JP2000505729A - タブレット圧縮のモニタリング及び制御方法及び装置 - Google Patents
タブレット圧縮のモニタリング及び制御方法及び装置Info
- Publication number
- JP2000505729A JP2000505729A JP9527094A JP52709497A JP2000505729A JP 2000505729 A JP2000505729 A JP 2000505729A JP 9527094 A JP9527094 A JP 9527094A JP 52709497 A JP52709497 A JP 52709497A JP 2000505729 A JP2000505729 A JP 2000505729A
- Authority
- JP
- Japan
- Prior art keywords
- compression
- tablet
- waveform
- data
- event
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000007906 compression Methods 0.000 title claims abstract description 197
- 230000006835 compression Effects 0.000 title claims abstract description 197
- 238000000034 method Methods 0.000 title claims description 50
- 238000012544 monitoring process Methods 0.000 title claims description 19
- 238000005070 sampling Methods 0.000 claims abstract description 11
- 230000006870 function Effects 0.000 claims description 18
- 230000002950 deficient Effects 0.000 claims description 11
- 239000000463 material Substances 0.000 claims description 6
- 238000013480 data collection Methods 0.000 claims description 5
- 238000012545 processing Methods 0.000 claims description 5
- 230000006978 adaptation Effects 0.000 claims description 2
- 238000010972 statistical evaluation Methods 0.000 claims description 2
- 230000007246 mechanism Effects 0.000 abstract description 14
- 238000004260 weight control Methods 0.000 abstract description 4
- 239000003826 tablet Substances 0.000 description 172
- 239000010410 layer Substances 0.000 description 25
- 230000007547 defect Effects 0.000 description 21
- 230000001276 controlling effect Effects 0.000 description 13
- 239000003814 drug Substances 0.000 description 11
- 229940079593 drug Drugs 0.000 description 11
- 239000000843 powder Substances 0.000 description 9
- 238000004519 manufacturing process Methods 0.000 description 8
- 238000005259 measurement Methods 0.000 description 6
- 238000006073 displacement reaction Methods 0.000 description 5
- 230000000630 rising effect Effects 0.000 description 4
- 239000007891 compressed tablet Substances 0.000 description 3
- 239000013618 particulate matter Substances 0.000 description 3
- 238000004080 punching Methods 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 230000009471 action Effects 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000012790 confirmation Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000013024 troubleshooting Methods 0.000 description 2
- 238000012795 verification Methods 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000003190 augmentative effect Effects 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000005056 compaction Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000000875 corresponding effect Effects 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000009795 derivation Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 239000002702 enteric coating Substances 0.000 description 1
- 238000009505 enteric coating Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 210000005095 gastrointestinal system Anatomy 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 239000007942 layered tablet Substances 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000002923 metal particle Substances 0.000 description 1
- 239000011236 particulate material Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000012887 quadratic function Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 238000010200 validation analysis Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B30—PRESSES
- B30B—PRESSES IN GENERAL
- B30B11/00—Presses specially adapted for forming shaped articles from material in particulate or plastic state, e.g. briquetting presses, tabletting presses
- B30B11/005—Control arrangements
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Encapsulation Of And Coatings For Semiconductor Or Solid State Devices (AREA)
- General Preparation And Processing Of Foods (AREA)
- Injection Moulding Of Plastics Or The Like (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/593,769 | 1996-01-29 | ||
| US08/593,769 US5838571A (en) | 1996-01-29 | 1996-01-29 | Tablet press monitoring and controlling method and apparatus |
| PCT/US1997/001358 WO1997027044A1 (en) | 1996-01-29 | 1997-01-22 | Tablet press monitoring and controlling method and apparatus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2000505729A true JP2000505729A (ja) | 2000-05-16 |
| JP2000505729A5 JP2000505729A5 (enExample) | 2004-11-11 |
Family
ID=24376090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP9527094A Pending JP2000505729A (ja) | 1996-01-29 | 1997-01-22 | タブレット圧縮のモニタリング及び制御方法及び装置 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US5838571A (enExample) |
| EP (1) | EP0879140B1 (enExample) |
| JP (1) | JP2000505729A (enExample) |
| AT (1) | ATE186874T1 (enExample) |
| DE (1) | DE69700834T2 (enExample) |
| WO (1) | WO1997027044A1 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011504796A (ja) * | 2007-10-12 | 2011-02-17 | ユーロタブ | 一定体積への粉末組成物の圧密化方法 |
| JP2022503577A (ja) * | 2018-08-20 | 2022-01-12 | ガムレン タブレッティング リミテッド | 識別システム、識別方法およびデータキャリア |
| JP2024078431A (ja) * | 2022-11-29 | 2024-06-10 | フェッテ コンパクティング ゲーエムベーハー | 回転プレス機の加圧パンチの状態を評価する方法および回転プレス機 |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6001287A (en) * | 1995-10-11 | 1999-12-14 | Sumitomo Chemical Company, Limited | Method of press-molding thermoplastic resin |
| DE19844390B4 (de) * | 1998-09-28 | 2005-09-22 | Wilhelm Fette Gmbh | Verfahren zur Herstellung von Tabletten in einer Rundläufertablettiermaschine |
| DE19902429C2 (de) * | 1999-01-22 | 2000-12-07 | Mannesmann Vdo Ag | Verfahren zur Entformung einer Gußform oder Preßform |
| EP1386251A4 (en) * | 2001-03-02 | 2005-11-23 | Euro Celtique Sa | METHOD AND DEVICE FOR COMPACTING INDIVIDUALIZED DOSAGE FORMS |
| AU2003235708A1 (en) * | 2002-01-16 | 2003-07-30 | Akzo Nobel N.V. | Polytartrate composition |
| DE10202820C1 (de) * | 2002-01-25 | 2003-03-13 | Fette Wilhelm Gmbh | Satz von Presstempeln und/oder Matrizen für eine Tablettiermaschine |
| JP3785393B2 (ja) * | 2002-10-23 | 2006-06-14 | 東芝機械株式会社 | 射出成形機の型締め工程における異常検知方法 |
| ES2242141T3 (es) * | 2003-02-10 | 2005-11-01 | Korsch Ag | Metodo y dispositivo para el control de una maquina rotativa para la fabricacion de tabletas. |
| DE102004008321B3 (de) * | 2004-02-20 | 2005-11-17 | Fette Gmbh | Verfahren und Vorrichtung zur Qualitätsüberwachung bei der Herstellung von Tabletten |
| US20050200038A1 (en) * | 2004-03-12 | 2005-09-15 | Courtoy Nv | Method for controlling a rotary tablet press and such a press |
| US20050236725A1 (en) * | 2004-04-23 | 2005-10-27 | Niewels Joachim J | Method and apparatus for countering mold deflection and misalignment using active material elements |
| JP4799074B2 (ja) * | 2005-08-04 | 2011-10-19 | 株式会社菊水製作所 | 粉末圧縮成形機、及びその制御方法 |
| WO2007132281A1 (en) * | 2006-05-15 | 2007-11-22 | Courtoy Nv | Method for controlling a tablet press and such a press |
| KR100745983B1 (ko) * | 2006-07-18 | 2007-08-06 | 삼성전자주식회사 | 최소값 샘플링을 이용한 신호 복원 장치 및 방법 |
| DE102008015820B4 (de) * | 2008-03-27 | 2013-02-28 | Fette Compacting Gmbh | Vorrichtung und Verfahren zur Messung der vertikalen Position von Ober- und Unterstempeln einer Rundläufer-Tablettenpresse |
| JP5347149B2 (ja) * | 2009-04-07 | 2013-11-20 | 株式会社菊水製作所 | 回転式粉体圧縮成形機 |
| DK2531178T3 (da) * | 2010-02-03 | 2014-09-01 | Merck Patent Gmbh | Direkte komprimerbart magnesiumhydroxidcarbonat |
| DE202010003848U1 (de) | 2010-03-17 | 2010-07-15 | Luxner, Peter, Dipl.-Ing. | Vorrichtung zum Verpressen von Pulver und Granulat |
| DE102010011995A1 (de) | 2010-03-17 | 2011-09-22 | Peter Luxner | Verfahren und Vorrichtung zum Verpressen von Pulver und Granulat |
| DE102011101288B4 (de) * | 2011-05-10 | 2013-11-14 | Fette Compacting Gmbh | Verfahren zum Betrieb einer Anlage zur Herstellung von Tabletten sowie entsprechende Anlage |
| US8984957B2 (en) * | 2012-01-30 | 2015-03-24 | The United States Of America, As Represented By The Secretary Of The Navy | System and method for testing of micro-sized materials |
| DE102013202975B4 (de) * | 2013-02-22 | 2015-02-05 | Korsch Ag | Einzelsortiervorrichtung zur sortierung von tabletten, system mit einer solchen einzelsortiervorrichtung und mit einer tablettiervorrichtung und verfahren zur überprüfung einer einzelsortiervorrichtung |
| EP3349733A1 (de) * | 2015-09-14 | 2018-07-25 | Merck Patent GmbH | Formulierung mit kontrollierter, verzögerter wirkstoffreisetzung |
| JP6775311B2 (ja) | 2016-03-29 | 2020-10-28 | 株式会社菊水製作所 | 成形品製造システム |
| US10875217B2 (en) * | 2016-12-12 | 2020-12-29 | Kikusui Seisakusho Ltd. | Controller and control method for rotary compression-molding machine |
| CN112912234A (zh) | 2019-05-22 | 2021-06-04 | 阿格鲁塑料技术有限公司 | 用于建立焊接连接的方法以及焊接设备 |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4030868A (en) * | 1976-03-15 | 1977-06-21 | Hoffmann-La Roche Inc. | Force measurement and analysis particularly relating to rotary tablet presses |
| JPS55129596U (enExample) * | 1979-02-28 | 1980-09-12 | ||
| JPS629733A (ja) * | 1985-07-05 | 1987-01-17 | Matsushita Electric Ind Co Ltd | プレス装置 |
| JPS62137200A (ja) * | 1985-12-10 | 1987-06-20 | Kikusui Seisakusho:Kk | 粉末圧縮成形機の成形品の重量制御における設定器の設定方法 |
| JPS63212099A (ja) * | 1987-02-27 | 1988-09-05 | Kikusui Seisakusho:Kk | 粉末圧縮成形機の成形品の重量制御における設定器の設定方法 |
| JPH01113200A (ja) * | 1987-10-27 | 1989-05-01 | Hata Tekkosho:Kk | 粉末圧縮成形機における成形品の重量制御方法 |
| JPH0516216U (ja) * | 1991-08-12 | 1993-03-02 | 京セラ株式会社 | セラミツクの自動プレス成形装置 |
| JPH0663797A (ja) * | 1992-08-21 | 1994-03-08 | Kikusui Seisakusho:Kk | 回転式錠剤機の成形品の重量制御におけるフィードバック調整方法 |
| JPH06504486A (ja) * | 1991-11-15 | 1994-05-26 | ラアイズ−ブッヒエル・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 塊状体圧縮成形機のプレス工程を制御および／または調節するための方法および装置 |
| JPH06304800A (ja) * | 1993-02-25 | 1994-11-01 | Toyota Motor Corp | プレス機械の異常診断方法 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3255716A (en) * | 1962-12-10 | 1966-06-14 | Upjohn Co | Measurement of forces within a tableting machine |
| US3982865A (en) * | 1974-03-21 | 1976-09-28 | Hoffmann-La Roche Inc. | Apparatus for high-speed accurate counting and handling of discrete objects such as tablets |
| US3890413A (en) * | 1974-08-15 | 1975-06-17 | Hydramet American Inc | Apparatus and method for compacting particulate materials |
| US4000231A (en) * | 1974-09-16 | 1976-12-28 | Hydramet American Inc. | Method for compacting powders |
| DE2520662C3 (de) * | 1975-05-09 | 1983-11-03 | Wilhelm Fette Gmbh, 2053 Schwarzenbek | Einrichtung zum Überwachen der Preßkräfte der Stempel einer Tablettenpresse |
| US4016744A (en) * | 1975-05-28 | 1977-04-12 | Hoffmann-La Roche Inc. | Applied instrumentation providing tabletting compression force |
| GB1551954A (en) * | 1975-05-28 | 1979-09-05 | Hoffmann La Roche | Standardization of a physiochemical parameter of a batch of formulation in tabletted form |
| US4100598A (en) * | 1975-09-05 | 1978-07-11 | Hoffmann-La Roche Inc. | Tablet press related instrumentation for use in development and control of formulations of pharmaceutical granulations |
| DE2742572B1 (de) * | 1977-09-22 | 1979-03-29 | Fette Wilhelm Gmbh | Verfahren zum Herstellen von Tabletten und Tablettenpresse |
| SU837901A1 (ru) * | 1978-09-26 | 1981-06-15 | Ждановский Филиал Ленинградскогонаучно-Производственного Объедине-Ния Технологического Оборудованиядля Производства Готовых Лекарст-Венных Средств "Прогресс" Министер-Ctba Медицинской Промышленности | Роторный таблеточный пресс |
| DE2952716A1 (de) * | 1979-01-04 | 1980-07-17 | Roltra Spa | Fensterheber, insbesondere fuer kraftfahrzeugfenster |
| US4253811A (en) * | 1979-07-13 | 1981-03-03 | Firma Wilhelm Fette Gmbh | Method of and a device for sorting pellets upon their molding in a preforming press |
| JPS5614098A (en) * | 1979-07-13 | 1981-02-10 | Takeda Chem Ind Ltd | Externally lubricating tablet making machine |
| DE2951716A1 (de) * | 1979-12-19 | 1981-07-02 | Mannesmann AG, 4000 Düsseldorf | Verfahren und vorrichtung zum pressen von formkoerpern |
| US4340937A (en) * | 1980-04-14 | 1982-07-20 | Beta Corporation Of St. Louis | Automatic control for a pellet producing apparatus |
| DE3131402A1 (de) * | 1981-08-07 | 1983-02-24 | Kilian & Co GmbH, 5000 Köln | Verfahren und tablettenpresse zum aufeinanderfolgenden herstellen einer vielzahl von tabletten mit gleichem gewicht |
| EG16028A (en) * | 1982-03-26 | 1986-12-30 | Warner Lambert Co | Apparatus and method for molding capsules |
| JPS5987031A (ja) * | 1982-11-08 | 1984-05-19 | Kiyoshi Hajikano | 微小径ペレツト用射出成型機 |
| US4570229A (en) * | 1983-09-19 | 1986-02-11 | Pennwalt Corporation | Tablet press controller and method |
| JPS61111800A (ja) * | 1984-11-05 | 1986-05-29 | Hata Tekkosho:Kk | 粉末圧縮成形機 |
| WO1986005743A1 (en) * | 1985-03-29 | 1986-10-09 | Thomas Engineering, Inc. | Pharmaceutical tablet press control mechanism |
| DE3520203A1 (de) * | 1985-06-05 | 1986-12-11 | Wilhelm Fette Gmbh, 2053 Schwarzenbek | Rundlaeufer-tablettiermaschine und verfahren zur steuerung ihrer druckrollen |
| ES2028793T3 (es) * | 1986-01-24 | 1992-07-16 | Buhler Ag | Prensa para hacer tacos de material aglomerado. |
| US4817006A (en) * | 1986-03-28 | 1989-03-28 | Thomas Engineering, Inc. | Pharmaceutical tablet press control mechanism |
| US4815001A (en) * | 1986-05-30 | 1989-03-21 | Crestek, Inc. | Ultrasonic wire bonding quality monitor and method |
| DE3715077A1 (de) * | 1987-05-06 | 1988-12-01 | Netzsch Maschinenfabrik | Verfahren zum steuern einer presse |
| DE3823417A1 (de) * | 1988-07-11 | 1990-01-18 | Fette Wilhelm Gmbh | Verfahren und einrichtung zum ueberwachen der presskraefte der stempel einer tablettenpresse |
| US5119311A (en) * | 1988-07-14 | 1992-06-02 | Coors Brewing Company | Monitor and control assembly for use with a can end press |
| US5223192A (en) * | 1989-12-02 | 1993-06-29 | Firma Wilhelm Fette Gmbh | Method of and arrangement for monitoring pressing forces in a pelletizing machine |
| DE3939956A1 (de) * | 1989-12-02 | 1991-06-06 | Fette Wilhelm Gmbh | Verfahren und einrichtung zum ueberwachen der presskraefte einer tablettiermaschine |
| JPH07112638B2 (ja) * | 1991-05-02 | 1995-12-06 | 株式会社ヨシツカ精機 | 粉末成形プレスの加圧制御方法 |
| US5211964A (en) * | 1991-05-20 | 1993-05-18 | Westinghouse Electric Corp. | Press machine with means to adjust punching force |
| US5202067A (en) * | 1991-11-12 | 1993-04-13 | Chemplex Industries, Inc. | Powder compacting press apparatus and methods |
| JPH0780076B2 (ja) * | 1992-04-28 | 1995-08-30 | 株式会社菊水製作所 | 回転式錠剤機の取着ロードセル点検方法 |
| US5322655A (en) * | 1993-02-19 | 1994-06-21 | Thomas Engineering, Inc. | Method for monitoring and controlling the weights of each layer of a multilayer tablet |
| JP2636743B2 (ja) * | 1994-08-03 | 1997-07-30 | 東京電力株式会社 | 部分放電測定方法 |
-
1996
- 1996-01-29 US US08/593,769 patent/US5838571A/en not_active Expired - Lifetime
-
1997
- 1997-01-22 WO PCT/US1997/001358 patent/WO1997027044A1/en not_active Ceased
- 1997-01-22 JP JP9527094A patent/JP2000505729A/ja active Pending
- 1997-01-22 DE DE69700834T patent/DE69700834T2/de not_active Expired - Lifetime
- 1997-01-22 AT AT97904039T patent/ATE186874T1/de active
- 1997-01-22 EP EP97904039A patent/EP0879140B1/en not_active Expired - Lifetime
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4030868A (en) * | 1976-03-15 | 1977-06-21 | Hoffmann-La Roche Inc. | Force measurement and analysis particularly relating to rotary tablet presses |
| JPS55129596U (enExample) * | 1979-02-28 | 1980-09-12 | ||
| JPS629733A (ja) * | 1985-07-05 | 1987-01-17 | Matsushita Electric Ind Co Ltd | プレス装置 |
| JPS62137200A (ja) * | 1985-12-10 | 1987-06-20 | Kikusui Seisakusho:Kk | 粉末圧縮成形機の成形品の重量制御における設定器の設定方法 |
| JPS63212099A (ja) * | 1987-02-27 | 1988-09-05 | Kikusui Seisakusho:Kk | 粉末圧縮成形機の成形品の重量制御における設定器の設定方法 |
| JPH01113200A (ja) * | 1987-10-27 | 1989-05-01 | Hata Tekkosho:Kk | 粉末圧縮成形機における成形品の重量制御方法 |
| JPH0516216U (ja) * | 1991-08-12 | 1993-03-02 | 京セラ株式会社 | セラミツクの自動プレス成形装置 |
| JPH06504486A (ja) * | 1991-11-15 | 1994-05-26 | ラアイズ−ブッヒエル・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 塊状体圧縮成形機のプレス工程を制御および／または調節するための方法および装置 |
| JPH0663797A (ja) * | 1992-08-21 | 1994-03-08 | Kikusui Seisakusho:Kk | 回転式錠剤機の成形品の重量制御におけるフィードバック調整方法 |
| JPH06304800A (ja) * | 1993-02-25 | 1994-11-01 | Toyota Motor Corp | プレス機械の異常診断方法 |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011504796A (ja) * | 2007-10-12 | 2011-02-17 | ユーロタブ | 一定体積への粉末組成物の圧密化方法 |
| JP2022503577A (ja) * | 2018-08-20 | 2022-01-12 | ガムレン タブレッティング リミテッド | 識別システム、識別方法およびデータキャリア |
| JP7267638B2 (ja) | 2018-08-20 | 2023-05-02 | ガムレン タブレッティング リミテッド | 識別システム、識別方法およびデータキャリア |
| JP2024078431A (ja) * | 2022-11-29 | 2024-06-10 | フェッテ コンパクティング ゲーエムベーハー | 回転プレス機の加圧パンチの状態を評価する方法および回転プレス機 |
Also Published As
| Publication number | Publication date |
|---|---|
| DE69700834D1 (de) | 1999-12-30 |
| WO1997027044A1 (en) | 1997-07-31 |
| DE69700834T2 (de) | 2000-06-21 |
| EP0879140A1 (en) | 1998-11-25 |
| EP0879140B1 (en) | 1999-11-24 |
| ATE186874T1 (de) | 1999-12-15 |
| US5838571A (en) | 1998-11-17 |
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