (de) * 1999-07-21 2001-01-25 Bayer Ag Neue antivirale Mittel
JP4234344B2 (ja) 1999-12-28 2009-03-04 エーザイ・アール・アンド・ディー・マネジメント株式会社 スルホンアミド含有複素環化合物
US6593341B2 (en) 2001-03-29 2003-07-15 Molecular Design International, Inc. β3-adrenoreceptor agonists, agonist compositions and methods of making and using the same
TW200403223A (en) 2002-02-15 2004-03-01 Glaxo Group Ltd Novel compounds
AR040126A1 (es) 2002-05-29 2005-03-16 Glaxo Group Ltd Compuesto de fenilsulfonilo, composicion farmaceutica que lo comprende y su uso para la elaboracion de un medicamento
US6596734B1 (en) 2002-10-11 2003-07-22 Molecular Design International, Inc. Tetrahydroisoquinoline compounds for use as β3-adrenoreceptor agonists
EP2061763B1 (en) * 2006-08-07 2016-03-16 Janssen Pharmaceutica NV Process for the preparation of substituted-1,2,3,4-tetrahydroisoquinoline derivates
KR101660059B1 (ko) 2008-08-22 2016-09-26 박스알타 인코퍼레이티드 중합체 벤질 카르보네이트-유도체
CA2929545C (en) 2009-05-01 2019-04-09 Aerie Pharmaceuticals, Inc. Dual mechanism inhibitors for the treatment of disease
WO2018045091A1 (en) 2016-08-31 2018-03-08 Aerie Pharmaceuticals, Inc. Ophthalmic compositions
US9840468B1 (en) * 2016-12-30 2017-12-12 Aerie Pharmaceuticals, Inc. Methods for the preparation of 6-aminoisoquinoline
US11427563B2 (en) 2018-09-14 2022-08-30 Aerie Pharmaceuticals, Inc. Aryl cyclopropyl-amino-isoquinolinyl amide compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE28034E (en) * 1972-12-14 1974-06-04 Alkylsulfinylalkyl- and sulfonyl- alkyl-i,z,j,x.tetrahydroisoqijinolines
DE3000377A1 (de) * 1980-01-07 1981-07-09 Boehringer Mannheim Gmbh, 6800 Mannheim Neue sulfonamide, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
US4321254A (en) * 1980-09-26 1982-03-23 Smithkline Corporation Antiallergic imidodisulfamides
US4350698A (en) * 1981-09-25 1982-09-21 Smithkline Corporation Antiallergic imidosulfamides
US4536510A (en) * 1983-07-22 1985-08-20 Smith Kline Beckman Corporation Method of antagonizing the effects of thromboxane

Also Published As

Publication number Publication date
US4812573A (en) 1989-03-14
AU600992B2 (en) 1990-08-30
DK160550B (da) 1991-03-25
JPH01503233A (ja) 1989-11-02
ES2036213T3 (es) 1993-05-16
DE3766472D1 (de) 1991-01-10
WO1988003137A1 (en) 1988-05-05
EP0266949B1 (en) 1990-11-28
CA1296011C (en) 1992-02-18
PT86000B (pt) 1990-08-31
AU8108187A (en) 1988-05-25
EP0266949A1 (en) 1988-05-11
DK351788D0 (da) 1988-06-24
GR3001267T3 (en) 1992-08-25
DK351788A (da) 1988-06-24
PT86000A (en) 1987-11-01

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