PE55698A1 - Nuevos derivados del acido hidroxamico utiles para el tratamiento de enfermedades relacionadas con la degradacion del tejido conectivo - Google Patents

Nuevos derivados del acido hidroxamico utiles para el tratamiento de enfermedades relacionadas con la degradacion del tejido conectivo

Info

Publication number
PE55698A1
PE55698A1 PE1997000155A PE00015597A PE55698A1 PE 55698 A1 PE55698 A1 PE 55698A1 PE 1997000155 A PE1997000155 A PE 1997000155A PE 00015597 A PE00015597 A PE 00015597A PE 55698 A1 PE55698 A1 PE 55698A1
Authority
PE
Peru
Prior art keywords
treatment
acid derivatives
connective tissue
hydroxamic acid
diseases related
Prior art date
Application number
PE1997000155A
Other languages
English (en)
Spanish (es)
Inventor
E Jon Jacobsen
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of PE55698A1 publication Critical patent/PE55698A1/es

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24Oxygen or sulfur atoms
    • C07D207/262-Pyrrolidones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/06Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D231/08Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with oxygen or sulfur atoms directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72Two oxygen atoms, e.g. hydantoin
    • C07D233/76Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Pyrrole Compounds (AREA)
PE1997000155A 1996-03-08 1997-03-04 Nuevos derivados del acido hidroxamico utiles para el tratamiento de enfermedades relacionadas con la degradacion del tejido conectivo PE55698A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1309896P 1996-03-08 1996-03-08

Publications (1)

Publication Number Publication Date
PE55698A1 true PE55698A1 (es) 1998-09-16

Family

ID=21758301

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1997000155A PE55698A1 (es) 1996-03-08 1997-03-04 Nuevos derivados del acido hidroxamico utiles para el tratamiento de enfermedades relacionadas con la degradacion del tejido conectivo

Country Status (23)

Country Link
US (1) US5712300A (enExample)
EP (1) EP0898562B1 (enExample)
JP (1) JP2000506163A (enExample)
KR (1) KR19990087597A (enExample)
CN (1) CN1210517A (enExample)
AT (1) ATE231490T1 (enExample)
AU (1) AU707180B2 (enExample)
BR (1) BR9707947A (enExample)
DE (1) DE69718634T2 (enExample)
DK (1) DK0898562T3 (enExample)
ES (1) ES2191823T3 (enExample)
ID (1) ID16144A (enExample)
MY (1) MY117762A (enExample)
NO (1) NO312956B1 (enExample)
NZ (1) NZ330922A (enExample)
PE (1) PE55698A1 (enExample)
PL (1) PL328693A1 (enExample)
PT (1) PT898562E (enExample)
RU (1) RU2168497C2 (enExample)
TW (1) TW448172B (enExample)
UA (1) UA61906C2 (enExample)
WO (1) WO1997032846A1 (enExample)
ZA (1) ZA971902B (enExample)

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US5883131A (en) * 1997-07-09 1999-03-16 Pfizer Inc. Cyclic sulfone derivatives
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ZA988967B (en) * 1997-10-03 2000-04-03 Du Pont Pharm Co Lactam metalloprotease inhibitors.
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EP1024134A4 (en) * 1997-10-09 2003-05-14 Ono Pharmaceutical Co DERIVATIVES OF AMINOBUTANIC ACID
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GB9825988D0 (en) * 1998-11-27 1999-01-20 Pfizer Ltd Indole derivatives
US20040122011A1 (en) * 1998-12-23 2004-06-24 Pharmacia Corporation Method of using a COX-2 inhibitor and a TACE inhibitors as a combination therapy
SK12452001A3 (sk) 1999-03-03 2002-04-04 The Procter & Gamble Company Zlúčenina vytvárajúca inhibítor metaloproteinázy, farmaceutický prostriedok, spôsob prípravy liečiva a liečivo
WO2000051993A2 (en) 1999-03-03 2000-09-08 The Procter & Gamble Company Dihetero-substituted metalloprotease inhibitors
EP1165546A2 (en) * 1999-04-02 2002-01-02 Du Pont Pharmaceuticals Company Novel lactam inhibitors of matrix metalloproteinases, tnf-alpha, and aggrecanase
US6797820B2 (en) 1999-12-17 2004-09-28 Vicuron Pharmaceuticals Inc. Succinate compounds, compositions and methods of use and preparation
AU2002230385A1 (en) * 2000-09-25 2002-04-15 Questcor Pharmaceuticals, Inc. Peptide deformylase inhibitors
EP1355901A2 (en) 2001-01-11 2003-10-29 Bristol-Myers Squibb Pharma Company 1,1-DISUBSTITUTED CYCLIC INHIBITORS OF MATRIX METALLOPROTEASE AND TNF-$g(a)
CA2434044A1 (en) 2001-01-11 2002-07-18 Bristol-Myers Squibb Pharma Company 1,2-disubstituted cyclic inhibitors of matrix metallorproteases and tnf-alpha
DE60207384T2 (de) * 2001-03-01 2006-08-03 Smithkline Beecham Corp. Peptid-deformylase-hemmer
JP4314340B2 (ja) * 2001-06-15 2009-08-12 ヴィキュロン ファーマシューティカルズ インコーポレイテッド ピロリジン二環性化合物
AR036053A1 (es) 2001-06-15 2004-08-04 Versicor Inc Compuestos de n-formil-hidroxilamina, un proceso para su preparacion y composiciones farmaceuticas
PE20030701A1 (es) 2001-12-20 2003-08-21 Schering Corp Compuestos para el tratamiento de trastornos inflamatorios
TWI294778B (en) * 2002-03-13 2008-03-21 Smithkline Beecham Corp Peptide deformylase inhibitors
US7622117B2 (en) * 2002-04-17 2009-11-24 Dynamis Therapeutics, Inc. 3-deoxyglucosone and skin
PL374117A1 (en) * 2002-05-29 2005-10-03 Merck & Co, Inc. Compounds useful in the treatment of anthrax and inhibiting lethal factor
US20050176686A1 (en) * 2002-07-23 2005-08-11 4Sc Ag Novel compounds as histone deacetylase inhibitors
EP1626961B1 (en) * 2003-05-17 2011-11-02 Korea Research Institute of Bioscience and Biotechnology Novel 2-oxo-heterocyclic compounds and the pharmaceutical compositions comprising the same
US7122560B2 (en) 2003-06-18 2006-10-17 Bristol-Myers Squibb Company Lactam derivatives as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme
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Also Published As

Publication number Publication date
NO984112L (no) 1998-11-06
KR19990087597A (ko) 1999-12-27
TW448172B (en) 2001-08-01
DK0898562T3 (da) 2003-05-12
MY117762A (en) 2004-08-30
BR9707947A (pt) 1999-07-27
WO1997032846A1 (en) 1997-09-12
DE69718634D1 (de) 2003-02-27
ES2191823T3 (es) 2003-09-16
ZA971902B (en) 1998-09-07
UA61906C2 (en) 2003-12-15
JP2000506163A (ja) 2000-05-23
ATE231490T1 (de) 2003-02-15
CN1210517A (zh) 1999-03-10
NO312956B1 (no) 2002-07-22
ID16144A (id) 1997-09-04
DE69718634T2 (de) 2003-10-30
NO984112D0 (no) 1998-09-07
EP0898562A1 (en) 1999-03-03
AU2052597A (en) 1997-09-22
EP0898562B1 (en) 2003-01-22
RU2168497C2 (ru) 2001-06-10
PL328693A1 (en) 1999-02-15
AU707180B2 (en) 1999-07-01
US5712300A (en) 1998-01-27
PT898562E (pt) 2003-06-30
NZ330922A (en) 2000-01-28

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