IN1998KO01500A - - Google Patents

Info

Publication number
IN1998KO01500A
IN1998KO01500A IN1500KO1998A IN1998KO01500A IN 1998KO01500 A IN1998KO01500 A IN 1998KO01500A IN 1500KO1998 A IN1500KO1998 A IN 1500KO1998A IN 1998KO01500 A IN1998KO01500 A IN 1998KO01500A
Authority
IN
India
Application number
Other languages
English (en)
Inventor
Bao-Shan Huang
Aris Christodoulou
Yansong Lu
Ben-Yi Ji
Original Assignee
Penick Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25401603&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IN1998KO01500(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Penick Corp filed Critical Penick Corp
Publication of IN1998KO01500A publication Critical patent/IN1998KO01500A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D489/00Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08Oxygen atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D489/00Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
IN1500KO1998 1997-07-11 1998-08-21 IN1998KO01500A (enExample)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/893,464 US5869669A (en) 1996-07-26 1997-07-11 Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates

Publications (1)

Publication Number Publication Date
IN1998KO01500A true IN1998KO01500A (enExample) 2005-03-11

Family

ID=25401603

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1500KO1998 IN1998KO01500A (enExample) 1997-07-11 1998-08-21

Country Status (19)

Country Link
US (7) US5869669A (enExample)
EP (1) EP1000065B1 (enExample)
JP (1) JP2001518444A (enExample)
KR (1) KR100363486B1 (enExample)
CN (1) CN1152880C (enExample)
AT (1) ATE291023T1 (enExample)
AU (1) AU740822B2 (enExample)
CA (1) CA2296035C (enExample)
DE (1) DE69829379D1 (enExample)
HU (1) HUP0003918A3 (enExample)
IL (1) IL133792A0 (enExample)
IN (1) IN1998KO01500A (enExample)
NO (1) NO20000111L (enExample)
RU (1) RU2183636C2 (enExample)
SK (1) SK102000A3 (enExample)
TR (1) TR200000033T2 (enExample)
TW (1) TW505648B (enExample)
WO (1) WO1999002529A1 (enExample)
ZA (1) ZA986144B (enExample)

Families Citing this family (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5912347A (en) * 1996-09-30 1999-06-15 Mallinckrodt Inc. Process for preparing a morphinan derivative
WO2000066588A1 (en) * 1999-05-05 2000-11-09 The Government Of The United States Of America, Represented By The Secretary, Departmentof Health A Nd Human Services Direct c-14 oxidation of opioids
US6177567B1 (en) * 1999-10-15 2001-01-23 Boehringer Ingelheim Chemicals, Inc. Method for preparing oxycodone
KR100901402B1 (ko) * 2001-08-23 2009-06-05 엔.브이.오가논 14-히드록시노르모르피논 유도체의 제조 방법
JP3961796B2 (ja) * 2001-08-27 2007-08-22 ソニー株式会社 情報提供システム、情報処理装置および方法、情報提供装置および方法、記録媒体、並びにプログラム
DE10161963A1 (de) * 2001-12-17 2003-07-03 Johannes Schuetz 6-Aminomorphinanderivate, Herstellungsverfahren dafür und deren Verwendung
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
US20040058946A1 (en) * 2002-07-05 2004-03-25 Buchwald Stephen L. Abuse-resistant prodrugs of oxycodone and other pharmaceuticals
RU2236412C2 (ru) * 2002-07-18 2004-09-20 Власов Михаил Иванович Способ получения производных морфинона, способ получения производных 14-гидроксиморфинона, и способ получения производных оксиморфона
RU2215741C1 (ru) * 2002-11-05 2003-11-10 Открытое Акционерное Общество "Международная Научно-Технологическая Корпорация" Сложные эфиры n-замещенных 14-гидроксиморфинанов и способ их получения
RU2215742C1 (ru) * 2002-11-05 2003-11-10 Открытое Акционерное Общество "Международная Научно-Технологическая Корпорация" Способ получения сложных эфиров n-замещенных 14-гидроксиморфинанов
US7285665B2 (en) * 2002-11-08 2007-10-23 Mallinckrodt Inc. Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
SI1575569T1 (sl) 2002-12-13 2010-12-31 Durect Corp Oralni sistem dostave zdravila, ki obsega visokoviskozne tekoče nosilne materiale
US6790959B1 (en) 2003-06-05 2004-09-14 Halsey Drug Company, Inc. Process for manufacturing thebaine
US6864370B1 (en) * 2003-06-05 2005-03-08 Zhaiwei Lin Process for manufacturing oxycodone
US7875718B2 (en) * 2003-09-22 2011-01-25 Johnson Matthey Public Limited Company Process for the synthesis of morphinane compounds and intermediates thereof
ES2627995T3 (es) 2003-09-22 2017-08-01 Glaxosmithkline Australia Pty Ltd Procedimiento para la síntesis de compuestos de morfinano y productos intermedios de los mismos
GEP20084454B (en) * 2004-02-06 2008-08-10 Euro Celtique Sa Methods for making 3-o-protected morphinones and 3-o-protected morphinone dienol carboxylates
TWI365880B (en) 2004-03-30 2012-06-11 Euro Celtique Sa Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone and oxycodone hydrochloride composition,pharmaceutical dosage form,sustained release oeal dosage form and pharmaceutically acceptable package having less than 25 pp
SK286047B6 (sk) * 2004-04-13 2008-01-07 Zentiva, A. S. Spôsob prípravy derivátov 4,5alfa-epoxy-6-oxomorfínanu
US6946556B1 (en) * 2004-05-21 2005-09-20 Acura Pharmaceuticals, Inc. Preparation of opioid analgesics by a one-pot process
CN1964976A (zh) * 2004-06-08 2007-05-16 马林克罗特公司 从鸦片中提取生物碱
DK1765292T3 (en) 2004-06-12 2018-01-02 Collegium Pharmaceutical Inc ABUSE PREVENTIONAL PHARMACEUTICAL FORMULATIONS
EP3103477A1 (en) 2004-09-17 2016-12-14 Durect Corporation Sustained local anesthetic composition containing saib
GB0421149D0 (en) * 2004-09-23 2004-10-27 Johnson Matthey Plc Preparation of oxycodone
GB0421687D0 (en) 2004-09-30 2004-11-03 Johnson Matthey Plc Preparation of opiate analgesics
WO2006084389A1 (de) * 2005-02-11 2006-08-17 Cilag Ltd. Verfahren zur reinigung von noroxymorphon-verbindungen
ME01594B (me) * 2005-03-04 2014-09-20 Euro Celtique Sa Postupak smanjenja alfa, beta nezasićenih ketona u opioidnim kompozicijama
CN101155814B (zh) * 2005-04-06 2010-06-16 东丽株式会社 吗啡喃衍生物的晶体及其制备方法
US8071768B2 (en) * 2005-06-10 2011-12-06 Janssen Pharmaceutica, N.V. Alkylquinoline and alkylquinazoline kinase modulators
ES2357216T3 (es) * 2005-06-16 2011-04-20 Mallinckrodt, Inc. Una ruta de síntesis de 14-hidroxil-opiáceos a través de 1-halo-tebaína o análogos.
US20070027105A1 (en) 2005-07-26 2007-02-01 Alza Corporation Peroxide removal from drug delivery vehicle
US20070117826A1 (en) * 2005-11-23 2007-05-24 Forest Laboratories, Inc. Pharmaceutical formulations comprising ibuprofen, oxycodone, and 14-hydroxycodeinone
CN101395159A (zh) 2006-03-02 2009-03-25 马林克罗特公司 制备含有低含量α,β-不饱和酮化合物的吗啡烷-6-酮产物的方法
SA07280459B1 (ar) 2006-08-25 2011-07-20 بيورديو فارما إل. بي. أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني
JP2010504325A (ja) * 2006-09-20 2010-02-12 マリンクロット インコーポレイテッド 置換モルフィナン−6−オン、並びにその塩および中間体の調製
CA2674915C (en) * 2006-10-17 2015-06-30 Penick Corporation Process for preparing oxymorphone
US20080125592A1 (en) * 2006-10-17 2008-05-29 Penick Corporation Process for preparing oxymorphone, naltrexone, and buprenorphine
AU2012216358B2 (en) * 2006-10-17 2014-11-20 Penick Corporation Process For Preparing Oxymorphone, Naltrexone and Buprenorphine
DK2073636T3 (da) 2006-10-17 2012-11-19 Penick Corp Fremgangsmåde til fremstilling af oxymorphon
PL2117521T3 (pl) 2006-11-03 2012-11-30 Durect Corp Transdermalne systemy dostarczania zawierające bupiwakainę
CA2671518C (en) * 2006-12-04 2016-06-07 Noramco, Inc. Process for preparing oxycodone having reduced levels of 14-hydroxycodeinone
ES2378710T3 (es) * 2006-12-04 2012-04-17 Noramco, Inc. Procedimiento para reducir impurezas en la base de oxicodona
GB0624880D0 (en) * 2006-12-14 2007-01-24 Johnson Matthey Plc Improved method for making analgesics
PL2137189T3 (pl) * 2007-03-06 2015-12-31 SpecGx LLC Sposób wytwarzania czwartorzędowych N-alkilowych soli alkaloidu morfinanowego
US9040726B2 (en) 2007-03-06 2015-05-26 Mallinckrodt Llc Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
CA2681740A1 (en) * 2007-03-23 2008-10-02 Mallinckrodt Inc. Improved preparation of oxymorphone from oripavine
ES2423180T3 (es) * 2007-04-16 2013-09-18 Mallinckrodt Llc Nueva reducción de opiáceos mediante reacción de transferencia de hidrógeno catalítica
US20090018154A1 (en) * 2007-05-17 2009-01-15 Endo Pharmaceuticals, Inc., A Corporation Of Delaware Opioid and methods of making and using the same
EP3326621A1 (en) 2007-12-06 2018-05-30 Durect Corporation Oral pharmaceutical dosage forms
NZ586187A (en) * 2007-12-17 2013-07-26 Mallinckrodt Llc Processes for the synthesis of sinomenine derivatives and their intermediate
AU2008338906B2 (en) * 2007-12-17 2013-06-27 SpecGx LLC Processes for the production of (+)-'nal' morphinan compounds
EP2250175B1 (en) 2008-02-29 2011-08-10 Mallinckrodt Inc. Process for the preparation of 3-hydroxymorphinan derivatives
AU2009239929B2 (en) * 2008-04-24 2014-02-13 Janssen Pharmaceutica Nv Nalmefene prodrugs
ES2641887T3 (es) * 2008-05-27 2017-11-14 Mallinckrodt Llc Procesos y compuestos para la preparación de normorfinanos
WO2010028004A2 (en) 2008-09-03 2010-03-11 Mallinckrodt Inc. Substituted berbines and processes for their synthesis
ES2566559T3 (es) * 2008-09-30 2016-04-13 Mallinckrodt Llc Procesos para la alquilación de grupos amino secundarios de derivados de morfinano
US20100260844A1 (en) 2008-11-03 2010-10-14 Scicinski Jan J Oral pharmaceutical dosage forms
UA102916C2 (uk) 2009-07-02 2013-08-27 Кемфарм, Інк. Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань
US10668060B2 (en) 2009-12-10 2020-06-02 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
TWI471289B (zh) 2010-06-11 2015-02-01 Rhodes Technologies 使三級胺進行n-脫烷反應之方法
EP2580201B1 (en) 2010-06-11 2017-08-02 Rhodes Technologies Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof
EP2588481B1 (en) 2010-07-02 2017-11-15 Johnson Matthey Public Limited Company Process for the synthesis and purification of oxycodone
RU2448709C1 (ru) * 2011-02-01 2012-04-27 Учреждение Российской академии наук Институт проблем химико-энергетических технологий Сибирского отделения РАН (ИПХЭТ СО РАН) Способ получения налтрексона
TWI560170B (en) * 2011-12-06 2016-12-01 Lundbeck & Co As H Process for recovery of nalmefene hydrochloride
US9315514B2 (en) 2012-08-27 2016-04-19 Rhodes Technologies 1,3-dioxanomorphides and 1,3-dioxanocodides
WO2014091297A1 (en) 2012-12-14 2014-06-19 Purdue Pharma L.P. Spirocyclic morphinans and their use
US8937084B2 (en) 2012-12-14 2015-01-20 Purdue Pharma L.P. Nitrogen containing morphinan derivatives and the use thereof
TWI513697B (zh) 2012-12-14 2015-12-21 Purdue Pharma Lp 吡啶酮並嗎啡喃類似物及其對類鴉片受體之生物活性
US8946255B2 (en) 2012-12-28 2015-02-03 Purdue Pharma L.P. Substituted morphinans and the use thereof
US8957084B2 (en) 2012-12-28 2015-02-17 Purdue Pharma L.P. 7,8-cyclicmorphinan analogs
JP6181770B2 (ja) 2012-12-31 2017-08-16 ローズ テクノロジーズ 7β−置換6α,14α−エテノモルフィナンおよび7β−置換6α,14α−エタノモルフィナンを調製するための方法
US9572885B2 (en) 2013-03-15 2017-02-21 Durect Corporation Compositions with a rheological modifier to reduce dissolution variability
EP2829541A1 (en) 2013-07-26 2015-01-28 Siegfried AG Novel synthesis of noroxymorphone from morphine
WO2015015146A1 (en) 2013-08-02 2015-02-05 Johnson Matthey Public Limited Company Process for the preparation of oxymorphone
EP3087073B1 (en) 2013-12-26 2018-07-04 Purdue Pharma LP 10-substituted morphinan hydantoins
EP3087079B1 (en) 2013-12-26 2019-04-03 Purdue Pharma LP Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans
EP3087078B1 (en) 2013-12-26 2019-05-15 Purdue Pharma LP 7-beta-alkyl analogs of orvinols
WO2015097546A1 (en) 2013-12-26 2015-07-02 Purdue Pharma L.P. Propellane-based compounds and their use as opioid receptor modulators
US9902726B2 (en) 2013-12-30 2018-02-27 Purdue Pharma L.P. Pyridone-sulfone morphinan analogs as opioid receptor ligands
US9850252B2 (en) 2014-11-25 2017-12-26 Kempharm, Inc. Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxycodone, prodrugs, methods of making and use thereof
ES2701855T3 (es) 2016-05-31 2019-02-26 Alcaliber Investig Desarrollo E Innovacion Slu Proceso para la obtención de 3,14-diacetiloximorfona a partir de oripavina
US9737530B1 (en) 2016-06-23 2017-08-22 Collegium Pharmaceutical, Inc. Process of making stable abuse-deterrent oral formulations
SG11201811760VA (en) 2016-07-06 2019-01-30 Durect Corp Oral dosage form with drug composition, barrier layer and drug layer
EP3559010B1 (en) 2016-12-23 2022-06-08 Minoryx Therapeutics S.L. Process for preparing 5-[[4-[2-[5-(1-hydroxyethyl)-2-pyridinyl]ethoxy]phenyl]methyl]-2,4-thiazolidinedione and salts thereof
SK592017A3 (sk) 2017-07-04 2019-01-08 Saneca Pharmaceuticals A. S. Spôsob prípravy morfínanových zlúčenín
CN111836813A (zh) 2018-02-23 2020-10-27 罗德科技公司 新型阿片样化合物及其用途
CN110054656B (zh) * 2019-05-28 2021-02-02 宜昌人福药业有限责任公司 一种10-羰基/羟基吗啡-6-葡萄糖苷酸的合成方法
WO2021007366A1 (en) * 2019-07-08 2021-01-14 St. Louis College Of Pharmacy G-protein biased opioid receptor agonist/analgesics with reduced arrestin recruitment
EP4090353A4 (en) 2020-01-13 2023-08-09 Durect Corporation DELAYED-RELEASE DRUG DELIVERY SYSTEMS WITH REDUCED IMPURITIES AND RELATED PROCEDURES
CN114621239B (zh) * 2020-12-10 2026-02-03 鲁南制药集团股份有限公司 一种纳曲酮的制备方法
EP4267583A4 (en) * 2020-12-28 2024-10-30 Navin Saxena Research & Technology Pvt. Ltd. NEW PROCESS FOR THE PRODUCTION OF NOROXYMORPHONE FROM MORPHINE
JP2024503402A (ja) 2021-01-12 2024-01-25 デュレクト コーポレーション 徐放性薬物送達システム及び関連の方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3819636A (en) * 1970-09-15 1974-06-25 American Home Prod 4a,10-(methaniminomethano)phenanthrene derivatives
US4795813A (en) * 1981-08-17 1989-01-03 The Florida Board Of Regents On Behalf Of The Florida State University Synthesis of derivatives of codeine and other 3-O-alkylmorphines
IT1199871B (it) * 1984-03-27 1989-01-05 Mallinckrodt Inc Procedimento per la preparazione di norossimorfone dalla morfina e composti intermedi per tale procedimento
US4639520A (en) * 1984-03-27 1987-01-27 Mallinckrodt, Inc. Preparation of 14-hydroxy-N-ethoxy-carbonyl-norcodeinone
US5112975A (en) * 1984-03-27 1992-05-12 Mallinckrodt Specialty Chemicals Company Preparation of noroxymorphone from morphine
US4668685A (en) * 1984-07-05 1987-05-26 E.I. Du Pont De Nemours And Company Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists
US4912114A (en) * 1988-03-18 1990-03-27 Sandoz Ltd. Morphinan derivatives

Also Published As

Publication number Publication date
US6008354A (en) 1999-12-28
SK102000A3 (en) 2000-07-11
HUP0003918A3 (en) 2003-04-28
TW505648B (en) 2002-10-11
TR200000033T2 (tr) 2000-12-21
US5922876A (en) 1999-07-13
HUP0003918A2 (hu) 2001-07-30
RU2183636C2 (ru) 2002-06-20
WO1999002529A1 (en) 1999-01-21
KR20010021693A (ko) 2001-03-15
NO20000111D0 (no) 2000-01-10
HK1028025A1 (en) 2001-02-02
EP1000065B1 (en) 2005-03-16
EP1000065A4 (en) 2001-09-12
CA2296035C (en) 2004-04-13
ATE291023T1 (de) 2005-04-15
CA2296035A1 (en) 1999-01-21
KR100363486B1 (ko) 2002-12-16
AU740822B2 (en) 2001-11-15
JP2001518444A (ja) 2001-10-16
NO20000111L (no) 2000-02-25
US5948788A (en) 1999-09-07
DE69829379D1 (de) 2005-04-21
US6008355A (en) 1999-12-28
EP1000065A1 (en) 2000-05-17
AU8379198A (en) 1999-02-08
CN1272845A (zh) 2000-11-08
US5869669A (en) 1999-02-09
IL133792A0 (en) 2001-04-30
US6013796A (en) 2000-01-11
CN1152880C (zh) 2004-06-09
US5952495A (en) 1999-09-14
ZA986144B (en) 1999-05-19

Similar Documents

Publication Publication Date Title
IN1998KO01500A (enExample)
BE2013C047I2 (enExample)
ITTO970535A0 (enExample)
ITTO970497A0 (enExample)
ITTO970387A0 (enExample)
ITPD970024V0 (enExample)
ITMI971551A0 (enExample)
ITMI971346A0 (enExample)
ITMI971095A0 (enExample)
ITMI971051A0 (enExample)
ITMI970307V0 (enExample)
CN3057730S (enExample)
CN3058138S (enExample)
CN3053170S (enExample)
CN3058088S (enExample)
CN3058057S (enExample)
CN3053500S (enExample)
CN3058025S (enExample)
CN3058000S (enExample)
CN3057997S (enExample)
CN3057977S (enExample)
CN3057976S (enExample)
CN3057614S (enExample)
CN3057613S (enExample)
CN3057436S (enExample)