JP2000515529A - 細胞質ホスホリパーゼa▲下2▼の阻害剤としてのアシルピロリドンジカルボン酸およびアシルインドールジカルボン酸ならびにその誘導体 - Google Patents
細胞質ホスホリパーゼa▲下2▼の阻害剤としてのアシルピロリドンジカルボン酸およびアシルインドールジカルボン酸ならびにその誘導体Info
- Publication number
- JP2000515529A JP2000515529A JP10507515A JP50751598A JP2000515529A JP 2000515529 A JP2000515529 A JP 2000515529A JP 10507515 A JP10507515 A JP 10507515A JP 50751598 A JP50751598 A JP 50751598A JP 2000515529 A JP2000515529 A JP 2000515529A
- Authority
- JP
- Japan
- Prior art keywords
- group
- residue
- alkyl
- aryl
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
- C07D207/416—2,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19631102.0 | 1996-08-01 | ||
DE19631102 | 1996-08-01 | ||
PCT/EP1997/003842 WO1998005637A1 (de) | 1996-08-01 | 1997-07-17 | Acylpyrroldicarbonsäuren und acylindoldicarbonsäuren sowie ihre derivate als hemmstoffe der cytosolischen phospholipase a¿2? |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2000515529A true JP2000515529A (ja) | 2000-11-21 |
Family
ID=7801510
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP10507515A Ceased JP2000515529A (ja) | 1996-08-01 | 1997-07-17 | 細胞質ホスホリパーゼa▲下2▼の阻害剤としてのアシルピロリドンジカルボン酸およびアシルインドールジカルボン酸ならびにその誘導体 |
Country Status (11)
Country | Link |
---|---|
US (1) | US6310217B1 (de) |
EP (1) | EP0923546B1 (de) |
JP (1) | JP2000515529A (de) |
KR (1) | KR100482268B1 (de) |
AT (1) | ATE255090T1 (de) |
AU (1) | AU3767997A (de) |
CA (1) | CA2262847C (de) |
DE (1) | DE59711058D1 (de) |
ES (1) | ES2208935T3 (de) |
NO (1) | NO312668B1 (de) |
WO (1) | WO1998005637A1 (de) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010524955A (ja) * | 2007-04-16 | 2010-07-22 | アボット・ラボラトリーズ | 7−置換されていないインドール系Mcl−1阻害薬 |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6569539B2 (en) | 1996-10-30 | 2003-05-27 | Tetra Level Holdings & Finance S.A. | Gas barrier packaging laminate method for production thereof and packaging containers |
IL137719A0 (en) * | 1998-02-25 | 2001-10-31 | Genetics Inst | Inhibitors of phospholipase enzymes |
CA2322161A1 (en) * | 1998-02-25 | 1999-09-02 | Yibin Xiang | Inhibitors of phospholipase enzymes |
US6916841B2 (en) | 1998-02-25 | 2005-07-12 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
US6828344B1 (en) | 1998-02-25 | 2004-12-07 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
SK12782000A3 (sk) * | 1998-02-25 | 2001-04-09 | Genetics Institute, Inc. | Inhibítory fosfolipázových enzýmov, farmaceutický prostriedok s ich obsahom a ich použitie |
PL347591A1 (en) | 1998-11-09 | 2002-04-08 | Gastrin and cholecystokinin receptor ligands | |
DE19951360A1 (de) * | 1999-10-26 | 2001-05-03 | Aventis Pharma Gmbh | Substituierte Indole |
WO2001060814A2 (en) * | 2000-02-15 | 2001-08-23 | Sugen, Inc. | Pyrrole substituted 2-indolinone protein kinase inhibitors |
WO2001090067A1 (fr) | 2000-05-22 | 2001-11-29 | Takeda Chemical Industries, Ltd. | Inhibiteurs de tyrosine phosphatase |
AR042586A1 (es) | 2001-02-15 | 2005-06-29 | Sugen Inc | 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa |
ATE401306T1 (de) | 2001-04-19 | 2008-08-15 | Dainippon Sumitomo Pharma Co | Pyrrolderivat |
US6642232B2 (en) | 2001-10-10 | 2003-11-04 | Sugen, Inc. | 3-[4-Substituted heterocyclyl)-pyrrol-2-ylmethylidene]-2- indolinone derivatives as kinase inhibitors |
US6984735B2 (en) | 2001-12-03 | 2006-01-10 | Wyeth | Process for making an aldehyde |
US7605156B2 (en) | 2001-12-03 | 2009-10-20 | Wyeth | Methods for the use of inhibitors of cytosolic phospholipase A2 |
US7713964B2 (en) | 2001-12-03 | 2010-05-11 | Wyeth Llc | Methods for treating asthmatic conditions |
US6797708B2 (en) | 2001-12-03 | 2004-09-28 | Wyeth | Inhibitors of cytosolic phospholipase A2 |
US7101875B2 (en) | 2001-12-03 | 2006-09-05 | Wyeth | Methods for treating arthritic disorders |
US6635771B2 (en) | 2001-12-03 | 2003-10-21 | Wyeth | N-benzhydryl indole compounds |
AU2003237397A1 (en) * | 2002-06-04 | 2003-12-19 | Sequenom, Inc. | Diagnosing predisposition to fat deposition and therapeutic methods for reducing fat deposition and treatment of associated conditions |
AUPS282602A0 (en) | 2002-06-07 | 2002-06-27 | Garvan Institute Of Medical Research | Method of inhibiting cell proliferation |
WO2004002295A2 (en) * | 2002-06-27 | 2004-01-08 | Sequenom, Inc. | Diagnosing predisposition to fat deposition and associated condition |
CA2490367A1 (en) * | 2002-06-27 | 2004-01-08 | Sequenom, Inc. | Therapeutic methods for reducing fat deposition and treating associated conditions |
DE10305089A1 (de) | 2003-02-07 | 2004-08-26 | Merckle Gmbh | Neue heteroarylsubstituierte Acetonderivate als Hemmstoffe der Phospholiphase A2 |
US20050244367A1 (en) * | 2004-05-03 | 2005-11-03 | Ilypsa, Inc. | Phospholipase inhibitors localized in the gastrointestinal lumen |
GT200600228A (es) | 2005-05-27 | 2006-12-26 | Inhibidores de la fosfolipasa a2 citosolica | |
WO2009102893A2 (en) | 2008-02-14 | 2009-08-20 | Amira Pharmaceuticals, Inc. | CYCLIC DIARYL ETHER COMPOUNDS AS ANTAGONISTS OF PROSTAGLANDIN D2 receptors |
EP2268611A2 (de) | 2008-04-02 | 2011-01-05 | Amira Pharmaceuticals, Inc. | Aminoalkylphenyl-antagonisten von prostaglandin-d2-rezeptoren |
US8383654B2 (en) | 2008-11-17 | 2013-02-26 | Panmira Pharmaceuticals, Llc | Heterocyclic antagonists of prostaglandin D2 receptors |
US20130045992A1 (en) | 2010-01-28 | 2013-02-21 | President And Fellows Of Harvard College | Compositions and Methods for Enhancing Proteasome Activity |
CA2835610C (en) | 2011-05-12 | 2017-03-14 | Proteostasis Therapeutics, Inc. | Proteostasis regulators |
US9849135B2 (en) | 2013-01-25 | 2017-12-26 | President And Fellows Of Harvard College | USP14 inhibitors for treating or preventing viral infections |
WO2015073528A1 (en) | 2013-11-12 | 2015-05-21 | Proteostasis Therapeutics, Inc. | Proteasome activity enhancing compounds |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3624103A (en) * | 1968-05-21 | 1971-11-30 | Abc Ist Biolog Chem Spa | 3-indoleacetohydroxamic acids |
JPH05502222A (ja) * | 1989-10-27 | 1993-04-22 | アメリカン・ホーム・プロダクツ・コーポレイション | Pla↓2およびリポキシゲナーゼの阻害剤としての置換インドール―、インデン―、ピラノインドール―およびテトラヒドロカルバゾール―アルカン酸誘導体 |
JPH0710838A (ja) * | 1993-04-16 | 1995-01-13 | Eli Lilly & Co | sPLA2阻害剤1H−インドール−3−酢酸ヒドラジド |
WO1995013266A1 (de) * | 1993-11-12 | 1995-05-18 | Merckle Gmbh Chem.-Pharm. Fabrik | Acylpyrrolalkansäuren und indol-2-alkansäuren sowie ihre derivate als hemmstoffe der phospholipase a¿2? |
JPH10503208A (ja) * | 1994-07-21 | 1998-03-24 | イーライ・リリー・アンド・カンパニー | 1H−インドール−1−官能性sPLA▲下2▼インヒビター |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2641464B1 (fr) * | 1989-01-06 | 1994-06-03 | Rolland Sa A | Nouvelles compositions pharmaceutiques manifestant des proprietes inhibitrices vis-a-vis de la phospholipase a2 |
JPH0684594B2 (ja) * | 1989-02-02 | 1994-10-26 | 株式会社神戸製鋼所 | 釣 糸 |
DE3915450A1 (de) * | 1989-05-11 | 1990-11-15 | Gerd Prof Dr Dannhardt | Substituierte pyrrolverbindungen und deren anwendung in der pharmazie |
US5260451A (en) | 1989-05-11 | 1993-11-09 | Merckle Gmbh | Substituted pyrrole compounds and use thereof in pharmaceutical compositions |
US5229516A (en) | 1989-10-27 | 1993-07-20 | American Home Products Corporation | Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase |
US5420289A (en) | 1989-10-27 | 1995-05-30 | American Home Products Corporation | Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase |
US5081145A (en) * | 1990-02-01 | 1992-01-14 | Merck Frosst Canada, Inc. | Indole-2-alkanoic acids compositions of and anti allergic use thereof |
DE4325204C2 (de) | 1993-07-27 | 2002-11-28 | Matthias Lehr | Acylpyrrolalkansäuren und ihre Derivate als Hemmstoffe der Phospholipase A¶2¶ |
-
1997
- 1997-07-17 DE DE59711058T patent/DE59711058D1/de not_active Expired - Fee Related
- 1997-07-17 AT AT97934481T patent/ATE255090T1/de not_active IP Right Cessation
- 1997-07-17 CA CA002262847A patent/CA2262847C/en not_active Expired - Fee Related
- 1997-07-17 AU AU37679/97A patent/AU3767997A/en not_active Abandoned
- 1997-07-17 KR KR10-1999-7000734A patent/KR100482268B1/ko not_active IP Right Cessation
- 1997-07-17 EP EP97934481A patent/EP0923546B1/de not_active Expired - Lifetime
- 1997-07-17 WO PCT/EP1997/003842 patent/WO1998005637A1/de active IP Right Grant
- 1997-07-17 JP JP10507515A patent/JP2000515529A/ja not_active Ceased
- 1997-07-17 ES ES97934481T patent/ES2208935T3/es not_active Expired - Lifetime
-
1999
- 1999-01-28 NO NO19990413A patent/NO312668B1/no unknown
- 1999-01-29 US US09/240,148 patent/US6310217B1/en not_active Expired - Fee Related
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3624103A (en) * | 1968-05-21 | 1971-11-30 | Abc Ist Biolog Chem Spa | 3-indoleacetohydroxamic acids |
JPH05502222A (ja) * | 1989-10-27 | 1993-04-22 | アメリカン・ホーム・プロダクツ・コーポレイション | Pla↓2およびリポキシゲナーゼの阻害剤としての置換インドール―、インデン―、ピラノインドール―およびテトラヒドロカルバゾール―アルカン酸誘導体 |
JPH0710838A (ja) * | 1993-04-16 | 1995-01-13 | Eli Lilly & Co | sPLA2阻害剤1H−インドール−3−酢酸ヒドラジド |
WO1995013266A1 (de) * | 1993-11-12 | 1995-05-18 | Merckle Gmbh Chem.-Pharm. Fabrik | Acylpyrrolalkansäuren und indol-2-alkansäuren sowie ihre derivate als hemmstoffe der phospholipase a¿2? |
JPH10503208A (ja) * | 1994-07-21 | 1998-03-24 | イーライ・リリー・アンド・カンパニー | 1H−インドール−1−官能性sPLA▲下2▼インヒビター |
Non-Patent Citations (1)
Title |
---|
J.MED.CHEM., vol. 40, JPN7007002795, 1997, pages 2694 - 2705, ISSN: 0000954807 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010524955A (ja) * | 2007-04-16 | 2010-07-22 | アボット・ラボラトリーズ | 7−置換されていないインドール系Mcl−1阻害薬 |
Also Published As
Publication number | Publication date |
---|---|
ES2208935T3 (es) | 2004-06-16 |
WO1998005637A1 (de) | 1998-02-12 |
DE59711058D1 (de) | 2004-01-08 |
KR20000029658A (ko) | 2000-05-25 |
CA2262847C (en) | 2007-06-05 |
CA2262847A1 (en) | 1998-02-12 |
ATE255090T1 (de) | 2003-12-15 |
EP0923546B1 (de) | 2003-11-26 |
EP0923546A1 (de) | 1999-06-23 |
NO990413D0 (no) | 1999-01-28 |
NO990413L (no) | 1999-01-28 |
US6310217B1 (en) | 2001-10-30 |
AU3767997A (en) | 1998-02-25 |
NO312668B1 (no) | 2002-06-17 |
KR100482268B1 (ko) | 2005-04-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP2000515529A (ja) | 細胞質ホスホリパーゼa▲下2▼の阻害剤としてのアシルピロリドンジカルボン酸およびアシルインドールジカルボン酸ならびにその誘導体 | |
JP2693576B2 (ja) | 置換された4―(キノリン―2―イル―メトキシ)フエニル酢酸誘導体及びその塩の製造方法 | |
KR100330816B1 (ko) | H-인돌-3-아세트산하이드라이드spla2억제제 | |
PT99154A (pt) | Processo para a preparacao de derivados de indole, uteis como agentes anti-alergicos e anti-inflamatorios | |
WO1995013266A1 (de) | Acylpyrrolalkansäuren und indol-2-alkansäuren sowie ihre derivate als hemmstoffe der phospholipase a¿2? | |
KR20010041346A (ko) | 포스포리파제 a2 억제제 | |
JP2000505810A (ja) | アポb−分泌/mtp阻害性アミド | |
JPS63246372A (ja) | 3−ヘテロ置換−n−ベンジル−インドール | |
JP2002513422A (ja) | 新規甲状腺レセプターリガンドおよび方法 | |
JP2006510673A (ja) | プラスミノゲンアクティベータインヒビター1(pai−1)のインヒビターとしての、アリール、アリールオキシ、および、アルキルオキシ置換1h−インドール−3−イルグリオキシル酸誘導体 | |
JPS61191683A (ja) | 新規な酸性インド−ル化合物 | |
JP2002518307A (ja) | 転写因子NF−κBの阻害剤 | |
KR20000010879A (ko) | 엔도텔린 수용체 길항제로서 유용한 인돌 유도체u | |
JPH07121937B2 (ja) | カルボスチリル誘導体 | |
JPH1160557A (ja) | アポb分泌/mtp阻害剤の塩酸塩 | |
TWI342775B (en) | N-aryl piperidine substituted biphenylcarboxamides | |
DE4325204C2 (de) | Acylpyrrolalkansäuren und ihre Derivate als Hemmstoffe der Phospholipase A¶2¶ | |
JPS59148764A (ja) | 1−フエニル−2−アミノカルボニルインド−ル化合物,および該化合物を含有する,抗不整脈作用を有する医薬 | |
CA1139763A (fr) | Procede d'obtention de nouveaux aryltrifluoroethanols | |
US7608633B2 (en) | Heteroaryl-substituted acetone derivatives as inhibitors of phospholipase A2 | |
FR2665160A1 (fr) | Nouveaux derives de 1-diphenylmethylpiperazine, leur preparation et leur application en tant que medicaments. | |
JP2833865B2 (ja) | 5−アルファ−リダクターゼ−1−阻害剤としてのインドール誘導体 | |
KR20050091086A (ko) | 인데논카르복실산 유도체 및 당뇨병 및 이상지혈증의 치료및 예방을 위한 이의 용도 | |
EP1383762A1 (de) | Tetrahydropyridyl-alkyl-heterozykle, verfahren zu ihrer herstellung und pharmazeutische zusammensetzungen die sie enthalten | |
JPH08501557A (ja) | Acat阻害剤としての1,2−二置換エチルアミド |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20040622 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20080115 |
|
A313 | Final decision of rejection without a dissenting response from the applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A313 Effective date: 20080617 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20080729 |