CN1104428C - 用作法呢基－蛋白转移酶抑制剂的取代的苯并芳庚并吡啶 - Google Patents

用作法呢基－蛋白转移酶抑制剂的取代的苯并芳庚并吡啶 Download PDF

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Publication number
CN1104428C
CN1104428C CN97199528A CN97199528A CN1104428C CN 1104428 C CN1104428 C CN 1104428C CN 97199528 A CN97199528 A CN 97199528A CN 97199528 A CN97199528 A CN 97199528A CN 1104428 C CN1104428 C CN 1104428C
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China
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alkyl
compound
aryl
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group
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Expired - Fee Related
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CN97199528A
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English (en)
Chinese (zh)
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CN1236365A (zh
Inventor
D·F·拉恩
A·B·库珀
A·K·马拉姆斯
R·J·多尔
F·G·尼奥罗格
A·G·塔韦拉斯
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Merck Sharp and Dohme LLC
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Schering Corp
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Publication of CN1236365A publication Critical patent/CN1236365A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pyridine Compounds (AREA)
CN97199528A 1996-09-13 1997-09-11 用作法呢基－蛋白转移酶抑制剂的取代的苯并芳庚并吡啶 Expired - Fee Related CN1104428C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71370596A 1996-09-13 1996-09-13
US08/713,705 1996-09-13

Publications (2)

Publication Number Publication Date
CN1236365A CN1236365A (zh) 1999-11-24
CN1104428C true CN1104428C (zh) 2003-04-02

Family

ID=24867191

Family Applications (1)

Application Number Title Priority Date Filing Date
CN97199528A Expired - Fee Related CN1104428C (zh) 1996-09-13 1997-09-11 用作法呢基－蛋白转移酶抑制剂的取代的苯并芳庚并吡啶

Country Status (13)

Country Link
EP (1) EP0931077B1 (enExample)
JP (1) JP2001500506A (enExample)
KR (1) KR20000036102A (enExample)
CN (1) CN1104428C (enExample)
AT (1) ATE294172T1 (enExample)
AU (1) AU4337597A (enExample)
CA (1) CA2264666A1 (enExample)
DE (1) DE69733142T2 (enExample)
ES (1) ES2242232T3 (enExample)
HU (1) HUP0000073A3 (enExample)
IL (1) IL128926A0 (enExample)
NZ (1) NZ334341A (enExample)
WO (1) WO1998011097A1 (enExample)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6613905B1 (en) 1998-01-21 2003-09-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
CA2318088A1 (en) 1998-01-21 1999-07-29 Yoshisuke Nakasato Chemokine receptor antagonists and methods of use therefor
US6509346B2 (en) 1998-01-21 2003-01-21 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
CN1289336A (zh) 1998-01-21 2001-03-28 千禧药品公司 趋化因子受体拮抗剂和其使用方法
US6503926B2 (en) 1998-09-04 2003-01-07 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US6288083B1 (en) 1998-09-04 2001-09-11 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
US7271176B2 (en) 1998-09-04 2007-09-18 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use thereof
US7541365B2 (en) 2001-11-21 2009-06-02 Millennium Pharmaceuticals, Inc. Chemokine receptor antagonists and methods of use therefor
TWI291467B (en) 2002-11-13 2007-12-21 Millennium Pharm Inc CCR1 antagonists and methods of use therefor
EP1656156A2 (en) 2003-08-13 2006-05-17 Children's Hospital Medical Center Mobilization of hematopoietic cells
ATE524445T1 (de) 2005-06-23 2011-09-15 Merck Sharp & Dohme Benzocycloheptapyridine als inhibitoren der tyrosinkinase met
TW200813021A (en) 2006-07-10 2008-03-16 Merck & Co Inc Tyrosine kinase inhibitors
CA2657247A1 (en) 2006-07-28 2008-01-31 Boehringer Ingelheim International Gmbh Compounds which modulate the cb2 receptor
CA2704684A1 (en) 2007-11-07 2009-05-14 Boehringer Ingelheim International Gmbh Compounds which modulate the cb2 receptor
WO2010005782A1 (en) 2008-07-10 2010-01-14 Boehringer Ingelheim International Gmbh Sulfone compounds which modulate the cb2 receptor
PE20110397A1 (es) 2008-09-25 2011-07-01 Boehringer Ingelheim Int Compuestos que modulan selectivamente el receptor cb2
EP2398771B1 (en) 2009-02-18 2015-07-29 Boehringer Ingelheim International GmbH Heterocyclic compounds which modulate the cb2 receptor
US8299103B2 (en) 2009-06-15 2012-10-30 Boehringer Ingelheim International Gmbh Compounds which selectively modulate the CB2 receptor
WO2010147791A1 (en) * 2009-06-16 2010-12-23 Boehringer Ingelheim International Gmbh Azetidine 2 -carboxamide derivatives which modulate the cb2 receptor
JP2013505295A (ja) 2009-09-22 2013-02-14 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｂ２受容体を選択的に調節する化合物
WO2011088015A1 (en) 2010-01-15 2011-07-21 Boehringer Ingelheim International Gmbh Compounds which modulate the cb2 receptor
EP2542539B1 (en) 2010-03-05 2014-02-26 Boehringer Ingelheim International GmbH Tetrazole compounds which selectively modulate the cb2 receptor
WO2012012307A1 (en) 2010-07-22 2012-01-26 Boehringer Ingelheim International Gmbh Sulfonyl compounds which modulate the cb2 rece
EP2803668A1 (en) 2013-05-17 2014-11-19 Boehringer Ingelheim International Gmbh Novel (cyano-dimethyl-methyl)-isoxazoles and -[1,3,4]thiadiazoles

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0396083A1 (en) * 1989-05-01 1990-11-07 Schering Corporation Heterocyclic N-oxide derivatives of substituted benzo[5,6]cycloheptapyridines, compositions and methods of use
WO1992000293A1 (en) * 1990-06-22 1992-01-09 Schering Corporation Bis-benzo or benzopyrido cyclo hepta piperidene, piperidylidene and piperazine compounds and compositions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1593417A (en) * 1976-12-22 1981-07-15 Squibb & Sons Inc Carbocyclic-fused pyrazolopyridine derivatives
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
NZ274749A (en) * 1993-10-15 1998-05-27 Schering Corp Tricyclic carbamate derivatives useful for inhibition of g-protein function and for treating proliferative diseases, medicaments

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0396083A1 (en) * 1989-05-01 1990-11-07 Schering Corporation Heterocyclic N-oxide derivatives of substituted benzo[5,6]cycloheptapyridines, compositions and methods of use
WO1992000293A1 (en) * 1990-06-22 1992-01-09 Schering Corporation Bis-benzo or benzopyrido cyclo hepta piperidene, piperidylidene and piperazine compounds and compositions

Also Published As

Publication number Publication date
HUP0000073A3 (en) 2002-02-28
CN1236365A (zh) 1999-11-24
CA2264666A1 (en) 1998-03-19
DE69733142D1 (de) 2005-06-02
ATE294172T1 (de) 2005-05-15
ES2242232T3 (es) 2005-11-01
AU4337597A (en) 1998-04-02
JP2001500506A (ja) 2001-01-16
EP0931077B1 (en) 2005-04-27
KR20000036102A (ko) 2000-06-26
DE69733142T2 (de) 2006-03-16
WO1998011097A1 (en) 1998-03-19
NZ334341A (en) 2001-01-26
IL128926A0 (en) 2000-02-17
EP0931077A1 (en) 1999-07-28
HUP0000073A2 (hu) 2001-10-28

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