JP2001500506A - ファルネシルタンパク質トランスフェラーゼのインヒビターとして有用な置換ベンゾシクロヘプタピリジン - Google Patents

ファルネシルタンパク質トランスフェラーゼのインヒビターとして有用な置換ベンゾシクロヘプタピリジン

Info

Publication number
JP2001500506A
JP2001500506A JP10513761A JP51376198A JP2001500506A JP 2001500506 A JP2001500506 A JP 2001500506A JP 10513761 A JP10513761 A JP 10513761A JP 51376198 A JP51376198 A JP 51376198A JP 2001500506 A JP2001500506 A JP 2001500506A
Authority
JP
Japan
Prior art keywords
compound
alkyl
halo
aryl
independently
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP10513761A
Other languages
English (en)
Japanese (ja)
Other versions
JP2001500506A5 (enExample
Inventor
エフ． レーン，ダイナナス
ビー． クーパー，アラン
ケイ． マラムス，アラン
ジェイ． ドール，ロナルド
ノロージ，エフ．ジョージ
ジー． タベラス，アーサー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of JP2001500506A publication Critical patent/JP2001500506A/ja
Publication of JP2001500506A5 publication Critical patent/JP2001500506A5/ja
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pyridine Compounds (AREA)
JP10513761A 1996-09-13 1997-09-11 ファルネシルタンパク質トランスフェラーゼのインヒビターとして有用な置換ベンゾシクロヘプタピリジン Ceased JP2001500506A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US71370596A 1996-09-13 1996-09-13
US08/713,705 1996-09-13
PCT/US1997/015902 WO1998011097A1 (en) 1996-09-13 1997-09-11 Substituted benzocycloheptapyridine useful as inhibitors of farnesyl-protein transferase

Publications (2)

Publication Number Publication Date
JP2001500506A true JP2001500506A (ja) 2001-01-16
JP2001500506A5 JP2001500506A5 (enExample) 2005-05-12

Family

ID=24867191

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10513761A Ceased JP2001500506A (ja) 1996-09-13 1997-09-11 ファルネシルタンパク質トランスフェラーゼのインヒビターとして有用な置換ベンゾシクロヘプタピリジン

Country Status (13)

Country Link
EP (1) EP0931077B1 (enExample)
JP (1) JP2001500506A (enExample)
KR (1) KR20000036102A (enExample)
CN (1) CN1104428C (enExample)
AT (1) ATE294172T1 (enExample)
AU (1) AU4337597A (enExample)
CA (1) CA2264666A1 (enExample)
DE (1) DE69733142T2 (enExample)
ES (1) ES2242232T3 (enExample)
HU (1) HUP0000073A3 (enExample)
IL (1) IL128926A0 (enExample)
NZ (1) NZ334341A (enExample)
WO (1) WO1998011097A1 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6613905B1 (en) 1998-01-21 2003-09-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
CA2318088A1 (en) 1998-01-21 1999-07-29 Yoshisuke Nakasato Chemokine receptor antagonists and methods of use therefor
US6509346B2 (en) 1998-01-21 2003-01-21 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
CN1289336A (zh) 1998-01-21 2001-03-28 千禧药品公司 趋化因子受体拮抗剂和其使用方法
US6503926B2 (en) 1998-09-04 2003-01-07 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US6288083B1 (en) 1998-09-04 2001-09-11 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US7271176B2 (en) 1998-09-04 2007-09-18 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use thereof
US7541365B2 (en) 2001-11-21 2009-06-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
TWI291467B (en) 2002-11-13 2007-12-21 Millennium Pharm Inc CCR1 antagonists and methods of use therefor
EP1656156A2 (en) 2003-08-13 2006-05-17 Children's Hospital Medical Center Mobilization of hematopoietic cells
ATE524445T1 (de) 2005-06-23 2011-09-15 Merck Sharp & Dohme Benzocycloheptapyridine als inhibitoren der tyrosinkinase met
TW200813021A (en) 2006-07-10 2008-03-16 Merck & Co Inc Tyrosine kinase inhibitors
CA2657247A1 (en) 2006-07-28 2008-01-31 Boehringer Ingelheim International Gmbh Compounds which modulate the cb2 receptor
CA2704684A1 (en) 2007-11-07 2009-05-14 Boehringer Ingelheim International Gmbh Compounds which modulate the cb2 receptor
WO2010005782A1 (en) 2008-07-10 2010-01-14 Boehringer Ingelheim International Gmbh Sulfone compounds which modulate the cb2 receptor
PE20110397A1 (es) 2008-09-25 2011-07-01 Boehringer Ingelheim Int Compuestos que modulan selectivamente el receptor cb2
EP2398771B1 (en) 2009-02-18 2015-07-29 Boehringer Ingelheim International GmbH Heterocyclic compounds which modulate the cb2 receptor
US8299103B2 (en) 2009-06-15 2012-10-30 Boehringer Ingelheim International Gmbh Compounds which selectively modulate the CB2 receptor
WO2010147791A1 (en) * 2009-06-16 2010-12-23 Boehringer Ingelheim International Gmbh Azetidine 2 -carboxamide derivatives which modulate the cb2 receptor
JP2013505295A (ja) 2009-09-22 2013-02-14 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｂ２受容体を選択的に調節する化合物
WO2011088015A1 (en) 2010-01-15 2011-07-21 Boehringer Ingelheim International Gmbh Compounds which modulate the cb2 receptor
EP2542539B1 (en) 2010-03-05 2014-02-26 Boehringer Ingelheim International GmbH Tetrazole compounds which selectively modulate the cb2 receptor
WO2012012307A1 (en) 2010-07-22 2012-01-26 Boehringer Ingelheim International Gmbh Sulfonyl compounds which modulate the cb2 rece
EP2803668A1 (en) 2013-05-17 2014-11-19 Boehringer Ingelheim International Gmbh Novel (cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1593417A (en) * 1976-12-22 1981-07-15 Squibb & Sons Inc Carbocyclic-fused pyrazolopyridine derivatives
US5089496A (en) * 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
IL98572A (en) * 1990-06-22 1995-07-31 Schering Corp Bis-benzo or benzopyrido cyclohepta piperidene, piperidylidene and piperazine compositions an methods of use
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
NZ274749A (en) * 1993-10-15 1998-05-27 Schering Corp Tricyclic carbamate derivatives useful for inhibition of g-protein function and for treating proliferative diseases, medicaments

Also Published As

Publication number Publication date
HUP0000073A3 (en) 2002-02-28
CN1236365A (zh) 1999-11-24
CA2264666A1 (en) 1998-03-19
DE69733142D1 (de) 2005-06-02
ATE294172T1 (de) 2005-05-15
ES2242232T3 (es) 2005-11-01
CN1104428C (zh) 2003-04-02
AU4337597A (en) 1998-04-02
EP0931077B1 (en) 2005-04-27
KR20000036102A (ko) 2000-06-26
DE69733142T2 (de) 2006-03-16
WO1998011097A1 (en) 1998-03-19
NZ334341A (en) 2001-01-26
IL128926A0 (en) 2000-02-17
EP0931077A1 (en) 1999-07-28
HUP0000073A2 (hu) 2001-10-28

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