WO1990008529A3 - 7-alkoxycoumarins, dihydropsoralens, and benzodipyranones as photo-activated therapeutic agents and inhibitors of epidermal growth factor - Google Patents

7-alkoxycoumarins, dihydropsoralens, and benzodipyranones as photo-activated therapeutic agents and inhibitors of epidermal growth factor Download PDF

Info

Publication number
WO1990008529A3
WO1990008529A3 PCT/US1990/000704 US9000704W WO9008529A3 WO 1990008529 A3 WO1990008529 A3 WO 1990008529A3 US 9000704 W US9000704 W US 9000704W WO 9008529 A3 WO9008529 A3 WO 9008529A3
Authority
WO
WIPO (PCT)
Prior art keywords
benzodipyranones
alkoxycoumarins
dihydropsoralens
inhibitors
photo
Prior art date
Application number
PCT/US1990/000704
Other languages
French (fr)
Other versions
WO1990008529A2 (en
Inventor
Ned Duane Heindel
Michele Carole Siller
Jeffrey Dean Laskin
Michael A Gallo
Original Assignee
Univ Lehigh
Univ New Jersey Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Lehigh, Univ New Jersey Med filed Critical Univ Lehigh
Publication of WO1990008529A2 publication Critical patent/WO1990008529A2/en
Publication of WO1990008529A3 publication Critical patent/WO1990008529A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

A photochemotherapeutic compound of formula (I), wherein (i) n is zero, W is a (C1-16) alkyl, alkenyl, or alkynyl linear or branched chain hydrocarbon, having no more than four O, N, or S atoms in or attached to the chain; or (ii) n is 1, W is CR2, and R, R', and R'' are independently H or CH3; or (iii) n is 2, W is CR2, and R, R', and R'' are independently H or CH3; and A, B, C, and D are independently selected from hydrogen, alkyl, aryl, halogen, amino, aminoalkyl, nitro, alkoxy, aryloxy, hydroxy, carboxy, haloalkyl, or haloalkoxy.
PCT/US1990/000704 1989-01-23 1990-01-23 7-alkoxycoumarins, dihydropsoralens, and benzodipyranones as photo-activated therapeutic agents and inhibitors of epidermal growth factor WO1990008529A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30086989A 1989-01-23 1989-01-23
US300,869 1989-01-23

Publications (2)

Publication Number Publication Date
WO1990008529A2 WO1990008529A2 (en) 1990-08-09
WO1990008529A3 true WO1990008529A3 (en) 1990-09-20

Family

ID=23160933

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1990/000704 WO1990008529A2 (en) 1989-01-23 1990-01-23 7-alkoxycoumarins, dihydropsoralens, and benzodipyranones as photo-activated therapeutic agents and inhibitors of epidermal growth factor

Country Status (1)

Country Link
WO (1) WO1990008529A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9027449D0 (en) * 1990-12-19 1991-02-06 Duck Edward W Skin care composition
US6255324B1 (en) 1998-11-25 2001-07-03 Ned D. Heindel Amino-and mercurio-substituted 4′,5'-dihydropsoralens and therapeutical uses thereof
US7026484B2 (en) * 2001-02-23 2006-04-11 Ligand Pharmaceuticals Incorporated Tricyclic androgen receptor modulator compounds and methods
WO2010132554A2 (en) 2009-05-12 2010-11-18 Mallinckrodt Inc. Diaza heterocyclic compounds for phototherapy
WO2010132515A1 (en) 2009-05-12 2010-11-18 Mallinckrodt Inc. Compounds containing acyclic n-n bonds for phototherapy
CN115197236B (en) * 2022-06-29 2023-09-19 广西中医药大学 Linear type glabra A analogue and preparation and application thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4151291A (en) * 1976-11-24 1979-04-24 Unicler Ethers of 7-hydroxy-coumarin useful as medicaments
US4208426A (en) * 1977-07-28 1980-06-17 Eisai Co., Ltd. Pyranochromone derivatives and therapeutic composition comprising same for treatment of allergic diseases
US4260630A (en) * 1977-08-29 1981-04-07 Agence Nationale De Valorisation De La Recherche (Anvar) Skin diseases
US4312883A (en) * 1979-08-20 1982-01-26 Consiglio Nazionale Delle Ricerche Furocoumarin for the photochemotherapy of psoriasis and related skin diseases
US4452811A (en) * 1977-11-17 1984-06-05 Fidia S.P.A. Monohalogenated derivatives of 7-hydroxy-coumarin, pharmaceutical compositions containing the same and methods of using said compositions
US4737517A (en) * 1983-07-29 1988-04-12 Fidia, S.P.A. Coumarin derivatives, pharmaceutical compositions containing the same, and the use thereof in the treatment of cancer

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4151291A (en) * 1976-11-24 1979-04-24 Unicler Ethers of 7-hydroxy-coumarin useful as medicaments
US4208426A (en) * 1977-07-28 1980-06-17 Eisai Co., Ltd. Pyranochromone derivatives and therapeutic composition comprising same for treatment of allergic diseases
US4260630A (en) * 1977-08-29 1981-04-07 Agence Nationale De Valorisation De La Recherche (Anvar) Skin diseases
US4452811A (en) * 1977-11-17 1984-06-05 Fidia S.P.A. Monohalogenated derivatives of 7-hydroxy-coumarin, pharmaceutical compositions containing the same and methods of using said compositions
US4312883A (en) * 1979-08-20 1982-01-26 Consiglio Nazionale Delle Ricerche Furocoumarin for the photochemotherapy of psoriasis and related skin diseases
US4737517A (en) * 1983-07-29 1988-04-12 Fidia, S.P.A. Coumarin derivatives, pharmaceutical compositions containing the same, and the use thereof in the treatment of cancer

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF HETEROCYCLIC CHEMISTRY, Vol. 24, (March-April 1987), RODIGHIERO et al., "Synthesis of Methyl Derivatives of 8-Desmethylxanthyleting and 8-Desmethylsoseline, Potential Antiproliverative Agents", pages 485-88. *

Also Published As

Publication number Publication date
WO1990008529A2 (en) 1990-08-09

Similar Documents

Publication Publication Date Title
DE69405425D1 (en) Oxazolidinedione derivatives, their preparation and their use for inhibiting sugar and lipid in blood
NO905572D0 (en) PROCEDURE FOR THE PREPARATION OF PEPTID RELATIONS.
IT1314184B1 (en) PHARMACEUTICAL COMPOSITIONS FOR THE THERAPY OF STRESS-OXIDATIVE CONDITIONS
CA2304713A1 (en) Biphenyl-5-alkanoic acid derivatives and use thereof
HU9203304D0 (en) 3-benzylidene-1-carbamoyl-2-pyrrolidone analogues
AU4523797A (en) Atherosclerosis treatment
ATE263771T1 (en) TOTAL SYNTHESIS OF ACYLFULVENE WITH ANTITUMOR EFFECT
ES2081120T3 (en) PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF BACATINE III AND DESACETIL-10 BACATINE III.
AU7517400A (en) N-substituted 4-aminopteridines, synthesis and use thereof as pharmaceutical agent
ES2064461T3 (en) XANTINA DERIVATIVES, PROCEDURE FOR ITS PREPARATION AND PHARMACEUTICAL COMPOSITION.
DE3677471D1 (en) PYRROLIDINYLAMIDESTER DERIVATIVES WITH ANTIPROLYLENE DOPEPTIDASE ACTIVITY, THEIR PRODUCTION, THEIR USE AND THE PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME.
NO940831D0 (en) Diode Compounds for Use in the Preparation of Morpholinyl Derivatives of Doxorubicin, and Their Preparation
WO1990008529A3 (en) 7-alkoxycoumarins, dihydropsoralens, and benzodipyranones as photo-activated therapeutic agents and inhibitors of epidermal growth factor
EP0357403A3 (en) Substituted beta-diketones
RU1804462C (en) Method of cefem compounds or theirs salts synthesis
ATE137759T1 (en) S'-ADENOSYL-METHIONINE DECARBOXYLASE INHIBITORS
DK0478194T3 (en) Bis- (2-aminocarbonylcycloalk-1-enyl) disulfides, preparation and use thereof
GR3020271T3 (en) (Benzhydryloxyethylpiperidyl)aliphatic acid derivatives and their use in the treatment of allergies and asthma
DE69905144D1 (en) N, N'-Diacylthiocystine
FI955680A (en) Psoralen derivatives, their preparation and use
DE69214180D1 (en) Use of bis (p-hydroxyphenylthio) methane derivatives to inhibit the progressive development of insulin-dependent diabetes mellitus
EP0443474A3 (en) 1-phenoxycarbonyl-2-pyrrolidinone derivatives and nootropic agents

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): CA JP

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): AT BE CH DE DK ES FR GB IT LU NL SE

AK Designated states

Kind code of ref document: A3

Designated state(s): CA JP

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): AT BE CH DE DK ES FR GB IT LU NL SE