|
US5912347A
(en)
*
|
1996-09-30 |
1999-06-15 |
Mallinckrodt Inc. |
Process for preparing a morphinan derivative
|
|
AU4823900A
(en)
*
|
1999-05-05 |
2000-11-17 |
Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The |
Direct c-14 oxidation of opioids
|
|
US6177567B1
(en)
|
1999-10-15 |
2001-01-23 |
Boehringer Ingelheim Chemicals, Inc. |
Method for preparing oxycodone
|
|
NZ531152A
(en)
*
|
2001-08-23 |
2005-11-25 |
Akzo Nobel Nv |
Process for the preparation of a 14 hydroxynormorphinone derivative
|
|
JP3961796B2
(ja)
*
|
2001-08-27 |
2007-08-22 |
ソニー株式会社 |
情報提供システム、情報処理装置および方法、情報提供装置および方法、記録媒体、並びにプログラム
|
|
DE10161963A1
(de)
*
|
2001-12-17 |
2003-07-03 |
Johannes Schuetz |
6-Aminomorphinanderivate, Herstellungsverfahren dafür und deren Verwendung
|
|
US20040001889A1
(en)
|
2002-06-25 |
2004-01-01 |
Guohua Chen |
Short duration depot formulations
|
|
US20040058946A1
(en)
*
|
2002-07-05 |
2004-03-25 |
Buchwald Stephen L. |
Abuse-resistant prodrugs of oxycodone and other pharmaceuticals
|
|
RU2236412C2
(ru)
*
|
2002-07-18 |
2004-09-20 |
Власов Михаил Иванович |
Способ получения производных морфинона, способ получения производных 14-гидроксиморфинона, и способ получения производных оксиморфона
|
|
RU2215741C1
(ru)
*
|
2002-11-05 |
2003-11-10 |
Открытое Акционерное Общество "Международная Научно-Технологическая Корпорация" |
Сложные эфиры n-замещенных 14-гидроксиморфинанов и способ их получения
|
|
RU2215742C1
(ru)
*
|
2002-11-05 |
2003-11-10 |
Открытое Акционерное Общество "Международная Научно-Технологическая Корпорация" |
Способ получения сложных эфиров n-замещенных 14-гидроксиморфинанов
|
|
DE60329520D1
(de)
*
|
2002-11-08 |
2009-11-12 |
Mallinckrodt Inc |
Verfahren zur herstellung von quaternäre n-alkyl morphinan alkaloid salzen
|
|
CA2507522C
(en)
|
2002-12-13 |
2015-02-24 |
Durect Corporation |
Oral drug delivery system
|
|
US6864370B1
(en)
|
2003-06-05 |
2005-03-08 |
Zhaiwei Lin |
Process for manufacturing oxycodone
|
|
US6790959B1
(en)
|
2003-06-05 |
2004-09-14 |
Halsey Drug Company, Inc. |
Process for manufacturing thebaine
|
|
US7875718B2
(en)
*
|
2003-09-22 |
2011-01-25 |
Johnson Matthey Public Limited Company |
Process for the synthesis of morphinane compounds and intermediates thereof
|
|
JP4879740B2
(ja)
|
2003-09-22 |
2012-02-22 |
ジョンソン、マッセイ、パブリック、リミテッド、カンパニー |
モルヒナン化合物およびその中間体の合成法
|
|
DK1864987T3
(da)
*
|
2004-02-06 |
2010-04-12 |
Euro Celtique Sa |
Fremgangsmåder til fremstilling af 3-O-beskyttede morphinoner og 3-O-beskyttede morphinon-dienol-carboxylater
|
|
TW201509943A
(zh)
|
2004-03-30 |
2015-03-16 |
Euro Celtique Sa |
含有小於25ppm14-羥可待因酮之羥可酮鹽酸鹽之組成物、醫藥劑型、延遲釋出口服劑型及醫藥上可以接受的包裝
|
|
SK286047B6
(sk)
*
|
2004-04-13 |
2008-01-07 |
Zentiva, A. S. |
Spôsob prípravy derivátov 4,5alfa-epoxy-6-oxomorfínanu
|
|
US6946556B1
(en)
*
|
2004-05-21 |
2005-09-20 |
Acura Pharmaceuticals, Inc. |
Preparation of opioid analgesics by a one-pot process
|
|
CA2569758A1
(en)
*
|
2004-06-08 |
2005-12-29 |
Mallinckrodt Inc. |
Extraction of alkaloids from opium
|
|
LT1765292T
(lt)
|
2004-06-12 |
2018-01-10 |
Collegium Pharmaceutical, Inc. |
Nuo piktnaudžiavimo apsaugotos vaistų formos
|
|
ATE537844T1
(de)
|
2004-09-17 |
2012-01-15 |
Durect Corp |
Dauerhafte lokalanästhetische zusammensetzung mit saib
|
|
GB0421149D0
(en)
*
|
2004-09-23 |
2004-10-27 |
Johnson Matthey Plc |
Preparation of oxycodone
|
|
GB0421687D0
(en)
†
|
2004-09-30 |
2004-11-03 |
Johnson Matthey Plc |
Preparation of opiate analgesics
|
|
WO2006084389A1
(de)
|
2005-02-11 |
2006-08-17 |
Cilag Ltd. |
Verfahren zur reinigung von noroxymorphon-verbindungen
|
|
DK2112153T3
(da)
*
|
2005-03-04 |
2011-02-14 |
Euro Celtique Sa |
Fremgangsmåde til reduktion af alpha, beta-umættede ketoner i opioidsammensætninger
|
|
BRPI0608671B1
(pt)
*
|
2005-04-06 |
2022-07-19 |
Toray Industries, Inc |
Processos para produzir um cristal de forma a de cloridrato de 17-ciclopropilmetil-3,14 b-diidróxi-4,5a-epóxi-6b-[n-metil-trans-3-(3-furil)-acril amido]-morfinano
|
|
US8071768B2
(en)
*
|
2005-06-10 |
2011-12-06 |
Janssen Pharmaceutica, N.V. |
Alkylquinoline and alkylquinazoline kinase modulators
|
|
ATE493417T1
(de)
*
|
2005-06-16 |
2011-01-15 |
Mallinckrodt Inc |
Synthetische route zu 14-hydroxylopiaten über 1- halogenthebain oder analoga
|
|
US20070027105A1
(en)
|
2005-07-26 |
2007-02-01 |
Alza Corporation |
Peroxide removal from drug delivery vehicle
|
|
US20070117826A1
(en)
*
|
2005-11-23 |
2007-05-24 |
Forest Laboratories, Inc. |
Pharmaceutical formulations comprising ibuprofen, oxycodone, and 14-hydroxycodeinone
|
|
EP1994034B1
(en)
|
2006-03-02 |
2009-11-11 |
Mallinckrodt, Inc. |
Processes for preparing morphinan-6-one products with low levels of alpha, beta-unsaturated ketone compounds
|
|
SA07280459B1
(ar)
|
2006-08-25 |
2011-07-20 |
بيورديو فارما إل. بي. |
أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني
|
|
ATE517869T1
(de)
*
|
2006-09-20 |
2011-08-15 |
Mallinckrodt Inc |
Herstellung substituierter morphinan-6-one und salzen und zwischenprodukten davon
|
|
AU2012216358B2
(en)
*
|
2006-10-17 |
2014-11-20 |
Penick Corporation |
Process For Preparing Oxymorphone, Naltrexone and Buprenorphine
|
|
CA2674915C
(en)
*
|
2006-10-17 |
2015-06-30 |
Penick Corporation |
Process for preparing oxymorphone
|
|
US20080125592A1
(en)
*
|
2006-10-17 |
2008-05-29 |
Penick Corporation |
Process for preparing oxymorphone, naltrexone, and buprenorphine
|
|
DK2073636T3
(da)
*
|
2006-10-17 |
2012-11-19 |
Penick Corp |
Fremgangsmåde til fremstilling af oxymorphon
|
|
DK2117521T3
(da)
|
2006-11-03 |
2012-09-03 |
Durect Corp |
Transdermale indgivelsessystemer omfattende bupivacain
|
|
JP2010511726A
(ja)
*
|
2006-12-04 |
2010-04-15 |
ノランコ・インコーポレーテツド |
14−ヒドロキシコデイノンの濃度が低いオキシコドンの製造方法
|
|
US7875719B2
(en)
*
|
2006-12-04 |
2011-01-25 |
Cox D Phillip |
Process for reducing impurities in oxycodone base
|
|
GB0624880D0
(en)
*
|
2006-12-14 |
2007-01-24 |
Johnson Matthey Plc |
Improved method for making analgesics
|
|
CA2680205C
(en)
*
|
2007-03-06 |
2015-06-30 |
Mallinckrodt Inc. |
Process for the preparation of quaternary n-alkyl morphinan alkaloid salts
|
|
US9040726B2
(en)
|
2007-03-06 |
2015-05-26 |
Mallinckrodt Llc |
Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
|
|
JP2010522189A
(ja)
*
|
2007-03-23 |
2010-07-01 |
マリンクロッド・インコーポレイテッド |
オリパビンからのオキシモルホンの改善された調製
|
|
AU2008241528B2
(en)
*
|
2007-04-16 |
2013-07-04 |
Mallinckrodt Llc |
Novel opiate reduction utilizing catalytic hydrogen transfer reaction
|
|
US20090018154A1
(en)
*
|
2007-05-17 |
2009-01-15 |
Endo Pharmaceuticals, Inc., A Corporation Of Delaware |
Opioid and methods of making and using the same
|
|
EP3326621A1
(en)
|
2007-12-06 |
2018-05-30 |
Durect Corporation |
Oral pharmaceutical dosage forms
|
|
ES2569655T3
(es)
*
|
2007-12-17 |
2016-05-12 |
Mallinckrodt Llc |
Procedimientos para la producción de compuestos de (+)-'nal' morfinano
|
|
PL2222643T3
(pl)
*
|
2007-12-17 |
2019-12-31 |
SpecGx LLC |
Pochodne synomeniny i sposób ich wytwarzania
|
|
EP2319845B1
(en)
|
2008-02-29 |
2013-07-24 |
Mallinckrodt LLC |
3-Hydroxymorphinan derivatives
|
|
PT2291380E
(pt)
*
|
2008-04-24 |
2011-12-22 |
Janssen Pharmaceutica Nv |
Pró-fármacos nalmefeno
|
|
AU2009251427B2
(en)
*
|
2008-05-27 |
2014-05-22 |
SpecGx LLC |
Processes and compounds for the preparation of normorphinans
|
|
US9458109B2
(en)
|
2008-09-03 |
2016-10-04 |
Mallinckrodt Llc |
Substituted berbines and processes for their synthesis
|
|
CA2738246C
(en)
*
|
2008-09-30 |
2017-09-05 |
Mallinckrodt Inc. |
Processes for the alkylation of secondary amine groups of morphinan derivatives
|
|
US20100260844A1
(en)
|
2008-11-03 |
2010-10-14 |
Scicinski Jan J |
Oral pharmaceutical dosage forms
|
|
UA102916C2
(uk)
|
2009-07-02 |
2013-08-27 |
Кемфарм, Інк. |
Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань
|
|
US10668060B2
(en)
|
2009-12-10 |
2020-06-02 |
Collegium Pharmaceutical, Inc. |
Tamper-resistant pharmaceutical compositions of opioids and other drugs
|
|
TWI478928B
(zh)
|
2010-06-11 |
2015-04-01 |
Rhodes Technologies |
用於製備n-烯丙基化合物之過渡金屬催化的製程及其用途
|
|
EP2580218B1
(en)
|
2010-06-11 |
2015-02-25 |
Rhodes Technologies |
Process for n-dealkylation of tertiary amines
|
|
GB2495062A
(en)
|
2010-07-02 |
2013-03-27 |
Johnson Matthey Plc |
Process for the synthesis and purification of oxycodone
|
|
RU2448709C1
(ru)
*
|
2011-02-01 |
2012-04-27 |
Учреждение Российской академии наук Институт проблем химико-энергетических технологий Сибирского отделения РАН (ИПХЭТ СО РАН) |
Способ получения налтрексона
|
|
TWI560170B
(en)
*
|
2011-12-06 |
2016-12-01 |
Lundbeck & Co As H |
Process for recovery of nalmefene hydrochloride
|
|
US9315514B2
(en)
|
2012-08-27 |
2016-04-19 |
Rhodes Technologies |
1,3-dioxanomorphides and 1,3-dioxanocodides
|
|
CA2894967A1
(en)
|
2012-12-14 |
2014-06-19 |
Purdue Pharma L.P. |
Spirocyclic morphinans and their use
|
|
TW201434836A
(zh)
|
2012-12-14 |
2014-09-16 |
Purdue Pharma Lp |
包含氮之嗎啡喃衍生物及其用途
|
|
WO2014091295A1
(en)
|
2012-12-14 |
2014-06-19 |
Purdue Pharma L.P. |
Pyridonemorphinan analogs and biological activity on opioid receptors
|
|
WO2014102587A1
(en)
|
2012-12-28 |
2014-07-03 |
Purdue Pharma L.P. |
7,8-cyclicmorphinan analogs
|
|
JP6159417B2
(ja)
|
2012-12-28 |
2017-07-05 |
パーデュー、ファーマ、リミテッド、パートナーシップ |
置換モルフィナンおよびその使用
|
|
US9834562B2
(en)
|
2012-12-31 |
2017-12-05 |
Rhodes Technologies |
7 beta-substituted 6a, 14a-ethenomorphinans and 7beta-substituted 6a, 14a-ethanomorphinans
|
|
WO2014144975A1
(en)
|
2013-03-15 |
2014-09-18 |
Durect Corporation |
Compositions with a rheological modifier to reduce dissolution variability
|
|
EP2829541A1
(en)
*
|
2013-07-26 |
2015-01-28 |
Siegfried AG |
Novel synthesis of noroxymorphone from morphine
|
|
CN105452253A
(zh)
|
2013-08-02 |
2016-03-30 |
庄信万丰股份有限公司 |
用于制备氢羟吗啡酮的方法
|
|
WO2015097546A1
(en)
|
2013-12-26 |
2015-07-02 |
Purdue Pharma L.P. |
Propellane-based compounds and their use as opioid receptor modulators
|
|
WO2015097548A1
(en)
|
2013-12-26 |
2015-07-02 |
Purdue Pharma L.P. |
7-beta-alkyl analogs of orvinols
|
|
EP3087073B1
(en)
|
2013-12-26 |
2018-07-04 |
Purdue Pharma LP |
10-substituted morphinan hydantoins
|
|
WO2015097545A1
(en)
|
2013-12-26 |
2015-07-02 |
Purdue Pharma L.P. |
Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans
|
|
WO2015102682A1
(en)
|
2013-12-30 |
2015-07-09 |
Purdue Pharma L.P. |
Pyridone-sulfone morphinan analogs as opioid receptor ligands
|
|
US9850252B2
(en)
|
2014-11-25 |
2017-12-26 |
Kempharm, Inc. |
Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxycodone, prodrugs, methods of making and use thereof
|
|
ES2701855T3
(es)
|
2016-05-31 |
2019-02-26 |
Alcaliber Investig Desarrollo E Innovacion Slu |
Proceso para la obtención de 3,14-diacetiloximorfona a partir de oripavina
|
|
WO2017222575A1
(en)
|
2016-06-23 |
2017-12-28 |
Collegium Pharmaceutical, Inc. |
Process of making more stable abuse-deterrent oral formulations
|
|
CN120617214A
(zh)
|
2016-07-06 |
2025-09-12 |
度瑞公司 |
具有药物组成物、屏障层及药物层的口服剂型
|
|
WO2018116281A1
(en)
|
2016-12-23 |
2018-06-28 |
Minoryx Therapeutics S.L. |
Process for preparing 5-[[4-[2-[5-(1-hydroxyethyl)-2-pyridinyl]ethoxy]phenyl]methyl]-2,4-thiazolidinedione and salts thereof
|
|
SK592017A3
(sk)
|
2017-07-04 |
2019-01-08 |
Saneca Pharmaceuticals A. S. |
Spôsob prípravy morfínanových zlúčenín
|
|
CA3091826A1
(en)
|
2018-02-23 |
2019-08-29 |
Rhodes Technologies |
Novel opioid compounds and uses thereof
|
|
CN110054656B
(zh)
*
|
2019-05-28 |
2021-02-02 |
宜昌人福药业有限责任公司 |
一种10-羰基/羟基吗啡-6-葡萄糖苷酸的合成方法
|
|
WO2021007366A1
(en)
*
|
2019-07-08 |
2021-01-14 |
St. Louis College Of Pharmacy |
G-protein biased opioid receptor agonist/analgesics with reduced arrestin recruitment
|
|
WO2021146215A1
(en)
|
2020-01-13 |
2021-07-22 |
Durect Corporation |
Sustained release drug delivery systems with reduced impurities and related methods
|
|
CN114621239A
(zh)
*
|
2020-12-10 |
2022-06-14 |
鲁南制药集团股份有限公司 |
一种纳曲酮的制备方法
|
|
JP7773548B2
(ja)
*
|
2020-12-28 |
2025-11-19 |
ナヴィン サクセナ リサーチ アンド テクノロジー ピーブイティー.エルティーディー. |
モルヒネからのノルオキシモルフォンの合成のための新規方法
|
|
CN116940358A
(zh)
|
2021-01-12 |
2023-10-24 |
度勒科特公司 |
持续释放药物递送系统和有关的方法
|