IN1998KO01500A - - Google Patents

Info

Publication number
IN1998KO01500A
IN1998KO01500A IN1500KO1998A IN1998KO01500A IN 1998KO01500 A IN1998KO01500 A IN 1998KO01500A IN 1500KO1998 A IN1500KO1998 A IN 1500KO1998A IN 1998KO01500 A IN1998KO01500 A IN 1998KO01500A
Authority
IN
India
Application number
Other languages
English (en)
Inventor
Bao-Shan Huang
Aris Christodoulou
Yansong Lu
Ben-Yi Ji
Original Assignee
Penick Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25401603&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IN1998KO01500(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Penick Corp filed Critical Penick Corp
Publication of IN1998KO01500A publication Critical patent/IN1998KO01500A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D489/00Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08Oxygen atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D489/00Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
IN1500KO1998 1997-07-11 1998-08-21 IN1998KO01500A (enExample)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/893,464 US5869669A (en) 1996-07-26 1997-07-11 Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates

Publications (1)

Publication Number Publication Date
IN1998KO01500A true IN1998KO01500A (enExample) 2005-03-11

Family

ID=25401603

Family Applications (1)

Application Number Title Priority Date Filing Date
IN1500KO1998 IN1998KO01500A (enExample) 1997-07-11 1998-08-21

Country Status (19)

Country Link
US (7) US5869669A (enExample)
EP (1) EP1000065B1 (enExample)
JP (1) JP2001518444A (enExample)
KR (1) KR100363486B1 (enExample)
CN (1) CN1152880C (enExample)
AT (1) ATE291023T1 (enExample)
AU (1) AU740822B2 (enExample)
CA (1) CA2296035C (enExample)
DE (1) DE69829379D1 (enExample)
HU (1) HUP0003918A3 (enExample)
IL (1) IL133792A0 (enExample)
IN (1) IN1998KO01500A (enExample)
NO (1) NO20000111L (enExample)
RU (1) RU2183636C2 (enExample)
SK (1) SK102000A3 (enExample)
TR (1) TR200000033T2 (enExample)
TW (1) TW505648B (enExample)
WO (1) WO1999002529A1 (enExample)
ZA (1) ZA986144B (enExample)

Families Citing this family (93)

* Cited by examiner, † Cited by third party
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US5912347A (en) * 1996-09-30 1999-06-15 Mallinckrodt Inc. Process for preparing a morphinan derivative
AU4823900A (en) * 1999-05-05 2000-11-17 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Direct c-14 oxidation of opioids
US6177567B1 (en) 1999-10-15 2001-01-23 Boehringer Ingelheim Chemicals, Inc. Method for preparing oxycodone
ATE466016T1 (de) * 2001-08-23 2010-05-15 Organon Nv Verfahren for zur herstellung eines 14- hydroxynormorphinon-derivats
JP3961796B2 (ja) * 2001-08-27 2007-08-22 ソニー株式会社 情報提供システム、情報処理装置および方法、情報提供装置および方法、記録媒体、並びにプログラム
DE10161963A1 (de) * 2001-12-17 2003-07-03 Johannes Schuetz 6-Aminomorphinanderivate, Herstellungsverfahren dafür und deren Verwendung
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
US20040058946A1 (en) * 2002-07-05 2004-03-25 Buchwald Stephen L. Abuse-resistant prodrugs of oxycodone and other pharmaceuticals
RU2236412C2 (ru) * 2002-07-18 2004-09-20 Власов Михаил Иванович Способ получения производных морфинона, способ получения производных 14-гидроксиморфинона, и способ получения производных оксиморфона
RU2215741C1 (ru) * 2002-11-05 2003-11-10 Открытое Акционерное Общество "Международная Научно-Технологическая Корпорация" Сложные эфиры n-замещенных 14-гидроксиморфинанов и способ их получения
RU2215742C1 (ru) * 2002-11-05 2003-11-10 Открытое Акционерное Общество "Международная Научно-Технологическая Корпорация" Способ получения сложных эфиров n-замещенных 14-гидроксиморфинанов
WO2004043964A2 (en) * 2002-11-08 2004-05-27 Mallinckrodt Inc. Process for the preparation of quaternary n-alkyl morphinan alkaloid salts
SI1575569T1 (sl) 2002-12-13 2010-12-31 Durect Corp Oralni sistem dostave zdravila, ki obsega visokoviskozne tekoče nosilne materiale
US6864370B1 (en) * 2003-06-05 2005-03-08 Zhaiwei Lin Process for manufacturing oxycodone
US6790959B1 (en) 2003-06-05 2004-09-14 Halsey Drug Company, Inc. Process for manufacturing thebaine
US7875718B2 (en) * 2003-09-22 2011-01-25 Johnson Matthey Public Limited Company Process for the synthesis of morphinane compounds and intermediates thereof
WO2005028483A1 (en) 2003-09-22 2005-03-31 Glaxosmithkline Australia Pty Ltd Process for the synthesis of morphinane compounds and intermediates thereof
HRP20080618T3 (hr) * 2004-02-06 2009-01-31 Euro-Celtique S.A. Postupci za pripravljanje 3-o-zaštićenih morfinona i 3-o-zaštićenih morfinon dienol karboksilata
TW201509943A (zh) * 2004-03-30 2015-03-16 Euro Celtique Sa 含有小於25ppm14-羥可待因酮之羥可酮鹽酸鹽之組成物、醫藥劑型、延遲釋出口服劑型及醫藥上可以接受的包裝
SK286047B6 (sk) * 2004-04-13 2008-01-07 Zentiva, A. S. Spôsob prípravy derivátov 4,5alfa-epoxy-6-oxomorfínanu
US6946556B1 (en) * 2004-05-21 2005-09-20 Acura Pharmaceuticals, Inc. Preparation of opioid analgesics by a one-pot process
WO2005123743A1 (en) * 2004-06-08 2005-12-29 Mallinckrodt Inc. Extraction of alkaloids from opium
CA2916869A1 (en) 2004-06-12 2005-12-29 Jane C. Hirsh Abuse-deterrent drug formulations
SI2767292T1 (sl) 2004-09-17 2017-01-31 Durect Corporation Pripravek, ki vsebuje lokalni anestetik SAIB, s podaljšanim sproščanjem
GB0421149D0 (en) * 2004-09-23 2004-10-27 Johnson Matthey Plc Preparation of oxycodone
GB0421687D0 (en) * 2004-09-30 2004-11-03 Johnson Matthey Plc Preparation of opiate analgesics
WO2006084389A1 (de) * 2005-02-11 2006-08-17 Cilag Ltd. Verfahren zur reinigung von noroxymorphon-verbindungen
PL1861405T3 (pl) * 2005-03-04 2009-10-30 Euro Celtique Sa Sposób redukcji alfa, beta -nienasyconych ketonów w kompozycjach opioidowych
EP1873158B1 (en) * 2005-04-06 2016-04-06 Toray Industries, Inc. Crystals of morphinan derivative and process for producing the same
US8071768B2 (en) * 2005-06-10 2011-12-06 Janssen Pharmaceutica, N.V. Alkylquinoline and alkylquinazoline kinase modulators
DE602006019246D1 (de) * 2005-06-16 2011-02-10 Mallinckrodt Inc Synthetische route zu 14-hydroxylopiaten über 1-halogenthebain oder analoga
US20070027105A1 (en) 2005-07-26 2007-02-01 Alza Corporation Peroxide removal from drug delivery vehicle
US20070117826A1 (en) * 2005-11-23 2007-05-24 Forest Laboratories, Inc. Pharmaceutical formulations comprising ibuprofen, oxycodone, and 14-hydroxycodeinone
US8871779B2 (en) 2006-03-02 2014-10-28 Mallinckrodt Llc Process for preparing morphinan-6-one products with low levels of α,β-unsaturated ketone compounds
SA07280459B1 (ar) 2006-08-25 2011-07-20 بيورديو فارما إل. بي. أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني
MX2009002844A (es) * 2006-09-20 2009-03-30 Mallinckrodt Inc Preparacion de morfinan-6-onas sustituidas y sales e intermediarios de las mismas.
AU2012216358B2 (en) * 2006-10-17 2014-11-20 Penick Corporation Process For Preparing Oxymorphone, Naltrexone and Buprenorphine
CA2674915C (en) 2006-10-17 2015-06-30 Penick Corporation Process for preparing oxymorphone
US20080125592A1 (en) * 2006-10-17 2008-05-29 Penick Corporation Process for preparing oxymorphone, naltrexone, and buprenorphine
AU2007313103C1 (en) * 2006-10-17 2014-01-30 Penick Corporation Process for preparing oxymorphone
EP2117521B1 (en) 2006-11-03 2012-06-27 Durect Corporation Transdermal delivery systems comprising bupivacaine
JP2010511725A (ja) * 2006-12-04 2010-04-15 ノランコ・インコーポレーテツド オキシコドン塩基中の不純物を減少させる方法
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GB0624880D0 (en) * 2006-12-14 2007-01-24 Johnson Matthey Plc Improved method for making analgesics
PL2137189T3 (pl) * 2007-03-06 2015-12-31 SpecGx LLC Sposób wytwarzania czwartorzędowych N-alkilowych soli alkaloidu morfinanowego
US9040726B2 (en) * 2007-03-06 2015-05-26 Mallinckrodt Llc Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
US8217175B2 (en) * 2007-03-23 2012-07-10 Mallinckrodt Llc Preparation of oxymorphone from oripavine
WO2008130553A1 (en) * 2007-04-16 2008-10-30 Mallinckrodt Inc. Novel opiate reduction utilizing catalytic hydrogen transfer reaction
WO2008144320A2 (en) * 2007-05-17 2008-11-27 Endo Pharmaceuticals, Inc. Opioid and methods of making and using the same
EP2067471B1 (en) 2007-12-06 2018-02-14 Durect Corporation Oral pharmaceutical dosage forms
AU2008338970B2 (en) * 2007-12-17 2013-08-22 SpecGx LLC Sinomenine derivatives and processes for their synthesis
WO2009079013A1 (en) * 2007-12-17 2009-06-25 Mallinckrodt Inc. Processes for the production of (+)-'nal' morphinan compounds
EP2250175B1 (en) * 2008-02-29 2011-08-10 Mallinckrodt Inc. Process for the preparation of 3-hydroxymorphinan derivatives
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CA2726220C (en) * 2008-05-27 2017-03-28 Mallinckrodt Inc. Processes and compounds for the preparation of normorphinans
US9458109B2 (en) 2008-09-03 2016-10-04 Mallinckrodt Llc Substituted berbines and processes for their synthesis
WO2010039209A2 (en) * 2008-09-30 2010-04-08 Mallinckrodt Inc. Processes for the synthesis of tertiary amines
US20100260844A1 (en) 2008-11-03 2010-10-14 Scicinski Jan J Oral pharmaceutical dosage forms
UA102916C2 (uk) 2009-07-02 2013-08-27 Кемфарм, Інк. Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань
US10668060B2 (en) 2009-12-10 2020-06-02 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
ES2645725T3 (es) 2010-06-11 2017-12-07 Rhodes Technologies Procesos catalizados por metales de transición para la preparación de compuestos de N-alilo y uso de los mismos
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JP7258561B2 (ja) 2016-07-06 2023-04-17 オリエント ファーマ シーオー.,エルティーディー. 薬物組成物、バリヤー層及び薬物層を有している経口投与形態
LT3559010T (lt) 2016-12-23 2022-10-10 Minoryx Therapeutics S.L. 5-[[4-[2-[5-(1-hidroksietil)-2-piridinil]etoksi]fenil]metil]-2,4-tiazolidindiono ir jo druskų gavimo būdas
SK592017A3 (sk) 2017-07-04 2019-01-08 Saneca Pharmaceuticals A. S. Spôsob prípravy morfínanových zlúčenín
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CN110054656B (zh) * 2019-05-28 2021-02-02 宜昌人福药业有限责任公司 一种10-羰基/羟基吗啡-6-葡萄糖苷酸的合成方法
CA3146163A1 (en) 2019-07-08 2021-01-14 University Of Health Sciences & Pharmacy In St. Louis G-protein biased opioid receptor agonist/analgesics with reduced arrestin recruitment
KR20220140711A (ko) 2020-01-13 2022-10-18 듀렉트 코퍼레이션 불순물이 감소된 지속 방출 약물 전달 시스템 및 관련 방법
CN114621239A (zh) * 2020-12-10 2022-06-14 鲁南制药集团股份有限公司 一种纳曲酮的制备方法
KR20230127222A9 (ko) * 2020-12-28 2024-03-25 나빈 삭세나 리서치 앤드 테크놀로지 피브이티. 엘티디. 모르핀으로부터 노르옥시모르폰의 합성을 위한 신규의 제조방법
KR20230145053A (ko) 2021-01-12 2023-10-17 듀렉트 코퍼레이션 지속 방출 약물 전달 시스템 및 관련 방법

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US4795813A (en) * 1981-08-17 1989-01-03 The Florida Board Of Regents On Behalf Of The Florida State University Synthesis of derivatives of codeine and other 3-O-alkylmorphines
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Also Published As

Publication number Publication date
US6013796A (en) 2000-01-11
US6008354A (en) 1999-12-28
KR100363486B1 (ko) 2002-12-16
AU740822B2 (en) 2001-11-15
CA2296035A1 (en) 1999-01-21
US5948788A (en) 1999-09-07
WO1999002529A1 (en) 1999-01-21
SK102000A3 (en) 2000-07-11
NO20000111L (no) 2000-02-25
HUP0003918A3 (en) 2003-04-28
HUP0003918A2 (hu) 2001-07-30
US5922876A (en) 1999-07-13
US5869669A (en) 1999-02-09
RU2183636C2 (ru) 2002-06-20
DE69829379D1 (de) 2005-04-21
HK1028025A1 (en) 2001-02-02
ZA986144B (en) 1999-05-19
EP1000065B1 (en) 2005-03-16
CA2296035C (en) 2004-04-13
JP2001518444A (ja) 2001-10-16
AU8379198A (en) 1999-02-08
IL133792A0 (en) 2001-04-30
EP1000065A4 (en) 2001-09-12
CN1272845A (zh) 2000-11-08
ATE291023T1 (de) 2005-04-15
KR20010021693A (ko) 2001-03-15
EP1000065A1 (en) 2000-05-17
US5952495A (en) 1999-09-14
TW505648B (en) 2002-10-11
NO20000111D0 (no) 2000-01-10
TR200000033T2 (tr) 2000-12-21
US6008355A (en) 1999-12-28
CN1152880C (zh) 2004-06-09

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