NO20000111L - Fremstilling av oksymorfon, oksykodon og derivater derav - Google Patents

Fremstilling av oksymorfon, oksykodon og derivater derav

Info

Publication number
NO20000111L
NO20000111L NO20000111A NO20000111A NO20000111L NO 20000111 L NO20000111 L NO 20000111L NO 20000111 A NO20000111 A NO 20000111A NO 20000111 A NO20000111 A NO 20000111A NO 20000111 L NO20000111 L NO 20000111L
Authority
NO
Norway
Prior art keywords
derivatives
oxymorphone
oxycodone
preparation
noroxymorphone
Prior art date
Application number
NO20000111A
Other languages
English (en)
Norwegian (no)
Other versions
NO20000111D0 (no
Inventor
Bao-Shan Huang
Aris P Christodoulou
Yansong Lu
Ben-Yi Ji
Original Assignee
Penick Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25401603&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20000111(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Penick Corp filed Critical Penick Corp
Publication of NO20000111D0 publication Critical patent/NO20000111D0/no
Publication of NO20000111L publication Critical patent/NO20000111L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D489/00Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08Oxygen atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D489/00Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
NO20000111A 1997-07-11 2000-01-10 Fremstilling av oksymorfon, oksykodon og derivater derav NO20000111L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/893,464 US5869669A (en) 1996-07-26 1997-07-11 Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
PCT/US1998/013592 WO1999002529A1 (en) 1997-07-11 1998-07-10 Preparation of oxymorphone, oxycodone and derivatives

Publications (2)

Publication Number Publication Date
NO20000111D0 NO20000111D0 (no) 2000-01-10
NO20000111L true NO20000111L (no) 2000-02-25

Family

ID=25401603

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20000111A NO20000111L (no) 1997-07-11 2000-01-10 Fremstilling av oksymorfon, oksykodon og derivater derav

Country Status (19)

Country Link
US (7) US5869669A (OSRAM)
EP (1) EP1000065B1 (OSRAM)
JP (1) JP2001518444A (OSRAM)
KR (1) KR100363486B1 (OSRAM)
CN (1) CN1152880C (OSRAM)
AT (1) ATE291023T1 (OSRAM)
AU (1) AU740822B2 (OSRAM)
CA (1) CA2296035C (OSRAM)
DE (1) DE69829379D1 (OSRAM)
HU (1) HUP0003918A3 (OSRAM)
IL (1) IL133792A0 (OSRAM)
IN (1) IN1998KO01500A (OSRAM)
NO (1) NO20000111L (OSRAM)
RU (1) RU2183636C2 (OSRAM)
SK (1) SK102000A3 (OSRAM)
TR (1) TR200000033T2 (OSRAM)
TW (1) TW505648B (OSRAM)
WO (1) WO1999002529A1 (OSRAM)
ZA (1) ZA986144B (OSRAM)

Families Citing this family (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5912347A (en) * 1996-09-30 1999-06-15 Mallinckrodt Inc. Process for preparing a morphinan derivative
AU4823900A (en) * 1999-05-05 2000-11-17 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Direct c-14 oxidation of opioids
US6177567B1 (en) 1999-10-15 2001-01-23 Boehringer Ingelheim Chemicals, Inc. Method for preparing oxycodone
BRPI0211899B8 (pt) * 2001-08-23 2021-05-25 Akzo Nobel Nv processos para a preparação de um derivado de 14- hidroxinormorfinona e para a produção de noroximorfona
JP3961796B2 (ja) * 2001-08-27 2007-08-22 ソニー株式会社 情報提供システム、情報処理装置および方法、情報提供装置および方法、記録媒体、並びにプログラム
DE10161963A1 (de) * 2001-12-17 2003-07-03 Johannes Schuetz 6-Aminomorphinanderivate, Herstellungsverfahren dafür und deren Verwendung
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
US20040058946A1 (en) * 2002-07-05 2004-03-25 Buchwald Stephen L. Abuse-resistant prodrugs of oxycodone and other pharmaceuticals
RU2236412C2 (ru) * 2002-07-18 2004-09-20 Власов Михаил Иванович Способ получения производных морфинона, способ получения производных 14-гидроксиморфинона, и способ получения производных оксиморфона
RU2215742C1 (ru) * 2002-11-05 2003-11-10 Открытое Акционерное Общество "Международная Научно-Технологическая Корпорация" Способ получения сложных эфиров n-замещенных 14-гидроксиморфинанов
RU2215741C1 (ru) * 2002-11-05 2003-11-10 Открытое Акционерное Общество "Международная Научно-Технологическая Корпорация" Сложные эфиры n-замещенных 14-гидроксиморфинанов и способ их получения
WO2004043964A2 (en) * 2002-11-08 2004-05-27 Mallinckrodt Inc. Process for the preparation of quaternary n-alkyl morphinan alkaloid salts
CA2507522C (en) 2002-12-13 2015-02-24 Durect Corporation Oral drug delivery system
US6864370B1 (en) 2003-06-05 2005-03-08 Zhaiwei Lin Process for manufacturing oxycodone
US6790959B1 (en) 2003-06-05 2004-09-14 Halsey Drug Company, Inc. Process for manufacturing thebaine
PT1664061T (pt) 2003-09-22 2017-06-22 Glaxosmithkline Australia Pty Ltd Processo para a síntese de compostos de morfinano e seus intermediários
US7875718B2 (en) * 2003-09-22 2011-01-25 Johnson Matthey Public Limited Company Process for the synthesis of morphinane compounds and intermediates thereof
HRP20080618T3 (hr) * 2004-02-06 2009-01-31 Euro-Celtique S.A. Postupci za pripravljanje 3-o-zaštićenih morfinona i 3-o-zaštićenih morfinon dienol karboksilata
TW201509943A (zh) 2004-03-30 2015-03-16 Euro Celtique Sa 含有小於25ppm14-羥可待因酮之羥可酮鹽酸鹽之組成物、醫藥劑型、延遲釋出口服劑型及醫藥上可以接受的包裝
SK286047B6 (sk) * 2004-04-13 2008-01-07 Zentiva, A. S. Spôsob prípravy derivátov 4,5alfa-epoxy-6-oxomorfínanu
US6946556B1 (en) * 2004-05-21 2005-09-20 Acura Pharmaceuticals, Inc. Preparation of opioid analgesics by a one-pot process
MXPA06014107A (es) * 2004-06-08 2007-03-07 Mallinckrodt Inc Extraccion de alcaloides del opio.
CA2569958C (en) 2004-06-12 2016-03-22 Jane C. Hirsh Abuse-deterrent drug formulations
ATE537844T1 (de) 2004-09-17 2012-01-15 Durect Corp Dauerhafte lokalanästhetische zusammensetzung mit saib
GB0421149D0 (en) * 2004-09-23 2004-10-27 Johnson Matthey Plc Preparation of oxycodone
GB0421687D0 (en) 2004-09-30 2004-11-03 Johnson Matthey Plc Preparation of opiate analgesics
WO2006084389A1 (de) * 2005-02-11 2006-08-17 Cilag Ltd. Verfahren zur reinigung von noroxymorphon-verbindungen
PT2112153E (pt) * 2005-03-04 2010-12-17 Euro Celtique Sa Método de diminuír a quantidade de cetonas insaturadas em alfa-beta em composições de opiáceos
WO2006109671A1 (ja) * 2005-04-06 2006-10-19 Toray Industries, Inc. モルヒナン誘導体の結晶及びその製造法
US8071768B2 (en) * 2005-06-10 2011-12-06 Janssen Pharmaceutica, N.V. Alkylquinoline and alkylquinazoline kinase modulators
CN101198612A (zh) * 2005-06-16 2008-06-11 马林克罗特公司 通过1-卤代-蒂巴因或类似物制备14-羟基阿片类的合成路线
US20070027105A1 (en) 2005-07-26 2007-02-01 Alza Corporation Peroxide removal from drug delivery vehicle
US20070117826A1 (en) * 2005-11-23 2007-05-24 Forest Laboratories, Inc. Pharmaceutical formulations comprising ibuprofen, oxycodone, and 14-hydroxycodeinone
CN101395159A (zh) 2006-03-02 2009-03-25 马林克罗特公司 制备含有低含量α,β-不饱和酮化合物的吗啡烷-6-酮产物的方法
SA07280459B1 (ar) 2006-08-25 2011-07-20 بيورديو فارما إل. بي. أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني
MX2009002844A (es) * 2006-09-20 2009-03-30 Mallinckrodt Inc Preparacion de morfinan-6-onas sustituidas y sales e intermediarios de las mismas.
CA2674915C (en) 2006-10-17 2015-06-30 Penick Corporation Process for preparing oxymorphone
AU2012216358B2 (en) * 2006-10-17 2014-11-20 Penick Corporation Process For Preparing Oxymorphone, Naltrexone and Buprenorphine
US20080125592A1 (en) * 2006-10-17 2008-05-29 Penick Corporation Process for preparing oxymorphone, naltrexone, and buprenorphine
EP2073636B1 (en) * 2006-10-17 2012-09-05 Penick Corporation Process for preparing oxymorphone
EP2484347A1 (en) 2006-11-03 2012-08-08 Durect Corporation Transdermal delivery systems comprising bupivacaine
ATE543823T1 (de) * 2006-12-04 2012-02-15 Noramco Inc Verfahren zur reduzierung von unreinheiten in oxycodonbase
JP2010511726A (ja) * 2006-12-04 2010-04-15 ノランコ・インコーポレーテツド 14−ヒドロキシコデイノンの濃度が低いオキシコドンの製造方法
GB0624880D0 (en) * 2006-12-14 2007-01-24 Johnson Matthey Plc Improved method for making analgesics
US9040726B2 (en) 2007-03-06 2015-05-26 Mallinckrodt Llc Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
ES2540534T3 (es) * 2007-03-06 2015-07-10 Mallinckrodt Llc Procedimiento para la preparación de sales cuaternarias de alcaloides de N-alquil morfinano
ES2438997T5 (es) * 2007-03-23 2024-09-03 SpecGx LLC Preparación mejorada de oximorfona a partir de oripavina
MX2009010931A (es) * 2007-04-16 2009-10-29 Mallinckrodt Inc Reduccion novedosa de opiaceos utilizando la reaccion de transferencia catalitica de hidrogeno.
US20090018154A1 (en) * 2007-05-17 2009-01-15 Endo Pharmaceuticals, Inc., A Corporation Of Delaware Opioid and methods of making and using the same
CA2706931C (en) 2007-12-06 2015-05-12 Durect Corporation Oral pharmaceutical dosage forms
CA2709886C (en) 2007-12-17 2016-10-25 Mallinckrodt Inc. Processes for the production of (+)-"nal" morphinan compounds
US8461337B2 (en) 2007-12-17 2013-06-11 Mallinckrodt Llc Sinomenine derivatives and processes for their synthesis
WO2009111162A1 (en) * 2008-02-29 2009-09-11 Mallinckrodt Inc. Process for the preparation of 3-hydroxymorphinan derivatives
ES2373364T3 (es) * 2008-04-24 2012-02-02 Janssen Pharmaceutica N.V. Profármacos de nalmefeno.
ES2641887T3 (es) * 2008-05-27 2017-11-14 Mallinckrodt Llc Procesos y compuestos para la preparación de normorfinanos
WO2010028004A2 (en) 2008-09-03 2010-03-11 Mallinckrodt Inc. Substituted berbines and processes for their synthesis
US8080661B2 (en) * 2008-09-30 2011-12-20 Mallinckrodt Llc Processes for the synthesis of tertiary amines
US20100260844A1 (en) 2008-11-03 2010-10-14 Scicinski Jan J Oral pharmaceutical dosage forms
UA102916C2 (uk) 2009-07-02 2013-08-27 Кемфарм, Інк. Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань
US10668060B2 (en) 2009-12-10 2020-06-02 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
CA2802295C (en) 2010-06-11 2016-09-20 Rhodes Technologies Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof
AU2011263416B2 (en) 2010-06-11 2014-04-10 Rhodes Technologies Process for N-dealkylation of tertiary amines
AU2011274361B2 (en) 2010-07-02 2014-09-18 Macfarlan Smith Limited Process for the synthesis and purification of oxycodone
RU2448709C1 (ru) * 2011-02-01 2012-04-27 Учреждение Российской академии наук Институт проблем химико-энергетических технологий Сибирского отделения РАН (ИПХЭТ СО РАН) Способ получения налтрексона
TWI560170B (en) * 2011-12-06 2016-12-01 Lundbeck & Co As H Process for recovery of nalmefene hydrochloride
US9315514B2 (en) 2012-08-27 2016-04-19 Rhodes Technologies 1,3-dioxanomorphides and 1,3-dioxanocodides
WO2014091297A1 (en) 2012-12-14 2014-06-19 Purdue Pharma L.P. Spirocyclic morphinans and their use
TW201434836A (zh) 2012-12-14 2014-09-16 Purdue Pharma Lp 包含氮之嗎啡喃衍生物及其用途
WO2014091295A1 (en) 2012-12-14 2014-06-19 Purdue Pharma L.P. Pyridonemorphinan analogs and biological activity on opioid receptors
CA2896202A1 (en) 2012-12-28 2014-07-03 Purdue Pharma L.P. Substituted morphinans and the use thereof
US8957084B2 (en) 2012-12-28 2015-02-17 Purdue Pharma L.P. 7,8-cyclicmorphinan analogs
ES2748803T3 (es) 2012-12-31 2020-03-18 Rhodes Tech Procedimiento para preparar 6,14-etenomorfinanos sustituidos en 7, 6,14-etanomorfinanos sustituidos en 7
HK1220579A1 (zh) 2013-03-15 2017-05-12 Durect Corporation 用於降低溶解可变性的具有流变改性剂的组合物
EP2829541A1 (en) 2013-07-26 2015-01-28 Siegfried AG Novel synthesis of noroxymorphone from morphine
US9120800B2 (en) 2013-08-02 2015-09-01 Johnson Matthey Public Limited Company Process for the preparation of oxymorphone alkaloid and oxymorphone salts
EP3087079B1 (en) 2013-12-26 2019-04-03 Purdue Pharma LP Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans
US9988392B2 (en) 2013-12-26 2018-06-05 Purdue Pharma L.P. 7-beta-alkyl analogs of orvinols
US9994571B2 (en) 2013-12-26 2018-06-12 Purdue Pharma L.P. 10-substituted morphinan hydantoins
WO2015097546A1 (en) 2013-12-26 2015-07-02 Purdue Pharma L.P. Propellane-based compounds and their use as opioid receptor modulators
WO2015102682A1 (en) 2013-12-30 2015-07-09 Purdue Pharma L.P. Pyridone-sulfone morphinan analogs as opioid receptor ligands
RU2683317C2 (ru) * 2014-11-25 2019-03-28 Кемфарм, Инк. Конъюгаты оксикодона с бензойной кислотой, производными бензойной кислоты и гетероарилкарбоновой кислотой
EP3252055B1 (en) 2016-05-31 2018-09-19 Alcaliber Investigacion Desarrollo e Innovacion SLU Process for obtaining 3,14-diacetyloxymorphone from oripavine
US9737530B1 (en) 2016-06-23 2017-08-22 Collegium Pharmaceutical, Inc. Process of making stable abuse-deterrent oral formulations
KR102413459B1 (ko) 2016-07-06 2022-06-24 듀렉트 코퍼레이션 약물 조성물, 장벽 층 및 약물 층을 갖는 경구 투여 형태
DK3559010T3 (da) 2016-12-23 2022-08-15 Minoryx Therapeutics S L Fremgangsmåde til fremstilling af 5-[[4-[2-[5-(1-hydroxyethyl)-2-pyridinyl]ethoxy]phenyl]methyl]-2,4-thiazolidinedion og salte deraf
SK592017A3 (sk) 2017-07-04 2019-01-08 Saneca Pharmaceuticals A. S. Spôsob prípravy morfínanových zlúčenín
IL276834B2 (en) 2018-02-23 2025-08-01 Rhodes Tech Novel opioid compounds and uses thereof
CN110054656B (zh) * 2019-05-28 2021-02-02 宜昌人福药业有限责任公司 一种10-羰基/羟基吗啡-6-葡萄糖苷酸的合成方法
US11613547B2 (en) 2019-07-08 2023-03-28 University Of Health Sciences & Pharmacy In St. Louis G-protein biased opioid receptor agonist/analgesics with reduced arrestin recruitment
CN115666621A (zh) 2020-01-13 2023-01-31 度勒科特公司 具有减少的杂质的持续释放药物递送系统及相关方法
CN114621239A (zh) * 2020-12-10 2022-06-14 鲁南制药集团股份有限公司 一种纳曲酮的制备方法
EP4267583A4 (en) * 2020-12-28 2024-10-30 Navin Saxena Research & Technology Pvt. Ltd. NEW PROCESS FOR THE PRODUCTION OF NOROXYMORPHONE FROM MORPHINE
EP4277702A1 (en) 2021-01-12 2023-11-22 Durect Corporation Sustained release drug delivery systems and related methods

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3819636A (en) * 1970-09-15 1974-06-25 American Home Prod 4a,10-(methaniminomethano)phenanthrene derivatives
US4795813A (en) * 1981-08-17 1989-01-03 The Florida Board Of Regents On Behalf Of The Florida State University Synthesis of derivatives of codeine and other 3-O-alkylmorphines
FR2562072B1 (fr) * 1984-03-27 1989-07-07 Mallinckrodt Inc Procede de preparation de la noroxymorphone a partir de la morphine, et composes intermediaires utilises dans ce procede
US5112975A (en) * 1984-03-27 1992-05-12 Mallinckrodt Specialty Chemicals Company Preparation of noroxymorphone from morphine
US4639520A (en) * 1984-03-27 1987-01-27 Mallinckrodt, Inc. Preparation of 14-hydroxy-N-ethoxy-carbonyl-norcodeinone
US4668685A (en) * 1984-07-05 1987-05-26 E.I. Du Pont De Nemours And Company Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists
US4912114A (en) * 1988-03-18 1990-03-27 Sandoz Ltd. Morphinan derivatives

Also Published As

Publication number Publication date
CN1152880C (zh) 2004-06-09
US6008355A (en) 1999-12-28
IN1998KO01500A (OSRAM) 2005-03-11
US5948788A (en) 1999-09-07
RU2183636C2 (ru) 2002-06-20
NO20000111D0 (no) 2000-01-10
US6013796A (en) 2000-01-11
SK102000A3 (en) 2000-07-11
AU8379198A (en) 1999-02-08
JP2001518444A (ja) 2001-10-16
US6008354A (en) 1999-12-28
US5922876A (en) 1999-07-13
ATE291023T1 (de) 2005-04-15
CN1272845A (zh) 2000-11-08
CA2296035A1 (en) 1999-01-21
EP1000065A4 (en) 2001-09-12
KR20010021693A (ko) 2001-03-15
HUP0003918A3 (en) 2003-04-28
TW505648B (en) 2002-10-11
US5952495A (en) 1999-09-14
TR200000033T2 (tr) 2000-12-21
US5869669A (en) 1999-02-09
IL133792A0 (en) 2001-04-30
WO1999002529A1 (en) 1999-01-21
HUP0003918A2 (hu) 2001-07-30
DE69829379D1 (de) 2005-04-21
EP1000065A1 (en) 2000-05-17
CA2296035C (en) 2004-04-13
EP1000065B1 (en) 2005-03-16
ZA986144B (en) 1999-05-19
AU740822B2 (en) 2001-11-15
KR100363486B1 (ko) 2002-12-16
HK1028025A1 (en) 2001-02-02

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