IN2015KN00323A - - Google Patents

Info

Publication number
IN2015KN00323A
IN2015KN00323A IN323KON2015A IN2015KN00323A IN 2015KN00323 A IN2015KN00323 A IN 2015KN00323A IN 323KON2015 A IN323KON2015 A IN 323KON2015A IN 2015KN00323 A IN2015KN00323 A IN 2015KN00323A
Authority
IN
India
Prior art keywords
preparation
umeclidinium bromide
processes
relates
present
Prior art date
Application number
Other languages
English (en)
Inventor
Frank Hossner
John Bryce Strachan
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of IN2015KN00323A publication Critical patent/IN2015KN00323A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D453/00Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
IN323KON2015 2012-08-15 2013-08-14 IN2015KN00323A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261683369P 2012-08-15 2012-08-15
PCT/EP2013/067035 WO2014027045A1 (en) 2012-08-15 2013-08-14 Chemical process

Publications (1)

Publication Number Publication Date
IN2015KN00323A true IN2015KN00323A (pt) 2015-07-10

Family

ID=49080842

Family Applications (1)

Application Number Title Priority Date Filing Date
IN323KON2015 IN2015KN00323A (pt) 2012-08-15 2013-08-14

Country Status (12)

Country Link
US (2) US9273001B2 (pt)
EP (2) EP2885298B1 (pt)
JP (2) JP6389174B2 (pt)
KR (1) KR20150043465A (pt)
CN (2) CN104619706B (pt)
AU (3) AU2013304102B2 (pt)
BR (1) BR112015003101B1 (pt)
CA (1) CA2881935A1 (pt)
ES (2) ES2893473T3 (pt)
IN (1) IN2015KN00323A (pt)
RU (1) RU2644160C2 (pt)
WO (1) WO2014027045A1 (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3148521B1 (en) 2014-05-28 2019-12-18 GlaxoSmithKline Intellectual Property Development Limited Fluticasone furoate in the treatment of copd
EP3215489B1 (en) 2014-11-03 2019-07-24 OLON S.p.A. Method for the preparation of 1-(2-halogen-ethyl)-4 piperidine-carboxylic acid ethyl esters
PT108370B (pt) 2015-03-30 2018-10-25 Hovione Farm S A Processo de preparação de brometo de aclidínio
EP3248970A1 (en) 2016-05-27 2017-11-29 Zentiva K.S. Forms of umeclidinium bromide
PT109740B (pt) * 2016-11-14 2020-07-30 Hovione Farmaciencia Sa Processo para a preparação de brometo de umeclidínio
CN108069956B (zh) * 2016-11-18 2021-03-16 扬州奥锐特药业有限公司 1-氮杂双环[2,2,2]辛-4-基苯基酮化合物及其制备方法和应用
IT201700058796A1 (it) * 2017-05-30 2018-11-30 Olon Spa Procedimento per la preparazione di un nuovo intermedio di sintesi dell’umeclidinio.
CN107935917A (zh) * 2017-10-30 2018-04-20 广东莱佛士制药技术有限公司 一种1‑(2‑氯乙基)‑4‑哌啶甲酸酯的合成方法
CN109956938A (zh) * 2017-12-26 2019-07-02 天津金耀集团有限公司 乌美溴铵中间体晶型及其制备方法和以该中间体制备乌美溴铵的方法
CN108558860B (zh) * 2018-06-04 2020-12-25 成都伊诺达博医药科技有限公司 一种合成芜地溴铵的方法
PT115583B (pt) * 2019-06-17 2022-05-02 Hovione Farm S A Processo contínuo para a preparação de medicamentos anticolinérgicos
PT117440B (pt) 2021-09-03 2024-04-26 Hovione Farm S A Processo para a preparação de aminas cíclicas cloroaquilo substituídas
CN117310022B (zh) * 2023-09-22 2024-05-17 山东泰合医药科技有限公司 一种分离和检测乌美溴铵中间体奎宁环二苯甲醇有关物质的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3998832A (en) * 1975-04-16 1976-12-21 G. D. Searle & Co. Anti-diarrheal compounds
US4540780A (en) * 1983-06-02 1985-09-10 Warner-Lambert Company Diphenylmethylene piperidines
FR2816618B1 (fr) * 2000-11-15 2002-12-27 Aventis Pharma Sa Derives heterocyclylalcoyl piperidine, leur preparation et les compositions qui les contiennent
MY144753A (en) * 2004-04-27 2011-10-31 Glaxo Group Ltd Muscarinic acetylcholine receptor antagonists
GB0519879D0 (en) * 2005-09-30 2005-11-09 Astrazeneca Ab Chemical process
JP4841279B2 (ja) * 2006-03-23 2011-12-21 一般財団法人 化学物質評価研究機構 被検物質の発がん性予測方法
WO2011029896A1 (en) * 2009-09-11 2011-03-17 Glaxo Group Limited Methods of preparation of muscarinic acetylcholine receptor antagonists
SG192144A1 (en) * 2011-01-31 2013-08-30 Bristol Myers Squibb Co C-17 and c-3 modified triterpenoids with hiv maturation inhibitory activity

Also Published As

Publication number Publication date
EP3401316A1 (en) 2018-11-14
AU2016213768B2 (en) 2018-01-04
EP2885298A1 (en) 2015-06-24
US20150232423A1 (en) 2015-08-20
US20160159786A1 (en) 2016-06-09
JP6799037B2 (ja) 2020-12-09
JP2015524832A (ja) 2015-08-27
AU2013304102B2 (en) 2016-09-01
AU2013304102A1 (en) 2015-02-26
AU2016213768A1 (en) 2016-09-01
BR112015003101A2 (pt) 2017-07-04
AU2016262787A1 (en) 2016-12-15
CN104619706B (zh) 2017-06-20
CN107163038A (zh) 2017-09-15
CN107163038B (zh) 2020-07-28
EP2885298B1 (en) 2018-06-13
US9273001B2 (en) 2016-03-01
ES2893473T3 (es) 2022-02-09
KR20150043465A (ko) 2015-04-22
EP3401316B1 (en) 2021-08-04
RU2644160C2 (ru) 2018-02-08
CN104619706A (zh) 2015-05-13
US9657011B2 (en) 2017-05-23
RU2015104269A (ru) 2016-10-10
ES2678697T3 (es) 2018-08-16
BR112015003101B1 (pt) 2022-06-14
CA2881935A1 (en) 2014-02-20
JP6389174B2 (ja) 2018-09-12
WO2014027045A1 (en) 2014-02-20
JP2018203752A (ja) 2018-12-27

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