CN1262667C - 利用颗粒标记物检测分析物 - Google Patents
利用颗粒标记物检测分析物 Download PDFInfo
- Publication number
- CN1262667C CN1262667C CNB971958688A CN97195868A CN1262667C CN 1262667 C CN1262667 C CN 1262667C CN B971958688 A CNB971958688 A CN B971958688A CN 97195868 A CN97195868 A CN 97195868A CN 1262667 C CN1262667 C CN 1262667C
- Authority
- CN
- China
- Prior art keywords
- particle
- light
- scattering
- sample
- particulate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000012491 analyte Substances 0.000 title claims description 130
- 239000002245 particle Substances 0.000 claims abstract description 952
- 238000000034 method Methods 0.000 claims abstract description 431
- 230000003321 amplification Effects 0.000 claims abstract description 15
- 238000003199 nucleic acid amplification method Methods 0.000 claims abstract description 15
- 239000010931 gold Substances 0.000 claims description 388
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical group [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 363
- 229910052737 gold Inorganic materials 0.000 claims description 362
- 239000000523 sample Substances 0.000 claims description 325
- 230000003287 optical effect Effects 0.000 claims description 261
- 238000001514 detection method Methods 0.000 claims description 207
- 239000000463 material Substances 0.000 claims description 186
- 238000000149 argon plasma sintering Methods 0.000 claims description 131
- 239000000203 mixture Substances 0.000 claims description 97
- 239000000126 substance Substances 0.000 claims description 97
- 239000003795 chemical substances by application Substances 0.000 claims description 84
- 238000005259 measurement Methods 0.000 claims description 75
- 238000012360 testing method Methods 0.000 claims description 66
- 239000007790 solid phase Substances 0.000 claims description 61
- 238000002493 microarray Methods 0.000 claims description 48
- 108020004707 nucleic acids Proteins 0.000 claims description 44
- 102000039446 nucleic acids Human genes 0.000 claims description 44
- 150000007523 nucleic acids Chemical class 0.000 claims description 44
- 230000008569 process Effects 0.000 claims description 43
- 229910052709 silver Inorganic materials 0.000 claims description 42
- 239000004332 silver Substances 0.000 claims description 42
- 230000008859 change Effects 0.000 claims description 36
- 150000001875 compounds Chemical class 0.000 claims description 36
- 229910052751 metal Inorganic materials 0.000 claims description 29
- 239000002184 metal Substances 0.000 claims description 29
- 102000004169 proteins and genes Human genes 0.000 claims description 18
- 108090000623 proteins and genes Proteins 0.000 claims description 18
- 239000003153 chemical reaction reagent Substances 0.000 claims description 16
- 238000009826 distribution Methods 0.000 claims description 13
- -1 albumen Chemical class 0.000 claims description 12
- 239000007791 liquid phase Substances 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 10
- 230000003993 interaction Effects 0.000 claims description 9
- 238000000576 coating method Methods 0.000 claims description 8
- 239000004065 semiconductor Substances 0.000 claims description 8
- 239000000872 buffer Substances 0.000 claims description 7
- 239000011248 coating agent Substances 0.000 claims description 7
- 239000003086 colorant Substances 0.000 claims description 7
- 230000003760 hair shine Effects 0.000 claims description 7
- 229910000765 intermetallic Inorganic materials 0.000 claims description 7
- 150000002894 organic compounds Chemical class 0.000 claims description 7
- 239000004615 ingredient Substances 0.000 claims description 5
- 229910044991 metal oxide Inorganic materials 0.000 claims description 5
- 150000004706 metal oxides Chemical class 0.000 claims description 5
- 239000006185 dispersion Substances 0.000 claims description 4
- 239000002887 superconductor Substances 0.000 claims description 4
- PLXMOAALOJOTIY-FPTXNFDTSA-N Aesculin Natural products OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)[C@H]1Oc2cc3C=CC(=O)Oc3cc2O PLXMOAALOJOTIY-FPTXNFDTSA-N 0.000 claims description 3
- 229910010272 inorganic material Inorganic materials 0.000 claims description 2
- 239000011147 inorganic material Substances 0.000 claims description 2
- 239000011368 organic material Substances 0.000 claims description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 claims 5
- 239000011707 mineral Substances 0.000 claims 5
- 238000011895 specific detection Methods 0.000 abstract description 3
- 235000013339 cereals Nutrition 0.000 description 314
- 239000000243 solution Substances 0.000 description 161
- 239000011521 glass Substances 0.000 description 136
- 238000005286 illumination Methods 0.000 description 120
- 239000004793 Polystyrene Substances 0.000 description 109
- 229920002223 polystyrene Polymers 0.000 description 109
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 98
- 239000008187 granular material Substances 0.000 description 83
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 77
- 238000004458 analytical method Methods 0.000 description 72
- 210000002966 serum Anatomy 0.000 description 66
- 238000004220 aggregation Methods 0.000 description 46
- 230000002776 aggregation Effects 0.000 description 44
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 42
- 238000002474 experimental method Methods 0.000 description 39
- 230000035945 sensitivity Effects 0.000 description 39
- 230000027455 binding Effects 0.000 description 38
- 239000007788 liquid Substances 0.000 description 36
- 238000010521 absorption reaction Methods 0.000 description 35
- 229940098773 bovine serum albumin Drugs 0.000 description 35
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 34
- 238000001914 filtration Methods 0.000 description 32
- 229910052755 nonmetal Inorganic materials 0.000 description 30
- 238000005516 engineering process Methods 0.000 description 29
- 230000010287 polarization Effects 0.000 description 28
- 108010090804 Streptavidin Proteins 0.000 description 26
- 229920003023 plastic Polymers 0.000 description 26
- 239000004033 plastic Substances 0.000 description 26
- 239000006059 cover glass Substances 0.000 description 22
- 238000002360 preparation method Methods 0.000 description 22
- 210000004027 cell Anatomy 0.000 description 21
- 239000003085 diluting agent Substances 0.000 description 21
- 230000000694 effects Effects 0.000 description 21
- 230000001965 increasing effect Effects 0.000 description 20
- 238000003384 imaging method Methods 0.000 description 19
- 238000007654 immersion Methods 0.000 description 19
- 238000011160 research Methods 0.000 description 19
- 239000013528 metallic particle Substances 0.000 description 18
- 239000010410 layer Substances 0.000 description 17
- 235000018102 proteins Nutrition 0.000 description 17
- 239000011735 vitamin B7 Substances 0.000 description 17
- 239000000427 antigen Substances 0.000 description 16
- 239000011324 bead Substances 0.000 description 16
- 230000008033 biological extinction Effects 0.000 description 16
- 238000013461 design Methods 0.000 description 16
- 102000036639 antigens Human genes 0.000 description 15
- 108091007433 antigens Proteins 0.000 description 15
- 239000010408 film Substances 0.000 description 15
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 14
- 239000013307 optical fiber Substances 0.000 description 14
- 238000000399 optical microscopy Methods 0.000 description 14
- 239000008188 pellet Substances 0.000 description 14
- 238000000386 microscopy Methods 0.000 description 13
- 229920001223 polyethylene glycol Polymers 0.000 description 13
- 108090000765 processed proteins & peptides Proteins 0.000 description 13
- 239000007787 solid Substances 0.000 description 13
- 230000015572 biosynthetic process Effects 0.000 description 12
- 238000006243 chemical reaction Methods 0.000 description 12
- 230000005672 electromagnetic field Effects 0.000 description 12
- 230000005284 excitation Effects 0.000 description 12
- 239000003550 marker Substances 0.000 description 12
- 238000001179 sorption measurement Methods 0.000 description 12
- 239000000725 suspension Substances 0.000 description 12
- 230000010748 Photoabsorption Effects 0.000 description 11
- 239000003814 drug Substances 0.000 description 11
- 238000009396 hybridization Methods 0.000 description 11
- 230000002285 radioactive effect Effects 0.000 description 11
- 241000196324 Embryophyta Species 0.000 description 10
- 230000000875 corresponding effect Effects 0.000 description 10
- 230000002829 reductive effect Effects 0.000 description 10
- 239000008279 sol Substances 0.000 description 10
- 239000006228 supernatant Substances 0.000 description 10
- 229930003756 Vitamin B7 Natural products 0.000 description 9
- 238000013459 approach Methods 0.000 description 9
- 238000003745 diagnosis Methods 0.000 description 9
- 238000010790 dilution Methods 0.000 description 9
- 239000012895 dilution Substances 0.000 description 9
- 238000001493 electron microscopy Methods 0.000 description 9
- 238000003756 stirring Methods 0.000 description 9
- 230000000007 visual effect Effects 0.000 description 9
- 235000011912 vitamin B7 Nutrition 0.000 description 9
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 8
- 108020004414 DNA Proteins 0.000 description 8
- 238000005537 brownian motion Methods 0.000 description 8
- 238000004364 calculation method Methods 0.000 description 8
- 239000000084 colloidal system Substances 0.000 description 8
- 239000000470 constituent Substances 0.000 description 8
- 239000010949 copper Substances 0.000 description 8
- 229910052802 copper Inorganic materials 0.000 description 8
- 238000010168 coupling process Methods 0.000 description 8
- 239000011859 microparticle Substances 0.000 description 8
- 239000004417 polycarbonate Substances 0.000 description 8
- 229920000515 polycarbonate Polymers 0.000 description 8
- 229920000642 polymer Polymers 0.000 description 8
- 239000000758 substrate Substances 0.000 description 8
- 239000011782 vitamin Substances 0.000 description 8
- 229940088594 vitamin Drugs 0.000 description 8
- 229960002685 biotin Drugs 0.000 description 7
- 239000011616 biotin Substances 0.000 description 7
- 125000003636 chemical group Chemical group 0.000 description 7
- 230000008878 coupling Effects 0.000 description 7
- 238000005859 coupling reaction Methods 0.000 description 7
- 230000008021 deposition Effects 0.000 description 7
- 238000002405 diagnostic procedure Methods 0.000 description 7
- 238000010586 diagram Methods 0.000 description 7
- 230000002708 enhancing effect Effects 0.000 description 7
- 230000006872 improvement Effects 0.000 description 7
- 238000011534 incubation Methods 0.000 description 7
- 230000007246 mechanism Effects 0.000 description 7
- 239000011236 particulate material Substances 0.000 description 7
- 238000012545 processing Methods 0.000 description 7
- 230000005855 radiation Effects 0.000 description 7
- 238000002310 reflectometry Methods 0.000 description 7
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 6
- 230000005540 biological transmission Effects 0.000 description 6
- 238000005119 centrifugation Methods 0.000 description 6
- 239000011246 composite particle Substances 0.000 description 6
- 230000006378 damage Effects 0.000 description 6
- 238000011161 development Methods 0.000 description 6
- 239000012530 fluid Substances 0.000 description 6
- 238000010191 image analysis Methods 0.000 description 6
- 230000033001 locomotion Effects 0.000 description 6
- 229910052752 metalloid Inorganic materials 0.000 description 6
- 150000002738 metalloids Chemical class 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical group [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 6
- 238000005070 sampling Methods 0.000 description 6
- 239000011669 selenium Substances 0.000 description 6
- 229910052711 selenium Inorganic materials 0.000 description 6
- 239000007921 spray Substances 0.000 description 6
- 238000010186 staining Methods 0.000 description 6
- 102000004190 Enzymes Human genes 0.000 description 5
- 108090000790 Enzymes Proteins 0.000 description 5
- 108010010803 Gelatin Proteins 0.000 description 5
- WTDHULULXKLSOZ-UHFFFAOYSA-N Hydroxylamine hydrochloride Chemical compound Cl.ON WTDHULULXKLSOZ-UHFFFAOYSA-N 0.000 description 5
- 239000002253 acid Substances 0.000 description 5
- 229910052782 aluminium Inorganic materials 0.000 description 5
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 5
- 230000000890 antigenic effect Effects 0.000 description 5
- 230000008901 benefit Effects 0.000 description 5
- 239000011230 binding agent Substances 0.000 description 5
- 238000004140 cleaning Methods 0.000 description 5
- 238000010226 confocal imaging Methods 0.000 description 5
- 238000012937 correction Methods 0.000 description 5
- 230000007547 defect Effects 0.000 description 5
- 230000005684 electric field Effects 0.000 description 5
- 230000005670 electromagnetic radiation Effects 0.000 description 5
- 239000005357 flat glass Substances 0.000 description 5
- 125000000524 functional group Chemical group 0.000 description 5
- 229920000159 gelatin Polymers 0.000 description 5
- 239000008273 gelatin Substances 0.000 description 5
- 235000019322 gelatine Nutrition 0.000 description 5
- 235000011852 gelatine desserts Nutrition 0.000 description 5
- 230000012010 growth Effects 0.000 description 5
- 238000003018 immunoassay Methods 0.000 description 5
- 238000002372 labelling Methods 0.000 description 5
- 238000010208 microarray analysis Methods 0.000 description 5
- 239000012071 phase Substances 0.000 description 5
- 238000004445 quantitative analysis Methods 0.000 description 5
- 230000001105 regulatory effect Effects 0.000 description 5
- 239000008223 sterile water Substances 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- 229920002554 vinyl polymer Polymers 0.000 description 5
- 239000002202 Polyethylene glycol Substances 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 239000004411 aluminium Substances 0.000 description 4
- 125000003368 amide group Chemical group 0.000 description 4
- 235000001014 amino acid Nutrition 0.000 description 4
- 150000001413 amino acids Chemical class 0.000 description 4
- 125000003277 amino group Chemical group 0.000 description 4
- 238000003556 assay Methods 0.000 description 4
- 239000012141 concentrate Substances 0.000 description 4
- 230000001186 cumulative effect Effects 0.000 description 4
- 239000000835 fiber Substances 0.000 description 4
- 238000000684 flow cytometry Methods 0.000 description 4
- 239000005556 hormone Substances 0.000 description 4
- 229940088597 hormone Drugs 0.000 description 4
- 230000002209 hydrophobic effect Effects 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- 239000002923 metal particle Substances 0.000 description 4
- 230000000149 penetrating effect Effects 0.000 description 4
- 238000002135 phase contrast microscopy Methods 0.000 description 4
- 230000005610 quantum mechanics Effects 0.000 description 4
- 238000006862 quantum yield reaction Methods 0.000 description 4
- 239000000700 radioactive tracer Substances 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- 238000002764 solid phase assay Methods 0.000 description 4
- 238000010532 solid phase synthesis reaction Methods 0.000 description 4
- 238000003860 storage Methods 0.000 description 4
- 230000003313 weakening effect Effects 0.000 description 4
- 208000002109 Argyria Diseases 0.000 description 3
- 108010017384 Blood Proteins Proteins 0.000 description 3
- 102000004506 Blood Proteins Human genes 0.000 description 3
- 102000000584 Calmodulin Human genes 0.000 description 3
- 108010041952 Calmodulin Proteins 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 230000004913 activation Effects 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 230000000996 additive effect Effects 0.000 description 3
- 238000007605 air drying Methods 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 230000006399 behavior Effects 0.000 description 3
- 235000020958 biotin Nutrition 0.000 description 3
- 125000004057 biotinyl group Chemical group [H]N1C(=O)N([H])[C@]2([H])[C@@]([H])(SC([H])([H])[C@]12[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(*)=O 0.000 description 3
- 238000011088 calibration curve Methods 0.000 description 3
- 150000001720 carbohydrates Chemical class 0.000 description 3
- 235000014633 carbohydrates Nutrition 0.000 description 3
- 230000000295 complement effect Effects 0.000 description 3
- 238000005336 cracking Methods 0.000 description 3
- 230000003203 everyday effect Effects 0.000 description 3
- 230000002349 favourable effect Effects 0.000 description 3
- 239000010946 fine silver Substances 0.000 description 3
- 238000003306 harvesting Methods 0.000 description 3
- 229920001519 homopolymer Polymers 0.000 description 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 3
- 230000000984 immunochemical effect Effects 0.000 description 3
- 238000007689 inspection Methods 0.000 description 3
- 238000005305 interferometry Methods 0.000 description 3
- 239000004816 latex Substances 0.000 description 3
- 229920000126 latex Polymers 0.000 description 3
- 229920002521 macromolecule Polymers 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 150000002739 metals Chemical class 0.000 description 3
- 210000004940 nucleus Anatomy 0.000 description 3
- 238000000879 optical micrograph Methods 0.000 description 3
- 239000002953 phosphate buffered saline Substances 0.000 description 3
- 229920001184 polypeptide Polymers 0.000 description 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- 238000003672 processing method Methods 0.000 description 3
- 230000000644 propagated effect Effects 0.000 description 3
- 239000011241 protective layer Substances 0.000 description 3
- 238000011002 quantification Methods 0.000 description 3
- 239000000376 reactant Substances 0.000 description 3
- 102000005962 receptors Human genes 0.000 description 3
- 108020003175 receptors Proteins 0.000 description 3
- 239000011347 resin Substances 0.000 description 3
- 229920005989 resin Polymers 0.000 description 3
- 229920006395 saturated elastomer Polymers 0.000 description 3
- 238000012216 screening Methods 0.000 description 3
- 238000007789 sealing Methods 0.000 description 3
- 238000011896 sensitive detection Methods 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 150000003384 small molecules Chemical class 0.000 description 3
- 239000001509 sodium citrate Substances 0.000 description 3
- 238000001228 spectrum Methods 0.000 description 3
- 239000012798 spherical particle Substances 0.000 description 3
- 238000005507 spraying Methods 0.000 description 3
- 239000003381 stabilizer Substances 0.000 description 3
- 238000006467 substitution reaction Methods 0.000 description 3
- 230000004304 visual acuity Effects 0.000 description 3
- 235000017060 Arachis glabrata Nutrition 0.000 description 2
- 244000105624 Arachis hypogaea Species 0.000 description 2
- 235000010777 Arachis hypogaea Nutrition 0.000 description 2
- 235000018262 Arachis monticola Nutrition 0.000 description 2
- 239000002028 Biomass Substances 0.000 description 2
- 102000053642 Catalytic RNA Human genes 0.000 description 2
- 108090000994 Catalytic RNA Proteins 0.000 description 2
- IGXWBGJHJZYPQS-SSDOTTSWSA-N D-Luciferin Chemical compound OC(=O)[C@H]1CSC(C=2SC3=CC=C(O)C=C3N=2)=N1 IGXWBGJHJZYPQS-SSDOTTSWSA-N 0.000 description 2
- CYCGRDQQIOGCKX-UHFFFAOYSA-N Dehydro-luciferin Natural products OC(=O)C1=CSC(C=2SC3=CC(O)=CC=C3N=2)=N1 CYCGRDQQIOGCKX-UHFFFAOYSA-N 0.000 description 2
- 101100117236 Drosophila melanogaster speck gene Proteins 0.000 description 2
- BJGNCJDXODQBOB-UHFFFAOYSA-N Fivefly Luciferin Natural products OC(=O)C1CSC(C=2SC3=CC(O)=CC=C3N=2)=N1 BJGNCJDXODQBOB-UHFFFAOYSA-N 0.000 description 2
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 description 2
- 244000283207 Indigofera tinctoria Species 0.000 description 2
- 244000178870 Lavandula angustifolia Species 0.000 description 2
- 235000010663 Lavandula angustifolia Nutrition 0.000 description 2
- DDWFXDSYGUXRAY-UHFFFAOYSA-N Luciferin Natural products CCc1c(C)c(CC2NC(=O)C(=C2C=C)C)[nH]c1Cc3[nH]c4C(=C5/NC(CC(=O)O)C(C)C5CC(=O)O)CC(=O)c4c3C DDWFXDSYGUXRAY-UHFFFAOYSA-N 0.000 description 2
- 229910002651 NO3 Inorganic materials 0.000 description 2
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- 241001085205 Prenanthella exigua Species 0.000 description 2
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 2
- 229920002334 Spandex Polymers 0.000 description 2
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 2
- 239000000370 acceptor Substances 0.000 description 2
- 238000005054 agglomeration Methods 0.000 description 2
- 230000003667 anti-reflective effect Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000033228 biological regulation Effects 0.000 description 2
- 229960000074 biopharmaceutical Drugs 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 235000008429 bread Nutrition 0.000 description 2
- 238000001311 chemical methods and process Methods 0.000 description 2
- 239000007822 coupling agent Substances 0.000 description 2
- 230000002354 daily effect Effects 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 230000023077 detection of light stimulus Effects 0.000 description 2
- 238000000502 dialysis Methods 0.000 description 2
- HRKQOINLCJTGBK-UHFFFAOYSA-N dihydroxidosulfur Chemical compound OSO HRKQOINLCJTGBK-UHFFFAOYSA-N 0.000 description 2
- 238000007865 diluting Methods 0.000 description 2
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 230000008020 evaporation Effects 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 230000007274 generation of a signal involved in cell-cell signaling Effects 0.000 description 2
- 150000002343 gold Chemical class 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 238000003317 immunochromatography Methods 0.000 description 2
- 238000003365 immunocytochemistry Methods 0.000 description 2
- 230000008676 import Effects 0.000 description 2
- 150000002484 inorganic compounds Chemical class 0.000 description 2
- 238000009434 installation Methods 0.000 description 2
- 230000001678 irradiating effect Effects 0.000 description 2
- 238000005304 joining Methods 0.000 description 2
- 239000001102 lavandula vera Substances 0.000 description 2
- 235000018219 lavender Nutrition 0.000 description 2
- 239000003446 ligand Substances 0.000 description 2
- 238000002796 luminescence method Methods 0.000 description 2
- 238000005374 membrane filtration Methods 0.000 description 2
- 238000005088 metallography Methods 0.000 description 2
- 230000009871 nonspecific binding Effects 0.000 description 2
- 238000005457 optimization Methods 0.000 description 2
- 210000002220 organoid Anatomy 0.000 description 2
- 239000012188 paraffin wax Substances 0.000 description 2
- 239000013618 particulate matter Substances 0.000 description 2
- 235000020232 peanut Nutrition 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 239000002985 plastic film Substances 0.000 description 2
- 238000007747 plating Methods 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 238000012797 qualification Methods 0.000 description 2
- 238000003908 quality control method Methods 0.000 description 2
- 239000011541 reaction mixture Substances 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- GHMLBKRAJCXXBS-UHFFFAOYSA-N resorcinol Chemical compound OC1=CC=CC(O)=C1 GHMLBKRAJCXXBS-UHFFFAOYSA-N 0.000 description 2
- 230000002441 reversible effect Effects 0.000 description 2
- 108091092562 ribozyme Proteins 0.000 description 2
- 239000012488 sample solution Substances 0.000 description 2
- 238000004626 scanning electron microscopy Methods 0.000 description 2
- 238000004062 sedimentation Methods 0.000 description 2
- LMEWRZSPCQHBOB-UHFFFAOYSA-M silver;2-hydroxypropanoate Chemical compound [Ag+].CC(O)C([O-])=O LMEWRZSPCQHBOB-UHFFFAOYSA-M 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 238000000935 solvent evaporation Methods 0.000 description 2
- 239000004759 spandex Substances 0.000 description 2
- 230000003595 spectral effect Effects 0.000 description 2
- 238000002798 spectrophotometry method Methods 0.000 description 2
- 239000010902 straw Substances 0.000 description 2
- 238000006557 surface reaction Methods 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 2
- 229940038773 trisodium citrate Drugs 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 239000003643 water by type Substances 0.000 description 2
- KHWCHTKSEGGWEX-RRKCRQDMSA-N 2'-deoxyadenosine 5'-monophosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@H]1C[C@H](O)[C@@H](COP(O)(O)=O)O1 KHWCHTKSEGGWEX-RRKCRQDMSA-N 0.000 description 1
- VOZKAJLKRJDJLL-UHFFFAOYSA-N 2,4-diaminotoluene Chemical group CC1=CC=C(N)C=C1N VOZKAJLKRJDJLL-UHFFFAOYSA-N 0.000 description 1
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 1
- QLKQORXPJAGYAT-UHFFFAOYSA-N 3-(methyliminomethylideneamino)propan-1-amine Chemical compound CN=C=NCCCN QLKQORXPJAGYAT-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
- DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 description 1
- 240000002791 Brassica napus Species 0.000 description 1
- 102000014914 Carrier Proteins Human genes 0.000 description 1
- 102000000844 Cell Surface Receptors Human genes 0.000 description 1
- 108010001857 Cell Surface Receptors Proteins 0.000 description 1
- 206010057248 Cell death Diseases 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 239000004593 Epoxy Substances 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 102000009109 Fc receptors Human genes 0.000 description 1
- 108010087819 Fc receptors Proteins 0.000 description 1
- 240000004859 Gamochaeta purpurea Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 102000029749 Microtubule Human genes 0.000 description 1
- 108091022875 Microtubule Proteins 0.000 description 1
- 240000000249 Morus alba Species 0.000 description 1
- 235000008708 Morus alba Nutrition 0.000 description 1
- 108020004711 Nucleic Acid Probes Proteins 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 241000757769 Octophialucium medium Species 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 206010034719 Personality change Diseases 0.000 description 1
- 241001363516 Plusia festucae Species 0.000 description 1
- 238000001919 Rayleigh scattering spectroscopy Methods 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 244000297179 Syringa vulgaris Species 0.000 description 1
- 235000004338 Syringa vulgaris Nutrition 0.000 description 1
- 231100000768 Toxicity label Toxicity 0.000 description 1
- 239000011358 absorbing material Substances 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 238000003916 acid precipitation Methods 0.000 description 1
- 238000001467 acupuncture Methods 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000004523 agglutinating effect Effects 0.000 description 1
- 230000004520 agglutination Effects 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 230000003466 anti-cipated effect Effects 0.000 description 1
- 230000005875 antibody response Effects 0.000 description 1
- 238000003149 assay kit Methods 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 1
- 108091008324 binding proteins Proteins 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- 230000006315 carbonylation Effects 0.000 description 1
- 238000005810 carbonylation reaction Methods 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000012292 cell migration Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- ZCDOYSPFYFSLEW-UHFFFAOYSA-N chromate(2-) Chemical compound [O-][Cr]([O-])(=O)=O ZCDOYSPFYFSLEW-UHFFFAOYSA-N 0.000 description 1
- 210000000349 chromosome Anatomy 0.000 description 1
- 239000007979 citrate buffer Substances 0.000 description 1
- 150000001860 citric acid derivatives Chemical class 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 239000008199 coating composition Substances 0.000 description 1
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 239000013066 combination product Substances 0.000 description 1
- 229940127555 combination product Drugs 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 230000001143 conditioned effect Effects 0.000 description 1
- 238000004624 confocal microscopy Methods 0.000 description 1
- 230000021615 conjugation Effects 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 239000007771 core particle Substances 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 210000004292 cytoskeleton Anatomy 0.000 description 1
- 238000013016 damping Methods 0.000 description 1
- 238000001446 dark-field microscopy Methods 0.000 description 1
- 238000000280 densification Methods 0.000 description 1
- KHWCHTKSEGGWEX-UHFFFAOYSA-N deoxyadenylic acid Natural products C1=NC=2C(N)=NC=NC=2N1C1CC(O)C(COP(O)(O)=O)O1 KHWCHTKSEGGWEX-UHFFFAOYSA-N 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000012631 diagnostic technique Methods 0.000 description 1
- 229910003460 diamond Inorganic materials 0.000 description 1
- 239000010432 diamond Substances 0.000 description 1
- RAABOESOVLLHRU-UHFFFAOYSA-N diazene Chemical compound N=N RAABOESOVLLHRU-UHFFFAOYSA-N 0.000 description 1
- 229910000071 diazene Inorganic materials 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000012470 diluted sample Substances 0.000 description 1
- 239000000539 dimer Substances 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 238000004043 dyeing Methods 0.000 description 1
- 238000002296 dynamic light scattering Methods 0.000 description 1
- 238000009713 electroplating Methods 0.000 description 1
- 230000009881 electrostatic interaction Effects 0.000 description 1
- 229910001254 electrum Inorganic materials 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 238000012869 ethanol precipitation Methods 0.000 description 1
- ZMMJGEGLRURXTF-UHFFFAOYSA-N ethidium bromide Chemical compound [Br-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CC)=C1C1=CC=CC=C1 ZMMJGEGLRURXTF-UHFFFAOYSA-N 0.000 description 1
- 229960005542 ethidium bromide Drugs 0.000 description 1
- 238000000695 excitation spectrum Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 210000000887 face Anatomy 0.000 description 1
- 238000010304 firing Methods 0.000 description 1
- 238000007667 floating Methods 0.000 description 1
- 238000002189 fluorescence spectrum Methods 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- 238000012252 genetic analysis Methods 0.000 description 1
- PQTCMBYFWMFIGM-UHFFFAOYSA-N gold silver Chemical compound [Ag].[Au] PQTCMBYFWMFIGM-UHFFFAOYSA-N 0.000 description 1
- 239000010940 green gold Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- CPBQJMYROZQQJC-UHFFFAOYSA-N helium neon Chemical compound [He].[Ne] CPBQJMYROZQQJC-UHFFFAOYSA-N 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 238000010166 immunofluorescence Methods 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 238000007901 in situ hybridization Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 239000006249 magnetic particle Substances 0.000 description 1
- 239000006148 magnetic separator Substances 0.000 description 1
- 238000013507 mapping Methods 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 238000000520 microinjection Methods 0.000 description 1
- 210000004688 microtubule Anatomy 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000003068 molecular probe Substances 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 239000002077 nanosphere Substances 0.000 description 1
- 230000006855 networking Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 102000044158 nucleic acid binding protein Human genes 0.000 description 1
- 108700020942 nucleic acid binding protein Proteins 0.000 description 1
- 239000002853 nucleic acid probe Substances 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 102000013415 peroxidase activity proteins Human genes 0.000 description 1
- 108040007629 peroxidase activity proteins Proteins 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 150000003016 phosphoric acids Chemical class 0.000 description 1
- 238000000053 physical method Methods 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 108010024951 plastein Proteins 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 238000003752 polymerase chain reaction Methods 0.000 description 1
- 108091033319 polynucleotide Proteins 0.000 description 1
- 102000040430 polynucleotide Human genes 0.000 description 1
- 239000002157 polynucleotide Substances 0.000 description 1
- 229920006389 polyphenyl polymer Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- KXXXUIKPSVVSAW-UHFFFAOYSA-K pyranine Chemical compound [Na+].[Na+].[Na+].C1=C2C(O)=CC(S([O-])(=O)=O)=C(C=C3)C2=C2C3=C(S([O-])(=O)=O)C=C(S([O-])(=O)=O)C2=C1 KXXXUIKPSVVSAW-UHFFFAOYSA-K 0.000 description 1
- 238000012372 quality testing Methods 0.000 description 1
- 238000011897 real-time detection Methods 0.000 description 1
- 238000012857 repacking Methods 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 238000009991 scouring Methods 0.000 description 1
- 238000005201 scrubbing Methods 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 238000004513 sizing Methods 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- SDKPSXWGRWWLKR-UHFFFAOYSA-M sodium;9,10-dioxoanthracene-1-sulfonate Chemical compound [Na+].O=C1C2=CC=CC=C2C(=O)C2=C1C=CC=C2S(=O)(=O)[O-] SDKPSXWGRWWLKR-UHFFFAOYSA-M 0.000 description 1
- GGCZERPQGJTIQP-UHFFFAOYSA-N sodium;9,10-dioxoanthracene-2-sulfonic acid Chemical compound [Na+].C1=CC=C2C(=O)C3=CC(S(=O)(=O)O)=CC=C3C(=O)C2=C1 GGCZERPQGJTIQP-UHFFFAOYSA-N 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000012732 spatial analysis Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 229940104230 thymidine Drugs 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 238000004454 trace mineral analysis Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000004627 transmission electron microscopy Methods 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 229910021642 ultra pure water Inorganic materials 0.000 description 1
- 239000012498 ultrapure water Substances 0.000 description 1
- 241001515965 unidentified phage Species 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
- G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N2015/0038—Investigating nanoparticles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N2015/1493—Particle size
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Dispersion Chemistry (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1638396P | 1996-04-25 | 1996-04-25 | |
| US60/016,383 | 1996-04-25 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1223692A CN1223692A (zh) | 1999-07-21 |
| CN1262667C true CN1262667C (zh) | 2006-07-05 |
Family
ID=21776844
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB971958688A Expired - Fee Related CN1262667C (zh) | 1996-04-25 | 1997-04-17 | 利用颗粒标记物检测分析物 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6214560B1 (enExample) |
| EP (1) | EP1021554B1 (enExample) |
| JP (3) | JP2000510582A (enExample) |
| CN (1) | CN1262667C (enExample) |
| AT (1) | ATE357663T1 (enExample) |
| AU (1) | AU736340B2 (enExample) |
| BR (1) | BR9710836A (enExample) |
| CA (1) | CA2253710A1 (enExample) |
| DE (1) | DE69737513T2 (enExample) |
| IL (1) | IL126544A (enExample) |
| RU (1) | RU2251572C2 (enExample) |
| WO (1) | WO1997040181A1 (enExample) |
Families Citing this family (327)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE43097E1 (en) | 1994-10-13 | 2012-01-10 | Illumina, Inc. | Massively parallel signature sequencing by ligation of encoded adaptors |
| US6586193B2 (en) * | 1996-04-25 | 2003-07-01 | Genicon Sciences Corporation | Analyte assay using particulate labels |
| US7169556B2 (en) | 1996-07-29 | 2007-01-30 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| US6361944B1 (en) | 1996-07-29 | 2002-03-26 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| US7098320B1 (en) | 1996-07-29 | 2006-08-29 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| US6984491B2 (en) | 1996-07-29 | 2006-01-10 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| US6506564B1 (en) | 1996-07-29 | 2003-01-14 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| US6750016B2 (en) | 1996-07-29 | 2004-06-15 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| US6582921B2 (en) | 1996-07-29 | 2003-06-24 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses thereof |
| EP0918885B1 (en) * | 1996-07-29 | 2007-04-11 | Nanosphere LLC | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| US20020172953A1 (en) * | 1996-07-29 | 2002-11-21 | Mirkin Chad A. | Movement of biomolecule-coated nanoparticles in an electric field |
| GB9618897D0 (en) | 1996-09-10 | 1996-10-23 | Bio Rad Micromeasurements Ltd | Micro defects in silicon wafers |
| US6819411B1 (en) | 1997-01-31 | 2004-11-16 | Xy, Inc. | Optical apparatus |
| AU748939B2 (en) | 1997-02-20 | 2002-06-13 | Regents Of The University Of California, The | Plasmon resonant particles, methods and apparatus |
| US6344272B1 (en) | 1997-03-12 | 2002-02-05 | Wm. Marsh Rice University | Metal nanoshells |
| US6852252B2 (en) | 1997-03-12 | 2005-02-08 | William Marsh Rice University | Use of metalnanoshells to impede the photo-oxidation of conjugated polymer |
| JP4294740B2 (ja) * | 1997-05-23 | 2009-07-15 | ソレクサ・インコーポレイテッド | 分析物の系列的プロセシングのためのシステムおよび装置 |
| US20050037397A1 (en) * | 2001-03-28 | 2005-02-17 | Nanosphere, Inc. | Bio-barcode based detection of target analytes |
| US6974669B2 (en) | 2000-03-28 | 2005-12-13 | Nanosphere, Inc. | Bio-barcodes based on oligonucleotide-modified nanoparticles |
| US6071689A (en) | 1997-12-31 | 2000-06-06 | Xy, Inc. | System for improving yield of sexed embryos in mammals |
| US6149867A (en) | 1997-12-31 | 2000-11-21 | Xy, Inc. | Sheath fluids and collection systems for sex-specific cytometer sorting of sperm |
| US6699724B1 (en) | 1998-03-11 | 2004-03-02 | Wm. Marsh Rice University | Metal nanoshells for biosensing applications |
| US6428811B1 (en) | 1998-03-11 | 2002-08-06 | Wm. Marsh Rice University | Temperature-sensitive polymer/nanoshell composites for photothermally modulated drug delivery |
| US20030153023A1 (en) * | 1999-05-13 | 2003-08-14 | Starzl Timothy W. | Enumeration method of analyte detection |
| EP1135682B1 (en) | 1998-11-30 | 2007-07-11 | Nanosphere, Inc. | Nanoparticles with polymer shells |
| EP1141762A1 (de) * | 1998-12-17 | 2001-10-10 | Leica Microsystems Heidelberg GmbH | Verfahren zur differenzierten untersuchung unterschiedlicher strukturen in vorzugsweise biologischen präparaten |
| EP1039291A1 (en) * | 1999-03-26 | 2000-09-27 | Sony International (Europe) GmbH | Optochemical sensor and method for its construction |
| US20050100943A1 (en) * | 2000-04-11 | 2005-05-12 | Hideki Kambara | Method of producing probe arrays for biological materials using fine particles |
| US7253435B2 (en) * | 1999-04-15 | 2007-08-07 | Millipore Corporation | Particles with light-polarizing codes |
| US6908737B2 (en) * | 1999-04-15 | 2005-06-21 | Vitra Bioscience, Inc. | Systems and methods of conducting multiplexed experiments |
| KR20020026421A (ko) * | 1999-04-15 | 2002-04-10 | 버츄얼 어레이즈 인코포레이티드 | 코딩 위치에 표시를 갖는 조합적인 화학 라이브러리지지체 및 이의 사용 방법 |
| US20030207249A1 (en) * | 1999-04-15 | 2003-11-06 | Beske Oren E. | Connection of cells to substrates using association pairs |
| US20030134330A1 (en) * | 1999-04-15 | 2003-07-17 | Ilya Ravkin | Chemical-library composition and method |
| US20030166015A1 (en) * | 1999-04-15 | 2003-09-04 | Zarowitz Michael A. | Multiplexed analysis of cell-substrate interactions |
| US20030129654A1 (en) * | 1999-04-15 | 2003-07-10 | Ilya Ravkin | Coded particles for multiplexed analysis of biological samples |
| US6868371B1 (en) * | 1999-05-03 | 2005-03-15 | General Electric Company | System and method to quantify appearance defects in molded plastic parts |
| US6608716B1 (en) | 1999-05-17 | 2003-08-19 | New Mexico State University Technology Transfer Corporation | Optical enhancement with nanoparticles and microcavities |
| US20030096321A1 (en) * | 1999-05-19 | 2003-05-22 | Jose Remacle | Method for the identification and/or the quantification of a target compound obtained from a biological sample upon chips |
| US6606566B1 (en) * | 1999-11-01 | 2003-08-12 | Steven A. Sunshine | Computer code for portable sensing |
| AU1591301A (en) | 1999-11-09 | 2001-06-06 | Sri International | Workstation, apparatus, and methods for the high-throughput synthesis, screeningand characterization of combinatorial libraries |
| US7033840B1 (en) | 1999-11-09 | 2006-04-25 | Sri International | Reaction calorimeter and differential scanning calorimeter for the high-throughput synthesis, screening and characterization of combinatorial libraries |
| US7208265B1 (en) | 1999-11-24 | 2007-04-24 | Xy, Inc. | Method of cryopreserving selected sperm cells |
| EP1294930B1 (en) | 2000-01-13 | 2011-03-30 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| WO2001096604A2 (en) * | 2000-06-12 | 2001-12-20 | Genicon Sciences Corporation | Assay for genetic polymorphisms using scattered light detectable labels |
| US6602669B2 (en) | 2000-07-11 | 2003-08-05 | Northwestern University | Method of detection by enhancement of silver staining |
| JP2004537712A (ja) | 2000-10-18 | 2004-12-16 | バーチャル・アレイズ・インコーポレーテッド | 多重細胞分析システム |
| BRPI0115792B1 (pt) | 2000-11-29 | 2020-05-05 | Colorado State Univ | sistema para separação de espermatozóides congelados/descongelados em populações portadoras de cromossomo-x e portadoras de cromossomo-y |
| US7713687B2 (en) | 2000-11-29 | 2010-05-11 | Xy, Inc. | System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations |
| US6726847B2 (en) | 2000-12-06 | 2004-04-27 | Northwestern University | Silver stain removal by chemical etching and sonication |
| US7015047B2 (en) * | 2001-01-26 | 2006-03-21 | Aviva Biosciences Corporation | Microdevices having a preferential axis of magnetization and uses thereof |
| US7811768B2 (en) * | 2001-01-26 | 2010-10-12 | Aviva Biosciences Corporation | Microdevice containing photorecognizable coding patterns and methods of using and producing the same |
| CA2439307A1 (en) | 2001-02-23 | 2002-09-06 | Genicon Sciences Corporation | Methods for providing extended dynamic range in analyte assays |
| US20040166502A1 (en) * | 2001-03-13 | 2004-08-26 | Yaming Lai | Microelectromagnetic dispenser heads and uses thereof |
| EP1379693B1 (en) * | 2001-03-28 | 2009-05-20 | Nanosphere, Inc. | Bio-barcodes based on oligonucleotide-modified particles |
| US20060040286A1 (en) * | 2001-03-28 | 2006-02-23 | Nanosphere, Inc. | Bio-barcode based detection of target analytes |
| AU2002251449B2 (en) * | 2001-03-29 | 2008-01-31 | Cellect Technologies Corp. | Methods devices and systems for sorting and separating particles |
| US20040121350A1 (en) * | 2002-12-24 | 2004-06-24 | Biosite Incorporated | System and method for identifying a panel of indicators |
| US7713705B2 (en) * | 2002-12-24 | 2010-05-11 | Biosite, Inc. | Markers for differential diagnosis and methods of use thereof |
| US20040203083A1 (en) * | 2001-04-13 | 2004-10-14 | Biosite, Inc. | Use of thrombus precursor protein and monocyte chemoattractant protein as diagnostic and prognostic indicators in vascular diseases |
| US20040126767A1 (en) * | 2002-12-27 | 2004-07-01 | Biosite Incorporated | Method and system for disease detection using marker combinations |
| US20040253637A1 (en) * | 2001-04-13 | 2004-12-16 | Biosite Incorporated | Markers for differential diagnosis and methods of use thereof |
| US20030113740A1 (en) * | 2001-04-26 | 2003-06-19 | Mirkin Chad A. | Oligonucleotide-modified ROMP polymers and co-polymers |
| WO2002096262A2 (en) | 2001-05-25 | 2002-12-05 | Northwestern University | Non-alloying core shell nanoparticles |
| US7147687B2 (en) | 2001-05-25 | 2006-12-12 | Nanosphere, Inc. | Non-alloying core shell nanoparticles |
| AU2002320058A1 (en) | 2001-06-06 | 2002-12-16 | The General Hspital Corporation | Magnetic-nanoparticle conjugates and methods of use |
| WO2002099382A2 (en) * | 2001-06-07 | 2002-12-12 | University Of Pennsylvania-Center For Technology Transfer | Multiplexing method |
| US6714299B2 (en) | 2001-07-13 | 2004-03-30 | Genicon Sciences Corporation | Use of light scattering particles in design, manufacture, and quality control of small volume instruments, devices, and processes |
| US20040146917A1 (en) * | 2001-08-03 | 2004-07-29 | Nanosphere, Inc. | Nanoparticle imaging system and method |
| AU2002365247B2 (en) * | 2001-08-03 | 2006-06-08 | Nanosphere, Inc. | Nanoparticle imaging system and method |
| US20030049866A1 (en) | 2001-09-05 | 2003-03-13 | Genicon Sciences Corporation | Sample device preservation |
| WO2003021231A2 (en) * | 2001-09-05 | 2003-03-13 | Genicon Sciences Corporation | Method and apparatus for normalization and deconvolution of assay data |
| EP1502101B1 (en) | 2001-09-06 | 2012-11-07 | Straus Holdings Inc. | Rapid and sensitive detection of cells and viruses |
| EP2287290B1 (en) | 2001-09-20 | 2016-05-11 | AntiCancer, Inc. | Nestin-expressing hair follicle stem cells |
| US6754414B2 (en) * | 2001-09-27 | 2004-06-22 | Bio-Rad Laboratories, Inc. | Imaging of microarrays using fiber optic exciter |
| CA2463323C (en) * | 2001-10-09 | 2010-12-21 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| US8148171B2 (en) * | 2001-10-09 | 2012-04-03 | Luminex Corporation | Multiplexed analysis of clinical specimens apparatus and methods |
| US20030219800A1 (en) * | 2001-10-18 | 2003-11-27 | Beske Oren E. | Multiplexed cell transfection using coded carriers |
| DE60228128D1 (de) | 2001-11-09 | 2008-09-18 | Nanosphere Inc | Biokonjugat-nanopartikelsonden |
| US7083975B2 (en) * | 2002-02-01 | 2006-08-01 | Roland Green | Microarray synthesis instrument and method |
| US7214427B2 (en) * | 2002-03-21 | 2007-05-08 | Aviva Biosciences Corporation | Composite beads comprising magnetizable substance and electro-conductive substance |
| US7029631B2 (en) * | 2002-04-19 | 2006-04-18 | Agilent Technologies, Inc. | Apparatus for improved light collection |
| US20030211488A1 (en) * | 2002-05-07 | 2003-11-13 | Northwestern University | Nanoparticle probs with Raman spectrocopic fingerprints for analyte detection |
| ATE423317T1 (de) * | 2002-05-08 | 2009-03-15 | Panasonic Corp | Biomolekulares substrat und testvorrichtung |
| US20040126773A1 (en) * | 2002-05-23 | 2004-07-01 | Beske Oren E. | Assays with coded sensor particles to sense assay conditions |
| DE10223706A1 (de) | 2002-05-28 | 2003-12-18 | Nat Taiwan University Taipeh T | Lichtemissionsdiode |
| US7253277B2 (en) | 2002-07-02 | 2007-08-07 | Nanosphere, Inc. | Nanoparticle polyanion conjugates and methods of use thereof in detecting analytes |
| EP2301333A1 (en) * | 2002-07-22 | 2011-03-30 | Xy, Llc | Non-human sperm cell process system |
| US20040018495A1 (en) * | 2002-07-24 | 2004-01-29 | Xing-Xiang Li | Microparticle based signal amplification for the detection of analytes |
| DK2275533T3 (en) * | 2002-08-01 | 2016-11-07 | Xy Llc | Sperm Cell Assessment Method |
| US8486618B2 (en) | 2002-08-01 | 2013-07-16 | Xy, Llc | Heterogeneous inseminate system |
| CA2534394C (en) | 2002-08-15 | 2013-01-08 | Xy, Inc. | High resolution flow cytometer |
| US7619819B2 (en) | 2002-08-20 | 2009-11-17 | Illumina, Inc. | Method and apparatus for drug product tracking using encoded optical identification elements |
| US7399643B2 (en) * | 2002-09-12 | 2008-07-15 | Cyvera Corporation | Method and apparatus for aligning microbeads in order to interrogate the same |
| US7872804B2 (en) | 2002-08-20 | 2011-01-18 | Illumina, Inc. | Encoded particle having a grating with variations in the refractive index |
| US7441703B2 (en) | 2002-08-20 | 2008-10-28 | Illumina, Inc. | Optical reader for diffraction grating-based encoded optical identification elements |
| US7164533B2 (en) * | 2003-01-22 | 2007-01-16 | Cyvera Corporation | Hybrid random bead/chip based microarray |
| EP1535242A1 (en) * | 2002-08-20 | 2005-06-01 | Cyvera Corporation | Diffraction grating-based encoded micro-particles for multiplexed experiments |
| US7508608B2 (en) | 2004-11-17 | 2009-03-24 | Illumina, Inc. | Lithographically fabricated holographic optical identification element |
| WO2004019276A1 (en) * | 2002-08-20 | 2004-03-04 | Cyvera Corporation | Diffraction grating-based optical identification element |
| US7900836B2 (en) | 2002-08-20 | 2011-03-08 | Illumina, Inc. | Optical reader system for substrates having an optically readable code |
| US7901630B2 (en) | 2002-08-20 | 2011-03-08 | Illumina, Inc. | Diffraction grating-based encoded microparticle assay stick |
| US7923260B2 (en) | 2002-08-20 | 2011-04-12 | Illumina, Inc. | Method of reading encoded particles |
| US20040043385A1 (en) * | 2002-09-03 | 2004-03-04 | Yo-Hsin Su | Microarray biochip |
| CA2499046A1 (en) * | 2002-09-12 | 2004-03-25 | Cyvera Corporation | Diffraction grating-based encoded micro-particles for multiplexed experiments |
| EP1552475A1 (en) * | 2002-09-12 | 2005-07-13 | Cyvera Corporation | Chemical synthesis using diffraction grating-based encoded optical elements |
| US20100255603A9 (en) * | 2002-09-12 | 2010-10-07 | Putnam Martin A | Method and apparatus for aligning microbeads in order to interrogate the same |
| EP1540592A1 (en) * | 2002-09-12 | 2005-06-15 | Cyvera Corporation | Method and apparatus for labeling using diffraction grating-based encoded optical identification elements |
| US7092160B2 (en) | 2002-09-12 | 2006-08-15 | Illumina, Inc. | Method of manufacturing of diffraction grating-based optical identification element |
| US7169548B2 (en) | 2002-09-13 | 2007-01-30 | Xy, Inc. | Sperm cell processing and preservation systems |
| EP1552025A4 (en) * | 2002-10-18 | 2006-12-13 | Cylene Pharmaceuticals Inc | METHODS FOR IDENTIFYING TARGETED ANTIVIRAL MOLECULES TO QUADRUPLEX STRUCTURES |
| AU2003289853A1 (en) * | 2002-11-04 | 2004-06-07 | Ludwig-Maximilian-Uni Versitat Munchen | Methods, device and instrument for detection of analytes |
| US7122384B2 (en) * | 2002-11-06 | 2006-10-17 | E. I. Du Pont De Nemours And Company | Resonant light scattering microparticle methods |
| AU2003302340B8 (en) * | 2002-12-24 | 2008-09-11 | Biosite Incorporated | Markers for differential diagnosis and methods of use thereof |
| EP1583473A2 (en) * | 2003-01-16 | 2005-10-12 | St. Johns University New York | Nanoparticle based stabilization of ir fluorescent dyes |
| US20050130174A1 (en) * | 2003-02-27 | 2005-06-16 | Nanosphere, Inc. | Label-free gene expression profiling with universal nanoparticle probes in microarray assay format |
| EP2305348B1 (en) * | 2003-03-27 | 2015-05-20 | The General Hospital Corporation | Method for cosmetic dermatological treatment and fractional skin resurfacing |
| ES2534395T3 (es) | 2003-03-28 | 2015-04-22 | Inguran, Llc | Aparato y métodos para proporcionar esperma animal clasificado por sexo |
| US7507727B2 (en) * | 2003-04-07 | 2009-03-24 | Cylene Pharmaceuticals, Inc. | Substituted quinobenzoxazine analogs and methods of using thereof |
| US7354916B2 (en) * | 2003-04-07 | 2008-04-08 | Cylene Pharmaceuticals | Substituted quinobenzoxazine analogs |
| WO2004091627A2 (en) * | 2003-04-07 | 2004-10-28 | Cylene Pharmaceuticals, Inc. | Heterocyclic substituted 1,4-dihydro-4-oxo-1,8-naphthpyridine analogs |
| WO2004091504A2 (en) * | 2003-04-07 | 2004-10-28 | Cylene Pharmaceuticals, Inc. | Substituted quinobenzoxazine analogs |
| GB0308182D0 (en) * | 2003-04-09 | 2003-05-14 | Aoti Operating Co Inc | Detection method and apparatus |
| US7177487B2 (en) * | 2003-04-21 | 2007-02-13 | Baxter International Inc. | Determination of particle size by image analysis |
| AU2004242121B2 (en) * | 2003-05-15 | 2010-06-24 | Xy, Llc. | Efficient haploid cell sorting for flow cytometer systems |
| US20050250094A1 (en) * | 2003-05-30 | 2005-11-10 | Nanosphere, Inc. | Method for detecting analytes based on evanescent illumination and scatter-based detection of nanoparticle probe complexes |
| US7341841B2 (en) * | 2003-07-12 | 2008-03-11 | Accelr8 Technology Corporation | Rapid microbial detection and antimicrobial susceptibility testing |
| JP4773348B2 (ja) * | 2003-07-12 | 2011-09-14 | アクセラー8 テクノロジー コーポレイション | 高感度かつ迅速なバイオ検出法 |
| US20120077206A1 (en) | 2003-07-12 | 2012-03-29 | Accelr8 Technology Corporation | Rapid Microbial Detection and Antimicrobial Susceptibility Testing |
| US7641971B2 (en) * | 2003-08-13 | 2010-01-05 | Crane Company | Metal-treated particles for remediation |
| WO2005074417A2 (en) * | 2003-09-03 | 2005-08-18 | Salk Institute For Biological Studies | Multiple antigen detection assays and reagents |
| EP1676133A4 (en) * | 2003-09-15 | 2008-05-21 | Millipore Corp | TESTS WITH PRIMARY CELLS |
| US7488451B2 (en) * | 2003-09-15 | 2009-02-10 | Millipore Corporation | Systems for particle manipulation |
| US7413868B2 (en) * | 2003-11-05 | 2008-08-19 | Trellis Bioscience, Inc. | Use of particulate labels in bioanalyte detection methods |
| EP1711623A4 (en) | 2003-12-22 | 2008-05-21 | Wayne John Cancer Inst | METHOD AND DEVICE FOR IN VIVO COLLECTION AND MONITORING OF CIRCULATING BIOLOGICAL COMPONENTS |
| US7553625B2 (en) | 2003-12-22 | 2009-06-30 | John Wayne Cancer Institute | Method and apparatus for in vivo collection of circulating biological components |
| US20050153309A1 (en) | 2003-12-22 | 2005-07-14 | David Hoon | Method and apparatus for in vivo surveillance of circulating biological components |
| AU2004312893B2 (en) | 2003-12-31 | 2010-06-17 | President And Fellows Of Harvard College | Assay device and method |
| US20050141843A1 (en) * | 2003-12-31 | 2005-06-30 | Invitrogen Corporation | Waveguide comprising scattered light detectable particles |
| US8030057B2 (en) * | 2004-01-26 | 2011-10-04 | President And Fellows Of Harvard College | Fluid delivery system and method |
| CA2564211C (en) | 2004-01-26 | 2010-08-03 | President And Fellows Of Harvard College | Fluid delivery system and method |
| DE102004006470B4 (de) * | 2004-02-06 | 2006-06-01 | Senova Gesellschaft für Biowissenschaft und Technik mbH | Absorptionsphotometrisches Verfahren zur quantitativen Stoffanalyse |
| US20050270603A1 (en) * | 2004-02-19 | 2005-12-08 | Cyuera Corporation | Optical identification element using separate or partially overlapped diffraction gratings |
| WO2005079545A2 (en) * | 2004-02-19 | 2005-09-01 | Illumina, Inc. | Optical identification element using separate or partially overlapped diffraction gratings |
| US20060023310A1 (en) * | 2004-02-19 | 2006-02-02 | Putnam Martin A | Optical identification element using separate or partially overlapped diffraction gratings |
| US7433123B2 (en) * | 2004-02-19 | 2008-10-07 | Illumina, Inc. | Optical identification element having non-waveguide photosensitive substrate with diffraction grating therein |
| BRPI0509488A (pt) | 2004-03-29 | 2007-09-11 | Monsanto Technology Llc | suspensões de esperma para seleção de populações enriquecidas carregando cromossomo x ou y |
| US7407816B2 (en) * | 2004-05-07 | 2008-08-05 | Gentius, Inc | Isoelectric particles and uses thereof |
| US20090054255A1 (en) * | 2004-07-01 | 2009-02-26 | The Regents Of The University Of California | Microfluidic devices and methods |
| DE102004034486B4 (de) * | 2004-07-16 | 2007-08-23 | Infineon Technologies Ag | Verfahren zum Nachweis von Lumineszenzlicht aus einer porösen Trägerstruktur |
| AR049732A1 (es) | 2004-07-22 | 2006-08-30 | Monsanto Co | Proceso para enriquecer una poblacion de celulas de esperma |
| CA2572178A1 (en) * | 2004-07-26 | 2006-03-16 | Nanosphere, Inc. | Method for distinguishing methicillin resistant s. aureus from methicillin sensitive s. aureus in a mixed culture |
| US20060024815A1 (en) * | 2004-07-30 | 2006-02-02 | Allman Steve L | High sensitivity array-based detection system |
| US9494581B2 (en) | 2004-08-24 | 2016-11-15 | University Of Wyoming | System and method for Raman spectroscopy assay using paramagnetic particles |
| US7288134B2 (en) * | 2004-09-10 | 2007-10-30 | International Business Machines Corporation | Dumbbell-like nanoparticles and a process of forming the same |
| US8183057B2 (en) * | 2004-09-14 | 2012-05-22 | Mitsubishi Chemical Corporation | Biomaterial construct, its producing method, biomaterial support, target material purifying method, affinity chromatography container, separation chip, analyzing method and analyzing separator for target material, biomaterial complex, and its support, sensor chip, solid support with biomaterial fixed thereon |
| US7612769B2 (en) * | 2004-09-14 | 2009-11-03 | E.I. Du Pont De Nemours And Company | Computer-implemented methods for organizing image data produced by resonant Mie scattering of light from microparticles and resulting data structures |
| US8486622B2 (en) * | 2004-09-24 | 2013-07-16 | Ingeneus Inc. | Genomic assay |
| WO2006055735A2 (en) * | 2004-11-16 | 2006-05-26 | Illumina, Inc | Scanner having spatial light modulator |
| US7604173B2 (en) | 2004-11-16 | 2009-10-20 | Illumina, Inc. | Holographically encoded elements for microarray and other tagging labeling applications, and method and apparatus for making and reading the same |
| CN101116086A (zh) | 2004-11-16 | 2008-01-30 | 伊路敏纳公司 | 读取编码微珠的方法和设备 |
| CA2604323A1 (en) | 2005-04-19 | 2006-10-26 | President And Fellows Of Harvard College | Fluidic structures including meandering and wide channels |
| CA2606924C (en) | 2005-05-09 | 2013-04-16 | The General Hospital Corporation | Water relaxation-based sensors |
| US8597576B2 (en) * | 2005-06-23 | 2013-12-03 | National Institute Of Advanced Industrial Science And Technology | Analyzer for glycan or complex carbohydrate |
| WO2007002567A2 (en) * | 2005-06-23 | 2007-01-04 | Nanosphere, Inc. | Selective isolation and concentration of nucleic acids from complex samples |
| TWI439684B (zh) * | 2005-07-06 | 2014-06-01 | Nanometrics Inc | 具自晶圓或其他工件特定材料層所發射光致發光信號優先偵測之光致發光成像 |
| TWI391645B (zh) * | 2005-07-06 | 2013-04-01 | Nanometrics Inc | 晶圓或其他工作表面下污染物及缺陷非接觸測量之差分波長光致發光 |
| CA2659640C (en) * | 2005-08-02 | 2011-11-15 | University Of Maryland Biotechnology Institute | Nanostructures for polarized imaging and receptor/ligand quantization: breaking the diffraction limit for imaging |
| ATE489482T1 (de) * | 2005-08-19 | 2010-12-15 | Nanosphere Inc | Verfahren zur herstellung von hybridsubstraten mit dna und antikörpern sowie verwendungen davon |
| EP1932009B1 (en) | 2005-08-31 | 2014-02-12 | T2 Biosystems, Inc. | Nmr device for detection of analytes involving magnetic particles |
| US20070134685A1 (en) * | 2005-09-06 | 2007-06-14 | Invitrogen Corporation | Control of chemical modification |
| US9057046B2 (en) | 2005-09-26 | 2015-06-16 | Rapid Micro Biosystems, Inc. | Cassette containing growth medium |
| US7723120B2 (en) | 2005-10-26 | 2010-05-25 | General Electric Company | Optical sensor array system and method for parallel processing of chemical and biochemical information |
| US8133741B2 (en) | 2005-10-26 | 2012-03-13 | General Electric Company | Methods and systems for delivery of fluidic samples to sensor arrays |
| WO2007056113A2 (en) * | 2005-11-02 | 2007-05-18 | Cylene Pharmaceuticals, Inc. | Methods for targeting quadruplex sequences |
| US7623624B2 (en) * | 2005-11-22 | 2009-11-24 | Illumina, Inc. | Method and apparatus for labeling using optical identification elements characterized by X-ray diffraction |
| USD580285S1 (en) | 2006-01-13 | 2008-11-11 | Invitrogen Corporation | Fluorometer |
| RU2298798C1 (ru) * | 2006-01-17 | 2007-05-10 | Общество с ограниченной ответственностью "Биочип-Аналитика" (ООО "Биочип-Аналитика") | Способ контроля биологической пробы в реакции латекс-агглютинации и аналитическая система для его осуществления |
| WO2007087582A1 (en) | 2006-01-24 | 2007-08-02 | Invitrogen Corporation | Device and methods for quantifying analytes |
| RU2327170C2 (ru) * | 2006-02-27 | 2008-06-20 | Закрытое акционерное общество "ДиТест" | Способ комплексной диагностики вирусного гепатита в, вирусного гепатита с, вич-инфекции и сифилиса |
| US7830575B2 (en) | 2006-04-10 | 2010-11-09 | Illumina, Inc. | Optical scanner with improved scan time |
| JP5200003B2 (ja) * | 2006-05-09 | 2013-05-15 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 磁場を用いた試料中の標的分子の検出 |
| US9810707B2 (en) * | 2006-05-17 | 2017-11-07 | Luminex Corporation | Chip-based flow cytometer type systems for analyzing fluorescently tagged particles |
| US8679741B2 (en) * | 2006-05-31 | 2014-03-25 | Sequenom, Inc. | Methods and compositions for the extraction and amplification of nucleic acid from a sample |
| US8207509B2 (en) * | 2006-09-01 | 2012-06-26 | Pacific Biosciences Of California, Inc. | Substrates, systems and methods for analyzing materials |
| JP5151097B2 (ja) * | 2006-09-01 | 2013-02-27 | 株式会社リコー | 複合金属ナノ粒子、複合金属ナノ粒子を含む多光子吸収反応材料と反応生成物、複合金属ナノ粒子を含む多光子吸収反応助剤 |
| US8124598B2 (en) | 2006-09-14 | 2012-02-28 | Sharon Sageman | 7-keto DHEA for psychiatric use |
| RU2442171C2 (ru) * | 2006-09-21 | 2012-02-10 | Промитьюс Лабораториз Инк. | Чипы на основе антител для определения множественных трансдукторов сигналов в редких циркулирующих клетках |
| US7902345B2 (en) | 2006-12-05 | 2011-03-08 | Sequenom, Inc. | Detection and quantification of biomolecules using mass spectrometry |
| US20120321759A1 (en) * | 2007-01-05 | 2012-12-20 | Myskin, Inc. | Characterization of food materials by optomagnetic fingerprinting |
| US9417176B2 (en) * | 2007-01-19 | 2016-08-16 | Tudor Arvinte | Method and apparatus for detecting and registering properties of samples |
| US8202492B2 (en) | 2007-05-04 | 2012-06-19 | Opko Diagnostics, Llc | Fluidic connectors and microfluidic systems |
| US7883898B2 (en) | 2007-05-07 | 2011-02-08 | General Electric Company | Method and apparatus for measuring pH of low alkalinity solutions |
| US8097422B2 (en) | 2007-06-20 | 2012-01-17 | Salk Institute For Biological Studies | Kir channel modulators |
| WO2009026164A1 (en) | 2007-08-17 | 2009-02-26 | The General Hospital Corporation | Magnetic resonance-based viscometers and methods |
| EP2195452B1 (en) | 2007-08-29 | 2012-03-14 | Sequenom, Inc. | Methods and compositions for universal size-specific polymerase chain reaction |
| US20100160274A1 (en) * | 2007-09-07 | 2010-06-24 | Sharon Sageman | 7-KETO DHEA for Psychiatric Use |
| US8278057B2 (en) * | 2007-09-14 | 2012-10-02 | Nestec S.A. | Addressable antibody arrays and methods of use |
| JP4597175B2 (ja) * | 2007-09-21 | 2010-12-15 | 株式会社日立ハイテクノロジーズ | 標的物質を検出するための分析装置、又は分析方法、若しくはこれら分析装置及び分析方法に用いるデバイス |
| CN101836102B (zh) * | 2007-10-25 | 2012-02-29 | 皇家飞利浦电子股份有限公司 | 用于样品中靶粒子的传感器装置 |
| JP4975599B2 (ja) * | 2007-12-17 | 2012-07-11 | シスメックス株式会社 | 標本作製装置および標本作製方法 |
| JP2009150799A (ja) * | 2007-12-21 | 2009-07-09 | Sysmex Corp | 分析装置、コンピュータプログラムおよび分析方法 |
| US20090181361A1 (en) * | 2008-01-14 | 2009-07-16 | Weidong Xu | Rapid test for detecting infection |
| US8852864B2 (en) | 2008-01-17 | 2014-10-07 | Sequenom Inc. | Methods and compositions for the analysis of nucleic acids |
| AU2009223671B2 (en) | 2008-03-11 | 2014-11-27 | Sequenom, Inc. | Nucleic acid-based tests for prenatal gender determination |
| JP2009229103A (ja) * | 2008-03-19 | 2009-10-08 | Toshiba Corp | 金属コロイドの定量方法 |
| RU2472221C2 (ru) * | 2008-03-21 | 2013-01-10 | Закрытое акционерное общество "СЕЛЬМАШПРОЕКТ" | Система для моделирования генетической и лингвистической информации |
| WO2009131677A1 (en) | 2008-04-25 | 2009-10-29 | Claros Diagnostics, Inc. | Flow control in microfluidic systems |
| EP3885743A1 (en) * | 2008-06-10 | 2021-09-29 | Xtralis Technologies Ltd | Particle detection |
| TW201017149A (en) * | 2008-08-06 | 2010-05-01 | Invitrox Inc | Use of focused light scattering techniques in biological applications |
| EP3629011B1 (en) | 2008-09-16 | 2023-11-01 | Pacific Biosciences Of California, Inc. | Integrated optical device |
| US8962247B2 (en) * | 2008-09-16 | 2015-02-24 | Sequenom, Inc. | Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses |
| US8476013B2 (en) * | 2008-09-16 | 2013-07-02 | Sequenom, Inc. | Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses |
| CN107121396B (zh) | 2008-09-24 | 2020-06-30 | 曙光生命科学公司 | 用于检测分析物的方法 |
| JP5759377B2 (ja) * | 2008-09-25 | 2015-08-05 | コーニンクレッカ フィリップス エヌ ヴェ | 検出システム及び方法 |
| EP2348976B1 (en) | 2008-10-29 | 2020-12-02 | T2 Biosystems, Inc. | Nmr detection of coagulation time |
| CN102224259B (zh) | 2008-11-24 | 2014-08-27 | 塞昆纳姆股份有限公司 | 核酸定量的产品和方法 |
| US8591829B2 (en) | 2008-12-18 | 2013-11-26 | Opko Diagnostics, Llc | Reagent storage in microfluidic systems and related articles and methods |
| CN102365543A (zh) | 2009-01-16 | 2012-02-29 | 纽约大学 | 用全息视频显微术的自动实时粒子表征和三维速度计量 |
| EP3278877B1 (en) | 2009-02-02 | 2020-06-03 | Opko Diagnostics, LLC | Structures for controlling light interaction with microfluidic devices |
| US20110171124A1 (en) | 2009-02-26 | 2011-07-14 | Osi Pharmaceuticals, Inc. | In situ methods for monitoring the EMT status of tumor cells in vivo |
| EP2408936A4 (en) * | 2009-03-18 | 2013-01-30 | Sequenom Inc | USE OF HEAT-STAINED ENDONUCLEASES FOR THE PREPARATION OF REPORTER MOLECULES |
| US8771948B2 (en) | 2009-04-03 | 2014-07-08 | Sequenom, Inc. | Nucleic acid preparation compositions and methods |
| CA2772020A1 (en) * | 2009-08-31 | 2011-03-03 | Mbio Diagnostics, Inc. | Integrated sample preparation and analyte detection |
| US20110143378A1 (en) * | 2009-11-12 | 2011-06-16 | CyVek LLC. | Microfluidic method and apparatus for high performance biological assays |
| US9500645B2 (en) | 2009-11-23 | 2016-11-22 | Cyvek, Inc. | Micro-tube particles for microfluidic assays and methods of manufacture |
| US10022696B2 (en) | 2009-11-23 | 2018-07-17 | Cyvek, Inc. | Microfluidic assay systems employing micro-particles and methods of manufacture |
| US9855735B2 (en) | 2009-11-23 | 2018-01-02 | Cyvek, Inc. | Portable microfluidic assay devices and methods of manufacture and use |
| WO2013134739A1 (en) | 2012-03-08 | 2013-09-12 | Cyvek, Inc. | Microfluidic assay operating system and methods of use |
| CA2781556C (en) | 2009-11-23 | 2015-05-19 | Cyvek, Inc. | Method and apparatus for performing assays |
| US10065403B2 (en) | 2009-11-23 | 2018-09-04 | Cyvek, Inc. | Microfluidic assay assemblies and methods of manufacture |
| US9700889B2 (en) | 2009-11-23 | 2017-07-11 | Cyvek, Inc. | Methods and systems for manufacture of microarray assay systems, conducting microfluidic assays, and monitoring and scanning to obtain microfluidic assay results |
| US9759718B2 (en) | 2009-11-23 | 2017-09-12 | Cyvek, Inc. | PDMS membrane-confined nucleic acid and antibody/antigen-functionalized microlength tube capture elements, and systems employing them, and methods of their use |
| EA024999B1 (ru) | 2009-11-24 | 2016-11-30 | Опкоу Дайагностикс, Ллк. | Смешивание и доставка текучих сред в микрофлюидных системах |
| US9339813B2 (en) | 2009-12-18 | 2016-05-17 | Koninklijke Philips N.V. | Substance determining apparatus |
| ES2577017T3 (es) | 2009-12-22 | 2016-07-12 | Sequenom, Inc. | Procedimientos y kits para identificar la aneuploidia |
| CN102939160B (zh) | 2010-04-16 | 2016-10-12 | 欧普科诊断有限责任公司 | 用于样本分析的系统和装置 |
| USD645971S1 (en) | 2010-05-11 | 2011-09-27 | Claros Diagnostics, Inc. | Sample cassette |
| USD653981S1 (en) | 2010-08-06 | 2012-02-14 | Life Technologies Corporation | Fluorometer |
| US9395371B2 (en) * | 2010-09-24 | 2016-07-19 | Warren Chan | Synthesis of fluorescent noble metal nanoparticles |
| CA2815085C (en) | 2010-10-22 | 2022-06-21 | T2 Biosystems, Inc. | Nmr systems and methods for the rapid detection of analytes |
| US8409807B2 (en) | 2010-10-22 | 2013-04-02 | T2 Biosystems, Inc. | NMR systems and methods for the rapid detection of analytes |
| US9527905B2 (en) | 2011-02-08 | 2016-12-27 | Medimmune, Llc | Antibodies that specifically bind Staphylococcus aureus alpha toxin and methods of use |
| JP5681517B2 (ja) * | 2011-02-15 | 2015-03-11 | 新日本空調株式会社 | 粒子導電性判別装置及び粒子導電性判別方法 |
| US10254204B2 (en) | 2011-03-07 | 2019-04-09 | Accelerate Diagnostics, Inc. | Membrane-assisted purification |
| EP2683831B1 (en) | 2011-03-07 | 2015-09-23 | Accelerate Diagnostics, Inc. | Rapid cell purification systems |
| CN103649759B (zh) | 2011-03-22 | 2016-08-31 | 西维克公司 | 微流体装置以及制造方法和用途 |
| CA2834218C (en) | 2011-04-29 | 2021-02-16 | Sequenom, Inc. | Quantification of a minority nucleic acid species using inhibitory oligonucleotides |
| WO2012177792A2 (en) | 2011-06-24 | 2012-12-27 | Sequenom, Inc. | Methods and processes for non-invasive assessment of a genetic variation |
| AU2012281017B2 (en) | 2011-07-13 | 2017-07-20 | T2 Biosystems, Inc. | NMR methods for monitoring blood clot formation |
| JP5762225B2 (ja) * | 2011-09-08 | 2015-08-12 | 新留 康郎 | 銀シェル金ナノロッドを用いる分析方法 |
| US10620205B2 (en) | 2011-09-21 | 2020-04-14 | T2 Biosystems, Inc. | NMR methods for endotoxin analysis |
| US9367663B2 (en) | 2011-10-06 | 2016-06-14 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US9984198B2 (en) | 2011-10-06 | 2018-05-29 | Sequenom, Inc. | Reducing sequence read count error in assessment of complex genetic variations |
| US10424394B2 (en) | 2011-10-06 | 2019-09-24 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US10196681B2 (en) | 2011-10-06 | 2019-02-05 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| CA2850785C (en) | 2011-10-06 | 2022-12-13 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US8688388B2 (en) | 2011-10-11 | 2014-04-01 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| JP6105613B2 (ja) | 2011-11-07 | 2017-03-29 | ラピッド マイクロ バイオシステムズ インコーポレイテッド | 無菌試験用カセット |
| DE102011087679B3 (de) * | 2011-12-02 | 2013-04-18 | Schildtec GmbH | Meßkammer für einen optisch arbeitenden Sensor zum Bestimmen einer Konzentration eines Stoffes |
| JP6431769B2 (ja) | 2012-01-20 | 2018-11-28 | セクエノム, インコーポレイテッド | 実験条件を要因として含める診断プロセス |
| EP3401399B1 (en) | 2012-03-02 | 2020-04-22 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| TWI596494B (zh) | 2012-03-05 | 2017-08-21 | Opko診斷法有限責任公司 | 預測前列腺癌風險及前列腺腺體體積之方法及裝置 |
| JP2013181935A (ja) * | 2012-03-05 | 2013-09-12 | Fujifilm Corp | クロマトグラフ方法 |
| CN107841461A (zh) | 2012-04-16 | 2018-03-27 | 快速微型生物系统公司 | 细胞培养装置 |
| US9562271B2 (en) | 2012-04-20 | 2017-02-07 | T2 Biosystems, Inc. | Compositions and methods for detection of Candida species |
| US10504613B2 (en) | 2012-12-20 | 2019-12-10 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US9920361B2 (en) | 2012-05-21 | 2018-03-20 | Sequenom, Inc. | Methods and compositions for analyzing nucleic acid |
| US10497461B2 (en) | 2012-06-22 | 2019-12-03 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US20140004105A1 (en) | 2012-06-29 | 2014-01-02 | Sequenom, Inc. | Age-related macular degeneration diagnostics |
| HK1206792A1 (en) | 2012-07-13 | 2016-01-15 | Sequenom, Inc. | Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses |
| US10482994B2 (en) | 2012-10-04 | 2019-11-19 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US20140146157A1 (en) * | 2012-11-29 | 2014-05-29 | Fluid Imaging Technologies, Inc. | System and method for sample dilution and particle imaging |
| WO2014089346A1 (en) | 2012-12-07 | 2014-06-12 | T2 Biosystems, Inc. | Methods for monitoring tight clot formation |
| US20130309666A1 (en) | 2013-01-25 | 2013-11-21 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| WO2014168711A1 (en) | 2013-03-13 | 2014-10-16 | Sequenom, Inc. | Primers for dna methylation analysis |
| CA2900708C (en) | 2013-03-13 | 2021-06-15 | Opko Diagnostics, Llc | Mixing of fluids in fluidic systems |
| US9677109B2 (en) | 2013-03-15 | 2017-06-13 | Accelerate Diagnostics, Inc. | Rapid determination of microbial growth and antimicrobial susceptibility |
| PL2981921T3 (pl) | 2013-04-03 | 2023-05-08 | Sequenom, Inc. | Metody i procesy nieinwazyjnej oceny zmienności genetycznych |
| AU2014268377B2 (en) | 2013-05-24 | 2020-10-08 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| SMT201900206T1 (it) | 2013-06-21 | 2019-05-10 | Sequenom Inc | Metodo per la valutazione non invasiva di variazioni genetiche |
| EP2827130A1 (en) * | 2013-07-15 | 2015-01-21 | F. Hoffmann-La Roche AG | Device for use in the detection of binding affinities |
| PL3053071T3 (pl) | 2013-10-04 | 2024-03-18 | Sequenom, Inc. | Metody i procesy nieinwazyjnej oceny zmienności genetycznych |
| EP3495496B1 (en) | 2013-10-07 | 2020-11-25 | Sequenom, Inc. | Methods and processes for non-invasive assessment of chromosome alterations |
| KR102425768B1 (ko) | 2014-02-12 | 2022-07-26 | 뉴욕 유니버시티 | 콜로이드 입자의 홀로그래픽 추적 및 특징화를 위한 고속 특징부 식별 |
| WO2015138774A1 (en) | 2014-03-13 | 2015-09-17 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| EP3175000B1 (en) | 2014-07-30 | 2020-07-29 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| ES2913524T3 (es) | 2014-11-12 | 2022-06-02 | Univ New York | Huellas coloidales para materiales blandos usando caracterización holográfica total |
| TWI728963B (zh) | 2014-12-12 | 2021-06-01 | 美商Opko診斷法有限責任公司 | 包含培養通道之流體系統,包括成型而成的流體系統及與其相關聯之方法 |
| AU2016243656A1 (en) | 2015-03-30 | 2017-11-09 | Accelerate Diagnostics, Inc. | Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing |
| US10253355B2 (en) | 2015-03-30 | 2019-04-09 | Accelerate Diagnostics, Inc. | Instrument and system for rapid microorganism identification and antimicrobial agent susceptibility testing |
| EP3091347A1 (en) * | 2015-05-04 | 2016-11-09 | The European Union, represented by the European Commission | Screening of nanoparticle properties |
| USD804682S1 (en) | 2015-08-10 | 2017-12-05 | Opko Diagnostics, Llc | Multi-layered sample cassette |
| JP6929560B2 (ja) | 2015-09-18 | 2021-09-01 | ニュー・ヨーク・ユニヴァーシティー | 精密スラリ内の大きい不純物粒子のホログラフィック検出及び特徴付け |
| US9983115B2 (en) | 2015-09-21 | 2018-05-29 | Fluid Imaging Technologies, Inc. | System and method for monitoring particles in a fluid using ratiometric cytometry |
| US10228367B2 (en) | 2015-12-01 | 2019-03-12 | ProteinSimple | Segmented multi-use automated assay cartridge |
| US20170160187A1 (en) * | 2015-12-08 | 2017-06-08 | Tdk Corporation | Laser Scanner Particle Counter and Imager |
| EP3387447A4 (en) | 2015-12-11 | 2019-08-28 | Opko Diagnostics, LLC | FLUID SYSTEMS WITH INCUBATION SAMPLES AND / OR REAGENTS |
| CA3011901A1 (en) | 2016-01-21 | 2017-07-27 | T2 Biosystems, Inc. | Nmr methods and systems for the rapid detection of bacteria |
| ES2901608T3 (es) | 2016-02-08 | 2022-03-23 | Univ New York | Caracterización holográfica de agregados proteicos |
| RU2631237C2 (ru) * | 2016-02-26 | 2017-09-19 | Государственное Научное Учреждение "Институт Физики Имени Б.И. Степанова Национальной Академии Наук Беларуси" | Способ контроля структурного качества тонких плёнок для светопоглощающих слоёв солнечных элементов и устройство для его реализации |
| US10670677B2 (en) | 2016-04-22 | 2020-06-02 | New York University | Multi-slice acceleration for magnetic resonance fingerprinting |
| US11160542B2 (en) | 2016-06-09 | 2021-11-02 | Haimachek, Inc. | Collector for detection and reversible capturing of cells from body fluids in vivo |
| RU169521U1 (ru) * | 2016-06-28 | 2017-03-21 | Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт глазных болезней" | Устройство для оценки интенсивности светорассеивающей способности биологической ткани |
| EP3491560A1 (en) | 2016-07-27 | 2019-06-05 | Sequenom, Inc. | Genetic copy number alteration classifications |
| EP3574424A1 (en) | 2017-01-24 | 2019-12-04 | Sequenom, Inc. | Methods and processes for assessment of genetic variations |
| EP3998350B1 (en) | 2017-03-17 | 2025-05-07 | Sequenom, Inc. | Methods and processes for assessment of genetic mosaicism |
| CN112740017B (zh) | 2018-04-19 | 2024-12-13 | 曙光诊断学公司 | 靶标检测 |
| EP3820610A1 (en) | 2018-07-12 | 2021-05-19 | Luminex Corporation | Systems and methods for performing variable sample preparation and analysis processes |
| US11017520B2 (en) * | 2018-09-04 | 2021-05-25 | Kla Corporation | Multi-wavelength interferometry for defect classification |
| US12480944B2 (en) | 2018-10-04 | 2025-11-25 | First Light Diagnostics, Inc. | Detection and analysis of cells |
| CN109254022B (zh) * | 2018-10-24 | 2021-07-20 | 首钢智新迁安电磁材料有限公司 | 一种测量晶粒尺寸的方法 |
| CN109540855B (zh) * | 2018-11-07 | 2021-03-23 | 沈阳化工大学 | 一种荧光金壳磁性椭球的制备方法 |
| FI129722B (en) * | 2018-12-28 | 2022-07-29 | Kemira Oyj | Monitoring and regulation of hydrophobic components in a pulping process |
| CN113454460B (zh) * | 2019-01-30 | 2024-06-11 | 瑞泽恩制药公司 | 表征生物制剂中的可见和/或亚可见粒子的方法 |
| IL265914B (en) * | 2019-04-08 | 2020-11-30 | Convergent R N R Ltd | System and method for optimization of radiotherapy treatments |
| US11543338B2 (en) | 2019-10-25 | 2023-01-03 | New York University | Holographic characterization of irregular particles |
| US11948302B2 (en) | 2020-03-09 | 2024-04-02 | New York University | Automated holographic video microscopy assay |
| US11921050B2 (en) | 2020-03-23 | 2024-03-05 | Johnson & Johnson Consumer Inc. | Predictive method using colorimetric analysis of bodily fluids |
| EP3941168A1 (de) * | 2020-07-14 | 2022-01-19 | ZKW Group GmbH | Fahrzeugmodul mit einer manipulationserkennenden elektronischen steuereinheit |
| CN112014369B (zh) * | 2020-08-25 | 2024-02-09 | 上海市皮肤病医院 | 超灵敏数字层析快速检测分析物的系统及方法 |
| US12066368B2 (en) * | 2020-10-15 | 2024-08-20 | Robert R. Alfano | Compact optical virus detection analyzer of nano- and micro-size bio particles using light scattering and fluorescence |
| CN112229769B (zh) * | 2020-10-22 | 2023-03-14 | 山东长信化学科技股份有限公司 | 一种n-甲基吡咯烷酮颗粒度的检测系统及检测方法 |
| TW202227806A (zh) * | 2021-01-14 | 2022-07-16 | 瑞士商通用表面增強光譜學股份有限公司 | 用於判定顆粒尺寸之方法 |
| CN113340894B (zh) * | 2021-05-28 | 2023-04-07 | 上海睿钰生物科技有限公司 | 一种非透明微粒的检测方法 |
| US20240272060A1 (en) * | 2021-06-08 | 2024-08-15 | Regents Of The University Of Minnesota | Method and apparatus for particle detection |
| CN115482643B (zh) * | 2022-08-24 | 2024-02-02 | 清华大学 | 火灾烟雾探测器及其探测方法 |
| CN115452667B (zh) * | 2022-08-31 | 2024-10-01 | 中南大学 | 一种颗粒物同步追踪装置和基于其的颗粒物同步追踪方法 |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3975084A (en) | 1973-09-27 | 1976-08-17 | Block Engineering, Inc. | Particle detecting system |
| US3939350A (en) * | 1974-04-29 | 1976-02-17 | Board Of Trustees Of The Leland Stanford Junior University | Fluorescent immunoassay employing total reflection for activation |
| US4157498A (en) * | 1977-08-01 | 1979-06-05 | Miles Laboratories, Inc. | Flow-through type particle analyzing apparatus |
| NL7807532A (nl) | 1978-07-13 | 1980-01-15 | Akzo Nv | Metaal-immunotest. |
| US4420558A (en) * | 1981-02-12 | 1983-12-13 | Janssen Pharmaceutica N.V. | Bright field light microscopic method of enumerating and characterizing subtypes of white blood cells and their precursors |
| GB2095258B (en) * | 1981-03-19 | 1984-09-05 | Janssen Pharmaceutica Nv | A bright field light microscopic method of localizing tissue antigens |
| US4480042A (en) | 1981-10-28 | 1984-10-30 | E. I. Du Pont De Nemours And Company | Covalently bonded high refractive index particle reagents and their use in light scattering immunoassays |
| US4597944A (en) * | 1983-10-18 | 1986-07-01 | Cottingham Hugh V | Agglutination reagent detection system |
| US4752567A (en) * | 1984-06-21 | 1988-06-21 | Janssen Pharmaceutica N.V. | Method of visualizing individual submicroscopic metal particles |
| US4647544A (en) * | 1984-06-25 | 1987-03-03 | Nicoli David F | Immunoassay using optical interference detection |
| US4983834A (en) * | 1985-10-10 | 1991-01-08 | Quantex Corporation | Large area particle detector system |
| US5501949A (en) * | 1985-12-10 | 1996-03-26 | Murex Diagnostics Corporation | Particle bound binding component immunoassay |
| CA1291031C (en) | 1985-12-23 | 1991-10-22 | Nikolaas C.J. De Jaeger | Method for the detection of specific binding agents and their correspondingbindable substances |
| US4851329A (en) | 1986-06-06 | 1989-07-25 | Massachusetts Institute Of Technology | Immunoassay employing optical pulse particle size analysis |
| AU7385387A (en) * | 1986-06-09 | 1987-12-10 | Ortho Diagnostic Systems Inc. | Immunoassay using detection of colloidal gold |
| US5514602A (en) | 1986-06-09 | 1996-05-07 | Ortho Diagnostic Systems, Inc. | Method of producing a metal sol reagent containing colloidal metal particles |
| US5017009A (en) * | 1986-06-26 | 1991-05-21 | Ortho Diagnostic Systems, Inc. | Scattered total internal reflectance immunoassay system |
| GB8623072D0 (en) * | 1986-09-25 | 1986-10-29 | Amersham Int Plc | Particle analysis |
| US5015580A (en) * | 1987-07-29 | 1991-05-14 | Agracetus | Particle-mediated transformation of soybean plants and lines |
| US5202231A (en) * | 1987-04-01 | 1993-04-13 | Drmanac Radoje T | Method of sequencing of genomes by hybridization of oligonucleotide probes |
| US5110727A (en) * | 1987-04-03 | 1992-05-05 | Cardiovascular Diagnostics, Inc. | Method for performing coagulation assays accurately, rapidly and simply, using dry chemical reagents and paramagnetic particles |
| GB8803000D0 (en) | 1988-02-10 | 1988-03-09 | Ekins Roger Philip | Determination of ambient concentrations of several analytes |
| US4859612A (en) * | 1987-10-07 | 1989-08-22 | Hygeia Sciences, Inc. | Metal sol capture immunoassay procedure, kit for use therewith and captured metal containing composite |
| US4952517A (en) * | 1988-02-08 | 1990-08-28 | Hygeia Sciences, Inc. | Positive step immunoassay |
| US5079172A (en) * | 1988-11-04 | 1992-01-07 | Board Of Trustees Operating Michigan State University | Method for detecting the presence of antibodies using gold-labeled antibodies and test kit |
| US5100805A (en) * | 1989-01-26 | 1992-03-31 | Seradyn, Inc. | Quantitative immunoassay system and method for agglutination assays |
| US5338353A (en) * | 1989-04-07 | 1994-08-16 | Nippon Shokubai Kagaku Kogyo | Method for production of powder of fine inorganic particles |
| US5120135A (en) * | 1989-12-13 | 1992-06-09 | Syntex (U.S.A.) Inc. | Method and apparatus for keeping particles in suspension |
| JP2899360B2 (ja) | 1990-05-21 | 1999-06-02 | 興和株式会社 | 流体中の粒子計測方法及びその装置 |
| US5350697A (en) * | 1990-08-28 | 1994-09-27 | Akzo N.V. | Scattered light detection apparatus |
| US5294369A (en) | 1990-12-05 | 1994-03-15 | Akzo N.V. | Ligand gold bonding |
| JP3115641B2 (ja) | 1991-04-24 | 2000-12-11 | シスメックス株式会社 | 粒子計数方法 |
| US5286452A (en) | 1991-05-20 | 1994-02-15 | Sienna Biotech, Inc. | Simultaneous multiple assays |
| JP2523227Y2 (ja) | 1991-07-30 | 1997-01-22 | 株式会社堀場製作所 | 異物検査装置 |
| US5516670A (en) * | 1991-09-30 | 1996-05-14 | Kuehnle; Adelheid R. | Magnetophoretic particle delivery method and apparatus for the treatment of cells |
| US5151956A (en) | 1991-12-20 | 1992-09-29 | The United Staes Of America As Represented By The Secretary Of The Army | Waveguide polarizer using localized surface plasmons |
| US5248772A (en) * | 1992-01-29 | 1993-09-28 | Coulter Corporation | Formation of colloidal metal dispersions using aminodextrans as reductants and protective agents |
| RU2009505C1 (ru) * | 1992-02-04 | 1994-03-15 | Государственный научно-исследовательский институт биологического приборостроения | Способ люминесцентного иммуноанализа |
| US5305073A (en) | 1992-02-12 | 1994-04-19 | Precision Detectors, Inc. | Methods and apparatus for molecular characterization |
| US5451525A (en) * | 1992-02-14 | 1995-09-19 | Coulter Corporation | Method and materials for determining particle count in a flow cytometer |
| US5357320A (en) * | 1992-09-04 | 1994-10-18 | Canon Kabushiki Kaisha | Electrophotographic apparatus |
| DE69331570T2 (de) * | 1992-10-21 | 2002-10-02 | Dade Behring Inc., Deerfield | Agglutinationstest unter Anwendung eines multivalenten Liganden |
| JP3410777B2 (ja) * | 1993-09-13 | 2003-05-26 | 株式会社東芝 | 超微粒子無機蛍光体標識特異的結合物質およびこれを用いた検出方法 |
| DE4414166C1 (de) * | 1994-04-22 | 1995-12-07 | Lorenz Mesgeraetebau | Verfahren und Vorrichtung zur Messung der Lichtstreuung an Partikeln |
| US5734498A (en) * | 1994-05-09 | 1998-03-31 | The Regents Of The University Of California | Illuminator elements for conventional light microscopes |
| JPH0881678A (ja) * | 1994-09-14 | 1996-03-26 | Toshiba Corp | 無機蛍光体および特異的結合物質 |
| US5599668A (en) * | 1994-09-22 | 1997-02-04 | Abbott Laboratories | Light scattering optical waveguide method for detecting specific binding events |
| US5851777A (en) * | 1996-02-05 | 1998-12-22 | Dade Behring Inc. | Homogeneous sol-sol assay |
| AU748939B2 (en) * | 1997-02-20 | 2002-06-13 | Regents Of The University Of California, The | Plasmon resonant particles, methods and apparatus |
-
1997
- 1997-04-17 JP JP09538227A patent/JP2000510582A/ja not_active Withdrawn
- 1997-04-17 AU AU28056/97A patent/AU736340B2/en not_active Ceased
- 1997-04-17 CN CNB971958688A patent/CN1262667C/zh not_active Expired - Fee Related
- 1997-04-17 WO PCT/US1997/006584 patent/WO1997040181A1/en not_active Ceased
- 1997-04-17 BR BR9710836-7A patent/BR9710836A/pt active Search and Examination
- 1997-04-17 DE DE69737513T patent/DE69737513T2/de not_active Expired - Lifetime
- 1997-04-17 CA CA002253710A patent/CA2253710A1/en not_active Abandoned
- 1997-04-17 AT AT97922363T patent/ATE357663T1/de not_active IP Right Cessation
- 1997-04-17 IL IL12654497A patent/IL126544A/en not_active IP Right Cessation
- 1997-04-17 RU RU98121007/15A patent/RU2251572C2/ru not_active IP Right Cessation
- 1997-04-17 EP EP97922363A patent/EP1021554B1/en not_active Expired - Lifetime
- 1997-04-18 US US08/844,217 patent/US6214560B1/en not_active Expired - Lifetime
-
2007
- 2007-06-05 JP JP2007149827A patent/JP2007263974A/ja active Pending
-
2009
- 2009-06-10 JP JP2009138755A patent/JP2009236921A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2805697A (en) | 1997-11-12 |
| RU2251572C2 (ru) | 2005-05-10 |
| EP1021554A1 (en) | 2000-07-26 |
| EP1021554A4 (en) | 2004-06-30 |
| ATE357663T1 (de) | 2007-04-15 |
| DE69737513T2 (de) | 2007-12-13 |
| DE69737513D1 (de) | 2007-05-03 |
| AU736340B2 (en) | 2001-07-26 |
| IL126544A (en) | 2004-08-31 |
| JP2009236921A (ja) | 2009-10-15 |
| BR9710836A (pt) | 2000-10-24 |
| JP2000510582A (ja) | 2000-08-15 |
| CN1223692A (zh) | 1999-07-21 |
| WO1997040181A1 (en) | 1997-10-30 |
| CA2253710A1 (en) | 1997-10-30 |
| IL126544A0 (en) | 1999-08-17 |
| US6214560B1 (en) | 2001-04-10 |
| EP1021554B1 (en) | 2007-03-21 |
| JP2007263974A (ja) | 2007-10-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1262667C (zh) | 利用颗粒标记物检测分析物 | |
| CN1282378A (zh) | 利用颗粒标记物检测分析物 | |
| AU2002245537B2 (en) | Methods for providing extended dynamic range in analyte assays | |
| WO1997040181A9 (en) | Analyte assay using particulate labels | |
| AU2002245537A1 (en) | Methods for providing extended dynamic range in analyte assays | |
| CN1879018A (zh) | 利用比色共振反射光学生物传感器进行测定的无标记方法 | |
| CN1636138A (zh) | 包括相关方法的磁性光学生物盘和系统 | |
| HK1020987A (en) | Analyte assay using particulate labels | |
| AU783941B2 (en) | Analyte assay using particulate labels | |
| HK1034291B (en) | Analyte assay using particulate labels | |
| AU2007200887A1 (en) | Analyte Assay Using Particulate Labels | |
| Mongra et al. | Study & analysis of optical-Based Biosensors |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C53 | Correction of patent of invention or patent application | ||
| CB02 | Change of applicant information |
Applicant after: Genecom Inc. Applicant before: Spectrametrix Inc. |
|
| COR | Change of bibliographic data |
Free format text: CORRECT: APPLICANT; FROM: SPECTRAMETRIX INC. TO: RUNNICOM SCIENTIFIC CO., LTD. |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: WD Ref document number: 1020987 Country of ref document: HK |
|
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20060705 Termination date: 20140417 |