IN2012DN00801A - - Google Patents

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Publication number
IN2012DN00801A
IN2012DN00801A IN801DEN2012A IN2012DN00801A IN 2012DN00801 A IN2012DN00801 A IN 2012DN00801A IN 801DEN2012 A IN801DEN2012 A IN 801DEN2012A IN 2012DN00801 A IN2012DN00801 A IN 2012DN00801A
Authority
IN
India
Prior art keywords
adamts
expression
methods
useful
proteins
Prior art date
Application number
Other languages
English (en)
Inventor
Grillberger Leopold
Spenger Alexandra
Hasslacher Meinhard
Grillberger Rana
Reiter Manfred
Original Assignee
Baxter Int
Baxter Healthcare Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxter Int, Baxter Healthcare Sa filed Critical Baxter Int
Publication of IN2012DN00801A publication Critical patent/IN2012DN00801A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0681—Cells of the genital tract; Non-germinal cells from gonads
    • C12N5/0682—Cells of the female genital tract, e.g. endometrium; Non-germinal cells from ovaries, e.g. ovarian follicle cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0684—Cells of the urinary tract or kidneys
    • C12N5/0686—Kidney cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24087—ADAMTS13 endopeptidase (3.4.24.87)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/12—Light metals, i.e. alkali, alkaline earth, Be, Al, Mg
    • C12N2500/14—Calcium; Ca chelators; Calcitonin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/22—Zinc; Zn chelators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/38—Vitamins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C12N2500/95—Protein-free medium and culture conditions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/99—Serum-free medium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
IN801DEN2012 2009-07-31 2010-07-30 IN2012DN00801A (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23047709P 2009-07-31 2009-07-31
PCT/US2010/044020 WO2011014838A1 (en) 2009-07-31 2010-07-30 Cell culture medium for adamts protein expression

Publications (1)

Publication Number Publication Date
IN2012DN00801A true IN2012DN00801A (de) 2015-06-26

Family

ID=42668009

Family Applications (1)

Application Number Title Priority Date Filing Date
IN801DEN2012 IN2012DN00801A (de) 2009-07-31 2010-07-30

Country Status (22)

Country Link
US (7) US8313926B2 (de)
EP (1) EP2459702B1 (de)
JP (5) JP5451884B2 (de)
KR (5) KR101573972B1 (de)
CN (2) CN102549145B (de)
AU (1) AU2010278751B2 (de)
BR (2) BR122021005965B1 (de)
CA (1) CA2769361A1 (de)
CO (1) CO6501191A2 (de)
EA (1) EA023193B1 (de)
ES (1) ES2583258T3 (de)
HK (1) HK1171790A1 (de)
HR (1) HRP20160783T1 (de)
HU (1) HUE029110T2 (de)
IN (1) IN2012DN00801A (de)
MX (2) MX2012001261A (de)
NZ (1) NZ597727A (de)
PL (1) PL2459702T3 (de)
PT (1) PT2459702T (de)
SG (1) SG178194A1 (de)
SI (1) SI2459702T1 (de)
WO (1) WO2011014838A1 (de)

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PL2459702T3 (pl) * 2009-07-31 2016-12-30 Pożywka do hodowli komórkowej do ekspresji białka adamts
CN107286235A (zh) * 2010-07-08 2017-10-24 百深有限责任公司 在细胞培养物中生产重组高分子量 vWF 的方法
CN103827292B (zh) 2011-07-01 2018-01-26 安姆根有限公司 哺乳动物细胞培养
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WO2014159831A1 (en) 2013-03-13 2014-10-02 Merck Sharp & Dohme Corp. Adapted lepidopteran insect cells for the production of recombinant proteins
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AR095196A1 (es) 2013-03-15 2015-09-30 Regeneron Pharma Medio de cultivo celular libre de suero
AU2014336555B2 (en) * 2013-10-14 2020-12-03 Ares Trading S.A New medium for high performance mammalian fed-batch cultures
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EP4155399A1 (de) * 2015-05-22 2023-03-29 DuPont Nutrition Biosciences ApS Acetolactat-decarboxylase
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JP2019527689A (ja) 2016-08-04 2019-10-03 バクスアルタ インコーポレイテッド 鎌状赤血球症における血管閉塞性クリーゼ、急性肺障害、および／または急性呼吸窮迫症候群を治療、改善および／または予防するためのａｄａｍｔｓ１３の使用
ES2948849T3 (es) * 2016-11-04 2023-09-20 Takeda Pharmaceuticals Co Métodos de purificación de virus adenoasociado
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CA3172625A1 (en) 2019-12-06 2021-06-10 Regeneron Pharmaceuticals, Inc. Anti-vegf protein compositions and methods for producing the same
CN115836126A (zh) 2020-04-02 2023-03-21 武田药品工业株式会社 Adamts13变体、组合物及其用途
US20230201319A1 (en) 2020-05-22 2023-06-29 Takeda Pharmaceutical Company Limited Adamts13 compositions and methods for treating and diagnosing complications of coronavirus disease
CN111808822B (zh) * 2020-07-02 2024-01-12 北京百普赛斯生物科技股份有限公司 细胞培养用补料液及提高重组hek293细胞蛋白表达量的方法

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Also Published As

Publication number Publication date
CN104962539B (zh) 2019-09-17
AU2010278751B2 (en) 2014-05-15
CN102549145B (zh) 2015-05-20
JP2013500724A (ja) 2013-01-10
SI2459702T1 (sl) 2016-11-30
US10724024B2 (en) 2020-07-28
US9441216B2 (en) 2016-09-13
PL2459702T3 (pl) 2016-12-30
MX2012001261A (es) 2012-05-22
JP7083059B2 (ja) 2022-06-09
CA2769361A1 (en) 2011-02-03
JP2019201661A (ja) 2019-11-28
BR112012002151B1 (pt) 2021-07-06
US20140329294A1 (en) 2014-11-06
US8313926B2 (en) 2012-11-20
US9127265B2 (en) 2015-09-08
CO6501191A2 (es) 2012-08-15
WO2011014838A1 (en) 2011-02-03
HK1171790A1 (zh) 2013-04-05
US11254921B2 (en) 2022-02-22
US20150329848A1 (en) 2015-11-19
US20130071906A1 (en) 2013-03-21
JP2014061005A (ja) 2014-04-10
ES2583258T3 (es) 2016-09-20
NZ597727A (en) 2013-08-30
JP2021112210A (ja) 2021-08-05
EA023193B1 (ru) 2016-05-31
JP2018093881A (ja) 2018-06-21
HUE029110T2 (en) 2017-02-28
KR20120046301A (ko) 2012-05-09
KR101808496B1 (ko) 2017-12-12
KR20150138425A (ko) 2015-12-09
US20190071660A1 (en) 2019-03-07
KR101574056B1 (ko) 2015-12-02
JP5451884B2 (ja) 2014-03-26
CN104962539A (zh) 2015-10-07
US8759026B2 (en) 2014-06-24
BR122021005965B1 (pt) 2022-01-25
BR112012002151A2 (pt) 2020-03-03
US10072254B2 (en) 2018-09-11
EA201270224A1 (ru) 2012-09-28
KR20170081747A (ko) 2017-07-12
CN102549145A (zh) 2012-07-04
US20170051270A1 (en) 2017-02-23
US20110086413A1 (en) 2011-04-14
US20200308566A1 (en) 2020-10-01
JP6883071B2 (ja) 2021-06-09
MX344970B (es) 2017-01-12
KR101756354B1 (ko) 2017-07-26
JP2016144471A (ja) 2016-08-12
KR20170140411A (ko) 2017-12-20
KR101912552B1 (ko) 2018-10-26
JP5936232B2 (ja) 2016-06-22
JP6567707B2 (ja) 2019-08-28
AU2010278751A1 (en) 2012-02-09
SG178194A1 (en) 2012-03-29
HRP20160783T1 (hr) 2016-08-12
EP2459702B1 (de) 2016-05-04
KR20150044981A (ko) 2015-04-27
EP2459702A1 (de) 2012-06-06
PT2459702T (pt) 2016-08-02
KR101573972B1 (ko) 2015-12-02
JP6511007B2 (ja) 2019-05-08

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