|
US5504188A
(en)
*
|
1994-06-16 |
1996-04-02 |
Eli Lilly And Company |
Preparation of stable zinc insulin analog crystals
|
|
US5474978A
(en)
*
|
1994-06-16 |
1995-12-12 |
Eli Lilly And Company |
Insulin analog formulations
|
|
YU18596A
(sh)
*
|
1995-03-31 |
1998-07-10 |
Eli Lilly And Company |
Analogne formulacije monomernog insulina
|
|
US5631347A
(en)
*
|
1995-06-07 |
1997-05-20 |
Eli Lilly And Company |
Reducing gelation of a fatty acid-acylated protein
|
|
US5869604A
(en)
*
|
1995-11-09 |
1999-02-09 |
Georgia Institute Of Technology |
Crystallization and purification of polypeptides
|
|
EP0969860B1
(en)
*
|
1997-03-20 |
2002-07-17 |
Novo Nordisk A/S |
Method for preparation of a therapeutic powder through coprecipitation of insulin and absorption enhancer
|
|
US6043214A
(en)
*
|
1997-03-20 |
2000-03-28 |
Novo Nordisk A/S |
Method for producing powder formulation comprising an insulin
|
|
CN1278737A
(zh)
*
|
1997-11-12 |
2001-01-03 |
阿尔萨公司 |
减少多肽自结合的方法
|
|
RU2205188C2
(ru)
|
1998-06-30 |
2003-05-27 |
Ново Нордиск А/С |
Затравочные кристаллы для получения пептидов или протеинов
|
|
US6956021B1
(en)
*
|
1998-08-25 |
2005-10-18 |
Advanced Inhalation Research, Inc. |
Stable spray-dried protein formulations
|
|
UA67798C2
(uk)
*
|
1998-10-16 |
2004-07-15 |
Ново Нордіск А/С |
Препарати інсуліну, які містять ментол, для доставки через легені
|
|
PT1121144E
(pt)
*
|
1998-10-16 |
2002-11-29 |
Novo Nordisk As |
Preparados de insulina concentrada estavel para administracao pulmonar
|
|
US6635617B1
(en)
|
1998-10-16 |
2003-10-21 |
Novo Nordisk A/S |
Insulin preparations for pulmonary delivery containing menthol
|
|
US6211144B1
(en)
|
1998-10-16 |
2001-04-03 |
Novo Nordisk A/S |
Stable concentrated insulin preparations for pulmonary delivery
|
|
US20040214747A1
(en)
*
|
1999-01-06 |
2004-10-28 |
Dimarchi Richard Dennis |
Method for administering monomeric insulin
|
|
US7169889B1
(en)
|
1999-06-19 |
2007-01-30 |
Biocon Limited |
Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin
|
|
US7678364B2
(en)
|
1999-08-25 |
2010-03-16 |
Alkermes, Inc. |
Particles for inhalation having sustained release properties
|
|
CN1406131A
(zh)
*
|
2000-12-25 |
2003-03-26 |
株式会社资生堂 |
活化交感神经的香料组合物
|
|
PL374181A1
(en)
*
|
2001-02-09 |
2005-10-03 |
Genentech, Inc. |
Crystallization of igf-1
|
|
US7060675B2
(en)
*
|
2001-02-15 |
2006-06-13 |
Nobex Corporation |
Methods of treating diabetes mellitus
|
|
US6867183B2
(en)
*
|
2001-02-15 |
2005-03-15 |
Nobex Corporation |
Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
|
|
US6835802B2
(en)
*
|
2001-06-04 |
2004-12-28 |
Nobex Corporation |
Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
|
|
US6858580B2
(en)
*
|
2001-06-04 |
2005-02-22 |
Nobex Corporation |
Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
|
|
US6828305B2
(en)
*
|
2001-06-04 |
2004-12-07 |
Nobex Corporation |
Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
|
|
US7713932B2
(en)
|
2001-06-04 |
2010-05-11 |
Biocon Limited |
Calcitonin drug-oligomer conjugates, and uses thereof
|
|
US6828297B2
(en)
*
|
2001-06-04 |
2004-12-07 |
Nobex Corporation |
Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
|
|
US6713452B2
(en)
|
2001-06-04 |
2004-03-30 |
Nobex Corporation |
Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
|
|
US6913903B2
(en)
|
2001-09-07 |
2005-07-05 |
Nobex Corporation |
Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
|
|
US7196059B2
(en)
*
|
2001-09-07 |
2007-03-27 |
Biocon Limited |
Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
|
|
US7166571B2
(en)
*
|
2001-09-07 |
2007-01-23 |
Biocon Limited |
Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
|
|
US7312192B2
(en)
*
|
2001-09-07 |
2007-12-25 |
Biocon Limited |
Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
|
|
US6770625B2
(en)
|
2001-09-07 |
2004-08-03 |
Nobex Corporation |
Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith
|
|
US7030082B2
(en)
*
|
2001-09-07 |
2006-04-18 |
Nobex Corporation |
Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
|
|
US20030068361A1
(en)
*
|
2001-10-09 |
2003-04-10 |
Rimona Margalit |
Liposome-encapsulated insulin formulations
|
|
JP4563675B2
(ja)
|
2001-10-12 |
2010-10-13 |
ハイ・ポイント・ファーマスーティカルズ、エルエルシー |
置換ピペリジン類、およびヒスタミンh3受容体関連疾患の治療のためのその使用
|
|
WO2003105768A2
(en)
*
|
2002-06-13 |
2003-12-24 |
Nobex Corporation |
Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
|
|
ATE482747T1
(de)
|
2003-04-11 |
2010-10-15 |
High Point Pharmaceuticals Llc |
Neue amide derivate und deren pharmazeutische verwendungen
|
|
CN113304250A
(zh)
|
2003-11-20 |
2021-08-27 |
诺和诺德股份有限公司 |
对于生产和用于注射装置中是最佳的含有丙二醇的肽制剂
|
|
RU2527893C2
(ru)
*
|
2004-07-19 |
2014-09-10 |
Биокон Лимитед |
Инсулин-олигомерные конъюгаты, их препараты и применения
|
|
MX2007001589A
(es)
*
|
2004-08-09 |
2007-08-02 |
Alios Biopharma Inc |
Variantes de polipeptido resistentes a proteasa, hiperglicosiladas sinteticas, formulaciones orales y metodos para utilizar las mismas.
|
|
US7597884B2
(en)
|
2004-08-09 |
2009-10-06 |
Alios Biopharma, Inc. |
Hyperglycosylated polypeptide variants and methods of use
|
|
US7833513B2
(en)
|
2004-12-03 |
2010-11-16 |
Rhode Island Hospital |
Treatment of Alzheimer's Disease
|
|
EP2233470B1
(en)
|
2005-07-04 |
2011-12-07 |
High Point Pharmaceuticals, LLC |
Histamine H3 receptor antagonists
|
|
ES2426345T3
(es)
|
2005-07-20 |
2013-10-22 |
Eli Lilly And Company |
Compuesto unidos en posición 1-amino
|
|
CA2629223C
(en)
|
2005-11-17 |
2013-08-06 |
Eli Lilly And Company |
Glucagon receptor antagonists, preparation and therapeutic uses
|
|
EP1996224B1
(en)
|
2006-03-15 |
2012-11-07 |
Novo Nordisk A/S |
Mixtures of amylin and insulin
|
|
SG170785A1
(en)
|
2006-03-28 |
2011-05-30 |
Transtech Pharma |
Benzothiazoles having histamine h3 receptor activity
|
|
US8927015B2
(en)
*
|
2006-04-12 |
2015-01-06 |
Emisphere Technologies, Inc. |
Formulations for delivering insulin
|
|
CA2649111C
(en)
|
2006-04-24 |
2013-09-10 |
Eli Lilly And Company |
Cyclohexyl substituted pyrrolidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
|
|
PT2079732E
(pt)
|
2006-05-29 |
2012-02-02 |
High Point Pharmaceuticals Llc |
3-(1,3-benzodioxol-5-il)-6-(4-ciclopropilpiperazin-1-il)- piridazina, os seus sais e solvatos e a sua utilização a título de antagonista do receptor h3 de histamina
|
|
US20080260820A1
(en)
*
|
2007-04-19 |
2008-10-23 |
Gilles Borrelly |
Oral dosage formulations of protease-resistant polypeptides
|
|
EP2514406A1
(en)
|
2007-06-01 |
2012-10-24 |
Novo Nordisk A/S |
Spontaneously dispersible preconcentrates including a peptide drug in a solid or semisolid carrier
|
|
RU2472492C2
(ru)
|
2007-06-01 |
2013-01-20 |
Ново Нордиск А/С |
Стабильные неводные фармацевтические композиции
|
|
US9034818B2
(en)
*
|
2007-06-13 |
2015-05-19 |
Novo Nordisk A/S |
Pharmaceutical formulations comprising an insulin derivative
|
|
NZ585135A
(en)
*
|
2007-10-16 |
2012-08-31 |
Biocon Ltd |
An orally administerable solid pharmaceutical composition comprising in-105 and a process thereof
|
|
US20090271021A1
(en)
*
|
2008-04-28 |
2009-10-29 |
Popp Shane M |
Execution system for the monitoring and execution of insulin manufacture
|
|
ES2477552T3
(es)
|
2008-09-08 |
2014-07-17 |
The Board Of Trustees Of The Leland Stanford Junior University |
Moduladores de la actividad de la aldehidodeshidrogenasa y métodos de uso de los mismos
|
|
US8389522B2
(en)
|
2008-10-28 |
2013-03-05 |
The Board Of Trustees Of The Leland Stanford Junior University |
Modulators of aldehyde dehydrogenase and methods of use thereof
|
|
EP2362730A4
(en)
|
2008-11-21 |
2012-08-29 |
High Point Pharmaceuticals Llc |
Adamantyl BENZAMIDE CONNECTIONS
|
|
US8940690B2
(en)
|
2009-01-28 |
2015-01-27 |
National Institutes Of Health (Nih) |
Synthetic conjugates and uses thereof
|
|
ES2791683T3
(es)
|
2009-01-28 |
2020-11-05 |
Smartcells Inc |
Sistemas a base de conjugados para la administración controlada de fármacos
|
|
WO2010107519A1
(en)
|
2009-03-20 |
2010-09-23 |
Smartcells, Inc. |
Terminally-functionalized conjugates and uses thereof
|
|
WO2011018745A1
(en)
*
|
2009-08-11 |
2011-02-17 |
Biocon Limited |
Chromatographic processes and purified compounds thereof
|
|
EP2670773A1
(en)
|
2011-02-01 |
2013-12-11 |
Novo Nordisk A/S |
Purification of insulin
|
|
US10130684B2
(en)
|
2011-02-03 |
2018-11-20 |
Pharmedica Ltd. |
Oral dissolving films for insulin administration, for treating diabetes
|
|
WO2012115641A1
(en)
|
2011-02-23 |
2012-08-30 |
Elona Biotechnologies |
Lis-pro proinsulin compositions and methods of producing lis-pro insulin analogs therefrom
|
|
US10457659B2
(en)
|
2011-04-29 |
2019-10-29 |
The Board Of Trustees Of The Leland Stanford Junior University |
Compositions and methods for increasing proliferation of adult salivary stem cells
|
|
CN102219851B
(zh)
*
|
2011-05-09 |
2012-05-30 |
甘李药业有限公司 |
甘精胰岛素结晶的制备方法
|
|
JP6735561B2
(ja)
|
2012-12-03 |
2020-08-05 |
メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. |
O−グリコシル化カルボキシ末端部分(ctp)ペプチド系のインスリンおよびインスリン類似体
|
|
JP6410790B2
(ja)
|
2013-03-14 |
2018-10-24 |
ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー |
ミトコンドリアアルデヒドデヒドロゲナーゼ−2調節因子およびその使用方法
|
|
CN103342746B
(zh)
*
|
2013-07-26 |
2014-07-30 |
珠海联邦制药股份有限公司 |
一种制备稳定的门冬胰岛素结晶的方法
|
|
EP3077414B1
(en)
|
2013-12-04 |
2020-06-17 |
Merck Sharp & Dohme Corp. |
Method for preparing crystalline insulin
|
|
EP2990033A1
(fr)
*
|
2014-08-26 |
2016-03-02 |
Carlina Technologies |
Procédé de préparation de nanoprécipites de peptide ou protéine de faible poids moléculaire
|
|
WO2016032869A1
(en)
|
2014-08-26 |
2016-03-03 |
Merck Sharp & Dohme Corp. |
Method for preparing crystalline insulin or insulin analog compositions
|
|
CN104193819B
(zh)
*
|
2014-09-03 |
2017-05-17 |
韩飞 |
胰岛素二聚体晶体的合成和保存方法
|
|
CN104761632A
(zh)
*
|
2015-04-14 |
2015-07-08 |
珠海联邦制药股份有限公司 |
一种地特胰岛素结晶的制备方法及应用
|
|
CN106117345B
(zh)
*
|
2015-05-05 |
2020-11-24 |
宜昌东阳光长江药业股份有限公司 |
一种制备甘精胰岛素结晶的方法
|
|
CN104892749B
(zh)
*
|
2015-06-16 |
2019-02-05 |
珠海联邦制药股份有限公司 |
一种德谷胰岛素结晶的制备方法及应用
|
|
CN105753966A
(zh)
*
|
2016-05-05 |
2016-07-13 |
通化东宝药业股份有限公司 |
一种重组人胰岛素结晶的制备方法
|
|
EP3740212A4
(en)
|
2017-12-18 |
2021-10-27 |
Merck Sharp & Dohme Corp. |
CONJUGATE-BASED SYSTEMS FOR CONTROLLED INSULIN DELIVERY
|
|
EP3727424A4
(en)
|
2017-12-18 |
2021-10-27 |
Merck Sharp & Dohme Corp. |
CONJUGATE-BASED SYSTEMS FOR CONTROLLED INSULIN RELEASE
|
|
PE20230457A1
(es)
|
2020-03-31 |
2023-03-10 |
Protomer Tech Inc |
Conjugados para reactividad selectiva a dioles vecinales
|
|
AU2021382599A1
(en)
|
2020-11-19 |
2023-06-22 |
Protomer Technologies Inc. |
Aromatic boron-containing compounds and insulin analogs
|
|
CN113896784B
(zh)
*
|
2021-10-18 |
2024-04-16 |
合肥天麦生物科技发展有限公司 |
一种胰岛素结晶的制备方法及其产品
|
|
CN119677541A
(zh)
|
2022-05-18 |
2025-03-21 |
原聚体科技公司 |
芳族含硼化合物和相关的胰岛素类似物
|