PT99014A - Processo para a preparacao de novos derivados isoprenoides inibidores da fosfolipase a2 e de composicoes farmaceuticas que os contem - Google Patents

Processo para a preparacao de novos derivados isoprenoides inibidores da fosfolipase a2 e de composicoes farmaceuticas que os contem

Info

Publication number
PT99014A
PT99014A PT99014A PT9901491A PT99014A PT 99014 A PT99014 A PT 99014A PT 99014 A PT99014 A PT 99014A PT 9901491 A PT9901491 A PT 9901491A PT 99014 A PT99014 A PT 99014A
Authority
PT
Portugal
Prior art keywords
inhibitor
pharmaceutical compositions
compositions containing
preparing new
phospholipase
Prior art date
Application number
PT99014A
Other languages
English (en)
Other versions
PT99014B (pt
Inventor
Kenneth Tramposch
F Ivy Carroll
Anita Lewin
Stephen A Steiner
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PT99014A publication Critical patent/PT99014A/pt
Publication of PT99014B publication Critical patent/PT99014B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/64—Monocyclic acids with unsaturation outside the aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/20—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by carboxyl groups or halides, anhydrides, or (thio)esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT99014A 1990-09-21 1991-09-19 Processo para a preparacao de novos derivados isoprenoides inibidores da fosfolipase a2 e de composicoes farmaceuticas que os contem PT99014B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/586,159 US5141959A (en) 1990-09-21 1990-09-21 Isoprenoid phospholipase a2 inhibitors and preparations comprising same

Publications (2)

Publication Number Publication Date
PT99014A true PT99014A (pt) 1992-08-31
PT99014B PT99014B (pt) 1999-02-26

Family

ID=24344545

Family Applications (1)

Application Number Title Priority Date Filing Date
PT99014A PT99014B (pt) 1990-09-21 1991-09-19 Processo para a preparacao de novos derivados isoprenoides inibidores da fosfolipase a2 e de composicoes farmaceuticas que os contem

Country Status (18)

Country Link
US (1) US5141959A (pt)
EP (1) EP0476682B1 (pt)
JP (1) JP2943089B2 (pt)
AT (1) ATE117979T1 (pt)
AU (1) AU637756B2 (pt)
CA (1) CA2051766A1 (pt)
DE (1) DE69107153T2 (pt)
DK (1) DK0476682T3 (pt)
ES (1) ES2067822T3 (pt)
FI (1) FI104168B1 (pt)
GR (1) GR3014944T3 (pt)
IE (1) IE66745B1 (pt)
IL (1) IL99536A (pt)
MX (1) MX9101163A (pt)
NZ (1) NZ239844A (pt)
OA (1) OA09514A (pt)
PT (1) PT99014B (pt)
ZA (1) ZA917531B (pt)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7189737B2 (en) 1991-08-09 2007-03-13 Research Triangle Institute Cocaine receptor binding ligands
US5688781A (en) 1994-08-19 1997-11-18 Bristol-Myers Squibb Company Method for treating vascular leak syndrome
FR2735371B1 (fr) * 1995-06-19 1997-07-18 Cird Galderma Procede pour identifier des composes antagonistes des recepteurs rars
US6900228B1 (en) * 1998-03-10 2005-05-31 Research Triangle Institute Opiate compounds, methods of making and methods of use
US6267945B1 (en) 1998-12-18 2001-07-31 Neuromed Technologies, Inc. Farnesol-related calcium channel blockers
US6538010B1 (en) * 2000-11-08 2003-03-25 Research Triangle Institute Compounds and methods for promoting smoking cessation
US7842727B2 (en) * 2001-03-27 2010-11-30 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
US8026280B2 (en) 2001-03-27 2011-09-27 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
US7312247B2 (en) 2001-03-27 2007-12-25 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
US6495719B2 (en) 2001-03-27 2002-12-17 Circagen Pharmaceutical Histone deacetylase inhibitors
EP1511477A4 (en) * 2002-05-22 2008-04-09 Errant Gene Therapeutics Llc HISTONE DEACETYLASE INHIBITORS BASED ON ALPHA-KETO-EPOXYDE COMPOUNDS
AU2003237397A1 (en) * 2002-06-04 2003-12-19 Sequenom, Inc. Diagnosing predisposition to fat deposition and therapeutic methods for reducing fat deposition and treatment of associated conditions
EP1581095A4 (en) * 2002-06-27 2006-10-18 Harkness Pharmaceuticals Inc THERAPEUTIC METHODS FOR REDUCING FAT DEPOSIT AND TREATING THE DISEASES THEREOF
US20050239077A1 (en) * 2002-06-27 2005-10-27 Adam Gail I R Diagnosing predisposition to fat deposition and associated conditions
WO2004046104A2 (en) * 2002-11-20 2004-06-03 Errant Gene Therapeutics, Llc Treatment of lung cells with histone deacetylase inhibitors
EP1817020A4 (en) * 2004-11-08 2012-11-21 Errant Gene Therapeutics Inc INHIBITORS OF HISTONATE ACETYLASE
US7872023B2 (en) * 2005-02-17 2011-01-18 Research Triangle Institute Kappa opioid receptor ligands
US7399762B2 (en) * 2005-04-25 2008-07-15 Research Triangle Institute Opioid receptor agonist compounds and their use in treatment of pain
US7476679B2 (en) * 2005-07-26 2009-01-13 Research Triangle Institute Octahydroisoquinoline compounds as opioid receptor modulators
CN101686665B (zh) * 2007-04-20 2014-04-23 奥克塞拉有限公司 用于治疗眼科疾病和紊乱的苯乙烯基衍生化合物
US8048895B2 (en) * 2008-04-18 2011-11-01 Research Triangle Institute Kappa opioid receptor ligands
US9273027B2 (en) 2010-02-24 2016-03-01 Research Triangle Institute Arylpiperazine opioid receptor antagonists

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4194007A (en) * 1978-01-13 1980-03-18 Scott Eugene J Van α-Hydroxyretinoic acid, α-ketoretinoic acid and mixtures and their use in treating skin conditions
US4456618A (en) * 1982-10-15 1984-06-26 Sri International Naphthenic and heterocyclic retinoic acid analogues
US4568757A (en) * 1984-01-30 1986-02-04 Research Triangle Institute Configurationally locked retinoids

Also Published As

Publication number Publication date
ES2067822T3 (es) 1995-04-01
AU8462691A (en) 1992-03-26
DK0476682T3 (da) 1995-04-03
EP0476682B1 (en) 1995-02-01
FI914405A0 (fi) 1991-09-19
IL99536A (en) 1995-10-31
AU637756B2 (en) 1993-06-03
US5141959A (en) 1992-08-25
CA2051766A1 (en) 1992-03-22
DE69107153T2 (de) 1995-05-24
FI104168B (fi) 1999-11-30
JP2943089B2 (ja) 1999-08-30
JPH04270261A (ja) 1992-09-25
IL99536A0 (en) 1992-08-18
IE66745B1 (en) 1996-02-07
PT99014B (pt) 1999-02-26
DE69107153D1 (de) 1995-03-16
ATE117979T1 (de) 1995-02-15
ZA917531B (en) 1992-07-29
NZ239844A (en) 1993-04-28
FI104168B1 (fi) 1999-11-30
IE913318A1 (en) 1992-02-25
GR3014944T3 (en) 1995-05-31
OA09514A (en) 1992-11-15
FI914405A (fi) 1992-03-22
EP0476682A1 (en) 1992-03-25
MX9101163A (es) 1992-05-04

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Legal Events

Date Code Title Description
BB1A Laying open of patent application

Effective date: 19920408

FG3A Patent granted, date of granting

Effective date: 19981110

MM3A Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20030531