JP2000516467A - 哺乳動物細胞表面抗原;関連試薬 - Google Patents
哺乳動物細胞表面抗原;関連試薬Info
- Publication number
- JP2000516467A JP2000516467A JP10509871A JP50987198A JP2000516467A JP 2000516467 A JP2000516467 A JP 2000516467A JP 10509871 A JP10509871 A JP 10509871A JP 50987198 A JP50987198 A JP 50987198A JP 2000516467 A JP2000516467 A JP 2000516467A
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- protein
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Transplantation (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.実質的に純粋なまたは組換えの312C2タンパク質またはその保存的に改変さ れた変異体。 2.配列番号2または4に示されるアミノ酸配列を有するタンパク質に対して作 製された抗体に特異的に結合する、請求項1に記載のタンパク質。 3.配列番号2に示されるアミノ酸配列を有するマウス312C2タンパク質である 、請求項2に記載のタンパク質。 4.配列番号4に示されるアミノ酸配列を有するヒト312C2タンパク質である、 請求項2に記載のタンパク質。 5.請求項1に記載のタンパク質を特異的に結合する抗体。 6.モノクローナル抗体である、請求項5に記載の抗体。 7.312C2タンパク質またはペプチドをコードする単離された核酸または組換え 核酸。 8.配列番号2に示されるアミノ酸配列をコードする、請求項7に記載の核酸。 9.配列番号4に示されるアミノ酸配列をコードする、請求項7に記載の核酸。 10.配列番号1に示される配列を有する、請求項8に記載の核酸。 11.配列番号3に示される配列を有する、請求項9に記載の核酸。 12.配列番号1または3に定義される312C2核酸配列に対して少なくとも約30 ヌクレオチドの範囲にわたって少なくとも約70%の同一性を有する配列を含む組 換え核酸。 13.配列番号2または4の312C2配列に対して少なくとも約20アミノ酸の範囲 にわたって少なくとも約60%の同一性を含むポリペプチドをコードする、請求項 12に記載の核酸。 14.請求項7に記載の核酸を含む発現ベクターまたは複製ベクター。 15.請求項14に記載のベクターを含む宿主細胞。 16.核酸が発現される条件下で請求項15に記載の宿主細胞を培養する工程を 包含する、312C2タンパク質を調製する方法。 17.細胞の生理機能を調整する方法であって、該細胞と以下: a)実質的に純粋な312C2タンパク質もしくはその活性フラグメント; b)312C2タンパク質を特異的に結合する抗体もしくは結合パートナー;また は c)312C2タンパク質もしくはペプチドをコードする核酸 とを接触させる工程を包含する、方法。 18.前記細胞がT細胞である、請求項17に記載の方法。 19.前記細胞が組織および/または生物中にある、請求項18に記載の方法。 20.以下: a)312C2タンパク質に特異的に結合する抗体もしくは結合パートナー; b)実質的に純粋な312C2タンパク質もしくはその活性フラグメント;または c)312C2ペプチドをコードする核酸 の有効用量を哺乳動物に投与することにより、異常な免疫応答を有する哺乳動物 を処置する方法。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68994396A | 1996-08-16 | 1996-08-16 | |
US2790196P | 1996-10-07 | 1996-10-07 | |
US60/027,901 | 1996-10-07 | ||
US08/689,943 | 1996-10-07 | ||
PCT/US1997/013931 WO1998006842A1 (en) | 1996-08-16 | 1997-08-14 | Mammalian cell surface antigens; related reagents |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007180366A Division JP2007326865A (ja) | 1996-08-16 | 2007-07-09 | 哺乳動物細胞表面抗原;関連試薬 |
Publications (2)
Publication Number | Publication Date |
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JP2000516467A true JP2000516467A (ja) | 2000-12-12 |
JP4440344B2 JP4440344B2 (ja) | 2010-03-24 |
Family
ID=26703005
Family Applications (5)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP50987198A Expired - Fee Related JP4440344B2 (ja) | 1996-08-16 | 1997-08-14 | 哺乳動物細胞表面抗原;関連試薬 |
JP2007180366A Withdrawn JP2007326865A (ja) | 1996-08-16 | 2007-07-09 | 哺乳動物細胞表面抗原;関連試薬 |
JP2010068911A Withdrawn JP2010187683A (ja) | 1996-08-16 | 2010-03-24 | 哺乳動物細胞表面抗原;関連試薬 |
JP2010068912A Expired - Fee Related JP5388302B2 (ja) | 1996-08-16 | 2010-03-24 | 哺乳動物細胞表面抗原;関連試薬 |
JP2013183661A Pending JP2014054249A (ja) | 1996-08-16 | 2013-09-05 | 哺乳動物細胞表面抗原;関連試薬 |
Family Applications After (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007180366A Withdrawn JP2007326865A (ja) | 1996-08-16 | 2007-07-09 | 哺乳動物細胞表面抗原;関連試薬 |
JP2010068911A Withdrawn JP2010187683A (ja) | 1996-08-16 | 2010-03-24 | 哺乳動物細胞表面抗原;関連試薬 |
JP2010068912A Expired - Fee Related JP5388302B2 (ja) | 1996-08-16 | 2010-03-24 | 哺乳動物細胞表面抗原;関連試薬 |
JP2013183661A Pending JP2014054249A (ja) | 1996-08-16 | 2013-09-05 | 哺乳動物細胞表面抗原;関連試薬 |
Country Status (9)
Country | Link |
---|---|
EP (2) | EP0920505B1 (ja) |
JP (5) | JP4440344B2 (ja) |
AT (1) | ATE397660T1 (ja) |
AU (1) | AU4055697A (ja) |
CA (1) | CA2263129C (ja) |
DE (1) | DE69738749D1 (ja) |
DK (1) | DK0920505T3 (ja) |
ES (1) | ES2308787T3 (ja) |
WO (1) | WO1998006842A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2002502607A (ja) * | 1998-02-09 | 2002-01-29 | ジェネンテク・インコーポレイテッド | 新規な腫瘍壊死因子レセプター相同体及びそれをコードする核酸 |
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WO1997033904A1 (en) | 1996-03-12 | 1997-09-18 | Human Genome Sciences, Inc. | Death domain containing receptors |
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JP4440344B2 (ja) * | 1996-08-16 | 2010-03-24 | シェーリング コーポレイション | 哺乳動物細胞表面抗原;関連試薬 |
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AU1102399A (en) | 1997-10-21 | 1999-05-10 | Human Genome Sciences, Inc. | Human tumor necrosis factor receptor-like proteins tr11, tr11sv1, and tr11sv2 |
US6689607B2 (en) | 1997-10-21 | 2004-02-10 | Human Genome Sciences, Inc. | Human tumor, necrosis factor receptor-like proteins TR11, TR11SV1 and TR11SV2 |
US6503184B1 (en) | 1997-10-21 | 2003-01-07 | Human Genome Sciences, Inc. | Human tumor necrosis factor receptor-like proteins TR11, TR11SV1 and TR11SV2 |
CA2363779A1 (en) | 1999-02-26 | 2000-08-31 | Human Genome Sciences, Inc. | Human endokine alpha and methods of use |
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JP2014054249A (ja) | 2014-03-27 |
CA2263129C (en) | 2007-01-09 |
EP1947183A1 (en) | 2008-07-23 |
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JP5388302B2 (ja) | 2014-01-15 |
DK0920505T3 (da) | 2008-09-08 |
CA2263129A1 (en) | 1998-02-19 |
AU4055697A (en) | 1998-03-06 |
ES2308787T3 (es) | 2008-12-01 |
JP4440344B2 (ja) | 2010-03-24 |
JP2007326865A (ja) | 2007-12-20 |
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