OA09514A - Isoprenoid phospholipase A2 inhibitors and preparation comprising same - Google Patents

Isoprenoid phospholipase A2 inhibitors and preparation comprising same

Info

Publication number
OA09514A
OA09514A OA60073A OA60073A OA09514A OA 09514 A OA09514 A OA 09514A OA 60073 A OA60073 A OA 60073A OA 60073 A OA60073 A OA 60073A OA 09514 A OA09514 A OA 09514A
Authority
OA
OAPI
Prior art keywords
phospholipase
isoprenoid
inhibitors
preparation
same
Prior art date
Application number
OA60073A
Other languages
English (en)
Inventor
Ivy F Carroll
Anita Lewin
Kenneth Tramposch
Stephen A Steiner
F Ivy Carroll
Original Assignee
Bristol Myers Squibb Co
Bristol Myers Squibb Company E
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co, Bristol Myers Squibb Company E filed Critical Bristol Myers Squibb Co
Publication of OA09514A publication Critical patent/OA09514A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/64—Monocyclic acids with unsaturation outside the aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/20—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by carboxyl groups or halides, anhydrides, or (thio)esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
OA60073A 1990-09-21 1991-09-19 Isoprenoid phospholipase A2 inhibitors and preparation comprising same OA09514A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/586,159 US5141959A (en) 1990-09-21 1990-09-21 Isoprenoid phospholipase a2 inhibitors and preparations comprising same

Publications (1)

Publication Number Publication Date
OA09514A true OA09514A (en) 1992-11-15

Family

ID=24344545

Family Applications (1)

Application Number Title Priority Date Filing Date
OA60073A OA09514A (en) 1990-09-21 1991-09-19 Isoprenoid phospholipase A2 inhibitors and preparation comprising same

Country Status (18)

Country Link
US (1) US5141959A (es)
EP (1) EP0476682B1 (es)
JP (1) JP2943089B2 (es)
AT (1) ATE117979T1 (es)
AU (1) AU637756B2 (es)
CA (1) CA2051766A1 (es)
DE (1) DE69107153T2 (es)
DK (1) DK0476682T3 (es)
ES (1) ES2067822T3 (es)
FI (1) FI104168B (es)
GR (1) GR3014944T3 (es)
IE (1) IE66745B1 (es)
IL (1) IL99536A (es)
MX (1) MX9101163A (es)
NZ (1) NZ239844A (es)
OA (1) OA09514A (es)
PT (1) PT99014B (es)
ZA (1) ZA917531B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7189737B2 (en) 1991-08-09 2007-03-13 Research Triangle Institute Cocaine receptor binding ligands
US5688781A (en) * 1994-08-19 1997-11-18 Bristol-Myers Squibb Company Method for treating vascular leak syndrome
FR2735371B1 (fr) * 1995-06-19 1997-07-18 Cird Galderma Procede pour identifier des composes antagonistes des recepteurs rars
US6900228B1 (en) 1998-03-10 2005-05-31 Research Triangle Institute Opiate compounds, methods of making and methods of use
US6267945B1 (en) 1998-12-18 2001-07-31 Neuromed Technologies, Inc. Farnesol-related calcium channel blockers
US6538010B1 (en) * 2000-11-08 2003-03-25 Research Triangle Institute Compounds and methods for promoting smoking cessation
US6495719B2 (en) * 2001-03-27 2002-12-17 Circagen Pharmaceutical Histone deacetylase inhibitors
US7314953B2 (en) * 2001-03-27 2008-01-01 Errant Gene Therapeutics, Llc Treatment of lung cells with histone deacetylase inhibitors
US7842727B2 (en) * 2001-03-27 2010-11-30 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
US8026280B2 (en) 2001-03-27 2011-09-27 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
US7312247B2 (en) 2001-03-27 2007-12-25 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
CA2486303C (en) * 2002-05-22 2013-04-30 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors based on alpha-ketoepoxide compounds
WO2003101177A2 (en) * 2002-06-04 2003-12-11 Sequenom, Inc. Diagnosing predisposition to fat deposition and therapeutic methods for reducing fat deposition and treatment of associated conditions
EP1581095A4 (en) * 2002-06-27 2006-10-18 Harkness Pharmaceuticals Inc THERAPEUTIC METHODS FOR REDUCING FAT DEPOSIT AND TREATING THE DISEASES THEREOF
US20050239077A1 (en) * 2002-06-27 2005-10-27 Adam Gail I R Diagnosing predisposition to fat deposition and associated conditions
CA2587013A1 (en) * 2004-11-08 2006-05-18 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
US7872023B2 (en) * 2005-02-17 2011-01-18 Research Triangle Institute Kappa opioid receptor ligands
US7399762B2 (en) * 2005-04-25 2008-07-15 Research Triangle Institute Opioid receptor agonist compounds and their use in treatment of pain
US7476679B2 (en) * 2005-07-26 2009-01-13 Research Triangle Institute Octahydroisoquinoline compounds as opioid receptor modulators
BRPI0810063A2 (pt) * 2007-04-20 2014-10-14 Acucela Inc Composto, composição farmacêutica, e, métodos para modular fluxo de cromóforo em um ciclo retinóide, para tratar uma doença ou distúrbio oftálmico em um indivíduo, para inibir adaptação ao escuro em uma célula fotorreceptora de bastão da retina, para inibir regeneração de rodopsina em uma célula fotoreceptora de bastão da retina, para reduzir isquemia em um olho de um indivíduo, para inibir neovascularização na retina de um olho de um indivíduo, e para inibir degeneração de uma célula da retina em uma retina
US8048895B2 (en) * 2008-04-18 2011-11-01 Research Triangle Institute Kappa opioid receptor ligands
US9273027B2 (en) 2010-02-24 2016-03-01 Research Triangle Institute Arylpiperazine opioid receptor antagonists

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4194007A (en) * 1978-01-13 1980-03-18 Scott Eugene J Van α-Hydroxyretinoic acid, α-ketoretinoic acid and mixtures and their use in treating skin conditions
US4456618A (en) * 1982-10-15 1984-06-26 Sri International Naphthenic and heterocyclic retinoic acid analogues
US4568757A (en) * 1984-01-30 1986-02-04 Research Triangle Institute Configurationally locked retinoids

Also Published As

Publication number Publication date
IL99536A0 (en) 1992-08-18
EP0476682A1 (en) 1992-03-25
IL99536A (en) 1995-10-31
ES2067822T3 (es) 1995-04-01
GR3014944T3 (en) 1995-05-31
FI104168B1 (fi) 1999-11-30
IE913318A1 (en) 1992-02-25
IE66745B1 (en) 1996-02-07
DK0476682T3 (da) 1995-04-03
DE69107153T2 (de) 1995-05-24
AU8462691A (en) 1992-03-26
ZA917531B (en) 1992-07-29
US5141959A (en) 1992-08-25
FI914405A0 (fi) 1991-09-19
DE69107153D1 (de) 1995-03-16
ATE117979T1 (de) 1995-02-15
EP0476682B1 (en) 1995-02-01
AU637756B2 (en) 1993-06-03
PT99014B (pt) 1999-02-26
PT99014A (pt) 1992-08-31
CA2051766A1 (en) 1992-03-22
MX9101163A (es) 1992-05-04
JP2943089B2 (ja) 1999-08-30
NZ239844A (en) 1993-04-28
FI914405A (fi) 1992-03-22
FI104168B (fi) 1999-11-30
JPH04270261A (ja) 1992-09-25

Similar Documents

Publication Publication Date Title
OA09514A (en) Isoprenoid phospholipase A2 inhibitors and preparation comprising same
TNSN87033A1 (fr) TOLUNITRILES SUBSTITUES PAR DESα - HETEROCYCLES
CA2143406A1 (en) High temperature corrosion inhibitor
ATE263771T1 (de) Totalsynthese von acylfulvenen mit antitumorwirkung
TW222638B (es)
SE8302694D0 (sv) Immunomodulating agent
IE811130L (en) Arylethanolamine derivatives.
AU9066498A (en) Substituted 6-alkylphenanthridines
SE8600046L (sv) Anvendning av en esterforening som temporer baktericid och produkt innehallande esterforeningen
GB1531946A (en) Cyclopentane derivatives useful as perfuming agents
ATE74269T1 (de) Zellproliferationsinhibitor.
WO1993025568A3 (en) Antihypercholesterolemic compounds and related pharmaceutical compositions and methods of use
AU6306190A (en) Novel substituted alkyl piperidines and their use as inhibitors of cholesterol synthesis
MX9603348A (es) Derivados de disulfuro de amida indano-2-mercaptoacetilica novedosos utiles como inhibidores de encefalinasa.
WO1990012577A3 (en) Topical anti-angiogenic as hair growth inhibitors
EP0638570A4 (en) TRICYCLIC COMPOUND WITH AN ANTIALLERGIC EFFECT.
ES8303372A1 (es) Procedimiento para la fabricacion de un compuesto de fenil-5-alquiltiazolidina-4-ona, 2-substituida
AU569152B2 (en) Enkephalinase inhibitors
WO1990008529A3 (en) 7-alkoxycoumarins, dihydropsoralens, and benzodipyranones as photo-activated therapeutic agents and inhibitors of epidermal growth factor
AU564799B2 (en) Composition for prophylactic and preventative of ketosis in livestock
ES2161870T3 (es) Esteres de benzoilacetato como fotoprotectores quelantes no sensibilizantes.
BR9611789A (pt) Processo para a preparação de derivados de ácido metoximino-fenilglioxílico
ES550972A0 (es) Un procedimiento para preparar nuevos derivados de imidiazol.
IT1194343B (it) Sali di endo-8,8-dialchil-8-azoniabiciclo (3.2.1) ottan-6,7-esso-epossi-3-alchilcarbossilati,processo per la loro preparazione e composizioni terapeutiche che li contengono come principio attivo
EP0885886A4 (en) NEW PYRIDINECARBOXAMIDE DERIVATIVES