|
WO2000023072A1
(en)
*
|
1998-10-20 |
2000-04-27 |
Omeros Medical Systems, Inc. |
Irrigation solution containing mapk inhibitors and their use for treating pain and inflammation
|
|
US7091181B2
(en)
|
1994-12-12 |
2006-08-15 |
Omeros Corporation |
Method of inhibition of pain and inflammation during surgery comprising administration of soluble TNF receptors
|
|
US6608060B1
(en)
*
|
1996-12-18 |
2003-08-19 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of p38
|
|
US6673768B1
(en)
|
1997-10-16 |
2004-01-06 |
Board Of Regents, The University Of Texas System |
Transgenic animal models for cardiac hypertrophy and methods of use thereof (treating)
|
|
JP2001526230A
(ja)
|
1997-12-19 |
2001-12-18 |
スミスクライン・ビーチャム・コーポレイション |
ヘテロアリール置換イミダゾール化合物、その医薬組成物および使用
|
|
MY132496A
(en)
|
1998-05-11 |
2007-10-31 |
Vertex Pharma |
Inhibitors of p38
|
|
WO1999061039A2
(en)
*
|
1998-05-22 |
1999-12-02 |
MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. |
Novel composition for modulating ischemic cell death
|
|
US6858617B2
(en)
|
1998-05-26 |
2005-02-22 |
Smithkline Beecham Corporation |
Substituted imidazole compounds
|
|
AU4429799A
(en)
|
1998-06-12 |
1999-12-30 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of p38
|
|
EP1277740A1
(en)
*
|
1998-06-12 |
2003-01-22 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of p38
|
|
US6184226B1
(en)
|
1998-08-28 |
2001-02-06 |
Scios Inc. |
Quinazoline derivatives as inhibitors of P-38 α
|
|
AR023659A1
(es)
|
1998-09-18 |
2002-09-04 |
Vertex Pharma |
Un compuesto inhibidor de p38, una composicion farmaceutica que lo comprende y el uso de dicha composicion en el tratamiento y prevencion de estados patologicos
|
|
CA2337755C
(en)
*
|
1998-09-18 |
2008-07-29 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of p38
|
|
ES2212657T3
(es)
|
1998-11-04 |
2004-07-16 |
Smithkline Beecham Corporation |
Pirazinas sustituidas piridin-4-il o pirimidin-4-il.
|
|
UA73492C2
(en)
*
|
1999-01-19 |
2005-08-15 |
|
Aromatic heterocyclic compounds as antiinflammatory agents
|
|
CA2360934A1
(en)
|
1999-02-22 |
2000-08-31 |
Lin-Hua Zhang |
Polycyclo heterocyclic derivatives as antiinflammatory agents
|
|
EP1163236B1
(en)
|
1999-03-12 |
2005-11-09 |
Boehringer Ingelheim Pharmaceuticals Inc. |
Aromatic heterocyclic compounds as anti-inflammatory agents
|
|
RU2242474C2
(ru)
|
1999-03-12 |
2004-12-20 |
Бёрингер Ингельхайм Фармасьютиклз, Инк. |
Соединения, пригодные в качестве противовоспалительных агентов
|
|
JP2000281588A
(ja)
*
|
1999-03-30 |
2000-10-10 |
Sankyo Co Ltd |
ガンの予防又は治療薬及びそのスクリーニング方法
|
|
AU777275B2
(en)
*
|
1999-07-02 |
2004-10-07 |
Stuart A. Lipton |
Method of reducing neuronal injury or apoptosis
|
|
WO2001004115A2
(en)
|
1999-07-09 |
2001-01-18 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Novel process for synthesis of heteroaryl-substituted urea compounds
|
|
HUP0203477A3
(en)
*
|
1999-10-21 |
2004-12-28 |
Hoffmann La Roche |
Alkylamino substituted bicyclic nitrogen heterocycles as inhibitors of p38 protein kinase, pharmaceutical compositions containing them and their preparations
|
|
AU776250B2
(en)
*
|
1999-10-21 |
2004-09-02 |
F. Hoffmann-La Roche Ag |
Heteroalkylamino-substituted bicyclic nitrogen heterocycles as inhibitors of P38 protein kinase
|
|
WO2001038314A1
(en)
|
1999-11-23 |
2001-05-31 |
Smithkline Beecham Corporation |
3,4-dihydro-(1h)quinazolin-2-one compounds as csbp/p38 kinase inhibitors
|
|
ES2249309T3
(es)
|
1999-11-23 |
2006-04-01 |
Smithkline Beecham Corp |
Compuestos de 3,4-dihidro-(1h)quinazolin-2-ona como inhibidores de csbp/p39 kinasa.
|
|
US6759410B1
(en)
|
1999-11-23 |
2004-07-06 |
Smithline Beecham Corporation |
3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors
|
|
US6525046B1
(en)
|
2000-01-18 |
2003-02-25 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Aromatic heterocyclic compounds as antiinflammatory agents
|
|
US6608052B2
(en)
|
2000-02-16 |
2003-08-19 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Compounds useful as anti-inflammatory agents
|
|
US7235551B2
(en)
|
2000-03-02 |
2007-06-26 |
Smithkline Beecham Corporation |
1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
|
|
CA2403828A1
(en)
*
|
2000-03-22 |
2001-09-27 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of p38
|
|
AU2001283237B2
(en)
*
|
2000-08-11 |
2007-09-20 |
Vertex Pharmaceuticals Incorporated |
Pyridine derivatives as inhibitors of p38
|
|
PE20020506A1
(es)
*
|
2000-08-22 |
2002-07-09 |
Glaxo Group Ltd |
Derivados de pirazol fusionados como inhibidores de la proteina cinasa
|
|
US7998507B2
(en)
*
|
2000-09-21 |
2011-08-16 |
Elan Pharma International Ltd. |
Nanoparticulate compositions of mitogen-activated protein (MAP) kinase inhibitors
|
|
WO2002059083A2
(en)
|
2000-10-23 |
2002-08-01 |
Smithkline Beecham Corporation |
Novel compounds
|
|
US6867300B2
(en)
*
|
2000-11-17 |
2005-03-15 |
Bristol-Myers Squibb Company |
Methods for the preparation of pyrrolotriazine compounds useful as kinase inhibitors
|
|
US6670357B2
(en)
|
2000-11-17 |
2003-12-30 |
Bristol-Myers Squibb Company |
Methods of treating p38 kinase-associated conditions and pyrrolotriazine compounds useful as kinase inhibitors
|
|
CA2431904A1
(en)
|
2000-12-20 |
2002-08-01 |
Merck & Co., Inc. |
(halo-benzo carbonyl)heterocyclo fused phenyl p38 kinase inhibiting agents
|
|
DE60206363T2
(de)
*
|
2001-02-12 |
2006-07-06 |
F. Hoffmann-La Roche Ag |
6-substituierte pyridopyrimidine
|
|
GB0112348D0
(en)
*
|
2001-05-19 |
2001-07-11 |
Smithkline Beecham Plc |
Compounds
|
|
GB2375771A
(en)
*
|
2001-05-24 |
2002-11-27 |
Univ Leeds |
Decellularisation of tissue implant material
|
|
EP2036891A3
(en)
|
2001-06-11 |
2009-03-25 |
Vertex Pharmaceuticals Incorporated |
Isoquinoline inhibitors of P38
|
|
US20030066998A1
(en)
|
2001-08-02 |
2003-04-10 |
Lee Howard Wing Hoon |
Quantum dots of Group IV semiconductor materials
|
|
US6710366B1
(en)
|
2001-08-02 |
2004-03-23 |
Ultradots, Inc. |
Nanocomposite materials with engineered properties
|
|
US6794265B2
(en)
|
2001-08-02 |
2004-09-21 |
Ultradots, Inc. |
Methods of forming quantum dots of Group IV semiconductor materials
|
|
US6819845B2
(en)
|
2001-08-02 |
2004-11-16 |
Ultradots, Inc. |
Optical devices with engineered nonlinear nanocomposite materials
|
|
US7005669B1
(en)
|
2001-08-02 |
2006-02-28 |
Ultradots, Inc. |
Quantum dots, nanocomposite materials with quantum dots, devices with quantum dots, and related fabrication methods
|
|
GB0124936D0
(en)
*
|
2001-10-17 |
2001-12-05 |
Glaxo Group Ltd |
Chemical compounds
|
|
GB0124941D0
(en)
*
|
2001-10-17 |
2001-12-05 |
Glaxo Group Ltd |
Chemical compounds
|
|
GB0124934D0
(en)
*
|
2001-10-17 |
2001-12-05 |
Glaxo Group Ltd |
Chemical compounds
|
|
GB0124939D0
(en)
*
|
2001-10-17 |
2001-12-05 |
Glaxo Group Ltd |
Chemical compounds
|
|
GB0124933D0
(en)
*
|
2001-10-17 |
2001-12-05 |
Glaxo Group Ltd |
Chemical compounds
|
|
GB0124932D0
(en)
*
|
2001-10-17 |
2001-12-05 |
Glaxo Group Ltd |
Chemical compounds
|
|
GB0124931D0
(en)
*
|
2001-10-17 |
2001-12-05 |
Glaxo Group Ltd |
Chemical compounds
|
|
GB0124938D0
(en)
*
|
2001-10-17 |
2001-12-05 |
Glaxo Group Ltd |
Chemical compounds
|
|
EP1476840A4
(en)
*
|
2002-01-11 |
2007-05-09 |
Vertex Pharma |
CRYSTALLINE STRUCTURES OF JNK INHIBITION COMPLEXES AND BINDING POCKETS THEREOF
|
|
JP2005519895A
(ja)
*
|
2002-01-18 |
2005-07-07 |
ファルマシア・コーポレーション |
Ｐ３８阻害剤としての置換ピリダジノン
|
|
PL212910B1
(pl)
|
2002-02-12 |
2012-12-31 |
Smithkline Beecham Corp |
Pochodna nikotynoamidu, srodek farmaceutyczny i zastosowanie pochodnej nikotynoamidu
|
|
ES2299689T3
(es)
|
2002-02-25 |
2008-06-01 |
Boehringer Ingelheim Pharmaceuticals Inc. |
Compuestos de cicloalquil-uera fusionada con benzo 1,4-disustituido, utiles para el tratamiento de enfermedades por citoquinas.
|
|
EP1494664A2
(en)
*
|
2002-04-18 |
2005-01-12 |
Pharmacia Corporation |
Combinations of cox-2 inhibitors and other agents for the treatment of parkinson's disease
|
|
JP4603268B2
(ja)
|
2002-04-19 |
2010-12-22 |
グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー |
新規化合物
|
|
US7388009B2
(en)
*
|
2002-04-23 |
2008-06-17 |
Bristol-Myers Squibb Company |
Heteroaryl-substituted pyrrolo-triazine compounds useful as kinase inhibitors
|
|
JP4669225B2
(ja)
|
2002-04-23 |
2011-04-13 |
ブリストル−マイヤーズ スクイブ カンパニー |
キナーゼ阻害剤として有用なピロロトリアジンアニリン化合物
|
|
AU2003221753A1
(en)
*
|
2002-04-23 |
2003-11-10 |
Bristol-Myers Squibb Company |
Aryl ketone pyrrolo-triazine compounds useful as kinase inhibitors
|
|
TW200400034A
(en)
*
|
2002-05-20 |
2004-01-01 |
Bristol Myers Squibb Co |
Pyrazolo-pyrimidine aniline compounds useful as kinase inhibitors
|
|
CA2486183C
(en)
*
|
2002-05-23 |
2012-01-10 |
Cytopia Pty Ltd. |
Protein kinase inhibitors
|
|
EP1534282B1
(en)
|
2002-07-09 |
2006-12-27 |
Boehringer Ingelheim Pharma GmbH & Co.KG |
Pharmaceutical compositions of anticholinergics and p38 kinase inhibitors in the treatment of respiratory diseases
|
|
GB0217757D0
(en)
|
2002-07-31 |
2002-09-11 |
Glaxo Group Ltd |
Novel compounds
|
|
CN102266272B
(zh)
|
2002-11-27 |
2012-12-26 |
Dmi生物科学公司 |
一种个人护理组合物及其产品
|
|
GB0308186D0
(en)
*
|
2003-04-09 |
2003-05-14 |
Smithkline Beecham Corp |
Novel compounds
|
|
GB0308201D0
(en)
*
|
2003-04-09 |
2003-05-14 |
Smithkline Beecham Corp |
Novel compounds
|
|
GB0308185D0
(en)
*
|
2003-04-09 |
2003-05-14 |
Smithkline Beecham Corp |
Novel compounds
|
|
CA2524321A1
(en)
|
2003-05-01 |
2004-11-18 |
Bristol-Myers Squibb Company |
Aryl-substituted pyrazole-amide compounds useful as kinase inhibitors
|
|
AU2004247626B8
(en)
|
2003-05-15 |
2011-05-19 |
Arqule, Inc. |
Imidazothiazoles and imidazoxazole derivatives as inhibitors of p38
|
|
ATE439837T1
(de)
*
|
2003-06-03 |
2009-09-15 |
Novartis Ag |
5-gliedrige heterocyclische p-38 inhibitoren
|
|
PT1641764E
(pt)
|
2003-06-26 |
2011-10-27 |
Novartis Ag |
Inibidores de p38 quinase a base de heterociclo de 5 elementos
|
|
WO2005007632A1
(en)
*
|
2003-07-18 |
2005-01-27 |
Pharmacia Corporation |
Substituted pyridazinones as inhibitors of p38
|
|
ES2315703T3
(es)
|
2003-07-25 |
2009-04-01 |
Novartis Ag |
Inhibidores de la quinasa p-38.
|
|
GB0318814D0
(en)
*
|
2003-08-11 |
2003-09-10 |
Smithkline Beecham Corp |
Novel compounds
|
|
US7419978B2
(en)
*
|
2003-10-22 |
2008-09-02 |
Bristol-Myers Squibb Company |
Phenyl-aniline substituted bicyclic compounds useful as kinase inhibitors
|
|
PT1689715E
(pt)
|
2003-12-03 |
2011-05-16 |
Ym Biosciences Australia Pty |
Inibidores da tubulina
|
|
GB0402143D0
(en)
*
|
2004-01-30 |
2004-03-03 |
Smithkline Beecham Corp |
Novel compounds
|
|
US7829560B2
(en)
|
2004-07-08 |
2010-11-09 |
Arqule, Inc. |
1,4-disubstituted naphthalenes as inhibitors of P38 MAP kinase
|
|
US7504521B2
(en)
*
|
2004-08-05 |
2009-03-17 |
Bristol-Myers Squibb Co. |
Methods for the preparation of pyrrolotriazine compounds
|
|
US20060035893A1
(en)
|
2004-08-07 |
2006-02-16 |
Boehringer Ingelheim International Gmbh |
Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders
|
|
PE20060421A1
(es)
|
2004-08-12 |
2006-06-01 |
Bristol Myers Squibb Co |
Procedimiento para preparar un compuesto de pirrolotriazina anilina como inhibidores de cinasa
|
|
WO2006021848A1
(en)
*
|
2004-08-27 |
2006-03-02 |
Ranbaxy Laboratories Limited |
Anti-inflammatory agents
|
|
US20080051416A1
(en)
*
|
2004-10-05 |
2008-02-28 |
Smithkline Beecham Corporation |
Novel Compounds
|
|
EP2258704A1
(en)
|
2004-10-19 |
2010-12-08 |
ArQule, Inc. |
Synthesis of imidazooxazole and imidazothiazole inhibitors of p38 map kinase
|
|
PE20060777A1
(es)
|
2004-12-24 |
2006-10-06 |
Boehringer Ingelheim Int |
Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
|
|
US20060178388A1
(en)
*
|
2005-02-04 |
2006-08-10 |
Wrobleski Stephen T |
Phenyl-substituted pyrimidine compounds useful as kinase inhibitors
|
|
UY29439A1
(es)
|
2005-03-25 |
2006-10-02 |
Glaxo Group Ltd |
Nuevos compuestos
|
|
US20090137550A1
(en)
|
2005-03-25 |
2009-05-28 |
Glaxo Group Limited |
Novel Compounds
|
|
PE20100737A1
(es)
|
2005-03-25 |
2010-11-27 |
Glaxo Group Ltd |
Nuevos compuestos
|
|
SG160438A1
(en)
|
2005-03-25 |
2010-04-29 |
Glaxo Group Ltd |
Process for preparing pyrido[2,3-d]pyrimidin-7-one and 3,4-dihydropyrimido[4,5- d]pyrimidin-2(1h)-one derivatives
|
|
US20060235020A1
(en)
*
|
2005-04-18 |
2006-10-19 |
Soojin Kim |
Process for preparing salts of 4-[[5-[(cyclopropylamino)carbonyl]-2-methylphenyl]amino]-5-methyl-N-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide and novel stable forms produced therein
|
|
GB0512429D0
(en)
*
|
2005-06-17 |
2005-07-27 |
Smithkline Beecham Corp |
Novel compound
|
|
US7473784B2
(en)
*
|
2005-08-01 |
2009-01-06 |
Bristol-Myers Squibb Company |
Benzothiazole and azabenzothiazole compounds useful as kinase inhibitors
|
|
AU2006280090B2
(en)
*
|
2005-08-12 |
2012-03-01 |
Merck Sharp & Dohme Corp. |
Heterobicyclic compounds useful as p38 kinase inhibiting agents
|
|
BRPI0617948A2
(pt)
|
2005-10-28 |
2011-08-09 |
Takeda Pharmaceutical |
composto, pró-droga de um composto, agente farmacêutico, método para inibir uma metaloproteinase de matriz, e, uso de um composto
|
|
EP2001886A2
(en)
*
|
2006-03-07 |
2008-12-17 |
Bristol-Myers Squibb Company |
Pyrrolotriazine aniline prodrug compounds useful as kinase inhibitors
|
|
JP2010508288A
(ja)
*
|
2006-10-27 |
2010-03-18 |
ブリストル−マイヤーズ スクイブ カンパニー |
キナーゼ阻害剤として有用なヘテロサイクリックアミド化合物
|
|
US7943617B2
(en)
|
2006-11-27 |
2011-05-17 |
Bristol-Myers Squibb Company |
Heterobicyclic compounds useful as kinase inhibitors
|
|
JP2010522155A
(ja)
*
|
2007-03-20 |
2010-07-01 |
カディラ ファーマシューティカルズ リミテッド |
Ｐ３８阻害剤
|
|
EP1992344A1
(en)
|
2007-05-18 |
2008-11-19 |
Institut Curie |
P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation
|
|
EP2108641A1
(en)
*
|
2008-04-11 |
2009-10-14 |
Laboratorios Almirall, S.A. |
New substituted spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one derivatives and their use as p38 mitogen-activated kinase inhibitors
|
|
EP2111861A1
(en)
|
2008-04-21 |
2009-10-28 |
Ranbaxy Laboratories Limited |
Compositions of phosphodiesterase type IV inhibitors
|
|
CN102131805A
(zh)
|
2008-06-20 |
2011-07-20 |
百时美施贵宝公司 |
用作激酶抑制剂的咪唑并吡啶和咪唑并吡嗪化合物
|
|
CN102131806A
(zh)
*
|
2008-06-20 |
2011-07-20 |
百时美施贵宝公司 |
用作激酶抑制剂的三唑并吡啶化合物
|
|
WO2010038428A1
(ja)
*
|
2008-09-30 |
2010-04-08 |
武田薬品工業株式会社 |
タキサン系抗がん剤の置き換え薬
|
|
EP2393806B1
(en)
|
2009-02-06 |
2017-10-25 |
Elan Pharmaceuticals, Inc. |
Inhibitors of jun n-terminal kinase
|
|
GB0902648D0
(en)
|
2009-02-17 |
2009-04-01 |
Argenta Discovery Ltd |
Pharmaceutical compounds and compositions
|
|
GB0908317D0
(en)
*
|
2009-05-14 |
2009-06-24 |
Argenta Discovery Ltd |
Pharmaceutical compounds and compositions
|
|
WO2012031057A1
(en)
|
2010-09-01 |
2012-03-08 |
Bristol-Myers Squibb Company |
Bms- 582949 for the treatment of resistant rheumatic disease
|
|
CA2835707C
(en)
*
|
2011-05-09 |
2019-02-26 |
Eip Pharma, Llc |
Compositions and methods for treating alzheimer's disease
|
|
ES2897740T3
(es)
|
2011-12-28 |
2022-03-02 |
Kyoto Prefectural Public Univ Corp |
Normalización del cultivo de células endoteliales de la córnea
|
|
CN103772392A
(zh)
*
|
2012-10-23 |
2014-05-07 |
杨子娇 |
一类治疗房角狭窄的化合物及其用途
|
|
WO2015072580A1
(ja)
|
2013-11-14 |
2015-05-21 |
学校法人同志社 |
細胞増殖促進または細胞障害抑制による角膜内皮治療薬
|
|
US9579322B2
(en)
|
2014-07-09 |
2017-02-28 |
Eip Pharma, Llc |
Methods for treating neurologic disorders
|
|
CA3003433A1
(en)
|
2015-10-27 |
2017-05-04 |
Children's Hospital Medical Center |
Use of mapk inhibitors to reduce loss of hematopoietic stem cells during ex vivo culture and/or genetic manipulation
|
|
US20190060286A1
(en)
|
2016-02-29 |
2019-02-28 |
University Of Florida Research Foundation, Incorpo |
Chemotherapeutic Methods
|
|
US11466008B2
(en)
|
2017-09-18 |
2022-10-11 |
Eip Pharma, Llc |
Co-crystals of neflamapimod (VX-745)
|
|
US10342786B2
(en)
|
2017-10-05 |
2019-07-09 |
Fulcrum Therapeutics, Inc. |
P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
|
|
EP3691620B1
(en)
|
2017-10-05 |
2022-07-27 |
Fulcrum Therapeutics, Inc. |
P38 kinase inhibitors reduce dux4 and downstream gene expression for the treatment of fshd
|
|
CR20200464A
(es)
|
2018-03-08 |
2021-04-14 |
Incyte Corp |
Compuestos diólicos de aminopirazina como inhibidores de pi3k-y
|
|
US11046658B2
(en)
|
2018-07-02 |
2021-06-29 |
Incyte Corporation |
Aminopyrazine derivatives as PI3K-γ inhibitors
|
|
US20220048915A1
(en)
*
|
2018-11-30 |
2022-02-17 |
Shanghai Pharmaceuticals Holding Co., Ltd. |
Nitrogen-containing Heterocyclic Compound and Composition Thereof, Preparation Method Therefor, and Application Thereof
|