HUP0003918A3 - Process for the preparation of oxymorphone, oxycodone and derivatives - Google Patents

Process for the preparation of oxymorphone, oxycodone and derivatives

Info

Publication number
HUP0003918A3
HUP0003918A3 HU0003918A HUP0003918A HUP0003918A3 HU P0003918 A3 HUP0003918 A3 HU P0003918A3 HU 0003918 A HU0003918 A HU 0003918A HU P0003918 A HUP0003918 A HU P0003918A HU P0003918 A3 HUP0003918 A3 HU P0003918A3
Authority
HU
Hungary
Prior art keywords
oxymorphone
oxycodone
derivatives
preparation
Prior art date
Application number
HU0003918A
Other languages
English (en)
Hungarian (hu)
Original Assignee
Penick Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25401603&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUP0003918(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Penick Corp filed Critical Penick Corp
Publication of HUP0003918A2 publication Critical patent/HUP0003918A2/hu
Publication of HUP0003918A3 publication Critical patent/HUP0003918A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
HU0003918A 1997-07-11 1998-07-10 Process for the preparation of oxymorphone, oxycodone and derivatives HUP0003918A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/893,464 US5869669A (en) 1996-07-26 1997-07-11 Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
PCT/US1998/013592 WO1999002529A1 (en) 1997-07-11 1998-07-10 Preparation of oxymorphone, oxycodone and derivatives

Publications (2)

Publication Number Publication Date
HUP0003918A2 HUP0003918A2 (hu) 2001-07-30
HUP0003918A3 true HUP0003918A3 (en) 2003-04-28

Family

ID=25401603

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0003918A HUP0003918A3 (en) 1997-07-11 1998-07-10 Process for the preparation of oxymorphone, oxycodone and derivatives

Country Status (19)

Country Link
US (7) US5869669A (enExample)
EP (1) EP1000065B1 (enExample)
JP (1) JP2001518444A (enExample)
KR (1) KR100363486B1 (enExample)
CN (1) CN1152880C (enExample)
AT (1) ATE291023T1 (enExample)
AU (1) AU740822B2 (enExample)
CA (1) CA2296035C (enExample)
DE (1) DE69829379D1 (enExample)
HU (1) HUP0003918A3 (enExample)
IL (1) IL133792A0 (enExample)
IN (1) IN1998KO01500A (enExample)
NO (1) NO20000111L (enExample)
RU (1) RU2183636C2 (enExample)
SK (1) SK102000A3 (enExample)
TR (1) TR200000033T2 (enExample)
TW (1) TW505648B (enExample)
WO (1) WO1999002529A1 (enExample)
ZA (1) ZA986144B (enExample)

Families Citing this family (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5912347A (en) * 1996-09-30 1999-06-15 Mallinckrodt Inc. Process for preparing a morphinan derivative
AU4823900A (en) * 1999-05-05 2000-11-17 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Direct c-14 oxidation of opioids
US6177567B1 (en) * 1999-10-15 2001-01-23 Boehringer Ingelheim Chemicals, Inc. Method for preparing oxycodone
US7435817B2 (en) * 2001-08-23 2008-10-14 N.V. Organon C-14 oxidation of morphine derivatives
JP3961796B2 (ja) * 2001-08-27 2007-08-22 ソニー株式会社 情報提供システム、情報処理装置および方法、情報提供装置および方法、記録媒体、並びにプログラム
DE10161963A1 (de) * 2001-12-17 2003-07-03 Johannes Schuetz 6-Aminomorphinanderivate, Herstellungsverfahren dafür und deren Verwendung
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
US20040058946A1 (en) * 2002-07-05 2004-03-25 Buchwald Stephen L. Abuse-resistant prodrugs of oxycodone and other pharmaceuticals
RU2236412C2 (ru) * 2002-07-18 2004-09-20 Власов Михаил Иванович Способ получения производных морфинона, способ получения производных 14-гидроксиморфинона, и способ получения производных оксиморфона
RU2215741C1 (ru) * 2002-11-05 2003-11-10 Открытое Акционерное Общество "Международная Научно-Технологическая Корпорация" Сложные эфиры n-замещенных 14-гидроксиморфинанов и способ их получения
RU2215742C1 (ru) * 2002-11-05 2003-11-10 Открытое Акционерное Общество "Международная Научно-Технологическая Корпорация" Способ получения сложных эфиров n-замещенных 14-гидроксиморфинанов
US7285665B2 (en) * 2002-11-08 2007-10-23 Mallinckrodt Inc. Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
EP2218448B1 (en) 2002-12-13 2015-09-23 Durect Corporation Oral drug delivery system comprising high viscosity liquid carrier materials
US6864370B1 (en) * 2003-06-05 2005-03-08 Zhaiwei Lin Process for manufacturing oxycodone
US6790959B1 (en) 2003-06-05 2004-09-14 Halsey Drug Company, Inc. Process for manufacturing thebaine
JP4879740B2 (ja) 2003-09-22 2012-02-22 ジョンソン、マッセイ、パブリック、リミテッド、カンパニー モルヒナン化合物およびその中間体の合成法
US7875718B2 (en) * 2003-09-22 2011-01-25 Johnson Matthey Public Limited Company Process for the synthesis of morphinane compounds and intermediates thereof
DE602005009321D1 (de) * 2004-02-06 2008-10-09 Euro Celtique Sa Hinonen und 3-o-geschützten morphinondienolcarboxylaten
TWI365880B (en) * 2004-03-30 2012-06-11 Euro Celtique Sa Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone and oxycodone hydrochloride composition,pharmaceutical dosage form,sustained release oeal dosage form and pharmaceutically acceptable package having less than 25 pp
SK286047B6 (sk) * 2004-04-13 2008-01-07 Zentiva, A. S. Spôsob prípravy derivátov 4,5alfa-epoxy-6-oxomorfínanu
US6946556B1 (en) * 2004-05-21 2005-09-20 Acura Pharmaceuticals, Inc. Preparation of opioid analgesics by a one-pot process
WO2005123743A1 (en) * 2004-06-08 2005-12-29 Mallinckrodt Inc. Extraction of alkaloids from opium
ES2653568T3 (es) 2004-06-12 2018-02-07 Collegium Pharmaceutical, Inc. Formulaciones de fármacos para la prevención del abuso
DK2767292T3 (en) 2004-09-17 2016-12-19 Durect Corp RENEWABLE local anesthetic COMPOSITION CONTAINING SAIB
GB0421149D0 (en) * 2004-09-23 2004-10-27 Johnson Matthey Plc Preparation of oxycodone
GB0421687D0 (en) * 2004-09-30 2004-11-03 Johnson Matthey Plc Preparation of opiate analgesics
WO2006084389A1 (de) * 2005-02-11 2006-08-17 Cilag Ltd. Verfahren zur reinigung von noroxymorphon-verbindungen
PT1861405E (pt) * 2005-03-04 2009-07-27 Euro Celtique Sa Método de diminuír a quantidade de cetonas insaturadas em alfa-beta numa composição de opiáceos
RU2397173C2 (ru) * 2005-04-06 2010-08-20 Торей Индастриз, Инк. Кристаллические производные морфинана и способ их получения
US8071768B2 (en) * 2005-06-10 2011-12-06 Janssen Pharmaceutica, N.V. Alkylquinoline and alkylquinazoline kinase modulators
DE602006019246D1 (de) * 2005-06-16 2011-02-10 Mallinckrodt Inc Synthetische route zu 14-hydroxylopiaten über 1-halogenthebain oder analoga
US20070027105A1 (en) 2005-07-26 2007-02-01 Alza Corporation Peroxide removal from drug delivery vehicle
US20070117826A1 (en) * 2005-11-23 2007-05-24 Forest Laboratories, Inc. Pharmaceutical formulations comprising ibuprofen, oxycodone, and 14-hydroxycodeinone
JP5695296B2 (ja) 2006-03-02 2015-04-01 マリンクロッド エルエルシー 低レベルのアルファ，ベータ−不飽和ケトン化合物を伴うモルフィナン−６−オン生成物の製造方法
SA07280459B1 (ar) 2006-08-25 2011-07-20 بيورديو فارما إل. بي. أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني
EP2099764B1 (en) * 2006-09-20 2011-07-27 Mallinckrodt Inc. Preparation of substituted morphinan-6-ones and salts and intermediates thereof
AU2012216358B2 (en) * 2006-10-17 2014-11-20 Penick Corporation Process For Preparing Oxymorphone, Naltrexone and Buprenorphine
CA2674915C (en) 2006-10-17 2015-06-30 Penick Corporation Process for preparing oxymorphone
US20080125592A1 (en) * 2006-10-17 2008-05-29 Penick Corporation Process for preparing oxymorphone, naltrexone, and buprenorphine
DK2073636T3 (da) 2006-10-17 2012-11-19 Penick Corp Fremgangsmåde til fremstilling af oxymorphon
AU2007325918B2 (en) 2006-11-03 2013-10-17 Durect Corporation Transdermal delivery systems comprising bupivacaine
CN101652370A (zh) * 2006-12-04 2010-02-17 诺拉姆科有限公司 制备14-羟基可待因酮水平减少的羟考酮的方法
ES2378710T3 (es) * 2006-12-04 2012-04-17 Noramco, Inc. Procedimiento para reducir impurezas en la base de oxicodona
GB0624880D0 (en) * 2006-12-14 2007-01-24 Johnson Matthey Plc Improved method for making analgesics
US9040726B2 (en) * 2007-03-06 2015-05-26 Mallinckrodt Llc Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
JP5875748B2 (ja) * 2007-03-06 2016-03-02 マリンクロッド エルエルシー 第４級ｎ−アルキルモルフィナンアルカロイド塩の調製のための方法
PL2125824T5 (pl) * 2007-03-23 2024-11-04 SpecGx LLC Ulepszony sposób wytwarzania oksymorfonu z oripawiny
WO2008130553A1 (en) * 2007-04-16 2008-10-30 Mallinckrodt Inc. Novel opiate reduction utilizing catalytic hydrogen transfer reaction
WO2008144320A2 (en) * 2007-05-17 2008-11-27 Endo Pharmaceuticals, Inc. Opioid and methods of making and using the same
EP2067471B1 (en) 2007-12-06 2018-02-14 Durect Corporation Oral pharmaceutical dosage forms
US8067596B2 (en) 2007-12-17 2011-11-29 Mallinckrodt Llc Processes for the production of (+)- “Nal” morphinan compounds
CA2709862C (en) * 2007-12-17 2016-03-15 Peter X. Wang Sinomenine derivatives and processes for their synthesis
ATE519765T1 (de) * 2008-02-29 2011-08-15 Mallinckrodt Inc Verfahren zur herstellung von 3-hydroxymorphinan- derivaten
EP2291380B1 (en) * 2008-04-24 2011-09-07 Janssen Pharmaceutica N.V. Nalmefene prodrugs
EP2896614B1 (en) * 2008-05-27 2017-07-12 Mallinckrodt LLC Processes and compounds for the preparation of normorphinans
WO2010028004A2 (en) 2008-09-03 2010-03-11 Mallinckrodt Inc. Substituted berbines and processes for their synthesis
CN102227433B (zh) * 2008-09-30 2015-01-07 马林克罗特有限公司 烷基化吗啡喃衍生物的仲胺基团的方法
US20100260844A1 (en) 2008-11-03 2010-10-14 Scicinski Jan J Oral pharmaceutical dosage forms
UA102916C2 (uk) 2009-07-02 2013-08-27 Кемфарм, Інк. Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань
US10668060B2 (en) 2009-12-10 2020-06-02 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
CA2936749C (en) 2010-06-11 2019-07-09 Rhodes Technologies Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof
TWI471289B (zh) 2010-06-11 2015-02-01 Rhodes Technologies 使三級胺進行ｎ－脫烷反應之方法
CA2804101C (en) 2010-07-02 2021-01-19 Johnson Matthey Public Limited Company Process for the synthesis and purification of oxycodone
RU2448709C1 (ru) * 2011-02-01 2012-04-27 Учреждение Российской академии наук Институт проблем химико-энергетических технологий Сибирского отделения РАН (ИПХЭТ СО РАН) Способ получения налтрексона
TWI560170B (en) * 2011-12-06 2016-12-01 Lundbeck & Co As H Process for recovery of nalmefene hydrochloride
US9315514B2 (en) 2012-08-27 2016-04-19 Rhodes Technologies 1,3-dioxanomorphides and 1,3-dioxanocodides
EP2931726B1 (en) 2012-12-14 2017-01-25 Purdue Pharma LP Spirocyclic morphinans and their use
US8937084B2 (en) 2012-12-14 2015-01-20 Purdue Pharma L.P. Nitrogen containing morphinan derivatives and the use thereof
ES2631197T3 (es) 2012-12-14 2017-08-29 Purdue Pharma Lp Análogos de piridonamorfinano y actividad biológica sobre los receptores opiodes
CA2896202A1 (en) 2012-12-28 2014-07-03 Purdue Pharma L.P. Substituted morphinans and the use thereof
EP2941430B1 (en) 2012-12-28 2017-04-26 Purdue Pharma LP 7,8-cyclicmorphinan analogs
WO2014102591A1 (en) 2012-12-31 2014-07-03 Rhodes Technologies PROCESS FOR PREPARING 7β-SUBSTITUTED 6α,14α -ETHENOMORPHINANS AND 7β-SUBSTITUTED 6α,14α-ETHANOMORPHINANS
CA2905131A1 (en) 2013-03-15 2014-09-18 Durect Corporation Compositions with a rheological modifier to reduce dissolution variability
EP2829541A1 (en) * 2013-07-26 2015-01-28 Siegfried AG Novel synthesis of noroxymorphone from morphine
EP3027622B8 (en) 2013-08-02 2019-06-12 Johnson Matthey Public Limited Company Process for the preparation of oxymorphone
EP3087078B1 (en) 2013-12-26 2019-05-15 Purdue Pharma LP 7-beta-alkyl analogs of orvinols
WO2015097547A1 (en) 2013-12-26 2015-07-02 Purdue Pharma L.P. 10-substituted morphinan hydantoins
WO2015097546A1 (en) 2013-12-26 2015-07-02 Purdue Pharma L.P. Propellane-based compounds and their use as opioid receptor modulators
US9862726B2 (en) 2013-12-26 2018-01-09 Purdue Pharma L.P. Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans
WO2015102682A1 (en) 2013-12-30 2015-07-09 Purdue Pharma L.P. Pyridone-sulfone morphinan analogs as opioid receptor ligands
MX2017006520A (es) 2014-11-25 2017-08-09 Kempharm Inc * Acido benzoico, derivados de acido benzoico y conjugados de oxicodona de acido heteroaril carboxilico.
EP3252055B1 (en) 2016-05-31 2018-09-19 Alcaliber Investigacion Desarrollo e Innovacion SLU Process for obtaining 3,14-diacetyloxymorphone from oripavine
US9737530B1 (en) 2016-06-23 2017-08-22 Collegium Pharmaceutical, Inc. Process of making stable abuse-deterrent oral formulations
CN109475505A (zh) 2016-07-06 2019-03-15 度瑞公司 具有药物组成物、屏障层及药物层的口服剂型
CN110198945B (zh) 2016-12-23 2023-06-27 米尼奥尔克斯治疗有限公司 用于制备噻唑烷二酮化合物及其盐的方法
SK592017A3 (sk) 2017-07-04 2019-01-08 Saneca Pharmaceuticals A. S. Spôsob prípravy morfínanových zlúčenín
CA3091826A1 (en) 2018-02-23 2019-08-29 Rhodes Technologies Novel opioid compounds and uses thereof
CN110054656B (zh) * 2019-05-28 2021-02-02 宜昌人福药业有限责任公司 一种10-羰基/羟基吗啡-6-葡萄糖苷酸的合成方法
CA3146163A1 (en) 2019-07-08 2021-01-14 University Of Health Sciences & Pharmacy In St. Louis G-protein biased opioid receptor agonist/analgesics with reduced arrestin recruitment
WO2021146215A1 (en) 2020-01-13 2021-07-22 Durect Corporation Sustained release drug delivery systems with reduced impurities and related methods
CN114621239B (zh) * 2020-12-10 2026-02-03 鲁南制药集团股份有限公司 一种纳曲酮的制备方法
JP7773548B2 (ja) * 2020-12-28 2025-11-19 ナヴィン サクセナ リサーチ アンド テクノロジー ピーブイティー．エルティーディー． モルヒネからのノルオキシモルフォンの合成のための新規方法
CA3203561A1 (en) 2021-01-12 2022-07-21 Adrian Neil Verity Sustained release drug delivery systems and related methods

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3819636A (en) * 1970-09-15 1974-06-25 American Home Prod 4a,10-(methaniminomethano)phenanthrene derivatives
US4795813A (en) * 1981-08-17 1989-01-03 The Florida Board Of Regents On Behalf Of The Florida State University Synthesis of derivatives of codeine and other 3-O-alkylmorphines
US5112975A (en) * 1984-03-27 1992-05-12 Mallinckrodt Specialty Chemicals Company Preparation of noroxymorphone from morphine
DE3581423D1 (de) * 1984-03-27 1991-02-28 Mallinckrodt Inc Herstellung von noroxymorphon aus morphin.
US4639520A (en) * 1984-03-27 1987-01-27 Mallinckrodt, Inc. Preparation of 14-hydroxy-N-ethoxy-carbonyl-norcodeinone
US4668685A (en) * 1984-07-05 1987-05-26 E.I. Du Pont De Nemours And Company Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists
US4912114A (en) * 1988-03-18 1990-03-27 Sandoz Ltd. Morphinan derivatives

Also Published As

Publication number Publication date
HK1028025A1 (en) 2001-02-02
EP1000065A1 (en) 2000-05-17
AU740822B2 (en) 2001-11-15
US5948788A (en) 1999-09-07
CA2296035A1 (en) 1999-01-21
TW505648B (en) 2002-10-11
NO20000111L (no) 2000-02-25
EP1000065A4 (en) 2001-09-12
CN1272845A (zh) 2000-11-08
US6008355A (en) 1999-12-28
WO1999002529A1 (en) 1999-01-21
EP1000065B1 (en) 2005-03-16
US6013796A (en) 2000-01-11
IN1998KO01500A (enExample) 2005-03-11
RU2183636C2 (ru) 2002-06-20
TR200000033T2 (tr) 2000-12-21
US6008354A (en) 1999-12-28
US5952495A (en) 1999-09-14
KR100363486B1 (ko) 2002-12-16
CA2296035C (en) 2004-04-13
KR20010021693A (ko) 2001-03-15
NO20000111D0 (no) 2000-01-10
SK102000A3 (en) 2000-07-11
US5869669A (en) 1999-02-09
US5922876A (en) 1999-07-13
JP2001518444A (ja) 2001-10-16
HUP0003918A2 (hu) 2001-07-30
ATE291023T1 (de) 2005-04-15
IL133792A0 (en) 2001-04-30
CN1152880C (zh) 2004-06-09
ZA986144B (en) 1999-05-19
AU8379198A (en) 1999-02-08
DE69829379D1 (de) 2005-04-21

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