JP2000506163A - 結合組織分解に関連する疾病の治療に有用な新規のヒドロキサム酸誘導体 - Google Patents
結合組織分解に関連する疾病の治療に有用な新規のヒドロキサム酸誘導体Info
- Publication number
- JP2000506163A JP2000506163A JP9531784A JP53178497A JP2000506163A JP 2000506163 A JP2000506163 A JP 2000506163A JP 9531784 A JP9531784 A JP 9531784A JP 53178497 A JP53178497 A JP 53178497A JP 2000506163 A JP2000506163 A JP 2000506163A
- Authority
- JP
- Japan
- Prior art keywords
- oxo
- hydroxy
- methylpropyl
- phenylethyl
- ethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- 150000001875 compounds Chemical class 0.000 claims abstract description 218
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- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 134
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- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 claims description 4
- IIIPROLBJFMFCX-UHFFFAOYSA-N 2-[1-(2-amino-2-oxoethyl)-2-phenylpyrrolidin-3-yl]acetamide Chemical compound C1(=CC=CC=C1)C1N(CCC1CC(=O)N)CC(=O)N IIIPROLBJFMFCX-UHFFFAOYSA-N 0.000 claims description 3
- OZEAJWYJXIQKCS-UHFFFAOYSA-N 2-[1-(2-amino-2-oxoethyl)-3-(2-methylpropyl)-2-oxopyrrolidin-3-yl]acetamide Chemical compound CC(C)CC1(CC(N)=O)CCN(CC(N)=O)C1=O OZEAJWYJXIQKCS-UHFFFAOYSA-N 0.000 claims description 3
- XOHFBWTYTXKTID-UHFFFAOYSA-N 3-fluoro-n-[3-[1-[2-(4-fluorophenyl)ethyl]-3-(2-methylpropyl)-2-oxopyrrolidin-3-yl]-4-(hydroxyamino)-4-oxobutyl]benzamide Chemical compound O=C1C(CC(C)C)(C(CCNC(=O)C=2C=C(F)C=CC=2)C(=O)NO)CCN1CCC1=CC=C(F)C=C1 XOHFBWTYTXKTID-UHFFFAOYSA-N 0.000 claims description 3
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- OQYDTCYMYOOVPD-UHFFFAOYSA-N tert-butyl 2-[3-(2-methylpropyl)-2-oxo-1-(2-phenylethyl)pyrrolidin-3-yl]acetate Chemical compound O=C1C(CC(C)C)(CC(=O)OC(C)(C)C)CCN1CCC1=CC=CC=C1 OQYDTCYMYOOVPD-UHFFFAOYSA-N 0.000 description 1
- GJJYYMXBCYYXPQ-UHFFFAOYSA-N tert-butyl 2-oxopyrrolidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCCC1=O GJJYYMXBCYYXPQ-UHFFFAOYSA-N 0.000 description 1
- GHUNUSAWVVKGNZ-UHFFFAOYSA-N tert-butyl 4-(5,6-difluoro-3-oxo-1h-isoindol-2-yl)-2-[3-(2-methylpropyl)-2-oxo-1-(2-phenylethyl)pyrrolidin-3-yl]butanoate Chemical compound O=C1C(CC(C)C)(C(CCN2C(C3=CC(F)=C(F)C=C3C2)=O)C(=O)OC(C)(C)C)CCN1CCC1=CC=CC=C1 GHUNUSAWVVKGNZ-UHFFFAOYSA-N 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
- 125000005505 thiomorpholino group Chemical group 0.000 description 1
- 229930192474 thiophene Natural products 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 229910000406 trisodium phosphate Inorganic materials 0.000 description 1
- 235000019801 trisodium phosphate Nutrition 0.000 description 1
- 238000001665 trituration Methods 0.000 description 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/06—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D231/08—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with oxygen or sulfur atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1309896P | 1996-03-08 | 1996-03-08 | |
| US60/013,098 | 1996-03-08 | ||
| PCT/US1997/002568 WO1997032846A1 (en) | 1996-03-08 | 1997-03-03 | Hydroxamic acid derivatives for use with the treatment of diseases related to connective tissue degradation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2000506163A true JP2000506163A (ja) | 2000-05-23 |
| JP2000506163A5 JP2000506163A5 (enExample) | 2004-11-25 |
Family
ID=21758301
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9531784A Withdrawn JP2000506163A (ja) | 1996-03-08 | 1997-03-03 | 結合組織分解に関連する疾病の治療に有用な新規のヒドロキサム酸誘導体 |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US5712300A (enExample) |
| EP (1) | EP0898562B1 (enExample) |
| JP (1) | JP2000506163A (enExample) |
| KR (1) | KR19990087597A (enExample) |
| CN (1) | CN1210517A (enExample) |
| AT (1) | ATE231490T1 (enExample) |
| AU (1) | AU707180B2 (enExample) |
| BR (1) | BR9707947A (enExample) |
| DE (1) | DE69718634T2 (enExample) |
| DK (1) | DK0898562T3 (enExample) |
| ES (1) | ES2191823T3 (enExample) |
| ID (1) | ID16144A (enExample) |
| MY (1) | MY117762A (enExample) |
| NO (1) | NO312956B1 (enExample) |
| NZ (1) | NZ330922A (enExample) |
| PE (1) | PE55698A1 (enExample) |
| PL (1) | PL328693A1 (enExample) |
| PT (1) | PT898562E (enExample) |
| RU (1) | RU2168497C2 (enExample) |
| TW (1) | TW448172B (enExample) |
| UA (1) | UA61906C2 (enExample) |
| WO (1) | WO1997032846A1 (enExample) |
| ZA (1) | ZA971902B (enExample) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008523123A (ja) * | 2004-12-15 | 2008-07-03 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | メタロプロテアーゼの阻害剤として使用される新規な環状尿素類 |
| US8618158B2 (en) | 2008-06-25 | 2013-12-31 | Cancer Research Technology Limited | Therapeutic agents |
| JP2014224152A (ja) * | 2009-06-30 | 2014-12-04 | ガルデルマ・リサーチ・アンド・デヴェロップメント | 新規なベンゼンスルホンアミド化合物、その合成方法、ならびに医薬および化粧品におけるその使用 |
| US10526311B2 (en) | 2015-09-29 | 2020-01-07 | Astex Therapeutics Limited | Isoindolinone inhibitors of the MDM2-P53 interaction having anticancer activity |
| US10544132B2 (en) | 2015-09-29 | 2020-01-28 | Astex Therapeutics Limited | Isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity |
| US11236047B2 (en) | 2017-03-28 | 2022-02-01 | Astex Therapeutics Limited | Combination of isoindolinone derivatives with SGI-110 |
| US11603367B2 (en) | 2017-03-28 | 2023-03-14 | Astex Therapeutics Limited | Isoindolinone inhibitors of the MDM2-P53 interaction and process for making them |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5932579A (en) * | 1996-06-18 | 1999-08-03 | Affymax Technologies N.V. | Collagenase-1 and stromelysin-1 inhibitors, pharmaceutical compositions comprising same and methods of their use |
| WO1997048688A1 (en) * | 1996-06-21 | 1997-12-24 | Pharmacia & Upjohn Company | Thiadiazole amide mmp inhibitors |
| ATE289590T1 (de) * | 1996-09-27 | 2005-03-15 | Upjohn Co | Beta-sulfonyl-hydroxamsäuren als matrix- metalloproteinaseinhibitoren |
| GB9702088D0 (en) | 1997-01-31 | 1997-03-19 | Pharmacia & Upjohn Spa | Matrix metalloproteinase inhibitors |
| US6362183B1 (en) | 1997-03-04 | 2002-03-26 | G. D. Searle & Company | Aromatic sulfonyl alpha-hydroxy hydroxamic acid compounds |
| US6566373B2 (en) | 1997-05-06 | 2003-05-20 | Smithkline Beecham Corporation | Protease inhibitors |
| AR013079A1 (es) * | 1997-05-06 | 2000-12-13 | Smithkline Beecham Corp | Derivados sustituidos de tetrahidrofurano-3-onas, de tetrahidropirano-3- onas y tetrahidrotiofen-3-onas, un procedimiento para su preparacion unacomposicion farmaceutica de un medicamento util como inhibidores de proteasas e intermediarios |
| US5883131A (en) * | 1997-07-09 | 1999-03-16 | Pfizer Inc. | Cyclic sulfone derivatives |
| WO1999006340A2 (en) | 1997-07-31 | 1999-02-11 | The Procter & Gamble Company | Sulfonylamino substituted hydroxamic acid derivatives as metalloprotease inhibitors |
| DE19741235A1 (de) * | 1997-09-18 | 1999-03-25 | Hoechst Marion Roussel De Gmbh | Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
| ZA988967B (en) * | 1997-10-03 | 2000-04-03 | Du Pont Pharm Co | Lactam metalloprotease inhibitors. |
| US6403632B1 (en) | 2000-03-01 | 2002-06-11 | Bristol Myers Squibb Pharma Co | Lactam metalloprotease inhibitors |
| EP1024134A4 (en) * | 1997-10-09 | 2003-05-14 | Ono Pharmaceutical Co | DERIVATIVES OF AMINOBUTANIC ACID |
| DE69915004T2 (de) * | 1998-11-05 | 2004-09-09 | Pfizer Products Inc., Groton | 5-Oxo-pyrrolidine-2-Carbonsäure-Hydroxamidderivate |
| GB9825988D0 (en) * | 1998-11-27 | 1999-01-20 | Pfizer Ltd | Indole derivatives |
| US20040122011A1 (en) * | 1998-12-23 | 2004-06-24 | Pharmacia Corporation | Method of using a COX-2 inhibitor and a TACE inhibitors as a combination therapy |
| SK12452001A3 (sk) | 1999-03-03 | 2002-04-04 | The Procter & Gamble Company | Zlúčenina vytvárajúca inhibítor metaloproteinázy, farmaceutický prostriedok, spôsob prípravy liečiva a liečivo |
| WO2000051993A2 (en) | 1999-03-03 | 2000-09-08 | The Procter & Gamble Company | Dihetero-substituted metalloprotease inhibitors |
| EP1165546A2 (en) * | 1999-04-02 | 2002-01-02 | Du Pont Pharmaceuticals Company | Novel lactam inhibitors of matrix metalloproteinases, tnf-alpha, and aggrecanase |
| US6797820B2 (en) | 1999-12-17 | 2004-09-28 | Vicuron Pharmaceuticals Inc. | Succinate compounds, compositions and methods of use and preparation |
| AU2002230385A1 (en) * | 2000-09-25 | 2002-04-15 | Questcor Pharmaceuticals, Inc. | Peptide deformylase inhibitors |
| EP1355901A2 (en) | 2001-01-11 | 2003-10-29 | Bristol-Myers Squibb Pharma Company | 1,1-DISUBSTITUTED CYCLIC INHIBITORS OF MATRIX METALLOPROTEASE AND TNF-$g(a) |
| CA2434044A1 (en) | 2001-01-11 | 2002-07-18 | Bristol-Myers Squibb Pharma Company | 1,2-disubstituted cyclic inhibitors of matrix metallorproteases and tnf-alpha |
| DE60207384T2 (de) * | 2001-03-01 | 2006-08-03 | Smithkline Beecham Corp. | Peptid-deformylase-hemmer |
| JP4314340B2 (ja) * | 2001-06-15 | 2009-08-12 | ヴィキュロン ファーマシューティカルズ インコーポレイテッド | ピロリジン二環性化合物 |
| AR036053A1 (es) | 2001-06-15 | 2004-08-04 | Versicor Inc | Compuestos de n-formil-hidroxilamina, un proceso para su preparacion y composiciones farmaceuticas |
| PE20030701A1 (es) | 2001-12-20 | 2003-08-21 | Schering Corp | Compuestos para el tratamiento de trastornos inflamatorios |
| TWI294778B (en) * | 2002-03-13 | 2008-03-21 | Smithkline Beecham Corp | Peptide deformylase inhibitors |
| US7622117B2 (en) * | 2002-04-17 | 2009-11-24 | Dynamis Therapeutics, Inc. | 3-deoxyglucosone and skin |
| PL374117A1 (en) * | 2002-05-29 | 2005-10-03 | Merck & Co, Inc. | Compounds useful in the treatment of anthrax and inhibiting lethal factor |
| US20050176686A1 (en) * | 2002-07-23 | 2005-08-11 | 4Sc Ag | Novel compounds as histone deacetylase inhibitors |
| EP1626961B1 (en) * | 2003-05-17 | 2011-11-02 | Korea Research Institute of Bioscience and Biotechnology | Novel 2-oxo-heterocyclic compounds and the pharmaceutical compositions comprising the same |
| US7122560B2 (en) | 2003-06-18 | 2006-10-17 | Bristol-Myers Squibb Company | Lactam derivatives as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme |
| EP1663201A4 (en) * | 2003-07-15 | 2009-10-28 | Korea Res Inst Of Bioscience | USE OF NOVEL 2-OXO-HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME |
| KR101070036B1 (ko) * | 2003-07-23 | 2011-10-04 | 노르딕 바이오사이언스 에이/에스 | 골관절염에 대한 칼시토닌의 용도 |
| CN1950354A (zh) * | 2004-05-11 | 2007-04-18 | 默克公司 | N－磺酰化－氨基酸衍生物的制备方法 |
| US20100003276A1 (en) * | 2004-12-07 | 2010-01-07 | Hermes Jeffery D | Methods for treating anthrax and inhibiting lethal factor |
| JP2008528624A (ja) * | 2005-01-28 | 2008-07-31 | アイアールエム・リミテッド・ライアビリティ・カンパニー | フェニル置換ピロリドン |
| US9738604B2 (en) | 2010-09-03 | 2017-08-22 | Duke University | Ethynylbenzene derivatives |
| US20140081017A1 (en) * | 2012-09-14 | 2014-03-20 | Methylgene Inc. | Histone Deacetylase Inhibitors for Enhancing Activity of Antifungal Agents |
| WO2015024011A2 (en) | 2013-08-16 | 2015-02-19 | Duke University | Antibacterial compounds |
| AU2014306451B2 (en) | 2013-08-16 | 2019-01-17 | Duke University | Substituted hydroxamic acid compounds |
| US9908851B2 (en) | 2013-08-16 | 2018-03-06 | Duke University | 2-piperidinyl substituted N,3-dihydroxybutanamides |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1360583A (en) * | 1918-02-18 | 1920-11-30 | Great Lakes Dredge And Dock Co | Car-dumper |
| EP0042100A1 (de) * | 1980-06-13 | 1981-12-23 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Pyrazolopyridazin-Derivate, Zwischenprodukte und Verfahren zu deren Herstellung, sowie diese enthaltende Arzneimittel |
| DE3420193A1 (de) * | 1984-05-30 | 1985-12-05 | Boehringer Ingelheim KG, 6507 Ingelheim | Neue substituierte pyrrolidinone, verfahren zu ihrer herstellung und arzneimittel |
| AU4267293A (en) * | 1992-05-01 | 1993-11-29 | British Biotech Pharmaceuticals Limited | Use of MMP inhibitors |
| US5318964A (en) * | 1992-06-11 | 1994-06-07 | Hoffmann-La Roche Inc. | Hydroxamic derivatives and pharmaceutical compositions |
| ATE195117T1 (de) * | 1993-03-31 | 2000-08-15 | Searle & Co | 1-amdinophenyl-pyrrolidone/piperidinone als blutblättchen-aggregations inhibitoren |
| EP0712390B1 (en) * | 1993-08-02 | 1998-12-09 | Celltech Therapeutics Limited | Succinamide derivatives, processes for their preparation and their use as gelatinase and collagenase inhibitors |
| GB9320660D0 (en) * | 1993-10-07 | 1993-11-24 | British Bio Technology | Inhibition of cytokine production |
| US5403952A (en) * | 1993-10-08 | 1995-04-04 | Merck & Co., Inc. | Substituted cyclic derivatives as novel antidegenerative agents |
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1997
- 1997-02-21 TW TW086102076A patent/TW448172B/zh not_active IP Right Cessation
- 1997-03-03 EP EP97908674A patent/EP0898562B1/en not_active Expired - Lifetime
- 1997-03-03 NZ NZ330922A patent/NZ330922A/xx unknown
- 1997-03-03 DK DK97908674T patent/DK0898562T3/da active
- 1997-03-03 ES ES97908674T patent/ES2191823T3/es not_active Expired - Lifetime
- 1997-03-03 BR BR9707947A patent/BR9707947A/pt active Search and Examination
- 1997-03-03 AT AT97908674T patent/ATE231490T1/de not_active IP Right Cessation
- 1997-03-03 UA UA98105283A patent/UA61906C2/uk unknown
- 1997-03-03 DE DE69718634T patent/DE69718634T2/de not_active Expired - Fee Related
- 1997-03-03 PT PT97908674T patent/PT898562E/pt unknown
- 1997-03-03 CN CN97192171A patent/CN1210517A/zh active Pending
- 1997-03-03 RU RU98118372/04A patent/RU2168497C2/ru not_active IP Right Cessation
- 1997-03-03 AU AU20525/97A patent/AU707180B2/en not_active Ceased
- 1997-03-03 JP JP9531784A patent/JP2000506163A/ja not_active Withdrawn
- 1997-03-03 PL PL97328693A patent/PL328693A1/xx unknown
- 1997-03-03 KR KR1019980707039A patent/KR19990087597A/ko not_active Abandoned
- 1997-03-03 WO PCT/US1997/002568 patent/WO1997032846A1/en not_active Ceased
- 1997-03-04 PE PE1997000155A patent/PE55698A1/es not_active Application Discontinuation
- 1997-03-04 US US08/811,821 patent/US5712300A/en not_active Expired - Fee Related
- 1997-03-05 ZA ZA971902A patent/ZA971902B/xx unknown
- 1997-03-06 ID IDP970713A patent/ID16144A/id unknown
- 1997-03-07 MY MYPI97000965A patent/MY117762A/en unknown
-
1998
- 1998-09-07 NO NO19984112A patent/NO312956B1/no unknown
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008523123A (ja) * | 2004-12-15 | 2008-07-03 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | メタロプロテアーゼの阻害剤として使用される新規な環状尿素類 |
| US8618158B2 (en) | 2008-06-25 | 2013-12-31 | Cancer Research Technology Limited | Therapeutic agents |
| US9358222B2 (en) | 2008-06-25 | 2016-06-07 | Cancer Research Technology Limited | Therapeutic agents |
| US10414726B2 (en) | 2008-06-25 | 2019-09-17 | Cancer Research Technology Limited | Therapeutic agents |
| JP2014224152A (ja) * | 2009-06-30 | 2014-12-04 | ガルデルマ・リサーチ・アンド・デヴェロップメント | 新規なベンゼンスルホンアミド化合物、その合成方法、ならびに医薬および化粧品におけるその使用 |
| US10544132B2 (en) | 2015-09-29 | 2020-01-28 | Astex Therapeutics Limited | Isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity |
| US10526311B2 (en) | 2015-09-29 | 2020-01-07 | Astex Therapeutics Limited | Isoindolinone inhibitors of the MDM2-P53 interaction having anticancer activity |
| US10981898B2 (en) | 2015-09-29 | 2021-04-20 | Astex Therapeutics Limited | Isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity |
| US11261171B1 (en) | 2015-09-29 | 2022-03-01 | Astex Therapeutics Limited | Isoindolinone inhibitors of the MDM2-P53 interaction having anticancer activity |
| US12071429B2 (en) | 2015-09-29 | 2024-08-27 | Astex Therapeutics Limited | Isoindolinone inhibitors of the MDM2-P53 interaction having anticancer activity |
| US11236047B2 (en) | 2017-03-28 | 2022-02-01 | Astex Therapeutics Limited | Combination of isoindolinone derivatives with SGI-110 |
| US11603367B2 (en) | 2017-03-28 | 2023-03-14 | Astex Therapeutics Limited | Isoindolinone inhibitors of the MDM2-P53 interaction and process for making them |
| US12077526B2 (en) | 2017-03-28 | 2024-09-03 | Astex Therapeutics Limited | Isoindolinone inhibitors of the MDM2-P53 interaction and process for making them |
Also Published As
| Publication number | Publication date |
|---|---|
| NO984112L (no) | 1998-11-06 |
| KR19990087597A (ko) | 1999-12-27 |
| TW448172B (en) | 2001-08-01 |
| PE55698A1 (es) | 1998-09-16 |
| DK0898562T3 (da) | 2003-05-12 |
| MY117762A (en) | 2004-08-30 |
| BR9707947A (pt) | 1999-07-27 |
| WO1997032846A1 (en) | 1997-09-12 |
| DE69718634D1 (de) | 2003-02-27 |
| ES2191823T3 (es) | 2003-09-16 |
| ZA971902B (en) | 1998-09-07 |
| UA61906C2 (en) | 2003-12-15 |
| ATE231490T1 (de) | 2003-02-15 |
| CN1210517A (zh) | 1999-03-10 |
| NO312956B1 (no) | 2002-07-22 |
| ID16144A (id) | 1997-09-04 |
| DE69718634T2 (de) | 2003-10-30 |
| NO984112D0 (no) | 1998-09-07 |
| EP0898562A1 (en) | 1999-03-03 |
| AU2052597A (en) | 1997-09-22 |
| EP0898562B1 (en) | 2003-01-22 |
| RU2168497C2 (ru) | 2001-06-10 |
| PL328693A1 (en) | 1999-02-15 |
| AU707180B2 (en) | 1999-07-01 |
| US5712300A (en) | 1998-01-27 |
| PT898562E (pt) | 2003-06-30 |
| NZ330922A (en) | 2000-01-28 |
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