IN2015DN02501A - - Google Patents

Info

Publication number
IN2015DN02501A
IN2015DN02501A IN2501DEN2015A IN2015DN02501A IN 2015DN02501 A IN2015DN02501 A IN 2015DN02501A IN 2501DEN2015 A IN2501DEN2015 A IN 2501DEN2015A IN 2015DN02501 A IN2015DN02501 A IN 2015DN02501A
Authority
IN
India
Prior art keywords
trpv
vanilloid
receptor
prevention
expression
Prior art date
Application number
Other languages
English (en)
Inventor
Anton Ana Isabel Jimenez
Fajardo Victoria Gonzalez
Palomar Veronica Ruz
Original Assignee
Sylentis Sau
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sylentis Sau filed Critical Sylentis Sau
Publication of IN2015DN02501A publication Critical patent/IN2015DN02501A/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/04Artificial tears; Irrigation solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering N.A.
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/32Chemical structure of the sugar
    • C12N2310/3212'-O-R Modification

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
IN2501DEN2015 2012-09-05 2013-09-04 IN2015DN02501A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1215857.2A GB201215857D0 (en) 2012-09-05 2012-09-05 siRNA and their use in methods and compositions for the treatment and/or prevention of eye conditions
PCT/EP2013/068245 WO2014037377A1 (fr) 2012-09-05 2013-09-04 Arnsi et leur utilisation dans des méthodes et des compositions de traitement et/ou de prévention d'états de l'œil

Publications (1)

Publication Number Publication Date
IN2015DN02501A true IN2015DN02501A (fr) 2015-09-11

Family

ID=47136985

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2501DEN2015 IN2015DN02501A (fr) 2012-09-05 2013-09-04

Country Status (30)

Country Link
US (1) US9808479B2 (fr)
EP (1) EP2893019B1 (fr)
JP (2) JP2015529210A (fr)
KR (1) KR102136539B1 (fr)
CN (2) CN104640988A (fr)
AU (1) AU2013311781B2 (fr)
BR (1) BR112015004469B8 (fr)
CA (1) CA2883040C (fr)
CL (1) CL2015000537A1 (fr)
CY (1) CY1121000T1 (fr)
DK (1) DK2893019T3 (fr)
EC (1) ECSP15009391A (fr)
ES (1) ES2685346T3 (fr)
GB (1) GB201215857D0 (fr)
HK (1) HK1212377A1 (fr)
HR (1) HRP20181079T1 (fr)
HU (1) HUE040096T2 (fr)
IL (1) IL237389B (fr)
IN (1) IN2015DN02501A (fr)
LT (1) LT2893019T (fr)
MX (1) MX362854B (fr)
PE (1) PE20150619A1 (fr)
PL (1) PL2893019T3 (fr)
PT (1) PT2893019T (fr)
RS (1) RS57620B1 (fr)
RU (1) RU2663100C2 (fr)
SG (1) SG11201501386TA (fr)
SI (1) SI2893019T1 (fr)
WO (1) WO2014037377A1 (fr)
ZA (1) ZA201501494B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2833778C (fr) 2011-06-30 2021-09-28 Arrowhead Research Corporation Compositions et methodes permettant d'inhiber l'expression d'un gene du virus de l'hepatite b
WO2017027350A2 (fr) 2015-08-07 2017-02-16 Arrowhead Pharmaceuticals, Inc. Thérapie par interférence arn pour l'infection par le virus de l'hépatite b
JOP20170161A1 (ar) 2016-08-04 2019-01-30 Arrowhead Pharmaceuticals Inc عوامل RNAi للعدوى بفيروس التهاب الكبد ب
JP2022520832A (ja) 2019-02-15 2022-04-01 ノバルティス アーゲー 眼表面疼痛を治療する方法
JP6994061B2 (ja) 2019-02-15 2022-01-14 ノバルティス アーゲー 4-(7-ヒドロキシ-2-イソプロピル-4-オキソ-4h-キナゾリン-3-イル)-ベンゾニトリルの製剤
JP7025094B2 (ja) * 2019-10-04 2022-02-24 千寿製薬株式会社 ヘテロシクリデンアセトアミド誘導体含有医薬

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4343794A (en) 1980-05-06 1982-08-10 Mt. Sinai Method of reducing intraocular pressure with salts of vanadic acid
US4652586A (en) 1980-11-07 1987-03-24 The General Hospital Corporation Selective beta-2 adrenergic antagonists for the treatment of glaucoma
US4617299A (en) 1983-12-19 1986-10-14 Knepper Paul A Method for the prevention of ocular hypertension, treatment of glaucoma and treatment of ocular hypertension
US5242943A (en) 1984-03-28 1993-09-07 William J. Louis 3-aminopropoxyphenyl derivatives, their preparation and pharmaceutical compositions containing them
US4812448A (en) 1984-10-22 1989-03-14 Knepper Paul A Method for the prevention of ocular hypertension, treatment of glaucoma and treatment of ocular hypertension
US4757089A (en) 1985-06-14 1988-07-12 Massachusetts Eye And Ear Infirmary Increasing aqueous humor outflow
US5075323A (en) 1988-08-24 1991-12-24 Aktiebolaget Hassle Compounds including omeprazole in the treatment of glaucoma
US5260059A (en) 1989-04-14 1993-11-09 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon Health Sciences University Treatment of open-angle glaucoma by modulation matrix metalloproteinases and their inhibitor
US6372249B1 (en) 1991-12-16 2002-04-16 Baylor College Of Medicine Senscent cell-derived inhibitors of DNA synthesis
US5464866A (en) 1992-08-17 1995-11-07 Alcon Laboratories, Inc. Substituted hydrindanes for the treatment of angiogenesis-dependent diseases
US5545626A (en) 1994-01-19 1996-08-13 The Trustees Of Columbia University In The City Of New York Method of treating glaucoma with oligonucleotides
US5585401A (en) 1994-12-09 1996-12-17 The Reents Of The University Of California Method for enhancing outflow of aqueous humor in treatment of glaucoma
US20020055536A1 (en) 1996-09-26 2002-05-09 Dewitte Robert S. System and method for structure-based drug design that includes accurate prediction of binding free energy
US6489307B1 (en) 1998-09-14 2002-12-03 University Of Florida Antisense compositions targeted to β1-adrenoceptor-specific mRNA and methods of use
EP1147204A1 (fr) 1999-01-28 2001-10-24 Medical College Of Georgia Research Institute, Inc. Composition et methode destinees a l'attenuation in vivo et in vitro de l'expression genique utilisant de l'arn double brin
US6365576B1 (en) 1999-06-24 2002-04-02 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Method for inhibiting herpes infection
CZ302719B6 (cs) 2000-12-01 2011-09-21 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Izolovaná molekula dvouretezcové RNA, zpusob její výroby a její použití
US20020165158A1 (en) 2001-03-27 2002-11-07 King George L. Methods of modulating angiogenesis
US20070049543A1 (en) 2001-05-18 2007-03-01 Sirna Therapeutics, Inc. RNA interference mediated inhibition of 11 beta-hydroxysteroid dehydrogenase-1 (11 beta-HSD-1) gene expression using short interfering nucleic acid siNA
US20040209832A1 (en) 2001-11-30 2004-10-21 Mcswiggen James RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
US20050148530A1 (en) 2002-02-20 2005-07-07 Sirna Therapeutics, Inc. RNA interference mediated inhibition of vascular endothelial growth factor and vascular endothelial growth factor receptor gene expression using short interfering nucleic acid (siNA)
US20030148987A1 (en) 2001-12-21 2003-08-07 Morris David J. Selective 11beta-HSD inhibitors and methods of use thereof
US7294504B1 (en) 2001-12-27 2007-11-13 Allele Biotechnology & Pharmaceuticals, Inc. Methods and compositions for DNA mediated gene silencing
AU2003207708A1 (en) 2002-02-20 2003-09-09 Sirna Therapeutics, Inc. Rna interference mediated inhibition of map kinase genes
GB2406568B (en) 2002-02-20 2005-09-28 Sirna Therapeutics Inc RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
EP1495120B1 (fr) 2002-04-18 2012-10-10 Acuity Pharmaceuticals, Inc Moyens et procedes pour la modulation specifique de genes cibles dans l'oeil
US20040115641A1 (en) 2002-12-11 2004-06-17 Isis Pharmaceuticals Inc. Modulation of ROCK 1 expression
EP1554386A2 (fr) 2002-07-24 2005-07-20 Immusol Incorporated Systeme a un seul promoteur pour la production de cassettes d'expression d'arnsi et genotheque d'expression reposant sur l'utilisation d'un lieur en epingle a cheveux d'amorce de polymerase
JP2005533503A (ja) 2002-07-24 2005-11-10 イミューソル インコーポレイテッド 新規なsiRNA遺伝子ライブラリー、その製造方法及び使用
MXPA05001355A (es) 2002-08-05 2005-09-30 Atugen Ag Formas nuevas adicionales de moleculas de arn de interferencia.
US20040029275A1 (en) 2002-08-10 2004-02-12 David Brown Methods and compositions for reducing target gene expression using cocktails of siRNAs or constructs expressing siRNAs
CA2881743A1 (fr) 2002-09-25 2004-04-08 University Of Massachusetts Silencage genique in vivo effectue par un siarn stable et chimiquement odifie
CA2504926C (fr) 2002-11-01 2014-01-14 The Trustees Of The University Of Pennsylvania Compositions et procedes destines a l'inhibition par arnsi des hif-1 alpha
DE10322662A1 (de) 2002-11-06 2004-10-07 Grünenthal GmbH Wirksame und stabile DNA-Enzyme
AU2003295600A1 (en) 2002-11-14 2004-06-15 Dharmacon, Inc. Functional and hyperfunctional sirna
WO2006006948A2 (fr) 2002-11-14 2006-01-19 Dharmacon, Inc. Methodes et compositions permettant de selectionner des arnsi presentant une fonctionnalite amelioree
US7250496B2 (en) 2002-11-14 2007-07-31 Rosetta Genomics Ltd. Bioinformatically detectable group of novel regulatory genes and uses thereof
US20060257851A1 (en) 2002-11-26 2006-11-16 Itzhak Bentwich Bioinformatically detectable group of novel viral regulatory genes and uses thereof
US20040167090A1 (en) 2003-02-21 2004-08-26 Monahan Sean D. Covalent modification of RNA for in vitro and in vivo delivery
GB0307206D0 (en) 2003-03-28 2003-04-30 Axordia Ltd Hyperproliferation
US20040198640A1 (en) 2003-04-02 2004-10-07 Dharmacon, Inc. Stabilized polynucleotides for use in RNA interference
WO2004099372A2 (fr) 2003-05-01 2004-11-18 University Of Florida Ribozymes anti-cicatrisants et methodes associees
US20040224405A1 (en) 2003-05-06 2004-11-11 Dharmacon Inc. siRNA induced systemic gene silencing in mammalian systems
US20060241072A1 (en) 2003-06-20 2006-10-26 Isis Pharmaceuticals, Inc. Oligomeric compounds for use in gene modulation
US7338950B2 (en) 2003-10-07 2008-03-04 Renovis, Inc. Amide compounds as ion channel ligands and uses thereof
KR20050039573A (ko) 2003-10-23 2005-04-29 주식회사 태평양 티오우레아계 유도체의 용해성과 생체이용률이 개선된약제학적 조성물
WO2005045037A2 (fr) 2003-10-23 2005-05-19 Sirna Therapeutics, Inc. Inhibition mediee par une interference arn de 5-alpha reductase et expression genique du recepteur d'androgenes faisant appel a un petit acide nucleique interferant (sina)
US20050208658A1 (en) 2003-11-21 2005-09-22 The University Of Maryland RNA interference mediated inhibition of 11beta hydroxysteriod dehydrogenase-1 (11beta HSD-1) gene expression
SG187381A1 (en) * 2003-12-03 2013-02-28 Coda Therapeutics Nz Ltd Antisense compounds targeted to connexins and methods of use thereof
US7544803B2 (en) 2004-01-23 2009-06-09 Amgen Inc. Vanilloid receptor ligands and their use in treatments
WO2005076998A2 (fr) 2004-02-05 2005-08-25 Intradigm Corporation Therapeutique par des agents rnai appliquee dans le traitement de maladies oculaires resultant d'une neovascularisation
GB0403600D0 (en) 2004-02-18 2004-03-24 Trinity College Dublin Methods and reagents for treating disease
WO2005089224A2 (fr) 2004-03-12 2005-09-29 Alnylam Pharmaceuticals, Inc. Agents arni ciblant le facteur de croissance de l'endothelium vasculaire (vegf)
KR101147147B1 (ko) 2004-04-01 2012-05-25 머크 샤프 앤드 돔 코포레이션 Rna 간섭의 오프 타겟 효과 감소를 위한 변형된폴리뉴클레오타이드
WO2005117938A2 (fr) 2004-04-13 2005-12-15 Regents Of The University Of Minnesota Methodes de traitement des pathologies oculaires
US7687665B2 (en) 2004-06-24 2010-03-30 Incyte Corporation 2-methylprop anamides and their use as pharmaceuticals
AU2005272816B2 (en) 2004-08-10 2011-08-11 Alnylam Pharmaceuticals, Inc. Chemically modified oligonucleotides
EP2298892A3 (fr) 2004-08-23 2011-11-16 Sylentis S.A.U. Traitement de troubles oculaires caractérisés par une pression intraoculaire élevée à l'aide de siRNAs
TW200639252A (en) 2005-02-01 2006-11-16 Alcon Inc RNAi-mediated inhibition of ocular hypertension targets
AU2006223131A1 (en) 2005-03-11 2006-09-21 Alcon, Inc. RNAi-mediated inhibition of frizzled related protein-1 for treatment of glaucoma
GB0521351D0 (en) 2005-10-20 2005-11-30 Genomica Sau Modulation of TRPV expression levels
US20080051361A1 (en) * 2006-08-24 2008-02-28 Alcon Manufacturing, Ltd. Rnai-mediated inhibition of gremlin for treatment of iop-related conditions
US20110160279A1 (en) 2007-08-13 2011-06-30 Board Of Trustees Of Southern Illinois University METHODS FOR TREATMENT AND PREVENTION OF OTOTOXICITY BY siRNA
TW200927192A (en) * 2007-11-19 2009-07-01 Alcon Res Ltd Use of TRPV1 receptor antagonists for treating dry eye and ocular pain
CN201337650Y (zh) * 2009-01-06 2009-11-04 河北科技大学 一次性药用单剂量液体容器
EP2390327A1 (fr) * 2010-05-27 2011-11-30 Sylentis S.A. ARNsi et leur utilisation dans des procédés et des compositions pour le traitement et/ou la prévention de maladies oculaires

Also Published As

Publication number Publication date
PT2893019T (pt) 2018-10-19
EP2893019B1 (fr) 2018-05-30
RU2015112121A (ru) 2016-10-27
KR20150047513A (ko) 2015-05-04
IL237389B (en) 2019-01-31
ZA201501494B (en) 2016-01-27
ECSP15009391A (es) 2015-12-31
EP2893019A1 (fr) 2015-07-15
HUE040096T2 (hu) 2019-02-28
DK2893019T3 (en) 2018-09-03
MX362854B (es) 2019-02-20
CA2883040A1 (fr) 2014-03-13
WO2014037377A1 (fr) 2014-03-13
GB201215857D0 (en) 2012-10-24
PL2893019T3 (pl) 2018-12-31
IL237389A0 (en) 2015-04-30
CA2883040C (fr) 2023-01-17
JP2015529210A (ja) 2015-10-05
KR102136539B1 (ko) 2020-07-23
MX2015002802A (es) 2015-05-15
CN104640988A (zh) 2015-05-20
PE20150619A1 (es) 2015-05-11
BR112015004469B8 (pt) 2022-12-06
LT2893019T (lt) 2018-08-10
CY1121000T1 (el) 2019-12-11
RU2663100C2 (ru) 2018-08-01
SG11201501386TA (en) 2015-03-30
CL2015000537A1 (es) 2015-07-10
CN108354944A (zh) 2018-08-03
US9808479B2 (en) 2017-11-07
JP6742362B2 (ja) 2020-08-19
AU2013311781A1 (en) 2015-03-12
HK1212377A1 (en) 2016-06-10
SI2893019T1 (sl) 2018-09-28
AU2013311781B2 (en) 2018-10-18
BR112015004469B1 (pt) 2022-11-16
ES2685346T3 (es) 2018-10-08
BR112015004469A2 (pt) 2017-08-08
JP2018138596A (ja) 2018-09-06
HRP20181079T1 (hr) 2018-09-07
US20150224131A1 (en) 2015-08-13
RS57620B1 (sr) 2018-11-30

Similar Documents

Publication Publication Date Title
AU2018236800B2 (en) DNA-PK inhibitors
PH12015500525A1 (en) Formulations of enzalutamide
MX2019003623A (es) Composiciones y metodos para el tratamiento de afecciones oftalmicas.
IN2015DN01156A (fr)
PH12016501578A1 (en) Pharmaceutical compounds
GB201103062D0 (en) Method
PH12016501724A1 (en) Isoindolinone compounds as gpr119 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders
MX2017004808A (es) Combinaciones que comprenden siponimod y laquinimod para el tratamiento de la esclerosis multiple.
PH12018501279A1 (en) Compositions comprising 15-hepe and methods of using the same
IN2015DN02501A (fr)
IN2013MU03641A (fr)
MY180844A (en) Solid pharmaceutical compositions comprising biopterin derivatives and uses of such compositions
MX2017014456A (es) Usos terapeuticos de l-4-cloroquinurenina.
PH12016500495A1 (en) Compositions for the treatment of hypertension and/or fibrosis
TR201909158T4 (tr) siRNA ve göz rahatsızlıklarının tedavisi ve/veya önlenmesine yönelik yöntemler ve bileşimlerde kullanımları.
GB201213484D0 (en) Pharmaceutical compositions comprising 15-OHEPA and methods of using the same
HK1210417A1 (en) Compositions, methods and/or devices for prevention and/or treatment of dry eye disorders //
MX363385B (es) Métodos para el tratamiento de enfermedad de células falciformes y otras condiciones inflamatorias.
GEP20186920B (en) Halogenated quinazolinthf-amines as pde1 inhibitors
IN2014DN08443A (fr)
MY182818A (en) Compositions for the treatment of fibrosis and fibrosis-related conditions
IN2013MU03317A (fr)
IN2014KN02584A (fr)
PH12016500824A1 (en) Compositions and methods for the treatment of viral diseases with pde4 modulators
WO2014068327A3 (fr) Agents pour la prévention et/ou le traitement de lésions du système nerveux central