IT1285770B1 - Composti corticoidei - Google Patents

Composti corticoidei

Info

Publication number
IT1285770B1
IT1285770B1 IT96MI002048A ITMI962048A IT1285770B1 IT 1285770 B1 IT1285770 B1 IT 1285770B1 IT 96MI002048 A IT96MI002048 A IT 96MI002048A IT MI962048 A ITMI962048 A IT MI962048A IT 1285770 B1 IT1285770 B1 IT 1285770B1
Authority
IT
Italy
Prior art keywords
compounds
corticoid compounds
corticoid
medicaments
formula
Prior art date
Application number
IT96MI002048A
Other languages
English (en)
Italian (it)
Inventor
Soldato Piero Del
Original Assignee
Nicox Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to IT96MI002048A priority Critical patent/IT1285770B1/it
Application filed by Nicox Sa filed Critical Nicox Sa
Priority to JP51715498A priority patent/JP4388600B2/ja
Priority to SI9730333T priority patent/SI0929565T1/xx
Priority to CA002267630A priority patent/CA2267630C/en
Priority to EP97910409A priority patent/EP0929565B1/en
Priority to BR9711586A priority patent/BR9711586A/pt
Priority to DE69712900T priority patent/DE69712900T2/de
Priority to AT97910409T priority patent/ATE218142T1/de
Priority to ES97910409T priority patent/ES2177952T3/es
Priority to RU99108661/04A priority patent/RU2186781C2/ru
Priority to HU9904149A priority patent/HUP9904149A3/hu
Priority to CNB97180284XA priority patent/CN1142939C/zh
Priority to DK97910409T priority patent/DK0929565T3/da
Priority to PCT/EP1997/005426 priority patent/WO1998015568A2/en
Priority to PT97910409T priority patent/PT929565E/pt
Priority to KR10-1999-7002942A priority patent/KR100487898B1/ko
Priority to AU47803/97A priority patent/AU719250B2/en
Priority to US09/269,729 priority patent/US6610676B1/en
Publication of ITMI962048A1 publication Critical patent/ITMI962048A1/it
Publication of IT1285770B1 publication Critical patent/IT1285770B1/it
Application granted granted Critical
Priority to US10/462,637 priority patent/US7056905B2/en
Priority to US11/374,219 priority patent/US7157450B2/en
Priority to US11/374,315 priority patent/US7196075B2/en
Priority to US11/374,220 priority patent/US7160871B2/en
Priority to US11/445,140 priority patent/US7205288B2/en
Priority to US11/714,724 priority patent/US7368442B2/en
Priority to US12/051,434 priority patent/US7605151B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IT96MI002048A 1996-10-04 1996-10-04 Composti corticoidei IT1285770B1 (it)

Priority Applications (25)

Application Number Priority Date Filing Date Title
IT96MI002048A IT1285770B1 (it) 1996-10-04 1996-10-04 Composti corticoidei
PCT/EP1997/005426 WO1998015568A2 (en) 1996-10-04 1997-10-02 Nitrate esters of corticoid compounds and pharmaceutical applications thereof
CA002267630A CA2267630C (en) 1996-10-04 1997-10-02 Nitrate esters of corticoid compounds and pharmaceutical applications thereof
EP97910409A EP0929565B1 (en) 1996-10-04 1997-10-02 Nitrate esters of corticoid compounds and pharmaceutical applications thereof
BR9711586A BR9711586A (pt) 1996-10-04 1997-10-02 Compostos e uso dos mesmo
DE69712900T DE69712900T2 (de) 1996-10-04 1997-10-02 Nitratester von corticoid verbindungen und die therapeutische verwendungen davon
AT97910409T ATE218142T1 (de) 1996-10-04 1997-10-02 Nitratester von corticoid verbindungen und die therapeutische verwendungen davon
ES97910409T ES2177952T3 (es) 1996-10-04 1997-10-02 Compuestos codrticoides de esteres de nitrato y su utilizacion farmaceutica.
RU99108661/04A RU2186781C2 (ru) 1996-10-04 1997-10-02 Нитроэфиры кортикоидных соединений
HU9904149A HUP9904149A3 (en) 1996-10-04 1997-10-02 Nitrate esters of corticoid compounds and pharmaceutical applications thereof
CNB97180284XA CN1142939C (zh) 1996-10-04 1997-10-02 类皮质激素化合物的硝酸酯及其药物应用
KR10-1999-7002942A KR100487898B1 (ko) 1996-10-04 1997-10-02 코르티코이드 화합물들의 에스테르 질산염들 및 그 약제학적인 응용물들
JP51715498A JP4388600B2 (ja) 1996-10-04 1997-10-02 コルチコイド化合物の硝酸エステル類およびその薬学的使用
DK97910409T DK0929565T3 (da) 1996-10-04 1997-10-02 Nitratestere af corticoidforbindelser og farmaceutiske anvendelser deraf
SI9730333T SI0929565T1 (en) 1996-10-04 1997-10-02 Nitrate esters of corticoid compounds and pharmaceutical applications thereof
AU47803/97A AU719250B2 (en) 1996-10-04 1997-10-02 Nitrate esters of corticoid compounds and pharmaceutical applications thereof
US09/269,729 US6610676B1 (en) 1996-10-04 1997-10-02 Nitrate esters of corticoid compounds and pharmaceutical applications thereof
PT97910409T PT929565E (pt) 1996-10-04 1997-10-02 Esteres de nitrato de compostos corticoides e suas aplicacoes farmaceuticas
US10/462,637 US7056905B2 (en) 1996-10-04 2003-06-17 Nitrate esters of corticoid compounds and pharmaceutical applications thereof
US11/374,219 US7157450B2 (en) 1996-10-04 2006-03-14 Nitrate esters of corticoid compounds and pharmaceutical applications thereof
US11/374,220 US7160871B2 (en) 1996-10-04 2006-03-14 Nitrate esters of corticoid compounds and pharmaceutical applications thereof
US11/374,315 US7196075B2 (en) 1996-10-04 2006-03-14 Nitrate esters of corticoid compounds and pharmaceutical applications thereof
US11/445,140 US7205288B2 (en) 1996-10-04 2006-06-02 Nitrate esters of corticoid compounds and pharmaceutical applications thereof
US11/714,724 US7368442B2 (en) 1996-10-04 2007-03-07 Nitrate esters of corticoid compounds and pharmaceutical applications thereof
US12/051,434 US7605151B2 (en) 1996-10-04 2008-03-19 Nitrate esters of corticoid compounds and pharmaceutical applications thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT96MI002048A IT1285770B1 (it) 1996-10-04 1996-10-04 Composti corticoidei

Publications (2)

Publication Number Publication Date
ITMI962048A1 ITMI962048A1 (it) 1998-04-04
IT1285770B1 true IT1285770B1 (it) 1998-06-18

Family

ID=11374972

Family Applications (1)

Application Number Title Priority Date Filing Date
IT96MI002048A IT1285770B1 (it) 1996-10-04 1996-10-04 Composti corticoidei

Country Status (18)

Country Link
US (8) US6610676B1 (enExample)
EP (1) EP0929565B1 (enExample)
JP (1) JP4388600B2 (enExample)
KR (1) KR100487898B1 (enExample)
CN (1) CN1142939C (enExample)
AT (1) ATE218142T1 (enExample)
AU (1) AU719250B2 (enExample)
BR (1) BR9711586A (enExample)
CA (1) CA2267630C (enExample)
DE (1) DE69712900T2 (enExample)
DK (1) DK0929565T3 (enExample)
ES (1) ES2177952T3 (enExample)
HU (1) HUP9904149A3 (enExample)
IT (1) IT1285770B1 (enExample)
PT (1) PT929565E (enExample)
RU (1) RU2186781C2 (enExample)
SI (1) SI0929565T1 (enExample)
WO (1) WO1998015568A2 (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5824669A (en) 1996-03-22 1998-10-20 Nitromed, Inc. Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
IT1285770B1 (it) * 1996-10-04 1998-06-18 Nicox Sa Composti corticoidei
IT1311922B1 (it) * 1999-04-13 2002-03-20 Nicox Sa Composti farmaceutici.
IT1314184B1 (it) 1999-08-12 2002-12-06 Nicox Sa Composizioni farmaceutiche per la terapia di condizioni di stressossidativo
IT1320176B1 (it) * 2000-12-22 2003-11-26 Nicox Sa Dispersioni solide di principi attivi nitrati.
EP1219306A1 (en) 2000-12-29 2002-07-03 Nicox S.A. Compositions comprising cyclodextrins and NO- releasing drugs
US6696592B2 (en) 2001-05-22 2004-02-24 Nicox-S.A. Methods of making 21-[4′-(nitrooxyalkyl)benzoate] corticosteroid derivatives and intermediates useful in the synthesis thereof
JP4490689B2 (ja) 2001-10-03 2010-06-30 メルク・シャープ・エンド・ドーム・コーポレイション アンドロゲン受容体調節剤としてのアンドロスタン１７β−カルボキサミド類
ITMI20020148A1 (it) * 2002-01-29 2003-07-29 Nicox Sa Nuovi corticosteroidi
RU2261481C2 (ru) * 2003-03-26 2005-09-27 ФГУ Омская государственная медицинская академия Способ моделирования септического шока и полиорганной недостаточности у мелких лабораторных животных
CN100513415C (zh) * 2005-08-03 2009-07-15 中国人民解放军军事医学科学院毒物药物研究所 胆汁酸衍生物及其医药用途
KR20080039442A (ko) 2005-09-02 2008-05-07 니콕스 에스. 에이. 스테로이드 니트록시 유도체들
US8802726B2 (en) 2006-02-03 2014-08-12 Nicox S.A. Use of nitrooxyderivative of drug for the treatment of muscular dystrophies
US7893058B2 (en) * 2006-05-15 2011-02-22 Janssen Pharmaceutica Nv Imidazolopyrazine compounds useful for the treatment of degenerative and inflammatory diseases
MX2009008334A (es) * 2007-02-05 2009-08-12 Nicox Sa Esteroides que liberan oxido nitrico.
US20090087425A1 (en) * 2007-08-10 2009-04-02 Topigen Pharmaceuticals Inc. Combination of nitroderivatized steroid and bronchodilator for treating respiratory disease
US20090088411A1 (en) * 2007-08-31 2009-04-02 Topigen Pharmaceuticals Inc. No-donating corticosteroid with improved pharmacokinetic, anti-inflammatory and vasodilatory properties
WO2010012567A1 (en) * 2008-07-31 2010-02-04 Nicox S.A. Glucocorticoids attached to nitrate esters via an aromatic linker in position 21 and their use in ophthalmology
CN102186873A (zh) 2008-08-05 2011-09-14 尼科克斯公司 用于治疗视网膜和黄斑疾病的新型释放no的甾类化合物
US20110130376A1 (en) * 2008-08-05 2011-06-02 Nicox S.A. New no releasing steroids derivatives
AU2011243947A1 (en) 2010-04-23 2012-12-06 Piramal Enterprises Limited Nitric oxide releasing prodrugs of therapeutic agents
CN102302501B (zh) * 2010-06-07 2012-10-03 刘超 糖皮质激素硝基衍生物在制备利尿药物制剂中的应用
US9844599B2 (en) 2013-01-21 2017-12-19 Apparao Satyam Nitric oxide releasing produgs of therapeutic agents
CN108191938B (zh) * 2018-01-11 2019-07-05 湖南新合新生物医药有限公司 9,11烯烃甾族化合物的制备方法
CN113069460B (zh) * 2021-03-24 2022-02-08 兰州大学 哈西奈德及其衍生物用于制备治疗和/或预防脑血管疾病药物中的应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2990401A (en) * 1958-06-18 1961-06-27 American Cyanamid Co 11-substituted 16alpha, 17alpha-substituted methylenedioxy steroids
GB1054290A (enExample) * 1963-05-01
US3183252A (en) * 1963-09-05 1965-05-11 Syntex Corp 16-nitratoalkyl-pregnanes
US3494941A (en) * 1967-12-04 1970-02-10 American Home Prod Nitrate esters of 17beta-(hydroxyalkoxy)steroid 3-ols,3-ones and 3-amidinohydrazones
HU164115B (enExample) * 1971-05-07 1973-12-28
NZ177056A (en) * 1974-03-27 1978-09-20 Plurichemie Anstalt Certain 9 -(chloro or flruoro)-16( or )-methyl-11 ,17 -dihydroxypregna-1,4-diene-3,20-dione 17 -acylates or 11 ,17 -diacylates and certain preparature processes
IE44534B1 (en) * 1975-09-08 1981-12-30 Squibb & Sons Inc Ethers of 11 -hydroxy steroids and processes for the preparation thereof
IT1256345B (it) 1992-08-20 1995-12-01 Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione
IT1256450B (it) 1992-11-26 1995-12-05 Soldato Piero Del Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione
US5457207A (en) 1993-10-05 1995-10-10 Regents Of The University Of Minnesota Spirovesamicols
JP3775796B2 (ja) 1993-10-06 2006-05-17 ニコックス エス エイ 抗炎症活性及び／又は鎮痛活性を有する硝酸エステル類及びそれらの製造方法
RU2145595C1 (ru) 1994-05-10 2000-02-20 Никокс С.А. Нитроксисоединения и фармацевтическая композиция на их основе, имеющие противовоспалительную, анальгетическую и антитромбоцитарную активности
US5824669A (en) * 1996-03-22 1998-10-20 Nitromed, Inc. Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
US5837698A (en) * 1996-05-02 1998-11-17 G. D. Searle & Co. Steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs
US5985862A (en) * 1996-05-02 1999-11-16 G.D. Searle & Co. Pharmaceutical compositions having steroid nitrate ester derivatives useful as anti-inflammatory drugs
IT1285770B1 (it) * 1996-10-04 1998-06-18 Nicox Sa Composti corticoidei

Also Published As

Publication number Publication date
US20060154905A1 (en) 2006-07-13
EP0929565B1 (en) 2002-05-29
KR100487898B1 (ko) 2005-05-09
US7196075B2 (en) 2007-03-27
KR20000048911A (ko) 2000-07-25
US20060160780A1 (en) 2006-07-20
US20050004089A1 (en) 2005-01-06
US7056905B2 (en) 2006-06-06
US20070161612A1 (en) 2007-07-12
US20080234242A1 (en) 2008-09-25
ATE218142T1 (de) 2002-06-15
PT929565E (pt) 2002-10-31
ES2177952T3 (es) 2002-12-16
HUP9904149A2 (hu) 2000-04-28
CN1253563A (zh) 2000-05-17
US7605151B2 (en) 2009-10-20
US7368442B2 (en) 2008-05-06
US20060270644A1 (en) 2006-11-30
EP0929565A2 (en) 1999-07-21
WO1998015568A2 (en) 1998-04-16
US6610676B1 (en) 2003-08-26
AU719250B2 (en) 2000-05-04
JP2001501637A (ja) 2001-02-06
US20060160781A1 (en) 2006-07-20
DE69712900T2 (de) 2002-12-12
HUP9904149A3 (en) 2001-03-28
WO1998015568A3 (en) 1998-06-18
CA2267630C (en) 2008-01-08
AU4780397A (en) 1998-05-05
US7160871B2 (en) 2007-01-09
US7205288B2 (en) 2007-04-17
JP4388600B2 (ja) 2009-12-24
SI0929565T1 (en) 2002-08-31
BR9711586A (pt) 1999-08-24
RU2186781C2 (ru) 2002-08-10
DE69712900D1 (de) 2002-07-04
DK0929565T3 (da) 2002-09-09
CN1142939C (zh) 2004-03-24
ITMI962048A1 (it) 1998-04-04
CA2267630A1 (en) 1998-04-16
US7157450B2 (en) 2007-01-02

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