JP2001503737A - 糖尿病の発生を防止するためのシブトラミン類似体の利用 - Google Patents
糖尿病の発生を防止するためのシブトラミン類似体の利用Info
- Publication number
- JP2001503737A JP2001503737A JP51427198A JP51427198A JP2001503737A JP 2001503737 A JP2001503737 A JP 2001503737A JP 51427198 A JP51427198 A JP 51427198A JP 51427198 A JP51427198 A JP 51427198A JP 2001503737 A JP2001503737 A JP 2001503737A
- Authority
- JP
- Japan
- Prior art keywords
- insulin
- formula
- compound
- human
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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- POULHZVOKOAJMA-UHFFFAOYSA-M dodecanoate Chemical compound CCCCCCCCCCCC([O-])=O POULHZVOKOAJMA-UHFFFAOYSA-M 0.000 description 1
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- 235000019359 magnesium stearate Nutrition 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
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- LSTZYJQJHGEVKH-UHFFFAOYSA-N n,n-dimethylpentan-2-amine Chemical compound CCCC(C)N(C)C LSTZYJQJHGEVKH-UHFFFAOYSA-N 0.000 description 1
- 210000003928 nasal cavity Anatomy 0.000 description 1
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- 239000012188 paraffin wax Substances 0.000 description 1
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- 238000007911 parenteral administration Methods 0.000 description 1
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- 229940066842 petrolatum Drugs 0.000 description 1
- 239000002953 phosphate buffered saline Substances 0.000 description 1
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- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
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- 102000005962 receptors Human genes 0.000 description 1
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- 230000009467 reduction Effects 0.000 description 1
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- 230000000717 retained effect Effects 0.000 description 1
- 229960003466 sibutramine hydrochloride Drugs 0.000 description 1
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- 150000003890 succinate salts Chemical class 0.000 description 1
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- 239000000375 suspending agent Substances 0.000 description 1
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- 229920003002 synthetic resin Polymers 0.000 description 1
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- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
Landscapes
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Electrotherapy Devices (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9619757.9 | 1996-09-21 | ||
| GBGB9619757.9A GB9619757D0 (en) | 1996-09-21 | 1996-09-21 | Chemical process |
| PCT/EP1997/005039 WO1998011884A1 (en) | 1996-09-21 | 1997-09-15 | Use of sibutramine analogues to prevent the development of diabetes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001503737A true JP2001503737A (ja) | 2001-03-21 |
| JP2001503737A5 JP2001503737A5 (https=) | 2005-04-07 |
Family
ID=10800326
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP51427198A Ceased JP2001503737A (ja) | 1996-09-21 | 1997-09-15 | 糖尿病の発生を防止するためのシブトラミン類似体の利用 |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US6174925B1 (https=) |
| EP (1) | EP0927028A1 (https=) |
| JP (1) | JP2001503737A (https=) |
| KR (1) | KR20000048501A (https=) |
| CN (1) | CN1237905A (https=) |
| AU (1) | AU724488B2 (https=) |
| BG (1) | BG64473B1 (https=) |
| BR (1) | BR9711517A (https=) |
| CA (1) | CA2266401C (https=) |
| CZ (1) | CZ93699A3 (https=) |
| GB (1) | GB9619757D0 (https=) |
| HR (1) | HRP970505A2 (https=) |
| HU (1) | HUP9904026A3 (https=) |
| ID (1) | ID18320A (https=) |
| IL (1) | IL128850A (https=) |
| MY (1) | MY116150A (https=) |
| NO (1) | NO991358D0 (https=) |
| NZ (1) | NZ334580A (https=) |
| PL (1) | PL332305A1 (https=) |
| RU (1) | RU2245709C2 (https=) |
| SK (1) | SK31999A3 (https=) |
| TR (1) | TR199900618T2 (https=) |
| TW (1) | TW580385B (https=) |
| UA (1) | UA64726C2 (https=) |
| WO (1) | WO1998011884A1 (https=) |
| ZA (1) | ZA978450B (https=) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9619757D0 (en) * | 1996-09-21 | 1996-11-06 | Knoll Ag | Chemical process |
| WO2000000195A1 (en) * | 1998-06-30 | 2000-01-06 | Takeda Chemical Industries, Ltd. | Pharmaceutical composition for the treatment of diabetes |
| JP2000080047A (ja) * | 1998-06-30 | 2000-03-21 | Takeda Chem Ind Ltd | 医 薬 |
| US6974838B2 (en) | 1998-08-24 | 2005-12-13 | Sepracor Inc. | Methods of treating or preventing pain using sibutramine metabolites |
| US6339106B1 (en) | 1999-08-11 | 2002-01-15 | Sepracor, Inc. | Methods and compositions for the treatment and prevention of sexual dysfunction |
| US6331571B1 (en) | 1998-08-24 | 2001-12-18 | Sepracor, Inc. | Methods of treating and preventing attention deficit disorders |
| US6476078B2 (en) * | 1999-08-11 | 2002-11-05 | Sepracor, Inc. | Methods of using sibutramine metabolites in combination with a phosphodiesterase inhibitor to treat sexual dysfunction |
| HK1040910B (en) * | 1998-11-12 | 2009-06-26 | Smithkline Beecham Plc | Pharmaceutical composition for modified release of an insulin sensitiser and metformin |
| US20040102486A1 (en) * | 1998-11-12 | 2004-05-27 | Smithkline Beecham Corporation | Novel method of treatment |
| AR023700A1 (es) * | 1998-11-12 | 2002-09-04 | Smithkline Beecham Plc | Un procedimiento para preparar una composicion farmaceutica que comprende un sensibilizador de insulina |
| US6696495B2 (en) | 1998-12-02 | 2004-02-24 | Snowden Pharmaceuticals, Llc | Treatment of disorders secondary to organic impairments |
| US6323242B1 (en) | 1998-12-02 | 2001-11-27 | Peter Sterling Mueller | Treatment of disorders secondary to organic impairments |
| US6552087B1 (en) | 1999-03-19 | 2003-04-22 | Abbott Gmbh & Co. Kg | Therapeutic agent comprising (+)-sibutramine |
| US6723717B1 (en) | 1999-06-01 | 2004-04-20 | The University Of Texas Southwestern Medical Center | Sulfur-containing thyroxane derivatives and their use as hair growth promotors |
| CA2374260A1 (en) | 1999-06-01 | 2000-12-07 | The University Of Texas Southwestern Medical Center | Method of treating hair loss using sulfonyl thyromimetic compounds |
| US6680344B1 (en) | 1999-06-01 | 2004-01-20 | The University Of Texas Southwestern Medical Center | Method of treating hair loss using diphenylmethane derivatives |
| GB9914744D0 (en) * | 1999-06-24 | 1999-08-25 | Knoll Ag | Therapeutic agents |
| US6399826B1 (en) | 1999-08-11 | 2002-06-04 | Sepracor Inc. | Salts of sibutramine metabolites, methods of making sibutramine metabolites and intermediates useful in the same, and methods of treating pain |
| US6610887B2 (en) | 2001-04-13 | 2003-08-26 | Sepracor Inc. | Methods of preparing didesmethylsibutramine and other sibutramine derivatives |
| WO2003105809A1 (en) | 2002-06-17 | 2003-12-24 | Themis Laboratories Private Limited | Multilayer tablets containing thiazolidinedione and biguanides and methods for producing them |
| JP4278652B2 (ja) * | 2002-10-05 | 2009-06-17 | ハンミ ファーム． シーオー．， エルティーディー． | 結晶性シブトラミンメタンスルホン酸塩半水和物を含む医薬組成物 |
| US20050131074A1 (en) * | 2003-08-04 | 2005-06-16 | Beckman Kristen M. | Methods for treating metabolic syndrome |
| PE20050335A1 (es) * | 2003-08-07 | 2005-06-01 | Sb Pharmco Inc | Forma de dosificacion oral que comprende 5-[4-[2-(n-metil-n-(2-piridil)amino)etoxi]bencil]tiazolidin-2,4-diona y procedimiento para la preparacion |
| GB0318824D0 (en) * | 2003-08-11 | 2003-09-10 | Glaxo Group Ltd | Novel composition |
| MXPA06004639A (es) * | 2003-10-31 | 2006-06-27 | Takeda Pharmaceutical | Preparacion solida que comprende sensibilizador de insulina, secretagogo de insulina y ester de acidos grasos de polioxietileno sorbitano. |
| KR100627687B1 (ko) * | 2005-04-20 | 2006-09-25 | 주식회사 씨티씨바이오 | 시부트라민 유리염기 함유 조성물 및 이의 제조방법 |
| US20070203111A1 (en) | 2006-01-06 | 2007-08-30 | Sepracor Inc. | Cycloalkylamines as monoamine reuptake inhibitors |
| WO2008034142A2 (en) | 2006-09-15 | 2008-03-20 | Reviva Pharmaceuticals, Inc. | Synthesis, methods of using, and compositions of cycloalkylmethylamines |
| US8604244B2 (en) | 2010-07-02 | 2013-12-10 | Reviva Pharmaceuticals, Inc. | Compositions, synthesis, and methods of using cycloalkylmethylamine derivatives |
| KR100812538B1 (ko) * | 2006-10-23 | 2008-03-11 | 한올제약주식회사 | 약물 제어방출형 메트포르민-글리메피리드 복합제제 |
| KR20080046601A (ko) * | 2006-11-22 | 2008-05-27 | 에스케이케미칼주식회사 | 보관안정성이 우수한 시부트라민 함유 포접복합체 |
| EP2952522B1 (en) | 2007-01-31 | 2019-10-30 | Dana-Farber Cancer Institute, Inc. | Stabilized p53 peptides and uses thereof |
| AU2008232709C1 (en) | 2007-03-28 | 2015-01-15 | President And Fellows Of Harvard College | Stitched polypeptides |
| US20110027458A1 (en) | 2009-07-02 | 2011-02-03 | Dexcom, Inc. | Continuous analyte sensors and methods of making same |
| KR20170058446A (ko) | 2010-08-13 | 2017-05-26 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티도미메틱 거대고리 |
| AR088392A1 (es) | 2011-10-18 | 2014-05-28 | Aileron Therapeutics Inc | Macrociclos peptidomimeticos |
| RU2642074C2 (ru) | 2011-12-30 | 2018-01-24 | Ревива Фармасьютикалс, Инк. | Композиции, синтез и способы применения производных фенилциклоалкилметиламина |
| HK1205454A1 (en) | 2012-02-15 | 2015-12-18 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
| CA2862038C (en) | 2012-02-15 | 2021-05-25 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| BR112015009470A2 (pt) | 2012-11-01 | 2019-12-17 | Aileron Therapeutics Inc | aminoácidos dissubstituídos e seus métodos de preparação e uso |
| WO2016049359A1 (en) | 2014-09-24 | 2016-03-31 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| US10253067B2 (en) | 2015-03-20 | 2019-04-09 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE52768B1 (en) * | 1981-04-06 | 1988-02-17 | Boots Co Ltd | 1-arylcyclobutylalkylamine compounds useful as therapeutic agents |
| GB8531071D0 (en) * | 1985-12-17 | 1986-01-29 | Boots Co Plc | Therapeutic compound |
| GB8704777D0 (en) * | 1987-02-28 | 1987-04-01 | Boots Co Plc | Medical treatment |
| JP2675573B2 (ja) * | 1988-03-31 | 1997-11-12 | 科研製薬株式会社 | 脳機能改善剤 |
| IE61928B1 (en) * | 1988-11-29 | 1994-11-30 | Boots Co Plc | Treatment of obesity |
| WO1995010292A1 (en) | 1993-10-14 | 1995-04-20 | Biomedica California, Inc. | Diabetes treatment and prophylaxis |
| US5459164A (en) * | 1994-02-03 | 1995-10-17 | Boots Pharmaceuticals, Inc. | Medical treatment |
| GB9619757D0 (en) * | 1996-09-21 | 1996-11-06 | Knoll Ag | Chemical process |
-
1996
- 1996-09-21 GB GBGB9619757.9A patent/GB9619757D0/en active Pending
-
1997
- 1997-09-15 RU RU99108468/14A patent/RU2245709C2/ru not_active IP Right Cessation
- 1997-09-15 UA UA99042263A patent/UA64726C2/uk unknown
- 1997-09-15 CN CN97199787A patent/CN1237905A/zh active Pending
- 1997-09-15 AU AU47740/97A patent/AU724488B2/en not_active Ceased
- 1997-09-15 KR KR1019990702397A patent/KR20000048501A/ko not_active Ceased
- 1997-09-15 PL PL97332305A patent/PL332305A1/xx unknown
- 1997-09-15 IL IL12885097A patent/IL128850A/xx not_active IP Right Cessation
- 1997-09-15 WO PCT/EP1997/005039 patent/WO1998011884A1/en not_active Ceased
- 1997-09-15 TR TR1999/00618T patent/TR199900618T2/xx unknown
- 1997-09-15 CZ CZ99936A patent/CZ93699A3/cs unknown
- 1997-09-15 CA CA002266401A patent/CA2266401C/en not_active Expired - Fee Related
- 1997-09-15 BR BR9711517A patent/BR9711517A/pt not_active IP Right Cessation
- 1997-09-15 SK SK319-99A patent/SK31999A3/sk unknown
- 1997-09-15 EP EP97910288A patent/EP0927028A1/en not_active Ceased
- 1997-09-15 JP JP51427198A patent/JP2001503737A/ja not_active Ceased
- 1997-09-15 US US09/254,924 patent/US6174925B1/en not_active Expired - Lifetime
- 1997-09-15 NZ NZ334580A patent/NZ334580A/xx not_active IP Right Cessation
- 1997-09-15 HU HU9904026A patent/HUP9904026A3/hu unknown
- 1997-09-18 HR HR9619757.9A patent/HRP970505A2/hr not_active Application Discontinuation
- 1997-09-19 ZA ZA978450A patent/ZA978450B/xx unknown
- 1997-09-20 MY MYPI97004383A patent/MY116150A/en unknown
- 1997-09-22 ID IDP973256A patent/ID18320A/id unknown
- 1997-09-24 TW TW086113897A patent/TW580385B/zh not_active IP Right Cessation
-
1999
- 1999-03-19 NO NO991358A patent/NO991358D0/no not_active Application Discontinuation
- 1999-03-24 BG BG103277A patent/BG64473B1/bg unknown
-
2000
- 2000-10-30 US US09/702,125 patent/US6617360B1/en not_active Expired - Fee Related
-
2003
- 2003-08-15 US US10/641,506 patent/US20040077730A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| TW580385B (en) | 2004-03-21 |
| PL332305A1 (en) | 1999-08-30 |
| MY116150A (en) | 2003-11-28 |
| HRP970505A2 (en) | 1998-08-31 |
| TR199900618T2 (xx) | 1999-06-21 |
| CA2266401C (en) | 2007-01-30 |
| AU4774097A (en) | 1998-04-14 |
| IL128850A0 (en) | 2000-01-31 |
| HUP9904026A2 (hu) | 2000-05-28 |
| UA64726C2 (uk) | 2004-03-15 |
| US20040077730A1 (en) | 2004-04-22 |
| NO991358L (no) | 1999-03-19 |
| ID18320A (id) | 1998-03-26 |
| WO1998011884A1 (en) | 1998-03-26 |
| CA2266401A1 (en) | 1998-03-26 |
| EP0927028A1 (en) | 1999-07-07 |
| BR9711517A (pt) | 1999-08-24 |
| ZA978450B (en) | 1999-03-19 |
| IL128850A (en) | 2003-07-31 |
| NO991358D0 (no) | 1999-03-19 |
| AU724488B2 (en) | 2000-09-21 |
| CZ93699A3 (cs) | 1999-08-11 |
| SK31999A3 (en) | 1999-12-10 |
| BG64473B1 (bg) | 2005-04-30 |
| US6174925B1 (en) | 2001-01-16 |
| US6617360B1 (en) | 2003-09-09 |
| CN1237905A (zh) | 1999-12-08 |
| BG103277A (en) | 2000-01-31 |
| RU2245709C2 (ru) | 2005-02-10 |
| NZ334580A (en) | 2000-09-29 |
| GB9619757D0 (en) | 1996-11-06 |
| HUP9904026A3 (en) | 2000-07-28 |
| KR20000048501A (ko) | 2000-07-25 |
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