JP2001507944A - 悪性細胞に対する、oncタンパク質を含む、免疫毒素 - Google Patents
悪性細胞に対する、oncタンパク質を含む、免疫毒素Info
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- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
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- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.B細胞に特異的な表面マーカーに対する抗体に連結した測定可能なリボ核 酸分解活性を有するoncタンパク質を含む、選択的細胞傷害性試薬。 2.前記oncタンパク質が、配列番号1に記載のアミノ酸配列を有する、請求 項1に記載の試薬。 3.前記oncタンパク質が組換え手段によって産生される、請求項1に記載の 試薬。 4.前記oncタンパク質が、配列番号3に記載のアミノ酸配列を有する、請求 項3に記載の試薬。 5.前記oncタンパク質が、配列番号2として同定された核酸分子によってコ ードされる、請求項3に記載の試薬。 6.前記抗体がモノクローナル抗体である、請求項1に記載の試薬。 7.前記モノクローナル抗体がヒト化される、請求項6に記載の試薬。 8.前記モノクローナル抗体が単鎖抗体である、請求項7に記載の試薬。 9.前記抗体が、B細胞リンパ腫に特異的である、請求項1に記載の試薬。 10.前記抗体が、RFB4およびLL2からなる群より選択される、請求項9に記 載の試薬。 11.前記表面マーカーがCD22である、請求項1に記載の試薬。 12.前記表面マーカーがCD74である、請求項1に記載の試薬。 13.前記抗体がLL1である、請求項12に記載の試薬。 14.前記oncタンパク質が、組換え融合によって前記抗体に結合される、請 求項1に記載の試薬。 15.請求項1に記載の試薬をコードする、核酸配列。 16.B細胞に特異的な細胞表面マーカーに対する抗体に連結した測定可能な リボ核酸分解活性を有するoncタンパク質を含む選択的細胞傷害性試薬を、薬学 的に受容可能なキャリアとともに含む、薬学的組成物。 17.前記oncタンパク質が、配列番号1に記載のアミノ酸配列を有する、請 求項16に記載の薬学的組成物。 18.前記oncタンパク質が組換え手段によって産生される、請求項16に記 載の薬学的組成物。 19.前記oncタンパク質が、配列番号3に記載のアミノ酸配列を有する、請 求項18に記載の薬学的組成物。 20.前記oncタンパク質が、配列番号2として同定された核酸分子によって コードされる、請求項18に記載の薬学的組成物。 21.前記oncタンパク質が、組換え手段によって前記抗体に結合される、請 求項16に記載の薬学的組成物。 22.前記抗体がモノクローナル抗体である、請求項16に記載の薬学的組成 物。 23.前記モノクローナル抗体がヒト化される、請求項22に記載の薬学的組 成物。 24.前記モノクローナル抗体が単鎖抗体である、請求項23に記載の薬学的 組成物。 25.前記抗体が、B細胞リンパ腫上に存在する表面マーカーに対する、請求 項16に記載の薬学的組成物。 26.前記抗体が、RFB4、LL1、およびLL2からなる群より選択される、請求項 25に記載の薬学的組成物。 27.B細胞に特異的な細胞表面マーカーに対する抗体に連結した測定可能な リボ核酸分解活性を有するoncタンパク質を含む選択的細胞傷害性試薬と、殺傷 させるべき細胞とを接触させる工程を包含する、悪性B細胞を殺傷する方法。 28.前記oncタンパク質が、配列番号1に記載のアミノ酸配列を有する、請 求項27に記載の方法。 29.前記oncタンパク質が組換え手段によって産生される、請求項27に記 載の方法。 30.前記oncタンパク質が、配列番号3に記載のアミノ酸配列を有する、請 求項29に記載の方法。 31.前記oncタンパク質が、配列番号2として同定された核酸分子によって コードされる、請求項29に記載の方法。 32.前記細胞表面マーカーがCD22である、請求項27に記載の方法。 33.CD74に対する抗体に連結した測定可能なリボ核酸分解活性を有するonc タンパク質を含む選択的組換え細胞傷害性試薬と、殺傷させるべき細胞とを接触 させる工程を包含する、CD74細胞表面マーカーを有する悪性細胞を殺傷する方法 。 34.前記殺傷させるべき細胞が、神経芽細胞腫、黒色腫、および骨髄腫から なる群より選択される、請求項33に記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US4689597P | 1997-05-02 | 1997-05-02 | |
US60/046,895 | 1997-05-02 | ||
PCT/US1998/008983 WO1998050435A1 (en) | 1997-05-02 | 1998-05-01 | Immunotoxins, comprising an onc protein, directed against malignant cells |
Related Child Applications (1)
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JP2003362606A Division JP2004115529A (ja) | 1997-05-02 | 2003-10-22 | 悪性細胞に対する、oncタンパク質を含む、免疫毒素 |
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JP2001507944A true JP2001507944A (ja) | 2001-06-19 |
JP3835827B2 JP3835827B2 (ja) | 2006-10-18 |
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JP54830198A Expired - Fee Related JP3835827B2 (ja) | 1997-05-02 | 1998-05-01 | 悪性細胞に対する、oncタンパク質を含む、免疫毒素 |
JP2003362606A Withdrawn JP2004115529A (ja) | 1997-05-02 | 2003-10-22 | 悪性細胞に対する、oncタンパク質を含む、免疫毒素 |
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JP2003362606A Withdrawn JP2004115529A (ja) | 1997-05-02 | 2003-10-22 | 悪性細胞に対する、oncタンパク質を含む、免疫毒素 |
Country Status (9)
Country | Link |
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US (3) | US6395276B1 (ja) |
EP (1) | EP0975674B1 (ja) |
JP (2) | JP3835827B2 (ja) |
AT (1) | ATE302217T1 (ja) |
AU (1) | AU745823B2 (ja) |
CA (1) | CA2288232A1 (ja) |
DE (1) | DE69831224T2 (ja) |
ES (1) | ES2248898T3 (ja) |
WO (1) | WO1998050435A1 (ja) |
Cited By (5)
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JP2007523857A (ja) * | 2003-06-17 | 2007-08-23 | イミューノメディクス、インコーポレイテッド | 抗cd74免疫複合体および方法 |
JP2007524686A (ja) * | 2004-02-13 | 2007-08-30 | イムノメディクス, インコーポレイテッド | 組み換え細胞毒性RNAseを含む融合タンパク質 |
JP2007524412A (ja) * | 2004-01-22 | 2007-08-30 | イムノメディクス, インコーポレイテッド | 葉酸コンジュゲートおよびコンプレックス |
JP2008505853A (ja) * | 2004-04-13 | 2008-02-28 | クインテセンス バイオサイエンシーズ インコーポレーティッド | 細胞傷害性薬剤としての非天然のリボヌクレアーゼ複合体 |
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- 1998-05-01 WO PCT/US1998/008983 patent/WO1998050435A1/en active IP Right Grant
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- 1998-05-01 DE DE69831224T patent/DE69831224T2/de not_active Expired - Fee Related
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2001
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2003
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JP2010088439A (ja) * | 2002-03-01 | 2010-04-22 | Immunomedics Inc | インターナライジング抗cd74抗体およびその使用方法 |
JP2007523857A (ja) * | 2003-06-17 | 2007-08-23 | イミューノメディクス、インコーポレイテッド | 抗cd74免疫複合体および方法 |
JP2007524412A (ja) * | 2004-01-22 | 2007-08-30 | イムノメディクス, インコーポレイテッド | 葉酸コンジュゲートおよびコンプレックス |
JP2007524686A (ja) * | 2004-02-13 | 2007-08-30 | イムノメディクス, インコーポレイテッド | 組み換え細胞毒性RNAseを含む融合タンパク質 |
JP2012197286A (ja) * | 2004-02-13 | 2012-10-18 | Immunomedics Inc | 組み換え細胞毒性RNAseを含む融合タンパク質 |
JP2008505853A (ja) * | 2004-04-13 | 2008-02-28 | クインテセンス バイオサイエンシーズ インコーポレーティッド | 細胞傷害性薬剤としての非天然のリボヌクレアーゼ複合体 |
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US20030114368A1 (en) | 2003-06-19 |
EP0975674B1 (en) | 2005-08-17 |
DE69831224D1 (de) | 2005-09-22 |
JP2004115529A (ja) | 2004-04-15 |
EP0975674A1 (en) | 2000-02-02 |
US6395276B1 (en) | 2002-05-28 |
AU7280398A (en) | 1998-11-27 |
US20050249738A1 (en) | 2005-11-10 |
DE69831224T2 (de) | 2006-03-23 |
AU745823B2 (en) | 2002-04-11 |
ATE302217T1 (de) | 2005-09-15 |
ES2248898T3 (es) | 2006-03-16 |
CA2288232A1 (en) | 1998-11-12 |
JP3835827B2 (ja) | 2006-10-18 |
WO1998050435A1 (en) | 1998-11-12 |
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