IT9020348A0 - Processo per la preparazione di intermedi per la sintesi del diltiazem - Google Patents

Processo per la preparazione di intermedi per la sintesi del diltiazem

Info

Publication number
IT9020348A0
IT9020348A0 IT9020348A IT2034890A IT9020348A0 IT 9020348 A0 IT9020348 A0 IT 9020348A0 IT 9020348 A IT9020348 A IT 9020348A IT 2034890 A IT2034890 A IT 2034890A IT 9020348 A0 IT9020348 A0 IT 9020348A0
Authority
IT
Italy
Prior art keywords
diltiazem
intermediates
synthesis
preparation
Prior art date
Application number
IT9020348A
Other languages
English (en)
Other versions
IT1249777B (it
IT9020348A1 (it
Inventor
Luca Ghirotto
Stefano Servi
Claudio Fuganti
Angelo Gentile
Original Assignee
Zambon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zambon Spa filed Critical Zambon Spa
Publication of IT9020348A0 publication Critical patent/IT9020348A0/it
Priority to IT02034890A priority Critical patent/IT1249777B/it
Priority to CH1329/91A priority patent/CH682670A5/it
Priority to DE4115697A priority patent/DE4115697C2/de
Priority to CA002042535A priority patent/CA2042535C/en
Priority to AT0099591A priority patent/AT400446B/de
Priority to FR9105866A priority patent/FR2662178B1/fr
Priority to NL9100854A priority patent/NL194616C/nl
Priority to GB9110610A priority patent/GB2246351B/en
Priority to ES9101193A priority patent/ES2033203B1/es
Priority to JP3210541A priority patent/JP3060187B2/ja
Priority to SE9101482A priority patent/SE509297C2/sv
Priority to BE9100458A priority patent/BE1005406A0/fr
Priority to GB9120710A priority patent/GB2247020B/en
Publication of IT9020348A1 publication Critical patent/IT9020348A1/it
Priority to US08/404,284 priority patent/US5571704A/en
Application granted granted Critical
Publication of IT1249777B publication Critical patent/IT1249777B/it
Priority to US08/487,584 priority patent/US6346632B1/en
Priority to JP35215499A priority patent/JP3223317B2/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IT02034890A 1990-05-17 1990-05-17 Processo per la preparazione di intermedi per la sintesi del diltiazem IT1249777B (it)

Priority Applications (16)

Application Number Priority Date Filing Date Title
IT02034890A IT1249777B (it) 1990-05-17 1990-05-17 Processo per la preparazione di intermedi per la sintesi del diltiazem
CH1329/91A CH682670A5 (it) 1990-05-17 1991-05-03 Processo per la preparazione di esteri dell'acido (2R,3S)-3-(4-metossifenil)-glicidico mediante transesterificazione enzimatica di miscele enantiomeriche.
DE4115697A DE4115697C2 (de) 1990-05-17 1991-05-14 Verfahren zur Herstellung von Zwischenverbindungen, die bei der Synthese von Benzothiazepinen verwendbar sind
CA002042535A CA2042535C (en) 1990-05-17 1991-05-14 Process for the preparation of intermediates useful for the synthesis of benzothiazepines
AT0099591A AT400446B (de) 1990-05-17 1991-05-14 Verfahren zur herstellung von estern der (2r,3s)-3-(4-methoxyphenyl)-glycidsäure
FR9105866A FR2662178B1 (fr) 1990-05-17 1991-05-15 Procede de preparation d'intermediaires utiles dans la synthese de benzothiazepines.
ES9101193A ES2033203B1 (es) 1990-05-17 1991-05-16 Procedimiento para la preparacion de intermediarios utiles para la sintesis de benzotiacepinas.
GB9110610A GB2246351B (en) 1990-05-17 1991-05-16 Preparation of methoxyphenyl-glycidic acid esters useful for the synthesis of benzothiazepines
NL9100854A NL194616C (nl) 1990-05-17 1991-05-16 Werkwijze voor het winnen van een (2R,3S)-3-(4-methoxyfenyl)- glycidinezuur ester.
JP3210541A JP3060187B2 (ja) 1990-05-17 1991-05-16 （２ｒ，３ｓ）−３−（４−メトキシ−フェニル）−グリシド酸エステルの製造方法
SE9101482A SE509297C2 (sv) 1990-05-17 1991-05-16 Förfarande för framställning av mellanprodukter som är användbara för syntes av bensotiazepiner
BE9100458A BE1005406A0 (fr) 1990-05-17 1991-05-16 Procede de preparation d'intermediaires utiles dans la synthese de benzothiazepines.
GB9120710A GB2247020B (en) 1990-05-17 1991-09-30 Increasing the enantiomeric purity of methoxyphenyl-glycidic acid esters
US08/404,284 US5571704A (en) 1990-05-17 1995-03-14 Process for the preparation of intermediates useful for the synthesis of benzothiazepines
US08/487,584 US6346632B1 (en) 1990-05-17 1995-06-07 Process for the preparation of intermediates useful for the synthesis for benzothiazepines
JP35215499A JP3223317B2 (ja) 1990-05-17 1999-11-05 （２ｒ，３ｓ）−３−（４−メトキシ−フェニル）−グリシド酸エステルのエナンシオメトリ−純度を増大せしめる方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT02034890A IT1249777B (it) 1990-05-17 1990-05-17 Processo per la preparazione di intermedi per la sintesi del diltiazem

Publications (3)

Publication Number Publication Date
IT9020348A0 true IT9020348A0 (it) 1990-05-17
IT9020348A1 IT9020348A1 (it) 1991-11-17
IT1249777B IT1249777B (it) 1995-03-18

Family

ID=11165937

Family Applications (1)

Application Number Title Priority Date Filing Date
IT02034890A IT1249777B (it) 1990-05-17 1990-05-17 Processo per la preparazione di intermedi per la sintesi del diltiazem

Country Status (13)

Country Link
US (2) US5571704A (it)
JP (2) JP3060187B2 (it)
AT (1) AT400446B (it)
BE (1) BE1005406A0 (it)
CA (1) CA2042535C (it)
CH (1) CH682670A5 (it)
DE (1) DE4115697C2 (it)
ES (1) ES2033203B1 (it)
FR (1) FR2662178B1 (it)
GB (2) GB2246351B (it)
IT (1) IT1249777B (it)
NL (1) NL194616C (it)
SE (1) SE509297C2 (it)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2687789B2 (ja) * 1991-08-13 1997-12-08 田辺製薬株式会社 光学活性３−フェニルグリシッド酸エステル類化合物の製法
ES2048653B1 (es) * 1992-06-08 1994-12-16 Menarini Lab Proceso para la produccion de acido s-(+)-2-(3-benzoilfenil) propionico por transesterificacion enantioselectiva catalizada enzimaticamente en un disolvente organico.
ES2050067B1 (es) * 1992-06-08 1994-12-16 Menarini Lab Proceso para la produccion de acido s-(+)-2-(3-benzoilfenil) propionico por transesterificacion enantioselectiva con un alcohol bifuncional catalizada enzimaticamente en medio organico.
US6020174A (en) * 1992-07-27 2000-02-01 The Board Of Governors For Higher Education Chemoenzymatic synthesis of the taxol C-13 side chain N-benzolyl- (2R,3S)-Phenylisoserine
DE4225155C1 (it) * 1992-07-30 1993-08-05 Hoechst Ag, 6230 Frankfurt, De
SG72731A1 (en) * 1996-03-15 2000-05-23 Nabe Seiyaku Co Ltd Process for preparing optically active trans-3-phenylglycidamide compounds
TW438787B (en) 1997-02-27 2001-06-07 Tanabe Seiyaku Co Process for preparing optically active trans-3-substituted glycidic acid ester
CN1266430A (zh) * 1997-06-11 2000-09-13 田边制药株式会社 制备光学活性的苯基环氧乙烷化合物的方法
IT1302261B1 (it) 1998-09-24 2000-09-05 Zambon Spa Processo per la risoluzione cinetica enzimatica di 3-fenilglicidatiper transesterificazione con amminoalcoli
DE19901925A1 (de) * 1999-01-19 2000-07-27 Aventis Res & Tech Gmbh & Co Verfahren zur Trennung optischer Isomerer durch simultane Durchführung einer enzymatischen Reaktion und einer chromatographischen Trennung
CN1617931A (zh) * 2002-02-06 2005-05-18 联邦科学技术研究组织 具有脂肪酶活性的酯酶
TWM583351U (zh) 2019-05-10 2019-09-11 北聯研磨科技股份有限公司 砂輪中心孔保護墊

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL8801311A (nl) * 1988-05-20 1989-12-18 Stamicarbon Fenylglycidaatstereoisomeren, omzettingsprodukten daarvan met 2-nitrothiofenol en de bereiding van diltiazem.
IT1217765B (it) * 1988-06-02 1990-03-30 Montedison Spa Processo per la risoluzione enzimatica degli isomeri ottici di derivati racemi esterei dell,acido 3 mercapto 2 alchilpropionico
FI95931C (fi) * 1988-09-02 1996-04-10 Tanabe Seiyaku Co Menetelmä (2R,3S)-3-(4-metoksifenyyli)glysidiinihapon alemman alkyyliesterin valmistamiseksi
DE3833774C1 (it) * 1988-10-05 1990-04-26 Fischer-Werke Artur Fischer Gmbh & Co Kg, 7244 Waldachtal, De
US5108916A (en) * 1989-06-05 1992-04-28 Rhone-Poulenc Rorer, S.A. Process for stereoselectively hydrolyzing, transesterifying or esterifying with immobilized isozyme of lipase from candida rugosa
US5244803A (en) * 1989-09-13 1993-09-14 Tanabe Seiyaku Co., Ltd. Process for preparing optically active 3-phenylglycidic acid esters
JPH0779706B2 (ja) * 1990-03-22 1995-08-30 田辺製薬株式会社 ２―クロロ―３―ヒドロキシ―３―フエニルプロピオン酸エステル類の製法
IT1240651B (it) * 1990-05-17 1993-12-17 Zambon Spa Processo per la risoluzione di derivati glicidici
FR2672600B1 (fr) * 1991-02-08 1994-10-14 Synthelabo Procede de preparation du (-)-(2r,3s)-2,3-epoxy-3-(4-methoxyphenyl) propionate de methyle.
NL9202208A (nl) * 1992-12-18 1994-07-18 Dsm Nv Werkwijze voor de enzymatische bereiding van optisch aktieve glycidezure esters.

Also Published As

Publication number Publication date
GB9120710D0 (en) 1991-11-13
ATA99591A (de) 1995-05-15
SE9101482D0 (sv) 1991-05-16
JPH04228095A (ja) 1992-08-18
GB2247020B (en) 1993-12-15
CH682670A5 (it) 1993-10-29
JP2000139492A (ja) 2000-05-23
ES2033203B1 (es) 1993-12-16
FR2662178A1 (fr) 1991-11-22
DE4115697A1 (de) 1991-11-21
SE509297C2 (sv) 1999-01-11
FR2662178B1 (fr) 1995-05-05
BE1005406A0 (fr) 1993-07-13
GB2247020A (en) 1992-02-19
IT1249777B (it) 1995-03-18
DE4115697C2 (de) 2000-09-07
NL194616B (nl) 2002-05-01
NL194616C (nl) 2002-09-03
GB2246351B (en) 1993-12-15
GB2246351A (en) 1992-01-29
GB9110610D0 (en) 1991-07-03
NL9100854A (nl) 1991-12-16
IT9020348A1 (it) 1991-11-17
SE9101482L (sv) 1991-11-18
JP3223317B2 (ja) 2001-10-29
US5571704A (en) 1996-11-05
AT400446B (de) 1995-12-27
US6346632B1 (en) 2002-02-12
CA2042535A1 (en) 1991-11-18
JP3060187B2 (ja) 2000-07-10
ES2033203A1 (es) 1993-03-01
CA2042535C (en) 1998-06-16

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970507