IL99536A - Isoprenoid phospholipase A2 inhibitors and pharmaceutical preparation comprising them - Google Patents

Isoprenoid phospholipase A2 inhibitors and pharmaceutical preparation comprising them

Info

Publication number
IL99536A
IL99536A IL9953691A IL9953691A IL99536A IL 99536 A IL99536 A IL 99536A IL 9953691 A IL9953691 A IL 9953691A IL 9953691 A IL9953691 A IL 9953691A IL 99536 A IL99536 A IL 99536A
Authority
IL
Israel
Prior art keywords
compound
pharmaceutical preparation
inflammation
preparation
mammal
Prior art date
Application number
IL9953691A
Other languages
English (en)
Other versions
IL99536A0 (en
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of IL99536A0 publication Critical patent/IL99536A0/xx
Publication of IL99536A publication Critical patent/IL99536A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/64—Monocyclic acids with unsaturation outside the aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/20—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by carboxyl groups or halides, anhydrides, or (thio)esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
IL9953691A 1990-09-21 1991-09-20 Isoprenoid phospholipase A2 inhibitors and pharmaceutical preparation comprising them IL99536A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/586,159 US5141959A (en) 1990-09-21 1990-09-21 Isoprenoid phospholipase a2 inhibitors and preparations comprising same

Publications (2)

Publication Number Publication Date
IL99536A0 IL99536A0 (en) 1992-08-18
IL99536A true IL99536A (en) 1995-10-31

Family

ID=24344545

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9953691A IL99536A (en) 1990-09-21 1991-09-20 Isoprenoid phospholipase A2 inhibitors and pharmaceutical preparation comprising them

Country Status (18)

Country Link
US (1) US5141959A (es)
EP (1) EP0476682B1 (es)
JP (1) JP2943089B2 (es)
AT (1) ATE117979T1 (es)
AU (1) AU637756B2 (es)
CA (1) CA2051766A1 (es)
DE (1) DE69107153T2 (es)
DK (1) DK0476682T3 (es)
ES (1) ES2067822T3 (es)
FI (1) FI104168B (es)
GR (1) GR3014944T3 (es)
IE (1) IE66745B1 (es)
IL (1) IL99536A (es)
MX (1) MX9101163A (es)
NZ (1) NZ239844A (es)
OA (1) OA09514A (es)
PT (1) PT99014B (es)
ZA (1) ZA917531B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7189737B2 (en) 1991-08-09 2007-03-13 Research Triangle Institute Cocaine receptor binding ligands
US5688781A (en) * 1994-08-19 1997-11-18 Bristol-Myers Squibb Company Method for treating vascular leak syndrome
FR2735371B1 (fr) * 1995-06-19 1997-07-18 Cird Galderma Procede pour identifier des composes antagonistes des recepteurs rars
US6900228B1 (en) 1998-03-10 2005-05-31 Research Triangle Institute Opiate compounds, methods of making and methods of use
US6267945B1 (en) 1998-12-18 2001-07-31 Neuromed Technologies, Inc. Farnesol-related calcium channel blockers
US6538010B1 (en) * 2000-11-08 2003-03-25 Research Triangle Institute Compounds and methods for promoting smoking cessation
US6495719B2 (en) * 2001-03-27 2002-12-17 Circagen Pharmaceutical Histone deacetylase inhibitors
US7314953B2 (en) * 2001-03-27 2008-01-01 Errant Gene Therapeutics, Llc Treatment of lung cells with histone deacetylase inhibitors
US7842727B2 (en) * 2001-03-27 2010-11-30 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
US8026280B2 (en) 2001-03-27 2011-09-27 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
US7312247B2 (en) 2001-03-27 2007-12-25 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
CA2486303C (en) * 2002-05-22 2013-04-30 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors based on alpha-ketoepoxide compounds
WO2003101177A2 (en) * 2002-06-04 2003-12-11 Sequenom, Inc. Diagnosing predisposition to fat deposition and therapeutic methods for reducing fat deposition and treatment of associated conditions
EP1581095A4 (en) * 2002-06-27 2006-10-18 Harkness Pharmaceuticals Inc THERAPEUTIC METHODS FOR REDUCING FAT DEPOSIT AND TREATING THE DISEASES THEREOF
US20050239077A1 (en) * 2002-06-27 2005-10-27 Adam Gail I R Diagnosing predisposition to fat deposition and associated conditions
CA2587013A1 (en) * 2004-11-08 2006-05-18 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
US7872023B2 (en) * 2005-02-17 2011-01-18 Research Triangle Institute Kappa opioid receptor ligands
US7399762B2 (en) * 2005-04-25 2008-07-15 Research Triangle Institute Opioid receptor agonist compounds and their use in treatment of pain
US7476679B2 (en) * 2005-07-26 2009-01-13 Research Triangle Institute Octahydroisoquinoline compounds as opioid receptor modulators
BRPI0810063A2 (pt) * 2007-04-20 2014-10-14 Acucela Inc Composto, composição farmacêutica, e, métodos para modular fluxo de cromóforo em um ciclo retinóide, para tratar uma doença ou distúrbio oftálmico em um indivíduo, para inibir adaptação ao escuro em uma célula fotorreceptora de bastão da retina, para inibir regeneração de rodopsina em uma célula fotoreceptora de bastão da retina, para reduzir isquemia em um olho de um indivíduo, para inibir neovascularização na retina de um olho de um indivíduo, e para inibir degeneração de uma célula da retina em uma retina
US8048895B2 (en) * 2008-04-18 2011-11-01 Research Triangle Institute Kappa opioid receptor ligands
US9273027B2 (en) 2010-02-24 2016-03-01 Research Triangle Institute Arylpiperazine opioid receptor antagonists

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4194007A (en) * 1978-01-13 1980-03-18 Scott Eugene J Van α-Hydroxyretinoic acid, α-ketoretinoic acid and mixtures and their use in treating skin conditions
US4456618A (en) * 1982-10-15 1984-06-26 Sri International Naphthenic and heterocyclic retinoic acid analogues
US4568757A (en) * 1984-01-30 1986-02-04 Research Triangle Institute Configurationally locked retinoids

Also Published As

Publication number Publication date
IL99536A0 (en) 1992-08-18
EP0476682A1 (en) 1992-03-25
ES2067822T3 (es) 1995-04-01
GR3014944T3 (en) 1995-05-31
FI104168B1 (fi) 1999-11-30
IE913318A1 (en) 1992-02-25
IE66745B1 (en) 1996-02-07
OA09514A (en) 1992-11-15
DK0476682T3 (da) 1995-04-03
DE69107153T2 (de) 1995-05-24
AU8462691A (en) 1992-03-26
ZA917531B (en) 1992-07-29
US5141959A (en) 1992-08-25
FI914405A0 (fi) 1991-09-19
DE69107153D1 (de) 1995-03-16
ATE117979T1 (de) 1995-02-15
EP0476682B1 (en) 1995-02-01
AU637756B2 (en) 1993-06-03
PT99014B (pt) 1999-02-26
PT99014A (pt) 1992-08-31
CA2051766A1 (en) 1992-03-22
MX9101163A (es) 1992-05-04
JP2943089B2 (ja) 1999-08-30
NZ239844A (en) 1993-04-28
FI914405A (fi) 1992-03-22
FI104168B (fi) 1999-11-30
JPH04270261A (ja) 1992-09-25

Similar Documents

Publication Publication Date Title
EP0476682B1 (en) Isoprenoid phospholipase A2 inhibitors and preparations comprising same
US5607966A (en) Esters and amides of non-steroidal anti-inflammatory carboxylic acids which may be used as anti-oxidants, 5-lipoxygenase inhibitors and non-steroidal anti-inflammatory prodrugs
US5874468A (en) Brain targeted low molecular weight hydrophobic antioxidant compounds
JP2008531558A (ja) 新規なリポオキシゲナーゼ阻害剤
US5624957A (en) Rary-specific retinobenzoic acid derivatives
EP0407200A1 (en) Cinnamamide derivatives
AU3032099A (en) Retinoid antagonists and use thereof
US6740676B2 (en) 4-[(8-ethynyl, 8-vinyl or 8-ethynyl-methyl)-6-chromanoyl]-benzoic and 2-[4-[(8-ethynyl, 8-vinyl or 8-ethynyl-methyl)-6-chromanoyl]-phenyl]-acetic acid, their esters and salts having cytochrome p450rai inhibitory activity
CA2512563C (en) Kynurenine 3-hydroxylase inhibitors for the treatment of diabetes
US4025649A (en) Acetic acid derivatives having pharmacological activity and compositions containing the same
US7019034B2 (en) Compositions and methods for reducing serum glucose and triglyceride levels in diabetic mammals
US4778818A (en) Substituted 2-(heteroaryl-2-propenyl)phenols useful as anti-inflammatory agents
FR2521992A1 (fr) Nouveaux composes de pyridine utiles comme medicaments
US4469705A (en) Saturated leukotriene derivatives as antiallergens
JP2754644B2 (ja) 新規リグナン類およびリグナン類を有効成分とする５―リポキシゲナーゼ阻害剤およびアルドースリダクターゼ阻害剤
HU211590A9 (hu) Izoprenoidvázas foszfolipáz A2 gátló vegyületek és az ezeket tartalmazó gyógyászati készítmények Az átmeneti oltalom az 1., 2. és 8-11. igénypontokra vonatkozik.
JP2003026636A (ja) 脂質代謝系酵素を阻害するチロゾール誘導体
JPH08502521A (ja) １０−置換 １，８−ジヒドロキシ−９（１０ｈ）アントラセノン医薬
JP3144662B2 (ja) スチルベン誘導体とスチルベン同族体誘導体及びそれらの用途
US20180185325A1 (en) 12H-BENZO[b]XANTHEN-12-ONES, COMPOSITIONS CONTAINING, AND USES OF, SAME
EP0504017A1 (fr) Dérivés du benzopyrane, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
US20040077721A1 (en) Compositions and methods using compounds having cytochrome P450RAI inhibitory activity co-administered with vitamin A
US6331570B1 (en) Active enantiomer of RARγ-specific agonist
CA2387164A1 (fr) Composes anti-ischemiques
EP0395526A1 (fr) Nouveaux dérivés benzothiazolinoniques, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed