JP2000510582A - 微粒子標識を使用した分析物アッセイ - Google Patents

微粒子標識を使用した分析物アッセイ

Info

Publication number
JP2000510582A
JP2000510582A JP09538227A JP53822797A JP2000510582A JP 2000510582 A JP2000510582 A JP 2000510582A JP 09538227 A JP09538227 A JP 09538227A JP 53822797 A JP53822797 A JP 53822797A JP 2000510582 A JP2000510582 A JP 2000510582A
Authority
JP
Japan
Prior art keywords
particles
light
particle
gold
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP09538227A
Other languages
English (en)
Japanese (ja)
Other versions
JP2000510582A5 (enExample
Inventor
イゲラバイド，ジュアン
イゲラバイド，エヴァンゲリーナ・イー
コーン，デビット・イー
ジャクソン，ジェフリー・ティー
Original Assignee
ゼニコン・サイエンシーズ・コーポレーション
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ゼニコン・サイエンシーズ・コーポレーション filed Critical ゼニコン・サイエンシーズ・コーポレーション
Publication of JP2000510582A publication Critical patent/JP2000510582A/ja
Publication of JP2000510582A5 publication Critical patent/JP2000510582A5/ja
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N2015/0038—Investigating nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1493—Particle size

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Cell Biology (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP09538227A 1996-04-25 1997-04-17 微粒子標識を使用した分析物アッセイ Withdrawn JP2000510582A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1638396P 1996-04-25 1996-04-25
US60/016,383 1996-04-25
PCT/US1997/006584 WO1997040181A1 (en) 1996-04-25 1997-04-17 Analyte assay using particulate labels

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2007149827A Division JP2007263974A (ja) 1996-04-25 2007-06-05 微粒子標識を使用した分析物アッセイ。
JP2009138755A Division JP2009236921A (ja) 1996-04-25 2009-06-10 微粒子標識を使用した分析物アッセイ

Publications (2)

Publication Number Publication Date
JP2000510582A true JP2000510582A (ja) 2000-08-15
JP2000510582A5 JP2000510582A5 (enExample) 2004-12-09

Family

ID=21776844

Family Applications (3)

Application Number Title Priority Date Filing Date
JP09538227A Withdrawn JP2000510582A (ja) 1996-04-25 1997-04-17 微粒子標識を使用した分析物アッセイ
JP2007149827A Pending JP2007263974A (ja) 1996-04-25 2007-06-05 微粒子標識を使用した分析物アッセイ。
JP2009138755A Pending JP2009236921A (ja) 1996-04-25 2009-06-10 微粒子標識を使用した分析物アッセイ

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2007149827A Pending JP2007263974A (ja) 1996-04-25 2007-06-05 微粒子標識を使用した分析物アッセイ。
JP2009138755A Pending JP2009236921A (ja) 1996-04-25 2009-06-10 微粒子標識を使用した分析物アッセイ

Country Status (12)

Country Link
US (1) US6214560B1 (enExample)
EP (1) EP1021554B1 (enExample)
JP (3) JP2000510582A (enExample)
CN (1) CN1262667C (enExample)
AT (1) ATE357663T1 (enExample)
AU (1) AU736340B2 (enExample)
BR (1) BR9710836A (enExample)
CA (1) CA2253710A1 (enExample)
DE (1) DE69737513T2 (enExample)
IL (1) IL126544A (enExample)
RU (1) RU2251572C2 (enExample)
WO (1) WO1997040181A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008055570A (ja) * 2006-09-01 2008-03-13 Ricoh Co Ltd 複合金属ナノ粒子、複合金属ナノ粒子を含む多光子吸収反応材料と反応生成物、複合金属ナノ粒子を含む多光子吸収反応助剤
JP2012500385A (ja) * 2008-08-06 2012-01-05 インビトロックス，インコーポレイテッド 生物学的応用における集束光散乱技術の使用
JP2013057605A (ja) * 2011-09-08 2013-03-28 Kyushu Univ 銀シェル金ナノロッドを用いる分析方法

Families Citing this family (324)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE43097E1 (en) 1994-10-13 2012-01-10 Illumina, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
US6586193B2 (en) * 1996-04-25 2003-07-01 Genicon Sciences Corporation Analyte assay using particulate labels
WO1998004740A1 (en) * 1996-07-29 1998-02-05 Nanosphere Llc Nanoparticles having oligonucleotides attached thereto and uses therefor
US7169556B2 (en) 1996-07-29 2007-01-30 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6582921B2 (en) * 1996-07-29 2003-06-24 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses thereof
US6506564B1 (en) 1996-07-29 2003-01-14 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6984491B2 (en) * 1996-07-29 2006-01-10 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6361944B1 (en) 1996-07-29 2002-03-26 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6750016B2 (en) 1996-07-29 2004-06-15 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US7098320B1 (en) 1996-07-29 2006-08-29 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US20020172953A1 (en) * 1996-07-29 2002-11-21 Mirkin Chad A. Movement of biomolecule-coated nanoparticles in an electric field
GB9618897D0 (en) 1996-09-10 1996-10-23 Bio Rad Micromeasurements Ltd Micro defects in silicon wafers
DE69830598T2 (de) 1997-01-31 2006-05-18 The Horticulture And Food Research Institute Of New Zealand Limited Optische vorrichtung und methode
WO1998037417A1 (en) 1997-02-20 1998-08-27 The Regents Of The University Of California Plasmon resonant particles, methods and apparatus
US6344272B1 (en) 1997-03-12 2002-02-05 Wm. Marsh Rice University Metal nanoshells
US6852252B2 (en) 1997-03-12 2005-02-08 William Marsh Rice University Use of metalnanoshells to impede the photo-oxidation of conjugated polymer
JP4294740B2 (ja) * 1997-05-23 2009-07-15 ソレクサ・インコーポレイテッド 分析物の系列的プロセシングのためのシステムおよび装置
US6974669B2 (en) 2000-03-28 2005-12-13 Nanosphere, Inc. Bio-barcodes based on oligonucleotide-modified nanoparticles
US20050037397A1 (en) * 2001-03-28 2005-02-17 Nanosphere, Inc. Bio-barcode based detection of target analytes
US6071689A (en) 1997-12-31 2000-06-06 Xy, Inc. System for improving yield of sexed embryos in mammals
US6149867A (en) 1997-12-31 2000-11-21 Xy, Inc. Sheath fluids and collection systems for sex-specific cytometer sorting of sperm
US6699724B1 (en) 1998-03-11 2004-03-02 Wm. Marsh Rice University Metal nanoshells for biosensing applications
US6428811B1 (en) 1998-03-11 2002-08-06 Wm. Marsh Rice University Temperature-sensitive polymer/nanoshell composites for photothermally modulated drug delivery
US20030153023A1 (en) * 1999-05-13 2003-08-14 Starzl Timothy W. Enumeration method of analyte detection
AU768535B2 (en) 1998-11-30 2003-12-18 Nanosphere, Inc. Nanoparticles with polymer shells
JP2002532728A (ja) * 1998-12-17 2002-10-02 ライカ ミクロジュステムス ハイデルベルク ゲーエムベーハー 有利には生体試料における種々の構造体を識別検査するための方法
EP1039291A1 (en) * 1999-03-26 2000-09-27 Sony International (Europe) GmbH Optochemical sensor and method for its construction
US20050100943A1 (en) * 2000-04-11 2005-05-12 Hideki Kambara Method of producing probe arrays for biological materials using fine particles
US20030166015A1 (en) * 1999-04-15 2003-09-04 Zarowitz Michael A. Multiplexed analysis of cell-substrate interactions
US20030207249A1 (en) * 1999-04-15 2003-11-06 Beske Oren E. Connection of cells to substrates using association pairs
AU4245900A (en) * 1999-04-15 2000-11-02 Virtual Arrays, Inc. Combinatorial chemical library supports having indicia at coding positions and methods of use
US7253435B2 (en) * 1999-04-15 2007-08-07 Millipore Corporation Particles with light-polarizing codes
US20030129654A1 (en) * 1999-04-15 2003-07-10 Ilya Ravkin Coded particles for multiplexed analysis of biological samples
US20030134330A1 (en) * 1999-04-15 2003-07-17 Ilya Ravkin Chemical-library composition and method
US6908737B2 (en) * 1999-04-15 2005-06-21 Vitra Bioscience, Inc. Systems and methods of conducting multiplexed experiments
US6868371B1 (en) * 1999-05-03 2005-03-15 General Electric Company System and method to quantify appearance defects in molded plastic parts
US6608716B1 (en) 1999-05-17 2003-08-19 New Mexico State University Technology Transfer Corporation Optical enhancement with nanoparticles and microcavities
US20030096321A1 (en) * 1999-05-19 2003-05-22 Jose Remacle Method for the identification and/or the quantification of a target compound obtained from a biological sample upon chips
US6606566B1 (en) * 1999-11-01 2003-08-12 Steven A. Sunshine Computer code for portable sensing
AU1476601A (en) 1999-11-09 2001-06-06 Sri International Array for the high-throughput synthesis, screening and characterization of combinatorial libraries, and methods for making the array
US7033840B1 (en) 1999-11-09 2006-04-25 Sri International Reaction calorimeter and differential scanning calorimeter for the high-throughput synthesis, screening and characterization of combinatorial libraries
US7208265B1 (en) 1999-11-24 2007-04-24 Xy, Inc. Method of cryopreserving selected sperm cells
CA2396113C (en) 2000-01-13 2009-04-07 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
AU2001275475A1 (en) * 2000-06-12 2001-12-24 Genicon Sciences Corporation Assay for genetic polymorphisms using scattered light detectable labels
AU2001276870B2 (en) * 2000-07-11 2006-07-20 Northwestern University Method of detection by enhancement of silver staining
JP2004537712A (ja) 2000-10-18 2004-12-16 バーチャル・アレイズ・インコーポレーテッド 多重細胞分析システム
AU2002237689B2 (en) 2000-11-29 2008-01-10 Xy, Llc. System to separate frozen-thawed spermatozoa into X-chromosome bearing and Y-chromosome bearing populations
US7713687B2 (en) 2000-11-29 2010-05-11 Xy, Inc. System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
WO2002046483A2 (en) 2000-12-06 2002-06-13 Northwestern University Silver stain removal from dna detection chips by cyanide etching or sonication
US7811768B2 (en) * 2001-01-26 2010-10-12 Aviva Biosciences Corporation Microdevice containing photorecognizable coding patterns and methods of using and producing the same
US7015047B2 (en) * 2001-01-26 2006-03-21 Aviva Biosciences Corporation Microdevices having a preferential axis of magnetization and uses thereof
US7361472B2 (en) 2001-02-23 2008-04-22 Invitrogen Corporation Methods for providing extended dynamic range in analyte assays
US20040166502A1 (en) * 2001-03-13 2004-08-26 Yaming Lai Microelectromagnetic dispenser heads and uses thereof
US20060040286A1 (en) * 2001-03-28 2006-02-23 Nanosphere, Inc. Bio-barcode based detection of target analytes
ATE431853T1 (de) * 2001-03-28 2009-06-15 Nanosphere Inc Auf oligonukleotid-modifizierten partikeln basierende bio-strichcodes
EP1565747B1 (en) * 2001-03-29 2013-11-27 Cellect Technologies Corp. Method and system for separating and sorting particles
US20040121350A1 (en) * 2002-12-24 2004-06-24 Biosite Incorporated System and method for identifying a panel of indicators
US7713705B2 (en) * 2002-12-24 2010-05-11 Biosite, Inc. Markers for differential diagnosis and methods of use thereof
US20040253637A1 (en) * 2001-04-13 2004-12-16 Biosite Incorporated Markers for differential diagnosis and methods of use thereof
US20040203083A1 (en) * 2001-04-13 2004-10-14 Biosite, Inc. Use of thrombus precursor protein and monocyte chemoattractant protein as diagnostic and prognostic indicators in vascular diseases
US20040126767A1 (en) * 2002-12-27 2004-07-01 Biosite Incorporated Method and system for disease detection using marker combinations
US20030113740A1 (en) * 2001-04-26 2003-06-19 Mirkin Chad A. Oligonucleotide-modified ROMP polymers and co-polymers
AU2002239726A1 (en) 2001-05-25 2002-12-09 Northwestern University Non-alloying core shell nanoparticles
US7147687B2 (en) * 2001-05-25 2006-12-12 Nanosphere, Inc. Non-alloying core shell nanoparticles
US20030092029A1 (en) 2001-06-06 2003-05-15 Lee Josephson Magneitc-nanoparticle conjugates and methods of use
AU2002310343A1 (en) * 2001-06-07 2002-12-16 University Of Pennsylvania-Center For Technology Transfer Multiplexing method
US6714299B2 (en) 2001-07-13 2004-03-30 Genicon Sciences Corporation Use of light scattering particles in design, manufacture, and quality control of small volume instruments, devices, and processes
ATE423975T1 (de) * 2001-08-03 2009-03-15 Nanosphere Inc Nanopartikelabbildungssystem und -verfahren
US20040146917A1 (en) * 2001-08-03 2004-07-29 Nanosphere, Inc. Nanoparticle imaging system and method
AU2002331833A1 (en) * 2001-09-05 2003-03-18 Genicon Sciences Corporation Method and apparatus for normalization and deconvolution of assay data
US20030049866A1 (en) * 2001-09-05 2003-03-13 Genicon Sciences Corporation Sample device preservation
ATE437216T1 (de) 2001-09-06 2009-08-15 Genomic Profiling Systems Inc Schnellnachweis replizierender zellen
EP2287290B1 (en) 2001-09-20 2016-05-11 AntiCancer, Inc. Nestin-expressing hair follicle stem cells
US6754414B2 (en) * 2001-09-27 2004-06-22 Bio-Rad Laboratories, Inc. Imaging of microarrays using fiber optic exciter
US8148171B2 (en) * 2001-10-09 2012-04-03 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
CA2463323C (en) * 2001-10-09 2010-12-21 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US20030219800A1 (en) * 2001-10-18 2003-11-27 Beske Oren E. Multiplexed cell transfection using coded carriers
CA2466656C (en) 2001-11-09 2013-07-02 Nanosphere, Inc. Bioconjugate-nanoparticle probes
US7083975B2 (en) * 2002-02-01 2006-08-01 Roland Green Microarray synthesis instrument and method
US7214427B2 (en) * 2002-03-21 2007-05-08 Aviva Biosciences Corporation Composite beads comprising magnetizable substance and electro-conductive substance
US7029631B2 (en) * 2002-04-19 2006-04-18 Agilent Technologies, Inc. Apparatus for improved light collection
US20030211488A1 (en) * 2002-05-07 2003-11-13 Northwestern University Nanoparticle probs with Raman spectrocopic fingerprints for analyte detection
WO2003096015A1 (en) * 2002-05-08 2003-11-20 Matsushita Electric Industrial Co., Ltd. Biomolecular substrate, method of testing or diagnosis with use thereof and apparatus therefor
US20040126773A1 (en) * 2002-05-23 2004-07-01 Beske Oren E. Assays with coded sensor particles to sense assay conditions
DE10223706A1 (de) 2002-05-28 2003-12-18 Nat Taiwan University Taipeh T Lichtemissionsdiode
JP2005532456A (ja) * 2002-07-02 2005-10-27 ナノスフェアー　インコーポレイテッド ナノ粒子ポリアニオン複合物ならびに分析物の検出における同複合物の用途
US20060067916A1 (en) * 2002-07-22 2006-03-30 Xy, Inc. Sperm cell process system
US20040018495A1 (en) * 2002-07-24 2004-01-29 Xing-Xiang Li Microparticle based signal amplification for the detection of analytes
US8486618B2 (en) 2002-08-01 2013-07-16 Xy, Llc Heterogeneous inseminate system
CA2532376C (en) * 2002-08-01 2015-05-12 Colorado State University Research Foundation Low pressure sperm cell separation system
BRPI0313476B1 (pt) 2002-08-15 2015-06-23 Xy Llc Citômetro de fluxo de alta resolução
US7900836B2 (en) 2002-08-20 2011-03-08 Illumina, Inc. Optical reader system for substrates having an optically readable code
US7901630B2 (en) 2002-08-20 2011-03-08 Illumina, Inc. Diffraction grating-based encoded microparticle assay stick
US7441703B2 (en) 2002-08-20 2008-10-28 Illumina, Inc. Optical reader for diffraction grating-based encoded optical identification elements
US7872804B2 (en) 2002-08-20 2011-01-18 Illumina, Inc. Encoded particle having a grating with variations in the refractive index
US7619819B2 (en) 2002-08-20 2009-11-17 Illumina, Inc. Method and apparatus for drug product tracking using encoded optical identification elements
US7923260B2 (en) 2002-08-20 2011-04-12 Illumina, Inc. Method of reading encoded particles
US7508608B2 (en) 2004-11-17 2009-03-24 Illumina, Inc. Lithographically fabricated holographic optical identification element
EP1535241A1 (en) * 2002-08-20 2005-06-01 Cyvera Corporation Diffraction grating-based optical identification element
WO2004019277A1 (en) * 2002-08-20 2004-03-04 Cyvera Corporation Diffraction grating-based encoded micro-particles for multiplexed experiments
US7164533B2 (en) 2003-01-22 2007-01-16 Cyvera Corporation Hybrid random bead/chip based microarray
US20040043385A1 (en) * 2002-09-03 2004-03-04 Yo-Hsin Su Microarray biochip
US20100255603A9 (en) * 2002-09-12 2010-10-07 Putnam Martin A Method and apparatus for aligning microbeads in order to interrogate the same
EP1552475A1 (en) * 2002-09-12 2005-07-13 Cyvera Corporation Chemical synthesis using diffraction grating-based encoded optical elements
AU2003270726A1 (en) * 2002-09-12 2004-04-30 Cidra Corporation Diffraction grating-based encoded micro-particles for multiplexed experiments
US7092160B2 (en) 2002-09-12 2006-08-15 Illumina, Inc. Method of manufacturing of diffraction grating-based optical identification element
EP1575707A1 (en) * 2002-09-12 2005-09-21 Cyvera Corporation Method and apparatus for aligning elongated microbeads in order to interrogate the same
CA2499037A1 (en) * 2002-09-12 2004-03-25 Cyvera Corporation Method and apparatus for labelling using diffraction grating-based encoded optical identification elements
US7169548B2 (en) 2002-09-13 2007-01-30 Xy, Inc. Sperm cell processing and preservation systems
EP1552025A4 (en) * 2002-10-18 2006-12-13 Cylene Pharmaceuticals Inc METHOD FOR IDENTIFYING ANTIVIRAL MOLECULES DETECTED BY A QUADRUPLEX STRUCTURE
AU2003289853A1 (en) * 2002-11-04 2004-06-07 Ludwig-Maximilian-Uni Versitat Munchen Methods, device and instrument for detection of analytes
US7122384B2 (en) * 2002-11-06 2006-10-17 E. I. Du Pont De Nemours And Company Resonant light scattering microparticle methods
JP2006526140A (ja) * 2002-12-24 2006-11-16 バイオサイト インコーポレイテッド 鑑別診断のためのマーカーおよびその使用方法
EP1583473A2 (en) * 2003-01-16 2005-10-12 St. Johns University New York Nanoparticle based stabilization of ir fluorescent dyes
US8081792B2 (en) 2003-08-20 2011-12-20 Illumina, Inc. Fourier scattering methods for encoding microbeads and methods and apparatus for reading the same
EP1597399A2 (en) * 2003-02-27 2005-11-23 Nanosphere, Inc. Label-free gene expression profiling with universal nanoparticle probes in microarray assay format
AU2004226378A1 (en) * 2003-03-27 2004-10-14 The General Hospital Corporation Method and apparatus for dermatological treatment and fractional skin resurfacing
DK2308419T3 (da) 2003-03-28 2016-06-06 Inguran Llc Fremgangsmåde til bedømmelse af farvningstilstandene for dyresperm, som skal sorteres.
JP2006522827A (ja) * 2003-04-07 2006-10-05 サイリーン ファーマシューティカルズ インコーポレーティッド 置換キノベンゾオキサジン類似体
US7507727B2 (en) * 2003-04-07 2009-03-24 Cylene Pharmaceuticals, Inc. Substituted quinobenzoxazine analogs and methods of using thereof
US7354916B2 (en) * 2003-04-07 2008-04-08 Cylene Pharmaceuticals Substituted quinobenzoxazine analogs
US7163948B2 (en) * 2003-04-07 2007-01-16 Cylene Pharmaceuticals, Inc. Heterocyclic substituted 1,4-dihydri-4ox9-1,8-naphthyridine analogs
GB0308182D0 (en) * 2003-04-09 2003-05-14 Aoti Operating Co Inc Detection method and apparatus
US7177487B2 (en) * 2003-04-21 2007-02-13 Baxter International Inc. Determination of particle size by image analysis
NZ544103A (en) * 2003-05-15 2010-10-29 Xy Llc Efficient haploid cell sorting for flow cytometer systems
US20050250094A1 (en) * 2003-05-30 2005-11-10 Nanosphere, Inc. Method for detecting analytes based on evanescent illumination and scatter-based detection of nanoparticle probe complexes
US7341841B2 (en) * 2003-07-12 2008-03-11 Accelr8 Technology Corporation Rapid microbial detection and antimicrobial susceptibility testing
ES2661168T3 (es) 2003-07-12 2018-03-27 Accelerate Diagnostics, Inc. Biodetección sensible y rápida
US20120077206A1 (en) 2003-07-12 2012-03-29 Accelr8 Technology Corporation Rapid Microbial Detection and Antimicrobial Susceptibility Testing
US7641971B2 (en) * 2003-08-13 2010-01-05 Crane Company Metal-treated particles for remediation
WO2005074417A2 (en) * 2003-09-03 2005-08-18 Salk Institute For Biological Studies Multiple antigen detection assays and reagents
US7488451B2 (en) * 2003-09-15 2009-02-10 Millipore Corporation Systems for particle manipulation
EP1676133A4 (en) * 2003-09-15 2008-05-21 Millipore Corp TESTS WITH PRIMARY CELLS
US7413868B2 (en) * 2003-11-05 2008-08-19 Trellis Bioscience, Inc. Use of particulate labels in bioanalyte detection methods
WO2005062940A2 (en) 2003-12-22 2005-07-14 John Wayne Cancer Institute Method and apparatus for in vivo collection and surveillance of circulating biological components
US20050153309A1 (en) 2003-12-22 2005-07-14 David Hoon Method and apparatus for in vivo surveillance of circulating biological components
US7553625B2 (en) * 2003-12-22 2009-06-30 John Wayne Cancer Institute Method and apparatus for in vivo collection of circulating biological components
US20050141843A1 (en) * 2003-12-31 2005-06-30 Invitrogen Corporation Waveguide comprising scattered light detectable particles
CA2834041C (en) * 2003-12-31 2017-05-16 President And Fellows Of Harvard College Assay device and method
JP4698613B2 (ja) 2004-01-26 2011-06-08 プレジデント アンド フェロウズ オブ ハーバード カレッジ 流体送達のシステムおよび方法
US8030057B2 (en) * 2004-01-26 2011-10-04 President And Fellows Of Harvard College Fluid delivery system and method
DE102004006470B4 (de) * 2004-02-06 2006-06-01 Senova Gesellschaft für Biowissenschaft und Technik mbH Absorptionsphotometrisches Verfahren zur quantitativen Stoffanalyse
US20050270603A1 (en) * 2004-02-19 2005-12-08 Cyuera Corporation Optical identification element using separate or partially overlapped diffraction gratings
US20060023310A1 (en) * 2004-02-19 2006-02-02 Putnam Martin A Optical identification element using separate or partially overlapped diffraction gratings
WO2005079545A2 (en) * 2004-02-19 2005-09-01 Illumina, Inc. Optical identification element using separate or partially overlapped diffraction gratings
US7433123B2 (en) * 2004-02-19 2008-10-07 Illumina, Inc. Optical identification element having non-waveguide photosensitive substrate with diffraction grating therein
JP2007531523A (ja) 2004-03-29 2007-11-08 モンサント テクノロジー エルエルシー Ｘまたはｙ染色体担持豊富化集団に仕分けるための精子懸濁液
US7407816B2 (en) * 2004-05-07 2008-08-05 Gentius, Inc Isoelectric particles and uses thereof
US20090054255A1 (en) * 2004-07-01 2009-02-26 The Regents Of The University Of California Microfluidic devices and methods
DE102004034486B4 (de) * 2004-07-16 2007-08-23 Infineon Technologies Ag Verfahren zum Nachweis von Lumineszenzlicht aus einer porösen Trägerstruktur
CA2574499C (en) 2004-07-22 2016-11-29 Monsanto Technology Llc Process for enriching a population of sperm cells
JP2008507296A (ja) * 2004-07-26 2008-03-13 ナノスフェアー　インコーポレイテッド 混合培養物中でメチシリン耐性黄色ブドウ球菌とメチシリン感受性黄色ブドウ球菌とを区別する方法
US20060024815A1 (en) * 2004-07-30 2006-02-02 Allman Steve L High sensitivity array-based detection system
US9494581B2 (en) 2004-08-24 2016-11-15 University Of Wyoming System and method for Raman spectroscopy assay using paramagnetic particles
US7288134B2 (en) 2004-09-10 2007-10-30 International Business Machines Corporation Dumbbell-like nanoparticles and a process of forming the same
CN101019027B (zh) * 2004-09-14 2012-09-26 三菱化学美迪恩斯株式会社 生物材料结构体、其制造方法及应用
US7612769B2 (en) * 2004-09-14 2009-11-03 E.I. Du Pont De Nemours And Company Computer-implemented methods for organizing image data produced by resonant Mie scattering of light from microparticles and resulting data structures
KR20070062575A (ko) * 2004-09-24 2007-06-15 인제네우스 인크. 게놈 분석
US7604173B2 (en) 2004-11-16 2009-10-20 Illumina, Inc. Holographically encoded elements for microarray and other tagging labeling applications, and method and apparatus for making and reading the same
US7602952B2 (en) * 2004-11-16 2009-10-13 Illumina, Inc. Scanner having spatial light modulator
WO2006113727A2 (en) 2005-04-19 2006-10-26 President And Fellows Of Harvard College Fluidic structures including meandering and wide channels
CA2606924C (en) 2005-05-09 2013-04-16 The General Hospital Corporation Water relaxation-based sensors
US8597576B2 (en) * 2005-06-23 2013-12-03 National Institute Of Advanced Industrial Science And Technology Analyzer for glycan or complex carbohydrate
WO2007002567A2 (en) * 2005-06-23 2007-01-04 Nanosphere, Inc. Selective isolation and concentration of nucleic acids from complex samples
TWI391645B (zh) * 2005-07-06 2013-04-01 Nanometrics Inc 晶圓或其他工作表面下污染物及缺陷非接觸測量之差分波長光致發光
TWI439684B (zh) * 2005-07-06 2014-06-01 Nanometrics Inc 具自晶圓或其他工件特定材料層所發射光致發光信號優先偵測之光致發光成像
ATE525655T1 (de) * 2005-08-02 2011-10-15 Univ Maryland Nanostrukturen zur polarisierten abbildung und rezeptor-/liganden-quantifizierung: überschreitung der diffraktionsgrenze für abbildungen
EP1915466B1 (en) * 2005-08-19 2010-11-24 Nanosphere, Inc. Methods for preparing hybrid substrates comprising dna and antibodies and uses thereof
EP1932009B1 (en) 2005-08-31 2014-02-12 T2 Biosystems, Inc. Nmr device for detection of analytes involving magnetic particles
WO2007030521A1 (en) * 2005-09-06 2007-03-15 Invitrogen Corporation Control of chemical modification
US9057046B2 (en) 2005-09-26 2015-06-16 Rapid Micro Biosystems, Inc. Cassette containing growth medium
US7723120B2 (en) 2005-10-26 2010-05-25 General Electric Company Optical sensor array system and method for parallel processing of chemical and biochemical information
US8133741B2 (en) 2005-10-26 2012-03-13 General Electric Company Methods and systems for delivery of fluidic samples to sensor arrays
WO2007056113A2 (en) * 2005-11-02 2007-05-18 Cylene Pharmaceuticals, Inc. Methods for targeting quadruplex sequences
US7623624B2 (en) * 2005-11-22 2009-11-24 Illumina, Inc. Method and apparatus for labeling using optical identification elements characterized by X-ray diffraction
USD580285S1 (en) 2006-01-13 2008-11-11 Invitrogen Corporation Fluorometer
RU2298798C1 (ru) * 2006-01-17 2007-05-10 Общество с ограниченной ответственностью "Биочип-Аналитика" (ООО "Биочип-Аналитика") Способ контроля биологической пробы в реакции латекс-агглютинации и аналитическая система для его осуществления
WO2007087582A1 (en) 2006-01-24 2007-08-02 Invitrogen Corporation Device and methods for quantifying analytes
RU2327170C2 (ru) * 2006-02-27 2008-06-20 Закрытое акционерное общество "ДиТест" Способ комплексной диагностики вирусного гепатита в, вирусного гепатита с, вич-инфекции и сифилиса
US7830575B2 (en) 2006-04-10 2010-11-09 Illumina, Inc. Optical scanner with improved scan time
BRPI0711346A8 (pt) * 2006-05-09 2015-10-06 Koninklije Philips Electronics N V Método para detectar um alvo em uma amostra suspeita de conter o alvo, e, uso de um magneto
KR20090027643A (ko) * 2006-05-17 2009-03-17 루미넥스 코포레이션 형광성 표지가 부착된 입자를 분석하기 위해 칩에 기초한 유세포분석기 시스템
EP3260556B1 (en) 2006-05-31 2019-07-31 Sequenom, Inc. Methods for the extraction of nucleic acid from a sample
US8471230B2 (en) 2006-09-01 2013-06-25 Pacific Biosciences Of California, Inc. Waveguide substrates and optical systems and methods of use thereof
US8207509B2 (en) 2006-09-01 2012-06-26 Pacific Biosciences Of California, Inc. Substrates, systems and methods for analyzing materials
US8124598B2 (en) 2006-09-14 2012-02-28 Sharon Sageman 7-keto DHEA for psychiatric use
CN104198705B (zh) * 2006-09-21 2017-06-09 雀巢产品技术援助有限公司 检测稀有循环细胞内多种信号转导分子的基于抗体的阵列
US7902345B2 (en) 2006-12-05 2011-03-08 Sequenom, Inc. Detection and quantification of biomolecules using mass spectrometry
US20120321759A1 (en) * 2007-01-05 2012-12-20 Myskin, Inc. Characterization of food materials by optomagnetic fingerprinting
JP2010516999A (ja) * 2007-01-19 2010-05-20 トゥドール・アービンテ 試料の特性を検出し自記する為の方法と装置
CN103495439B (zh) * 2007-05-04 2015-09-16 欧普科诊断有限责任公司 流体连接器和微流体系统
US7883898B2 (en) 2007-05-07 2011-02-08 General Electric Company Method and apparatus for measuring pH of low alkalinity solutions
US8097422B2 (en) 2007-06-20 2012-01-17 Salk Institute For Biological Studies Kir channel modulators
US9097644B2 (en) 2007-08-17 2015-08-04 Massachusetts Institute Of Technology Magnetic resonance-based viscometers and methods
WO2009032781A2 (en) 2007-08-29 2009-03-12 Sequenom, Inc. Methods and compositions for universal size-specific polymerase chain reaction
US20100160274A1 (en) * 2007-09-07 2010-06-24 Sharon Sageman 7-KETO DHEA for Psychiatric Use
US8278057B2 (en) * 2007-09-14 2012-10-02 Nestec S.A. Addressable antibody arrays and methods of use
JP4597175B2 (ja) * 2007-09-21 2010-12-15 株式会社日立ハイテクノロジーズ 標的物質を検出するための分析装置、又は分析方法、若しくはこれら分析装置及び分析方法に用いるデバイス
WO2009053902A2 (en) * 2007-10-25 2009-04-30 Koninklijke Philips Electronics N. V. Sensor device for target particles in a sample
JP4975599B2 (ja) * 2007-12-17 2012-07-11 シスメックス株式会社 標本作製装置および標本作製方法
JP2009150799A (ja) * 2007-12-21 2009-07-09 Sysmex Corp 分析装置、コンピュータプログラムおよび分析方法
US20090181361A1 (en) * 2008-01-14 2009-07-16 Weidong Xu Rapid test for detecting infection
WO2009092035A2 (en) 2008-01-17 2009-07-23 Sequenom, Inc. Methods and compositions for the analysis of biological molecules
WO2009114543A2 (en) 2008-03-11 2009-09-17 Sequenom, Inc. Nucleic acid-based tests for prenatal gender determination
JP2009229103A (ja) * 2008-03-19 2009-10-08 Toshiba Corp 金属コロイドの定量方法
RU2472221C2 (ru) * 2008-03-21 2013-01-10 Закрытое акционерное общество "СЕЛЬМАШПРОЕКТ" Система для моделирования генетической и лингвистической информации
EP2285491A1 (en) 2008-04-25 2011-02-23 Claros Diagnostics, Inc. Flow control in microfluidic systems
MY174816A (en) * 2008-06-10 2020-05-17 Xtralis Technologies Ltd Particle detection
US8962247B2 (en) * 2008-09-16 2015-02-24 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
US8476013B2 (en) 2008-09-16 2013-07-02 Sequenom, Inc. Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
CN102224410B (zh) 2008-09-24 2017-02-08 施特劳斯控股公司 用于测试分析物的成像分析仪
EP2331941B1 (en) * 2008-09-25 2014-11-12 Koninklijke Philips N.V. Detection system and method
AU2009308841B2 (en) 2008-10-29 2014-07-17 T2 Biosystems, Inc. NMR detection of coagulation time
EP2358911B1 (en) 2008-11-24 2016-12-21 Sequenom, Inc. Improving nucleic acid hybridisation assay by compressing the dynamic range of high-abundance molecules
WO2010080115A2 (en) 2008-12-18 2010-07-15 Claros Diagnostics, Inc. Improved reagent storage in microfluidic systems and related articles and methods
JP5269207B2 (ja) 2009-01-16 2013-08-21 ニューヨーク ユニバーシティー ホログラフィビデオ顕微鏡観察を伴う自動的リアルタイム粒子特徴付け及び三次元速度測定
ES2812260T3 (es) * 2009-02-02 2021-03-16 Opko Diagnostics Llc Estructuras para controlar la interacción de luz con dispositivos microfluídicos
US20110171124A1 (en) 2009-02-26 2011-07-14 Osi Pharmaceuticals, Inc. In situ methods for monitoring the EMT status of tumor cells in vivo
CN102428191A (zh) * 2009-03-18 2012-04-25 塞昆纳姆股份有限公司 热稳定性内切核酸酶在产生报道分子中的应用
US8771948B2 (en) 2009-04-03 2014-07-08 Sequenom, Inc. Nucleic acid preparation compositions and methods
CA2772020A1 (en) * 2009-08-31 2011-03-03 Mbio Diagnostics, Inc. Integrated sample preparation and analyte detection
US20110143378A1 (en) * 2009-11-12 2011-06-16 CyVek LLC. Microfluidic method and apparatus for high performance biological assays
US9700889B2 (en) 2009-11-23 2017-07-11 Cyvek, Inc. Methods and systems for manufacture of microarray assay systems, conducting microfluidic assays, and monitoring and scanning to obtain microfluidic assay results
US9651568B2 (en) 2009-11-23 2017-05-16 Cyvek, Inc. Methods and systems for epi-fluorescent monitoring and scanning for microfluidic assays
WO2011063408A1 (en) 2009-11-23 2011-05-26 Cyvek, Inc. Method and apparatus for performing assays
US10065403B2 (en) 2009-11-23 2018-09-04 Cyvek, Inc. Microfluidic assay assemblies and methods of manufacture
US9500645B2 (en) 2009-11-23 2016-11-22 Cyvek, Inc. Micro-tube particles for microfluidic assays and methods of manufacture
US9759718B2 (en) 2009-11-23 2017-09-12 Cyvek, Inc. PDMS membrane-confined nucleic acid and antibody/antigen-functionalized microlength tube capture elements, and systems employing them, and methods of their use
US9855735B2 (en) 2009-11-23 2018-01-02 Cyvek, Inc. Portable microfluidic assay devices and methods of manufacture and use
PL2504105T3 (pl) 2009-11-24 2021-06-28 Opko Diagnostics, Llc Mieszanie i dostarczanie płynów w układach mikroprzepływowych
US9339813B2 (en) 2009-12-18 2016-05-17 Koninklijke Philips N.V. Substance determining apparatus
DK2516680T3 (en) 2009-12-22 2016-05-02 Sequenom Inc Method and kits to identify aneuploidy
JP6104793B2 (ja) 2010-04-16 2017-03-29 オプコ・ダイアグノスティクス・リミテッド・ライアビリティ・カンパニーＯｐｋｏ Ｄｉａｇｎｏｓｔｉｃｓ，Ｌｌｃ マイクロ流体システム内でのフィードバック制御
USD645971S1 (en) 2010-05-11 2011-09-27 Claros Diagnostics, Inc. Sample cassette
USD653981S1 (en) 2010-08-06 2012-02-14 Life Technologies Corporation Fluorometer
CA2812208C (en) * 2010-09-24 2019-10-22 The Governing Council Of The University Of Toronto Synthesis of fluorescent noble metal nanoparticles
EP3974831A1 (en) 2010-10-22 2022-03-30 T2 Biosystems, Inc. Methods for detecting the presence of a bacterium in a whole blood sample
US8409807B2 (en) 2010-10-22 2013-04-02 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
RS58190B2 (sr) 2011-02-08 2021-08-31 Medimmune Llc Antitela koja specifično vezuju staphylococcus aureus alfa toksin i postupci njihove primene
JP5681517B2 (ja) * 2011-02-15 2015-03-11 新日本空調株式会社 粒子導電性判別装置及び粒子導電性判別方法
US10254204B2 (en) 2011-03-07 2019-04-09 Accelerate Diagnostics, Inc. Membrane-assisted purification
WO2012122314A2 (en) 2011-03-07 2012-09-13 Accelr8 Technology Corporation Rapid cell purification systems
JP5978287B2 (ja) 2011-03-22 2016-08-24 サイヴェク・インコーポレイテッド マイクロ流体装置並びに製造及び使用の方法
WO2012149339A2 (en) 2011-04-29 2012-11-01 Sequenom, Inc. Quantification of a minority nucleic acid species
WO2012177792A2 (en) 2011-06-24 2012-12-27 Sequenom, Inc. Methods and processes for non-invasive assessment of a genetic variation
AU2012281017B2 (en) 2011-07-13 2017-07-20 T2 Biosystems, Inc. NMR methods for monitoring blood clot formation
US10620205B2 (en) 2011-09-21 2020-04-14 T2 Biosystems, Inc. NMR methods for endotoxin analysis
US9984198B2 (en) 2011-10-06 2018-05-29 Sequenom, Inc. Reducing sequence read count error in assessment of complex genetic variations
US10424394B2 (en) 2011-10-06 2019-09-24 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
EP2764458B1 (en) 2011-10-06 2021-04-07 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10196681B2 (en) 2011-10-06 2019-02-05 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2013052913A2 (en) 2011-10-06 2013-04-11 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US8688388B2 (en) 2011-10-11 2014-04-01 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2013070730A2 (en) 2011-11-07 2013-05-16 Rapid Micro Biosystems, Inc. Cassette for sterility testing
DE102011087679B3 (de) * 2011-12-02 2013-04-18 Schildtec GmbH Meßkammer für einen optisch arbeitenden Sensor zum Bestimmen einer Konzentration eines Stoffes
ES2929923T3 (es) 2012-01-20 2022-12-02 Sequenom Inc Procesos de diagnóstico que condicionan las condiciones experimentales
EP4155401A1 (en) 2012-03-02 2023-03-29 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
JP6308954B2 (ja) 2012-03-05 2018-04-11 オサケユキテュア・アークティック・パートナーズ・アクチボラゲットＯｙ Ａｒｃｔｉｃ Ｐａｒｔｎｅｒｓ Ａｂ 前立腺癌のリスク及び前立腺容積を予測する方法及び装置
JP2013181935A (ja) * 2012-03-05 2013-09-12 Fujifilm Corp クロマトグラフ方法
EP2822688B1 (en) 2012-03-08 2019-09-25 Cyvek, Inc. Microfluidic assay assemblies and methods of manufacture
JP6444859B2 (ja) 2012-04-16 2018-12-26 ラピッド マイクロ バイオシステムズ インコーポレイテッド 細胞培養デバイス
WO2013158281A1 (en) 2012-04-20 2013-10-24 T2 Biosystems, Inc. Compositions and methods for detection of candida species
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
US10504613B2 (en) 2012-12-20 2019-12-10 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US10497461B2 (en) 2012-06-22 2019-12-03 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US20140004105A1 (en) 2012-06-29 2014-01-02 Sequenom, Inc. Age-related macular degeneration diagnostics
US20140093873A1 (en) 2012-07-13 2014-04-03 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
US10482994B2 (en) 2012-10-04 2019-11-19 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US20140146157A1 (en) * 2012-11-29 2014-05-29 Fluid Imaging Technologies, Inc. System and method for sample dilution and particle imaging
JP2016500443A (ja) 2012-12-07 2016-01-12 ティー２ バイオシステムズ，インコーポレーテッド 強固な血餅形成をモニタリングするための方法
US20130309666A1 (en) 2013-01-25 2013-11-21 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
EP3597774A1 (en) 2013-03-13 2020-01-22 Sequenom, Inc. Primers for dna methylation analysis
CA2900708C (en) 2013-03-13 2021-06-15 Opko Diagnostics, Llc Mixing of fluids in fluidic systems
US9677109B2 (en) 2013-03-15 2017-06-13 Accelerate Diagnostics, Inc. Rapid determination of microbial growth and antimicrobial susceptibility
EP4187543A1 (en) 2013-04-03 2023-05-31 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
AU2014268377B2 (en) 2013-05-24 2020-10-08 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
DK3011051T3 (en) 2013-06-21 2019-04-23 Sequenom Inc Method for non-invasive evaluation of genetic variations
EP2827130A1 (en) * 2013-07-15 2015-01-21 F. Hoffmann-La Roche AG Device for use in the detection of binding affinities
US10964409B2 (en) 2013-10-04 2021-03-30 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
JP6680680B2 (ja) 2013-10-07 2020-04-15 セクエノム， インコーポレイテッド 染色体変化の非侵襲性評価のための方法およびプロセス
KR102425768B1 (ko) 2014-02-12 2022-07-26 뉴욕 유니버시티 콜로이드 입자의 홀로그래픽 추적 및 특징화를 위한 고속 특징부 식별
WO2015138774A1 (en) 2014-03-13 2015-09-17 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US11783911B2 (en) 2014-07-30 2023-10-10 Sequenom, Inc Methods and processes for non-invasive assessment of genetic variations
DK3218690T3 (da) 2014-11-12 2022-05-02 Univ New York Kolloidt fingeraftryk til bløde materialer med brug af total holografisk karakterisation
EA038479B1 (ru) 2014-12-12 2021-09-03 Опкоу Дайагностикс, Ллк Устройство для проведения анализа пробы и способ эксплуатации указанного устройства
US10253355B2 (en) 2015-03-30 2019-04-09 Accelerate Diagnostics, Inc. Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
WO2016161022A2 (en) 2015-03-30 2016-10-06 Accerlate Diagnostics, Inc. Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing
EP3091347A1 (en) * 2015-05-04 2016-11-09 The European Union, represented by the European Commission Screening of nanoparticle properties
USD804682S1 (en) 2015-08-10 2017-12-05 Opko Diagnostics, Llc Multi-layered sample cassette
JP6929560B2 (ja) 2015-09-18 2021-09-01 ニュー・ヨーク・ユニヴァーシティー 精密スラリ内の大きい不純物粒子のホログラフィック検出及び特徴付け
US9983115B2 (en) 2015-09-21 2018-05-29 Fluid Imaging Technologies, Inc. System and method for monitoring particles in a fluid using ratiometric cytometry
US10228367B2 (en) 2015-12-01 2019-03-12 ProteinSimple Segmented multi-use automated assay cartridge
US20170160187A1 (en) * 2015-12-08 2017-06-08 Tdk Corporation Laser Scanner Particle Counter and Imager
CA3005084A1 (en) 2015-12-11 2017-06-15 Opko Diagnostics, Llc Fluidic systems involving incubation of samples and/or reagents
US11519016B2 (en) 2016-01-21 2022-12-06 T2 Biosystems, Inc. NMR methods and systems for the rapid detection of bacteria
ES2901608T3 (es) 2016-02-08 2022-03-23 Univ New York Caracterización holográfica de agregados proteicos
RU2631237C2 (ru) * 2016-02-26 2017-09-19 Государственное Научное Учреждение "Институт Физики Имени Б.И. Степанова Национальной Академии Наук Беларуси" Способ контроля структурного качества тонких плёнок для светопоглощающих слоёв солнечных элементов и устройство для его реализации
US10670677B2 (en) 2016-04-22 2020-06-02 New York University Multi-slice acceleration for magnetic resonance fingerprinting
SG11201810969RA (en) 2016-06-09 2019-01-30 Haimachek Inc Collector for detection and reversible capturing of cells from body fluids in vivo
RU169521U1 (ru) * 2016-06-28 2017-03-21 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт глазных болезней" Устройство для оценки интенсивности светорассеивающей способности биологической ткани
US11200963B2 (en) 2016-07-27 2021-12-14 Sequenom, Inc. Genetic copy number alteration classifications
CA3207879C (en) 2017-01-24 2026-06-16 Sequenom, Inc. Methods and processes for assessment of genetic variations
EP3998350B1 (en) 2017-03-17 2025-05-07 Sequenom, Inc. Methods and processes for assessment of genetic mosaicism
US12031985B2 (en) 2018-04-19 2024-07-09 First Light Diagnostics, Inc. Detection of targets
CN112423883A (zh) 2018-07-12 2021-02-26 卢米耐克斯公司 用于进行可变样品制备和分析过程的系统和方法
US11017520B2 (en) * 2018-09-04 2021-05-25 Kla Corporation Multi-wavelength interferometry for defect classification
CA3115279A1 (en) 2018-10-04 2020-04-09 First Light Diagnostics, Inc. Analysis instrument
CN109254022B (zh) * 2018-10-24 2021-07-20 首钢智新迁安电磁材料有限公司 一种测量晶粒尺寸的方法
CN109540855B (zh) * 2018-11-07 2021-03-23 沈阳化工大学 一种荧光金壳磁性椭球的制备方法
FI129722B (en) * 2018-12-28 2022-07-29 Kemira Oyj Monitoring and regulation of hydrophobic components in a pulping process
WO2020160161A1 (en) * 2019-01-30 2020-08-06 Regeneron Pharmaceuticals, Inc. Method of characterization of visible and/or sub-visible particles in biologics
IL265914B (en) * 2019-04-08 2020-11-30 Convergent R N R Ltd System and method for optimization of radiotherapy treatments
US11543338B2 (en) 2019-10-25 2023-01-03 New York University Holographic characterization of irregular particles
US11948302B2 (en) 2020-03-09 2024-04-02 New York University Automated holographic video microscopy assay
US12158430B2 (en) 2020-03-23 2024-12-03 Kenvue Brands Llc Disposable indicator component for measuring analyte concentration in bodily fluids
EP3941168A1 (de) * 2020-07-14 2022-01-19 ZKW Group GmbH Fahrzeugmodul mit einer manipulationserkennenden elektronischen steuereinheit
CN112014369B (zh) * 2020-08-25 2024-02-09 上海市皮肤病医院 超灵敏数字层析快速检测分析物的系统及方法
US12066368B2 (en) * 2020-10-15 2024-08-20 Robert R. Alfano Compact optical virus detection analyzer of nano- and micro-size bio particles using light scattering and fluorescence
CN112229769B (zh) * 2020-10-22 2023-03-14 山东长信化学科技股份有限公司 一种n-甲基吡咯烷酮颗粒度的检测系统及检测方法
TWI912371B (zh) * 2021-01-14 2026-01-21 瑞士商通用表面增強光譜學股份有限公司 用於判定顆粒尺寸之方法及用於該方法之總成
CN113340894B (zh) * 2021-05-28 2023-04-07 上海睿钰生物科技有限公司 一种非透明微粒的检测方法
US20240272060A1 (en) * 2021-06-08 2024-08-15 Regents Of The University Of Minnesota Method and apparatus for particle detection
CN115482643B (zh) * 2022-08-24 2024-02-02 清华大学 火灾烟雾探测器及其探测方法
CN115452667B (zh) * 2022-08-31 2024-10-01 中南大学 一种颗粒物同步追踪装置和基于其的颗粒物同步追踪方法

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3975084A (en) 1973-09-27 1976-08-17 Block Engineering, Inc. Particle detecting system
US3939350A (en) * 1974-04-29 1976-02-17 Board Of Trustees Of The Leland Stanford Junior University Fluorescent immunoassay employing total reflection for activation
US4157498A (en) * 1977-08-01 1979-06-05 Miles Laboratories, Inc. Flow-through type particle analyzing apparatus
NL7807532A (nl) 1978-07-13 1980-01-15 Akzo Nv Metaal-immunotest.
US4420558A (en) * 1981-02-12 1983-12-13 Janssen Pharmaceutica N.V. Bright field light microscopic method of enumerating and characterizing subtypes of white blood cells and their precursors
GB2095258B (en) * 1981-03-19 1984-09-05 Janssen Pharmaceutica Nv A bright field light microscopic method of localizing tissue antigens
US4480042A (en) 1981-10-28 1984-10-30 E. I. Du Pont De Nemours And Company Covalently bonded high refractive index particle reagents and their use in light scattering immunoassays
US4597944A (en) * 1983-10-18 1986-07-01 Cottingham Hugh V Agglutination reagent detection system
US4752567A (en) * 1984-06-21 1988-06-21 Janssen Pharmaceutica N.V. Method of visualizing individual submicroscopic metal particles
US4647544A (en) * 1984-06-25 1987-03-03 Nicoli David F Immunoassay using optical interference detection
US4983834A (en) * 1985-10-10 1991-01-08 Quantex Corporation Large area particle detector system
US5501949A (en) * 1985-12-10 1996-03-26 Murex Diagnostics Corporation Particle bound binding component immunoassay
CA1291031C (en) 1985-12-23 1991-10-22 Nikolaas C.J. De Jaeger Method for the detection of specific binding agents and their correspondingbindable substances
US4851329A (en) 1986-06-06 1989-07-25 Massachusetts Institute Of Technology Immunoassay employing optical pulse particle size analysis
US5514602A (en) 1986-06-09 1996-05-07 Ortho Diagnostic Systems, Inc. Method of producing a metal sol reagent containing colloidal metal particles
AU7385387A (en) * 1986-06-09 1987-12-10 Ortho Diagnostic Systems Inc. Immunoassay using detection of colloidal gold
US5017009A (en) * 1986-06-26 1991-05-21 Ortho Diagnostic Systems, Inc. Scattered total internal reflectance immunoassay system
GB8623072D0 (en) * 1986-09-25 1986-10-29 Amersham Int Plc Particle analysis
US5015580A (en) * 1987-07-29 1991-05-14 Agracetus Particle-mediated transformation of soybean plants and lines
US5202231A (en) * 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
US5110727A (en) * 1987-04-03 1992-05-05 Cardiovascular Diagnostics, Inc. Method for performing coagulation assays accurately, rapidly and simply, using dry chemical reagents and paramagnetic particles
GB8803000D0 (en) 1988-02-10 1988-03-09 Ekins Roger Philip Determination of ambient concentrations of several analytes
US4859612A (en) * 1987-10-07 1989-08-22 Hygeia Sciences, Inc. Metal sol capture immunoassay procedure, kit for use therewith and captured metal containing composite
US4952517A (en) * 1988-02-08 1990-08-28 Hygeia Sciences, Inc. Positive step immunoassay
US5079172A (en) * 1988-11-04 1992-01-07 Board Of Trustees Operating Michigan State University Method for detecting the presence of antibodies using gold-labeled antibodies and test kit
US5100805A (en) * 1989-01-26 1992-03-31 Seradyn, Inc. Quantitative immunoassay system and method for agglutination assays
US5338353A (en) * 1989-04-07 1994-08-16 Nippon Shokubai Kagaku Kogyo Method for production of powder of fine inorganic particles
US5120135A (en) * 1989-12-13 1992-06-09 Syntex (U.S.A.) Inc. Method and apparatus for keeping particles in suspension
JP2899360B2 (ja) 1990-05-21 1999-06-02 興和株式会社 流体中の粒子計測方法及びその装置
US5350697A (en) * 1990-08-28 1994-09-27 Akzo N.V. Scattered light detection apparatus
US5294369A (en) 1990-12-05 1994-03-15 Akzo N.V. Ligand gold bonding
JP3115641B2 (ja) 1991-04-24 2000-12-11 シスメックス株式会社 粒子計数方法
US5286452A (en) 1991-05-20 1994-02-15 Sienna Biotech, Inc. Simultaneous multiple assays
JP2523227Y2 (ja) 1991-07-30 1997-01-22 株式会社堀場製作所 異物検査装置
US5516670A (en) * 1991-09-30 1996-05-14 Kuehnle; Adelheid R. Magnetophoretic particle delivery method and apparatus for the treatment of cells
US5151956A (en) 1991-12-20 1992-09-29 The United Staes Of America As Represented By The Secretary Of The Army Waveguide polarizer using localized surface plasmons
US5248772A (en) * 1992-01-29 1993-09-28 Coulter Corporation Formation of colloidal metal dispersions using aminodextrans as reductants and protective agents
RU2009505C1 (ru) * 1992-02-04 1994-03-15 Государственный научно-исследовательский институт биологического приборостроения Способ люминесцентного иммуноанализа
US5305073A (en) 1992-02-12 1994-04-19 Precision Detectors, Inc. Methods and apparatus for molecular characterization
US5451525A (en) * 1992-02-14 1995-09-19 Coulter Corporation Method and materials for determining particle count in a flow cytometer
US5357320A (en) * 1992-09-04 1994-10-18 Canon Kabushiki Kaisha Electrophotographic apparatus
EP0593956B1 (en) * 1992-10-21 2002-02-13 Dade Behring Inc. Agglutination assays using multivalent ligands
JP3410777B2 (ja) * 1993-09-13 2003-05-26 株式会社東芝 超微粒子無機蛍光体標識特異的結合物質およびこれを用いた検出方法
DE4414166C1 (de) * 1994-04-22 1995-12-07 Lorenz Mesgeraetebau Verfahren und Vorrichtung zur Messung der Lichtstreuung an Partikeln
US5734498A (en) * 1994-05-09 1998-03-31 The Regents Of The University Of California Illuminator elements for conventional light microscopes
JPH0881678A (ja) * 1994-09-14 1996-03-26 Toshiba Corp 無機蛍光体および特異的結合物質
US5599668A (en) * 1994-09-22 1997-02-04 Abbott Laboratories Light scattering optical waveguide method for detecting specific binding events
US5851777A (en) * 1996-02-05 1998-12-22 Dade Behring Inc. Homogeneous sol-sol assay
WO1998037417A1 (en) * 1997-02-20 1998-08-27 The Regents Of The University Of California Plasmon resonant particles, methods and apparatus

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008055570A (ja) * 2006-09-01 2008-03-13 Ricoh Co Ltd 複合金属ナノ粒子、複合金属ナノ粒子を含む多光子吸収反応材料と反応生成物、複合金属ナノ粒子を含む多光子吸収反応助剤
JP2012500385A (ja) * 2008-08-06 2012-01-05 インビトロックス，インコーポレイテッド 生物学的応用における集束光散乱技術の使用
JP2013057605A (ja) * 2011-09-08 2013-03-28 Kyushu Univ 銀シェル金ナノロッドを用いる分析方法

Also Published As

Publication number Publication date
DE69737513D1 (de) 2007-05-03
EP1021554A4 (en) 2004-06-30
CA2253710A1 (en) 1997-10-30
AU2805697A (en) 1997-11-12
BR9710836A (pt) 2000-10-24
CN1223692A (zh) 1999-07-21
ATE357663T1 (de) 2007-04-15
JP2007263974A (ja) 2007-10-11
IL126544A (en) 2004-08-31
RU2251572C2 (ru) 2005-05-10
JP2009236921A (ja) 2009-10-15
WO1997040181A1 (en) 1997-10-30
EP1021554B1 (en) 2007-03-21
DE69737513T2 (de) 2007-12-13
CN1262667C (zh) 2006-07-05
EP1021554A1 (en) 2000-07-26
AU736340B2 (en) 2001-07-26
US6214560B1 (en) 2001-04-10
IL126544A0 (en) 1999-08-17

Similar Documents

Publication Publication Date Title
US6214560B1 (en) Analyte assay using particulate labels
CN100379876C (zh) 利用颗粒标记物检测分析物
AU2002245537B2 (en) Methods for providing extended dynamic range in analyte assays
WO1997040181A9 (en) Analyte assay using particulate labels
AU2002245537A1 (en) Methods for providing extended dynamic range in analyte assays
WO2004042403A2 (en) Methods, device and instrument for detection of analytes
AU783941B2 (en) Analyte assay using particulate labels
HK1034291B (en) Analyte assay using particulate labels
AU2010212491A1 (en) Analyte Assay Using Particulate Labels

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20040419

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20040419

A72 Notification of change in name of applicant

Free format text: JAPANESE INTERMEDIATE CODE: A721

Effective date: 20040419

A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20050201

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20050705

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20051004

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20051121

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20060105

RD02 Notification of acceptance of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7422

Effective date: 20060105

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20060105

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20060307

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20060525

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20060710

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20060907

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20061205

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20070305

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20070423

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20070605

RD02 Notification of acceptance of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7422

Effective date: 20070820

Free format text: JAPANESE INTERMEDIATE CODE: A7422

Effective date: 20070822

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20070824

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20071106

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20080204

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20080324

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20080303

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20080414

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20080402

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20080519

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20080507

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20080624

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20080919

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20081027

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20081022

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20081201

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20081121

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20090210

A72 Notification of change in name of applicant

Free format text: JAPANESE INTERMEDIATE CODE: A721

Effective date: 20090225

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20090511

A761 Written withdrawal of application

Free format text: JAPANESE INTERMEDIATE CODE: A761

Effective date: 20090701