JP2000508171A - 希少細胞の富化方法 - Google Patents

希少細胞の富化方法

Info

Publication number
JP2000508171A
JP2000508171A JP9536336A JP53633697A JP2000508171A JP 2000508171 A JP2000508171 A JP 2000508171A JP 9536336 A JP9536336 A JP 9536336A JP 53633697 A JP53633697 A JP 53633697A JP 2000508171 A JP2000508171 A JP 2000508171A
Authority
JP
Japan
Prior art keywords
cells
rare
fluid
blood
blood cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP9536336A
Other languages
English (en)
Japanese (ja)
Inventor
ツオ，ポール・オー・ピー
ワン，ツェン―ピン
レスコ，スティーブン・エイ
ネルソン，ウィリアム・ジー
パーティン，アラン・ダブリュー
Original Assignee
ザ・ジョンズ・ホプキンス・ユニバーシティ・スクール・オブ・メディシン
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ザ・ジョンズ・ホプキンス・ユニバーシティ・スクール・オブ・メディシン filed Critical ザ・ジョンズ・ホプキンス・ユニバーシティ・スクール・オブ・メディシン
Publication of JP2000508171A publication Critical patent/JP2000508171A/ja
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57434—Specifically defined cancers of prostate
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57438—Specifically defined cancers of liver, pancreas or kidney
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
JP9536336A 1996-04-05 1997-04-02 希少細胞の富化方法 Ceased JP2000508171A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1492996P 1996-04-05 1996-04-05
US60/014,929 1996-04-05
PCT/US1997/005586 WO1997038313A1 (en) 1996-04-05 1997-04-02 A method of enriching rare cells

Publications (1)

Publication Number Publication Date
JP2000508171A true JP2000508171A (ja) 2000-07-04

Family

ID=21768614

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9536336A Ceased JP2000508171A (ja) 1996-04-05 1997-04-02 希少細胞の富化方法

Country Status (8)

Country Link
US (2) US5962237A (zh)
EP (1) EP0891550A1 (zh)
JP (1) JP2000508171A (zh)
CN (1) CN1153064C (zh)
AU (1) AU2438497A (zh)
CA (1) CA2251186A1 (zh)
TW (1) TW589380B (zh)
WO (1) WO1997038313A1 (zh)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004514548A (ja) * 2000-11-22 2004-05-20 アメルシャム・バイオサイエンシーズ・アクチボラグ 下層コロイド媒体からのフローティングにより生物サンプルを回収または除去する多段階法
JP2011527003A (ja) * 2008-06-24 2011-10-20 サイトシステムズ リミテッド アッセイ
JP2012175976A (ja) * 2005-09-20 2012-09-13 Veridex Llc ユニーク配列のｄｎａプローブを作製するための方法および組成物、ｄｎａプローブの標識、ならびにこれらプローブの使用
JP2012522217A (ja) * 2009-03-24 2012-09-20 バイオセプト インコーポレイティッド 細胞の捕捉および解析のデバイスおよび方法
JP2014527615A (ja) * 2011-06-19 2014-10-16 アボゲン，インコーポレイティド サンプル収集のためのデバイス、溶液及び方法
US9134237B2 (en) 2005-09-20 2015-09-15 Janssen Diagnotics, LLC High sensitivity multiparameter method for rare event analysis in a biological sample
JP2016513462A (ja) * 2013-03-14 2016-05-16 アボツト・モレキユラー・インコーポレイテツド 細胞作製物及び細胞支持体、及びテラノーシスにおけるその使用
US9671407B2 (en) 2009-03-24 2017-06-06 Biocept, Inc. Devices and methods of cell capture and analysis
JP6173577B1 (ja) * 2016-03-03 2017-08-02 康生 梅津 細胞増殖法を用いた循環腫瘍細胞の検出・分離取得方法
KR101844188B1 (ko) * 2017-04-06 2018-03-30 재단법인대구경북과학기술원 미세 유동 장치
JP2020074694A (ja) * 2018-11-06 2020-05-21 東ソー株式会社 血液試料からの目的細胞濃縮方法
US11572581B2 (en) 2002-06-07 2023-02-07 DNA Genotek, Inc. Compositions and methods for obtaining nucleic acids from sputum

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6718053B1 (en) 1996-11-27 2004-04-06 Chromavision Medical Systems, Inc. Method and apparatus for automated image analysis of biological specimens
US6215892B1 (en) 1995-11-30 2001-04-10 Chromavision Medical Systems, Inc. Method and apparatus for automated image analysis of biological specimens
WO1997038313A1 (en) * 1996-04-05 1997-10-16 The Johns Hopkins University A method of enriching rare cells
DE19736691A1 (de) * 1997-08-22 1999-02-25 Michael Prof Dr Med Giesing Verfahren zur Charakterisierung und Identifizierung disseminierter und metastasierter Krebszellen
AU772603B2 (en) * 1998-10-29 2004-05-06 Cell Works Diagnostics, Inc. Multiple marker characterization of single cells
CA2360073C (en) * 1999-01-28 2011-01-18 Gen-Probe Incorporated Probes and primers for detecting prostate specific antigen (psa) in a biological sample
DE19904267A1 (de) * 1999-02-03 2000-08-10 Michael W Dahm Verfahren zur Anreicherung von Tumorzellen aus einer Körperflüssigkeit und dazu geeigneter Kit
AU2876900A (en) * 1999-02-10 2000-08-29 Cell Works Inc. Class characterization of circulating cancer cells isolated from body fluids andmethods of use
AU4056500A (en) * 1999-04-01 2000-10-23 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Methods for detecting cancer cells
US6897062B1 (en) * 1999-04-09 2005-05-24 Sloan-Kettering Institute For Cancer Research DNA encoding the prostate-specific membrane antigen-like gene and uses thereof
US20040058401A1 (en) * 1999-04-13 2004-03-25 Blaise Bossy Method for detecting rare event
FR2792332B1 (fr) * 1999-04-14 2001-07-27 Labonord Procede de preparation d'une suspension cytologique
EP1268854A4 (en) * 2000-03-27 2003-05-02 Univ Jefferson HIGH SPECIFICITY MARKER DETECTION
US6379550B1 (en) * 2000-07-24 2002-04-30 Health Research, Inc. Method for detecting PSA and its molecular forms using thiophilic gel
US7108969B1 (en) * 2000-09-08 2006-09-19 Affymetrix, Inc. Methods for detecting and diagnosing oral cancer
WO2003001884A2 (en) * 2001-06-26 2003-01-09 Trustees Of Tufts College Targeting tumor cell antigens: antibodies useful for the diagnosis, prognosis, and treatment of cancer
ES2253533T3 (es) 2001-09-06 2006-06-01 Adnagen Ag Procedimiento para la deteccion cualitativa y/o cuantitativa de celulas.
US7316932B2 (en) * 2001-10-01 2008-01-08 Stemcell Technologies Inc. Method for separating cells
US7452712B2 (en) 2002-07-30 2008-11-18 Applied Biosystems Inc. Sample block apparatus and method of maintaining a microcard on a sample block
WO2004029221A2 (en) 2002-09-27 2004-04-08 The General Hospital Corporation Microfluidic device for cell separation and uses thereof
FR2846426B1 (fr) * 2002-10-28 2004-12-10 Bio Merieux Procede de dosage du ngf pour le diagnostic in vitro du cancer du sein et utilisation en therapie
CA2557819A1 (en) * 2004-03-03 2005-09-15 The General Hospital Corporation Magnetic device for isolation of cells and biomolecules in a microfluidic environment
US20060246575A1 (en) * 2005-01-13 2006-11-02 Micronics, Inc. Microfluidic rare cell detection device
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
DE602006018595D1 (de) * 2005-04-08 2011-01-13 Medical Discovery Partners Llc Verfahren zum anreichern von subpopulationen seltener zellen aus dem blut
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
PT2027470E (pt) * 2006-06-02 2013-01-28 Pfizer Prod Inc Ensaio de células tumorais circulantes
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
WO2007147074A2 (en) 2006-06-14 2007-12-21 Living Microsystems, Inc. Use of highly parallel snp genotyping for fetal diagnosis
US8372584B2 (en) 2006-06-14 2013-02-12 The General Hospital Corporation Rare cell analysis using sample splitting and DNA tags
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
US8110393B2 (en) * 2007-03-23 2012-02-07 Beckman Coulter, Inc. Method and apparatus for separating and harvesting cells from a whole blood sample
EP3388086B1 (en) 2007-08-17 2020-10-07 Purdue Research Foundation Psma binding ligand-linker conjugates and methods for using
CA2703794C (en) * 2007-12-10 2017-03-21 The Medical Research, Infrastructure, And Health Services Fund Of The Tel Aviv Medical Center Methods of diagnosing cancer
CN102313813B (zh) * 2008-05-20 2014-01-15 北京莱尔生物医药科技有限公司 从生物体液样本中富集与检测稀有细胞的整合方法
CN101587043B (zh) * 2008-05-20 2013-10-02 北京莱尔生物医药科技有限公司 从生物体液样本中富集与检测稀有细胞的整合方法
CA3069081C (en) 2008-09-20 2023-05-23 The Board Of Trustees Of The Leland Stanford Junior University Noninvasive diagnosis of fetal aneuploidy by sequencing
US9951324B2 (en) 2010-02-25 2018-04-24 Purdue Research Foundation PSMA binding ligand-linker conjugates and methods for using
WO2012024690A1 (en) 2010-08-20 2012-02-23 President And Fellows Of Harvard College Multiphase systems having multiple phase properties
CN103091491B (zh) * 2011-11-01 2015-01-07 李彦萍 鉴别从人或动物生物体液中富集的非血源性有核细胞的方法
US20150056649A1 (en) * 2012-01-13 2015-02-26 Konica Minolta, Inc. Method for quantifying cell of interest in blood, and method for evaluating system for quantifying said cell
ITRM20120028A1 (it) * 2012-01-25 2013-07-26 Natalia Malara Metodo per isolare cellule tumorali circolanti.
BR112014028396A2 (pt) * 2012-05-15 2018-05-29 Diatech Oncology processo de isolamento/purificação de célula de tumor e métodos para uso da mesma
WO2014078484A1 (en) 2012-11-15 2014-05-22 Endocyte, Inc. Conjugates for treating diseases caused by psma expressing cells
US9513291B2 (en) 2012-11-30 2016-12-06 Rarecyte, Inc. Apparatus, system, and method for collecting a target material
US9217697B2 (en) 2012-11-30 2015-12-22 Rarecyte, Inc. Apparatus, system, and method for collecting a target material
CN105264127B (zh) 2013-03-15 2019-04-09 Gpb科学有限责任公司 颗粒的片上微流体处理
US20150064153A1 (en) 2013-03-15 2015-03-05 The Trustees Of Princeton University High efficiency microfluidic purification of stem cells to improve transplants
US10324011B2 (en) 2013-03-15 2019-06-18 The Trustees Of Princeton University Methods and devices for high throughput purification
MY194484A (en) 2013-10-18 2022-11-30 Deutsches Krebsforsch Labeled Inhibitors of Prostate Specific Membrane Antigen (PSMA), Their use as Imaging Agents and Pharmaceutical Agents for the Treatment of Prostate Cancer
WO2015070079A1 (en) * 2013-11-07 2015-05-14 The Board Of Trustees Of The Leland Stanford Junior University Methods for enumeration of rare cells
US10188759B2 (en) 2015-01-07 2019-01-29 Endocyte, Inc. Conjugates for imaging
US10976232B2 (en) 2015-08-24 2021-04-13 Gpb Scientific, Inc. Methods and devices for multi-step cell purification and concentration
IT201700024609A1 (it) * 2017-03-06 2018-09-06 Mollace Vincenzo Metodo e kit per la diagnosi e/o prognosi di tumori non ematologici
JP7393328B2 (ja) 2017-09-01 2023-12-06 ジーピービー・サイエンティフィック・インコーポレイテッド マイクロ流体を使用した治療的に活性な細胞を調製する方法

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4255256A (en) * 1978-12-13 1981-03-10 Antonio Ferrante Medium for the separation of human blood leucocytes
US4751001A (en) * 1984-09-24 1988-06-14 Becton Dickinson And Company Blood partitioning apparatus
US4888278A (en) * 1985-10-22 1989-12-19 University Of Massachusetts Medical Center In-situ hybridization to detect nucleic acid sequences in morphologically intact cells
US4927750A (en) * 1986-04-09 1990-05-22 Jeanette Simpson Cell separation process
JPH05501612A (ja) * 1989-11-13 1993-03-25 チルドレンズ・メデイカル・センター・コーポレーシヨン 胎児ｄｎａ単離および検出のための非侵入性方法
US5153117A (en) * 1990-03-27 1992-10-06 Genetype A.G. Fetal cell recovery method
US5541072A (en) * 1994-04-18 1996-07-30 Immunivest Corporation Method for magnetic separation featuring magnetic particles in a multi-phase system
US5646001A (en) * 1991-03-25 1997-07-08 Immunivest Corporation Affinity-binding separation and release of one or more selected subset of biological entities from a mixed population thereof
US5273883A (en) * 1991-05-07 1993-12-28 Hoffmann-La Roche Inc. Methods and reagents for γ-globin typing
US5629147A (en) * 1992-07-17 1997-05-13 Aprogenex, Inc. Enriching and identifying fetal cells in maternal blood for in situ hybridization
CA2140278C (en) * 1992-07-17 2009-03-17 Morteza Asgari Enriching and identyfing fetal cells in maternal blood for in situ hybridization
DE4244715C2 (de) * 1992-08-26 1995-06-14 Kuebler Gmbh Dr Verfahren zur Herstellung individuum-spezifischer, gegen Tumorantigene gerichtete monoklonale Antikörper
US5275933A (en) * 1992-09-25 1994-01-04 The Board Of Trustees Of The Leland Stanford Junior University Triple gradient process for recovering nucleated fetal cells from maternal blood
WO1994009363A1 (en) * 1992-10-14 1994-04-28 Board Of Regents, The University Of Texas System Cancer diagnosis and therapy
EP1757694A3 (en) * 1992-11-05 2008-02-27 Sloan Kettering Institute For Cancer Research Prostate-specific membrane antigen
AU6949794A (en) * 1993-05-14 1994-12-12 Aprogenex, Inc. Target cell isolation method
WO1995003431A1 (en) * 1993-07-19 1995-02-02 Aprogenex, Inc. Enriching and identifying fetal cells in maternal blood for in situ hybridization
US5714325A (en) * 1993-09-24 1998-02-03 New England Medical Center Hospitals Prenatal diagnosis by isolation of fetal granulocytes from maternal blood
US5432054A (en) * 1994-01-31 1995-07-11 Applied Imaging Method for separating rare cells from a population of cells
US5648223A (en) * 1994-08-31 1997-07-15 Activated Cell Therapy, Inc. Methods for enriching breast tumor cells
WO1997038313A1 (en) * 1996-04-05 1997-10-16 The Johns Hopkins University A method of enriching rare cells

Cited By (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4684533B2 (ja) * 2000-11-22 2011-05-18 ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ 下層コロイド媒体からのフローティングにより生物サンプルを回収または除去する多段階法
JP2004514548A (ja) * 2000-11-22 2004-05-20 アメルシャム・バイオサイエンシーズ・アクチボラグ 下層コロイド媒体からのフローティングにより生物サンプルを回収または除去する多段階法
US11572581B2 (en) 2002-06-07 2023-02-07 DNA Genotek, Inc. Compositions and methods for obtaining nucleic acids from sputum
US9127302B2 (en) 2005-09-20 2015-09-08 Janssen Diagnostics, Llc System for the detection and enumeration of suspect target cells in a mixed cell population
US11015227B2 (en) 2005-09-20 2021-05-25 Menarini Silicon Biosystems S.P.A. Methods and compositions to generate unique sequence DNA probes, labeling of DNA probes and the use of these probes
US9957571B2 (en) 2005-09-20 2018-05-01 Menarini Silicon Biosystems, Inc. Methods and composition to generate unique sequence DNA probes, labeling of DNA probes and the use of these probes
US9134237B2 (en) 2005-09-20 2015-09-15 Janssen Diagnotics, LLC High sensitivity multiparameter method for rare event analysis in a biological sample
JP2012175976A (ja) * 2005-09-20 2012-09-13 Veridex Llc ユニーク配列のｄｎａプローブを作製するための方法および組成物、ｄｎａプローブの標識、ならびにこれらプローブの使用
JP2011527003A (ja) * 2008-06-24 2011-10-20 サイトシステムズ リミテッド アッセイ
JP2012522217A (ja) * 2009-03-24 2012-09-20 バイオセプト インコーポレイティッド 細胞の捕捉および解析のデバイスおよび方法
US9671407B2 (en) 2009-03-24 2017-06-06 Biocept, Inc. Devices and methods of cell capture and analysis
US10527611B2 (en) 2009-03-24 2020-01-07 Biocept, Inc. Devices and methods of cell capture and analysis
US11719692B2 (en) 2009-03-24 2023-08-08 Biocept, Inc. Devices and methods of cell capture and analysis
US11592368B2 (en) 2011-06-19 2023-02-28 DNA Genotek, Inc. Method for collecting and preserving a biological sample
US11549870B2 (en) 2011-06-19 2023-01-10 DNA Genotek, Inc. Cell preserving solution
US11002646B2 (en) 2011-06-19 2021-05-11 DNA Genotek, Inc. Devices, solutions and methods for sample collection
JP2014527615A (ja) * 2011-06-19 2014-10-16 アボゲン，インコーポレイティド サンプル収集のためのデバイス、溶液及び方法
US11536632B2 (en) 2011-06-19 2022-12-27 DNA Genotek, Inc. Biological collection system
JP2019013228A (ja) * 2013-03-14 2019-01-31 アボツト・モレキユラー・インコーポレイテツド 細胞作製物及び細胞支持体、及びテラノーシスにおけるその使用
JP2016513462A (ja) * 2013-03-14 2016-05-16 アボツト・モレキユラー・インコーポレイテツド 細胞作製物及び細胞支持体、及びテラノーシスにおけるその使用
WO2017149564A1 (ja) * 2016-03-03 2017-09-08 康生 梅津 細胞増殖法を用いた循環腫瘍細胞の検出・分離取得方法
JP6173577B1 (ja) * 2016-03-03 2017-08-02 康生 梅津 細胞増殖法を用いた循環腫瘍細胞の検出・分離取得方法
KR101844188B1 (ko) * 2017-04-06 2018-03-30 재단법인대구경북과학기술원 미세 유동 장치
WO2018186676A1 (ko) * 2017-04-06 2018-10-11 재단법인대구경북과학기술원 미세 유동 장치 및 표적 세포 분리 방법
KR101904883B1 (ko) * 2017-04-06 2018-10-10 재단법인대구경북과학기술원 표적 세포 분리 방법
JP2020074694A (ja) * 2018-11-06 2020-05-21 東ソー株式会社 血液試料からの目的細胞濃縮方法

Also Published As

Publication number Publication date
TW589380B (en) 2004-06-01
CN1153064C (zh) 2004-06-09
US20030119077A1 (en) 2003-06-26
US5962237A (en) 1999-10-05
WO1997038313A1 (en) 1997-10-16
EP0891550A1 (en) 1999-01-20
CN1221492A (zh) 1999-06-30
CA2251186A1 (en) 1997-10-16
AU2438497A (en) 1997-10-29

Similar Documents

Publication Publication Date Title
JP2000508171A (ja) 希少細胞の富化方法
US20110195413A1 (en) Integrated Method for Enriching and Detecting Rare Cells from Biological Body Fluid Sample
US6682940B2 (en) Products and methods for single parameter and multiparameter phenotyping of cells
CN103946373B (zh) 细胞分离方法
US8263404B2 (en) Method for enriching rare cell subpopulations from blood
US6190870B1 (en) Efficient enrichment and detection of disseminated tumor cells
US5648222A (en) Method for preserving cells, and uses of said method
Krag et al. Breast cancer cells in the blood: a pilot study
US6630314B2 (en) Noninvasive detection of colorectal cancer and other gastrointestinal pathology
US20090081689A1 (en) Reagents and methods to enrich rare cells from body fluids
WO2013063981A1 (zh) 鉴别从人或动物生物体液中富集的非血源性有核细胞的方法
JP2004534210A (ja) 希少細胞検出アッセイにおける内部機能対照として用いる標識細胞
JPH09510779A (ja) 特定化あるいは混合した細胞母集団または混合細胞母集団を含む溶液内の特定標的細胞を検出する方法および装置
JP2002533723A (ja) 結合相手を検出するための検定法
JPH08501390A (ja) 特殊細胞集団もしくは混合細胞集団および混合細胞集団を含有する溶液中の特異標的細胞の検出方法
JPH06503171A (ja) 顕微鏡的細胞の光学的スクリーニング方法及び装置
CN106771185A (zh) 一种鼻咽癌循环肿瘤细胞检测试剂盒
AU776155B2 (en) Noninvasive detection of colorectal cancer and other gastro intestinal pathology
CN111351937A (zh) 一种mmr蛋白表达缺失检测试剂盒及其检测方法
Fodstad et al. Immunobead-based detection and characterization of circulating tumor cells in melanoma patients
CN109439624A (zh) 一种用于识别或富集有核红细胞的方法
JP4590109B2 (ja) 細胞の単一パラメータ及び複数パラメーター表現型解析のための生成物と方法
WO2021010369A1 (ja) ウイルスを用いた循環腫瘍細胞の検出方法
Belov et al. Surface profiling of extracellular vesicles from plasma or ascites fluid using DotScan antibody microarrays
KR20180114209A (ko) 세포 증식법을 이용한 순환종양세포의 검출·분리취득방법

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20040205

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20070123

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20070328

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20070521

A313 Final decision of rejection without a dissenting response from the applicant

Free format text: JAPANESE INTERMEDIATE CODE: A313

Effective date: 20070905

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20071030