JP2001501637A5 - - Google Patents
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- Publication number
- JP2001501637A5 JP2001501637A5 JP1998517154A JP51715498A JP2001501637A5 JP 2001501637 A5 JP2001501637 A5 JP 2001501637A5 JP 1998517154 A JP1998517154 A JP 1998517154A JP 51715498 A JP51715498 A JP 51715498A JP 2001501637 A5 JP2001501637 A5 JP 2001501637A5
- Authority
- JP
- Japan
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT96MI002048A IT1285770B1 (it) | 1996-10-04 | 1996-10-04 | Composti corticoidei |
| IT96A002048 | 1996-10-04 | ||
| PCT/EP1997/005426 WO1998015568A2 (en) | 1996-10-04 | 1997-10-02 | Nitrate esters of corticoid compounds and pharmaceutical applications thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2001501637A JP2001501637A (ja) | 2001-02-06 |
| JP2001501637A5 true JP2001501637A5 (enExample) | 2005-05-12 |
| JP4388600B2 JP4388600B2 (ja) | 2009-12-24 |
Family
ID=11374972
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP51715498A Expired - Fee Related JP4388600B2 (ja) | 1996-10-04 | 1997-10-02 | コルチコイド化合物の硝酸エステル類およびその薬学的使用 |
Country Status (18)
| Country | Link |
|---|---|
| US (8) | US6610676B1 (enExample) |
| EP (1) | EP0929565B1 (enExample) |
| JP (1) | JP4388600B2 (enExample) |
| KR (1) | KR100487898B1 (enExample) |
| CN (1) | CN1142939C (enExample) |
| AT (1) | ATE218142T1 (enExample) |
| AU (1) | AU719250B2 (enExample) |
| BR (1) | BR9711586A (enExample) |
| CA (1) | CA2267630C (enExample) |
| DE (1) | DE69712900T2 (enExample) |
| DK (1) | DK0929565T3 (enExample) |
| ES (1) | ES2177952T3 (enExample) |
| HU (1) | HUP9904149A3 (enExample) |
| IT (1) | IT1285770B1 (enExample) |
| PT (1) | PT929565E (enExample) |
| RU (1) | RU2186781C2 (enExample) |
| SI (1) | SI0929565T1 (enExample) |
| WO (1) | WO1998015568A2 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5824669A (en) | 1996-03-22 | 1998-10-20 | Nitromed, Inc. | Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders |
| IT1285770B1 (it) * | 1996-10-04 | 1998-06-18 | Nicox Sa | Composti corticoidei |
| IT1311922B1 (it) | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
| IT1314184B1 (it) | 1999-08-12 | 2002-12-06 | Nicox Sa | Composizioni farmaceutiche per la terapia di condizioni di stressossidativo |
| IT1320176B1 (it) * | 2000-12-22 | 2003-11-26 | Nicox Sa | Dispersioni solide di principi attivi nitrati. |
| EP1219306A1 (en) | 2000-12-29 | 2002-07-03 | Nicox S.A. | Compositions comprising cyclodextrins and NO- releasing drugs |
| US6696592B2 (en) | 2001-05-22 | 2004-02-24 | Nicox-S.A. | Methods of making 21-[4′-(nitrooxyalkyl)benzoate] corticosteroid derivatives and intermediates useful in the synthesis thereof |
| WO2003029268A1 (en) | 2001-10-03 | 2003-04-10 | Merck & Co., Inc. | Androstane 17-beta-carboxamides as androgen receptor modulators |
| ITMI20020148A1 (it) | 2002-01-29 | 2003-07-29 | Nicox Sa | Nuovi corticosteroidi |
| RU2261481C2 (ru) * | 2003-03-26 | 2005-09-27 | ФГУ Омская государственная медицинская академия | Способ моделирования септического шока и полиорганной недостаточности у мелких лабораторных животных |
| CN100513415C (zh) * | 2005-08-03 | 2009-07-15 | 中国人民解放军军事医学科学院毒物药物研究所 | 胆汁酸衍生物及其医药用途 |
| AU2006286838C1 (en) | 2005-09-02 | 2013-05-02 | Ferrer Internacional S.A. | Nitrooxy derivatives of glucocorticoids |
| US8802726B2 (en) | 2006-02-03 | 2014-08-12 | Nicox S.A. | Use of nitrooxyderivative of drug for the treatment of muscular dystrophies |
| US7893058B2 (en) * | 2006-05-15 | 2011-02-22 | Janssen Pharmaceutica Nv | Imidazolopyrazine compounds useful for the treatment of degenerative and inflammatory diseases |
| CN101652380A (zh) * | 2007-02-05 | 2010-02-17 | 尼科克斯公司 | 释放一氧化氮的类固醇 |
| CA2695435A1 (en) * | 2007-08-10 | 2009-03-26 | Nicox S.A. | Combination of nitroderivatized steroid and bronchodilator for treating respiratory disease |
| WO2009071990A2 (en) * | 2007-08-31 | 2009-06-11 | Topigen Pharmaceuticals Inc. | No-donating cordicosteroid with improved pharmacokinetic, anti-inflammatory and vasodilatory properties |
| EP2318427B1 (en) * | 2008-07-31 | 2013-10-23 | Nicox S.A. | Glucocorticoids attached to nitrate esters via an aromatic linker in position 21 and their use in ophthalmology |
| CA2731477A1 (en) * | 2008-08-05 | 2010-02-11 | Nicox S.A. | New no releasing steroids derivatives |
| US20110130375A1 (en) | 2008-08-05 | 2011-06-02 | Nicox S.A. | New no-releasing steroids for the treatment of retina and macula lutea diseases |
| AU2011243947A1 (en) | 2010-04-23 | 2012-12-06 | Piramal Enterprises Limited | Nitric oxide releasing prodrugs of therapeutic agents |
| US8716268B2 (en) | 2010-06-07 | 2014-05-06 | Chao Liu | Nitrate esters of corticoid compounds useful as diuretics |
| CA2897571C (en) | 2013-01-21 | 2018-12-18 | Apparao Satyam | Nitric oxide releasing prodrugs of therapeutic agents containing at least one carboxylic acid group |
| CN108191938B (zh) * | 2018-01-11 | 2019-07-05 | 湖南新合新生物医药有限公司 | 9,11烯烃甾族化合物的制备方法 |
| CN113069460B (zh) * | 2021-03-24 | 2022-02-08 | 兰州大学 | 哈西奈德及其衍生物用于制备治疗和/或预防脑血管疾病药物中的应用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2990401A (en) * | 1958-06-18 | 1961-06-27 | American Cyanamid Co | 11-substituted 16alpha, 17alpha-substituted methylenedioxy steroids |
| GB1054290A (enExample) * | 1963-05-01 | |||
| US3183252A (en) * | 1963-09-05 | 1965-05-11 | Syntex Corp | 16-nitratoalkyl-pregnanes |
| US3494941A (en) * | 1967-12-04 | 1970-02-10 | American Home Prod | Nitrate esters of 17beta-(hydroxyalkoxy)steroid 3-ols,3-ones and 3-amidinohydrazones |
| HU164115B (enExample) * | 1971-05-07 | 1973-12-28 | ||
| CH622811A5 (enExample) * | 1974-03-27 | 1981-04-30 | Plurichemie Anstalt | |
| CA1058161A (en) * | 1975-09-08 | 1979-07-10 | Ravi K. Varma | 3,20-DIKETOPREGNENES HAVING AN 11.beta.-ACETAL GROUP AND DERIVATIVES THEREOF |
| IT1256345B (it) | 1992-08-20 | 1995-12-01 | Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione | |
| IT1256450B (it) | 1992-11-26 | 1995-12-05 | Soldato Piero Del | Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione |
| US5457207A (en) | 1993-10-05 | 1995-10-10 | Regents Of The University Of Minnesota | Spirovesamicols |
| JP3775796B2 (ja) | 1993-10-06 | 2006-05-17 | ニコックス エス エイ | 抗炎症活性及び／又は鎮痛活性を有する硝酸エステル類及びそれらの製造方法 |
| ATE184589T1 (de) | 1994-05-10 | 1999-10-15 | Nicox Sa | Nitroverbindingen und ihre zubereitungen mit entzündungsremmenden, schmertzlindernden und antithrombotischen wirkungen |
| US5824669A (en) * | 1996-03-22 | 1998-10-20 | Nitromed, Inc. | Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders |
| US5985862A (en) * | 1996-05-02 | 1999-11-16 | G.D. Searle & Co. | Pharmaceutical compositions having steroid nitrate ester derivatives useful as anti-inflammatory drugs |
| US5837698A (en) * | 1996-05-02 | 1998-11-17 | G. D. Searle & Co. | Steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs |
| IT1285770B1 (it) * | 1996-10-04 | 1998-06-18 | Nicox Sa | Composti corticoidei |
-
1996
- 1996-10-04 IT IT96MI002048A patent/IT1285770B1/it active IP Right Grant
-
1997
- 1997-10-02 JP JP51715498A patent/JP4388600B2/ja not_active Expired - Fee Related
- 1997-10-02 DE DE69712900T patent/DE69712900T2/de not_active Expired - Lifetime
- 1997-10-02 CN CNB97180284XA patent/CN1142939C/zh not_active Expired - Fee Related
- 1997-10-02 PT PT97910409T patent/PT929565E/pt unknown
- 1997-10-02 AU AU47803/97A patent/AU719250B2/en not_active Ceased
- 1997-10-02 RU RU99108661/04A patent/RU2186781C2/ru not_active IP Right Cessation
- 1997-10-02 WO PCT/EP1997/005426 patent/WO1998015568A2/en not_active Ceased
- 1997-10-02 ES ES97910409T patent/ES2177952T3/es not_active Expired - Lifetime
- 1997-10-02 AT AT97910409T patent/ATE218142T1/de active
- 1997-10-02 DK DK97910409T patent/DK0929565T3/da active
- 1997-10-02 HU HU9904149A patent/HUP9904149A3/hu unknown
- 1997-10-02 SI SI9730333T patent/SI0929565T1/xx unknown
- 1997-10-02 BR BR9711586A patent/BR9711586A/pt not_active Application Discontinuation
- 1997-10-02 EP EP97910409A patent/EP0929565B1/en not_active Expired - Lifetime
- 1997-10-02 CA CA002267630A patent/CA2267630C/en not_active Expired - Fee Related
- 1997-10-02 US US09/269,729 patent/US6610676B1/en not_active Expired - Fee Related
- 1997-10-02 KR KR10-1999-7002942A patent/KR100487898B1/ko not_active Expired - Fee Related
-
2003
- 2003-06-17 US US10/462,637 patent/US7056905B2/en not_active Expired - Fee Related
-
2006
- 2006-03-14 US US11/374,219 patent/US7157450B2/en not_active Expired - Fee Related
- 2006-03-14 US US11/374,220 patent/US7160871B2/en not_active Expired - Fee Related
- 2006-03-14 US US11/374,315 patent/US7196075B2/en not_active Expired - Fee Related
- 2006-06-02 US US11/445,140 patent/US7205288B2/en not_active Expired - Fee Related
-
2007
- 2007-03-07 US US11/714,724 patent/US7368442B2/en not_active Expired - Fee Related
-
2008
- 2008-03-19 US US12/051,434 patent/US7605151B2/en not_active Expired - Fee Related