AU719250B2 - Nitrate esters of corticoid compounds and pharmaceutical applications thereof - Google Patents

Nitrate esters of corticoid compounds and pharmaceutical applications thereof Download PDF

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Publication number
AU719250B2
AU719250B2 AU47803/97A AU4780397A AU719250B2 AU 719250 B2 AU719250 B2 AU 719250B2 AU 47803/97 A AU47803/97 A AU 47803/97A AU 4780397 A AU4780397 A AU 4780397A AU 719250 B2 AU719250 B2 AU 719250B2
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AU
Australia
Prior art keywords
disorders
compounds according
preparation
treatment
medicaments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU47803/97A
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English (en)
Other versions
AU4780397A (en
Inventor
Piero Del Soldato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nicox SA
Original Assignee
Nicox SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox SA filed Critical Nicox SA
Publication of AU4780397A publication Critical patent/AU4780397A/en
Application granted granted Critical
Publication of AU719250B2 publication Critical patent/AU719250B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AU47803/97A 1996-10-04 1997-10-02 Nitrate esters of corticoid compounds and pharmaceutical applications thereof Ceased AU719250B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT96MI002048A IT1285770B1 (it) 1996-10-04 1996-10-04 Composti corticoidei
ITMI96A002048 1996-10-04
PCT/EP1997/005426 WO1998015568A2 (en) 1996-10-04 1997-10-02 Nitrate esters of corticoid compounds and pharmaceutical applications thereof

Publications (2)

Publication Number Publication Date
AU4780397A AU4780397A (en) 1998-05-05
AU719250B2 true AU719250B2 (en) 2000-05-04

Family

ID=11374972

Family Applications (1)

Application Number Title Priority Date Filing Date
AU47803/97A Ceased AU719250B2 (en) 1996-10-04 1997-10-02 Nitrate esters of corticoid compounds and pharmaceutical applications thereof

Country Status (18)

Country Link
US (8) US6610676B1 (enExample)
EP (1) EP0929565B1 (enExample)
JP (1) JP4388600B2 (enExample)
KR (1) KR100487898B1 (enExample)
CN (1) CN1142939C (enExample)
AT (1) ATE218142T1 (enExample)
AU (1) AU719250B2 (enExample)
BR (1) BR9711586A (enExample)
CA (1) CA2267630C (enExample)
DE (1) DE69712900T2 (enExample)
DK (1) DK0929565T3 (enExample)
ES (1) ES2177952T3 (enExample)
HU (1) HUP9904149A3 (enExample)
IT (1) IT1285770B1 (enExample)
PT (1) PT929565E (enExample)
RU (1) RU2186781C2 (enExample)
SI (1) SI0929565T1 (enExample)
WO (1) WO1998015568A2 (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5824669A (en) 1996-03-22 1998-10-20 Nitromed, Inc. Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
IT1285770B1 (it) * 1996-10-04 1998-06-18 Nicox Sa Composti corticoidei
IT1311922B1 (it) * 1999-04-13 2002-03-20 Nicox Sa Composti farmaceutici.
IT1314184B1 (it) 1999-08-12 2002-12-06 Nicox Sa Composizioni farmaceutiche per la terapia di condizioni di stressossidativo
IT1320176B1 (it) * 2000-12-22 2003-11-26 Nicox Sa Dispersioni solide di principi attivi nitrati.
EP1219306A1 (en) 2000-12-29 2002-07-03 Nicox S.A. Compositions comprising cyclodextrins and NO- releasing drugs
US6696592B2 (en) 2001-05-22 2004-02-24 Nicox-S.A. Methods of making 21-[4′-(nitrooxyalkyl)benzoate] corticosteroid derivatives and intermediates useful in the synthesis thereof
US7402577B2 (en) 2001-10-03 2008-07-22 Merck & Co., Inc. Androstane 17-beta-carboxamides as androgen receptor modulators
ITMI20020148A1 (it) 2002-01-29 2003-07-29 Nicox Sa Nuovi corticosteroidi
RU2261481C2 (ru) * 2003-03-26 2005-09-27 ФГУ Омская государственная медицинская академия Способ моделирования септического шока и полиорганной недостаточности у мелких лабораторных животных
CN100513415C (zh) * 2005-08-03 2009-07-15 中国人民解放军军事医学科学院毒物药物研究所 胆汁酸衍生物及其医药用途
CN101300265A (zh) 2005-09-02 2008-11-05 尼科克斯公司 糖皮质激素硝酰氧基衍生物
US8802726B2 (en) 2006-02-03 2014-08-12 Nicox S.A. Use of nitrooxyderivative of drug for the treatment of muscular dystrophies
US7893058B2 (en) * 2006-05-15 2011-02-22 Janssen Pharmaceutica Nv Imidazolopyrazine compounds useful for the treatment of degenerative and inflammatory diseases
US20100041633A1 (en) * 2007-02-05 2010-02-18 Nicox S.A. Nitric oxide releasing steroids
WO2009037584A2 (en) * 2007-08-10 2009-03-26 Topigen Pharmaceuticals Inc. Combination of nitroderivatized steroid and bronchodilator for treating respiratory disease
US20090088411A1 (en) * 2007-08-31 2009-04-02 Topigen Pharmaceuticals Inc. No-donating corticosteroid with improved pharmacokinetic, anti-inflammatory and vasodilatory properties
NZ590454A (en) * 2008-07-31 2012-09-28 Nicox Sa Glucocorticoids attached to nitrate esters via an aromatic linker in position 21 and their use in ophthalmology
WO2010015529A1 (en) * 2008-08-05 2010-02-11 Nicox S.A. New no releasing steroids derivatives
CN102186873A (zh) 2008-08-05 2011-09-14 尼科克斯公司 用于治疗视网膜和黄斑疾病的新型释放no的甾类化合物
EP2560634A1 (en) 2010-04-23 2013-02-27 Piramal Enterprises Limited Nitric oxide releasing prodrugs of therapeutic agents
CN102302501B (zh) 2010-06-07 2012-10-03 刘超 糖皮质激素硝基衍生物在制备利尿药物制剂中的应用
WO2014111957A1 (en) 2013-01-21 2014-07-24 Apparao Satyam Nitric oxide releasing prodrugs of therapeutic agents
CN108191938B (zh) * 2018-01-11 2019-07-05 湖南新合新生物医药有限公司 9,11烯烃甾族化合物的制备方法
CN113069460B (zh) * 2021-03-24 2022-02-08 兰州大学 哈西奈德及其衍生物用于制备治疗和/或预防脑血管疾病药物中的应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3494941A (en) * 1967-12-04 1970-02-10 American Home Prod Nitrate esters of 17beta-(hydroxyalkoxy)steroid 3-ols,3-ones and 3-amidinohydrazones
AU4172272A (en) * 1971-05-07 1973-11-08 Richter Gedeon Vegyeszeti Gyaki. T Nitric acid esters of 21-alcohols belonging tothe pregnane series anda process forthe preparation thereof
WO1997034871A1 (en) * 1996-03-22 1997-09-25 Nitromed, Inc. Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2990401A (en) * 1958-06-18 1961-06-27 American Cyanamid Co 11-substituted 16alpha, 17alpha-substituted methylenedioxy steroids
GB1054290A (enExample) * 1963-05-01
US3183252A (en) * 1963-09-05 1965-05-11 Syntex Corp 16-nitratoalkyl-pregnanes
CH622811A5 (enExample) * 1974-03-27 1981-04-30 Plurichemie Anstalt
IE44534B1 (en) * 1975-09-08 1981-12-30 Squibb & Sons Inc Ethers of 11 -hydroxy steroids and processes for the preparation thereof
IT1256345B (it) 1992-08-20 1995-12-01 Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione
IT1256450B (it) 1992-11-26 1995-12-05 Soldato Piero Del Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione
US5457207A (en) 1993-10-05 1995-10-10 Regents Of The University Of Minnesota Spirovesamicols
WO1995009831A1 (en) 1993-10-06 1995-04-13 Nicox S.A. Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation
JP4043046B2 (ja) 1994-05-10 2008-02-06 ニコックス エス エイ 消炎、鎮痛および抗血栓活性を有するニトロ化合物およびそれらの組成物
US5985862A (en) * 1996-05-02 1999-11-16 G.D. Searle & Co. Pharmaceutical compositions having steroid nitrate ester derivatives useful as anti-inflammatory drugs
US5837698A (en) * 1996-05-02 1998-11-17 G. D. Searle & Co. Steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs
IT1285770B1 (it) * 1996-10-04 1998-06-18 Nicox Sa Composti corticoidei

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3494941A (en) * 1967-12-04 1970-02-10 American Home Prod Nitrate esters of 17beta-(hydroxyalkoxy)steroid 3-ols,3-ones and 3-amidinohydrazones
AU4172272A (en) * 1971-05-07 1973-11-08 Richter Gedeon Vegyeszeti Gyaki. T Nitric acid esters of 21-alcohols belonging tothe pregnane series anda process forthe preparation thereof
WO1997034871A1 (en) * 1996-03-22 1997-09-25 Nitromed, Inc. Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders

Also Published As

Publication number Publication date
US7196075B2 (en) 2007-03-27
EP0929565A2 (en) 1999-07-21
SI0929565T1 (en) 2002-08-31
US7368442B2 (en) 2008-05-06
PT929565E (pt) 2002-10-31
AU4780397A (en) 1998-05-05
US7160871B2 (en) 2007-01-09
US7205288B2 (en) 2007-04-17
CN1142939C (zh) 2004-03-24
WO1998015568A2 (en) 1998-04-16
US7056905B2 (en) 2006-06-06
US20060160781A1 (en) 2006-07-20
HUP9904149A3 (en) 2001-03-28
DK0929565T3 (da) 2002-09-09
US7605151B2 (en) 2009-10-20
US6610676B1 (en) 2003-08-26
US20050004089A1 (en) 2005-01-06
ITMI962048A1 (it) 1998-04-04
CN1253563A (zh) 2000-05-17
HUP9904149A2 (hu) 2000-04-28
US20080234242A1 (en) 2008-09-25
ATE218142T1 (de) 2002-06-15
CA2267630C (en) 2008-01-08
US20060160780A1 (en) 2006-07-20
KR100487898B1 (ko) 2005-05-09
DE69712900D1 (de) 2002-07-04
WO1998015568A3 (en) 1998-06-18
JP2001501637A (ja) 2001-02-06
DE69712900T2 (de) 2002-12-12
BR9711586A (pt) 1999-08-24
JP4388600B2 (ja) 2009-12-24
US20060154905A1 (en) 2006-07-13
KR20000048911A (ko) 2000-07-25
RU2186781C2 (ru) 2002-08-10
IT1285770B1 (it) 1998-06-18
US7157450B2 (en) 2007-01-02
ES2177952T3 (es) 2002-12-16
US20060270644A1 (en) 2006-11-30
CA2267630A1 (en) 1998-04-16
US20070161612A1 (en) 2007-07-12
EP0929565B1 (en) 2002-05-29

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