CN1142939C - 类皮质激素化合物的硝酸酯及其药物应用 - Google Patents

类皮质激素化合物的硝酸酯及其药物应用 Download PDF

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Publication number
CN1142939C
CN1142939C CNB97180284XA CN97180284A CN1142939C CN 1142939 C CN1142939 C CN 1142939C CN B97180284X A CNB97180284X A CN B97180284XA CN 97180284 A CN97180284 A CN 97180284A CN 1142939 C CN1142939 C CN 1142939C
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China
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integer
group
application
medicine
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Chinese (zh)
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CN1253563A (zh
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P
P·德索尔达托
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Nicox SA
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Nicox SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CNB97180284XA 1996-10-04 1997-10-02 类皮质激素化合物的硝酸酯及其药物应用 Expired - Fee Related CN1142939C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT96MI002048A IT1285770B1 (it) 1996-10-04 1996-10-04 Composti corticoidei
ITMI96A002048 1996-10-04

Publications (2)

Publication Number Publication Date
CN1253563A CN1253563A (zh) 2000-05-17
CN1142939C true CN1142939C (zh) 2004-03-24

Family

ID=11374972

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB97180284XA Expired - Fee Related CN1142939C (zh) 1996-10-04 1997-10-02 类皮质激素化合物的硝酸酯及其药物应用

Country Status (18)

Country Link
US (8) US6610676B1 (enExample)
EP (1) EP0929565B1 (enExample)
JP (1) JP4388600B2 (enExample)
KR (1) KR100487898B1 (enExample)
CN (1) CN1142939C (enExample)
AT (1) ATE218142T1 (enExample)
AU (1) AU719250B2 (enExample)
BR (1) BR9711586A (enExample)
CA (1) CA2267630C (enExample)
DE (1) DE69712900T2 (enExample)
DK (1) DK0929565T3 (enExample)
ES (1) ES2177952T3 (enExample)
HU (1) HUP9904149A3 (enExample)
IT (1) IT1285770B1 (enExample)
PT (1) PT929565E (enExample)
RU (1) RU2186781C2 (enExample)
SI (1) SI0929565T1 (enExample)
WO (1) WO1998015568A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100513415C (zh) * 2005-08-03 2009-07-15 中国人民解放军军事医学科学院毒物药物研究所 胆汁酸衍生物及其医药用途

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5824669A (en) 1996-03-22 1998-10-20 Nitromed, Inc. Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
IT1285770B1 (it) * 1996-10-04 1998-06-18 Nicox Sa Composti corticoidei
IT1311922B1 (it) * 1999-04-13 2002-03-20 Nicox Sa Composti farmaceutici.
IT1314184B1 (it) 1999-08-12 2002-12-06 Nicox Sa Composizioni farmaceutiche per la terapia di condizioni di stressossidativo
IT1320176B1 (it) * 2000-12-22 2003-11-26 Nicox Sa Dispersioni solide di principi attivi nitrati.
EP1219306A1 (en) 2000-12-29 2002-07-03 Nicox S.A. Compositions comprising cyclodextrins and NO- releasing drugs
US6696592B2 (en) 2001-05-22 2004-02-24 Nicox-S.A. Methods of making 21-[4′-(nitrooxyalkyl)benzoate] corticosteroid derivatives and intermediates useful in the synthesis thereof
JP4490689B2 (ja) 2001-10-03 2010-06-30 メルク・シャープ・エンド・ドーム・コーポレイション アンドロゲン受容体調節剤としてのアンドロスタン１７β−カルボキサミド類
ITMI20020148A1 (it) * 2002-01-29 2003-07-29 Nicox Sa Nuovi corticosteroidi
RU2261481C2 (ru) * 2003-03-26 2005-09-27 ФГУ Омская государственная медицинская академия Способ моделирования септического шока и полиорганной недостаточности у мелких лабораторных животных
KR20080039442A (ko) 2005-09-02 2008-05-07 니콕스 에스. 에이. 스테로이드 니트록시 유도체들
US8802726B2 (en) 2006-02-03 2014-08-12 Nicox S.A. Use of nitrooxyderivative of drug for the treatment of muscular dystrophies
US7893058B2 (en) * 2006-05-15 2011-02-22 Janssen Pharmaceutica Nv Imidazolopyrazine compounds useful for the treatment of degenerative and inflammatory diseases
MX2009008334A (es) * 2007-02-05 2009-08-12 Nicox Sa Esteroides que liberan oxido nitrico.
US20090087425A1 (en) * 2007-08-10 2009-04-02 Topigen Pharmaceuticals Inc. Combination of nitroderivatized steroid and bronchodilator for treating respiratory disease
US20090088411A1 (en) * 2007-08-31 2009-04-02 Topigen Pharmaceuticals Inc. No-donating corticosteroid with improved pharmacokinetic, anti-inflammatory and vasodilatory properties
WO2010012567A1 (en) * 2008-07-31 2010-02-04 Nicox S.A. Glucocorticoids attached to nitrate esters via an aromatic linker in position 21 and their use in ophthalmology
CN102186873A (zh) 2008-08-05 2011-09-14 尼科克斯公司 用于治疗视网膜和黄斑疾病的新型释放no的甾类化合物
US20110130376A1 (en) * 2008-08-05 2011-06-02 Nicox S.A. New no releasing steroids derivatives
AU2011243947A1 (en) 2010-04-23 2012-12-06 Piramal Enterprises Limited Nitric oxide releasing prodrugs of therapeutic agents
CN102302501B (zh) * 2010-06-07 2012-10-03 刘超 糖皮质激素硝基衍生物在制备利尿药物制剂中的应用
US9844599B2 (en) 2013-01-21 2017-12-19 Apparao Satyam Nitric oxide releasing produgs of therapeutic agents
CN108191938B (zh) * 2018-01-11 2019-07-05 湖南新合新生物医药有限公司 9,11烯烃甾族化合物的制备方法
CN113069460B (zh) * 2021-03-24 2022-02-08 兰州大学 哈西奈德及其衍生物用于制备治疗和/或预防脑血管疾病药物中的应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2990401A (en) * 1958-06-18 1961-06-27 American Cyanamid Co 11-substituted 16alpha, 17alpha-substituted methylenedioxy steroids
GB1054290A (enExample) * 1963-05-01
US3183252A (en) * 1963-09-05 1965-05-11 Syntex Corp 16-nitratoalkyl-pregnanes
US3494941A (en) * 1967-12-04 1970-02-10 American Home Prod Nitrate esters of 17beta-(hydroxyalkoxy)steroid 3-ols,3-ones and 3-amidinohydrazones
HU164115B (enExample) * 1971-05-07 1973-12-28
NZ177056A (en) * 1974-03-27 1978-09-20 Plurichemie Anstalt Certain 9 -(chloro or flruoro)-16( or )-methyl-11 ,17 -dihydroxypregna-1,4-diene-3,20-dione 17 -acylates or 11 ,17 -diacylates and certain preparature processes
IE44534B1 (en) * 1975-09-08 1981-12-30 Squibb & Sons Inc Ethers of 11 -hydroxy steroids and processes for the preparation thereof
IT1256345B (it) 1992-08-20 1995-12-01 Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione
IT1256450B (it) 1992-11-26 1995-12-05 Soldato Piero Del Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione
US5457207A (en) 1993-10-05 1995-10-10 Regents Of The University Of Minnesota Spirovesamicols
JP3775796B2 (ja) 1993-10-06 2006-05-17 ニコックス エス エイ 抗炎症活性及び／又は鎮痛活性を有する硝酸エステル類及びそれらの製造方法
RU2145595C1 (ru) 1994-05-10 2000-02-20 Никокс С.А. Нитроксисоединения и фармацевтическая композиция на их основе, имеющие противовоспалительную, анальгетическую и антитромбоцитарную активности
US5824669A (en) * 1996-03-22 1998-10-20 Nitromed, Inc. Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
US5837698A (en) * 1996-05-02 1998-11-17 G. D. Searle & Co. Steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs
US5985862A (en) * 1996-05-02 1999-11-16 G.D. Searle & Co. Pharmaceutical compositions having steroid nitrate ester derivatives useful as anti-inflammatory drugs
IT1285770B1 (it) * 1996-10-04 1998-06-18 Nicox Sa Composti corticoidei

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100513415C (zh) * 2005-08-03 2009-07-15 中国人民解放军军事医学科学院毒物药物研究所 胆汁酸衍生物及其医药用途

Also Published As

Publication number Publication date
US20060154905A1 (en) 2006-07-13
EP0929565B1 (en) 2002-05-29
KR100487898B1 (ko) 2005-05-09
US7196075B2 (en) 2007-03-27
KR20000048911A (ko) 2000-07-25
US20060160780A1 (en) 2006-07-20
US20050004089A1 (en) 2005-01-06
US7056905B2 (en) 2006-06-06
US20070161612A1 (en) 2007-07-12
IT1285770B1 (it) 1998-06-18
US20080234242A1 (en) 2008-09-25
ATE218142T1 (de) 2002-06-15
PT929565E (pt) 2002-10-31
ES2177952T3 (es) 2002-12-16
HUP9904149A2 (hu) 2000-04-28
CN1253563A (zh) 2000-05-17
US7605151B2 (en) 2009-10-20
US7368442B2 (en) 2008-05-06
US20060270644A1 (en) 2006-11-30
EP0929565A2 (en) 1999-07-21
WO1998015568A2 (en) 1998-04-16
US6610676B1 (en) 2003-08-26
AU719250B2 (en) 2000-05-04
JP2001501637A (ja) 2001-02-06
US20060160781A1 (en) 2006-07-20
DE69712900T2 (de) 2002-12-12
HUP9904149A3 (en) 2001-03-28
WO1998015568A3 (en) 1998-06-18
CA2267630C (en) 2008-01-08
AU4780397A (en) 1998-05-05
US7160871B2 (en) 2007-01-09
US7205288B2 (en) 2007-04-17
JP4388600B2 (ja) 2009-12-24
SI0929565T1 (en) 2002-08-31
BR9711586A (pt) 1999-08-24
RU2186781C2 (ru) 2002-08-10
DE69712900D1 (de) 2002-07-04
DK0929565T3 (da) 2002-09-09
ITMI962048A1 (it) 1998-04-04
CA2267630A1 (en) 1998-04-16
US7157450B2 (en) 2007-01-02

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Granted publication date: 20040324

Termination date: 20131002