ES2067822T3 - Inhibidores de la fosfolipasa a2 isoprenoide y preparaciones que los contienen. - Google Patents

Inhibidores de la fosfolipasa a2 isoprenoide y preparaciones que los contienen.

Info

Publication number
ES2067822T3
ES2067822T3 ES91116015T ES91116015T ES2067822T3 ES 2067822 T3 ES2067822 T3 ES 2067822T3 ES 91116015 T ES91116015 T ES 91116015T ES 91116015 T ES91116015 T ES 91116015T ES 2067822 T3 ES2067822 T3 ES 2067822T3
Authority
ES
Spain
Prior art keywords
isoprenoid
phospholipase
inhibitors
preparations containing
sub
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91116015T
Other languages
English (en)
Inventor
Ivy F Carroll
Anita Lewin
Kenneth Tramposch
Stephen A Steiner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of ES2067822T3 publication Critical patent/ES2067822T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/64—Monocyclic acids with unsaturation outside the aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/20—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by carboxyl groups or halides, anhydrides, or (thio)esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SON COMPUESTOS DE FORMULA: DONDE R SUB 1 ES CH=CY-C(CH SUB 3)=CHX DONDE X E Y SON DISTINTOS Y CADA UNO TIENE LA FORMULA: DONDE R'' Y R" SON INDEPENDIENTEMENTE H O ALQUILO C SUB 1-6 Y R SUB 1 INCLUYE TODOS LOS ISOMEROS GEOMETRICAMENTE POSIBLES. SE HA DEMOSTRADO QUE SON EFECTIVOS PARA EL TRATAMIENTO DE INFLAMACIONES, TANTO EXTERNAS COMO INTERNAS. EL MECANISMO PARECE SER LA INHIBICION DE LAS ENZIMAS DE LA FOSFOLIPASA A SUB 2.
ES91116015T 1990-09-21 1991-09-20 Inhibidores de la fosfolipasa a2 isoprenoide y preparaciones que los contienen. Expired - Lifetime ES2067822T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/586,159 US5141959A (en) 1990-09-21 1990-09-21 Isoprenoid phospholipase a2 inhibitors and preparations comprising same

Publications (1)

Publication Number Publication Date
ES2067822T3 true ES2067822T3 (es) 1995-04-01

Family

ID=24344545

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91116015T Expired - Lifetime ES2067822T3 (es) 1990-09-21 1991-09-20 Inhibidores de la fosfolipasa a2 isoprenoide y preparaciones que los contienen.

Country Status (18)

Country Link
US (1) US5141959A (es)
EP (1) EP0476682B1 (es)
JP (1) JP2943089B2 (es)
AT (1) ATE117979T1 (es)
AU (1) AU637756B2 (es)
CA (1) CA2051766A1 (es)
DE (1) DE69107153T2 (es)
DK (1) DK0476682T3 (es)
ES (1) ES2067822T3 (es)
FI (1) FI104168B (es)
GR (1) GR3014944T3 (es)
IE (1) IE66745B1 (es)
IL (1) IL99536A (es)
MX (1) MX9101163A (es)
NZ (1) NZ239844A (es)
OA (1) OA09514A (es)
PT (1) PT99014B (es)
ZA (1) ZA917531B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7189737B2 (en) 1991-08-09 2007-03-13 Research Triangle Institute Cocaine receptor binding ligands
US5688781A (en) 1994-08-19 1997-11-18 Bristol-Myers Squibb Company Method for treating vascular leak syndrome
FR2735371B1 (fr) * 1995-06-19 1997-07-18 Cird Galderma Procede pour identifier des composes antagonistes des recepteurs rars
US6900228B1 (en) 1998-03-10 2005-05-31 Research Triangle Institute Opiate compounds, methods of making and methods of use
US6267945B1 (en) * 1998-12-18 2001-07-31 Neuromed Technologies, Inc. Farnesol-related calcium channel blockers
US6538010B1 (en) * 2000-11-08 2003-03-25 Research Triangle Institute Compounds and methods for promoting smoking cessation
US8026280B2 (en) 2001-03-27 2011-09-27 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
US7314953B2 (en) * 2001-03-27 2008-01-01 Errant Gene Therapeutics, Llc Treatment of lung cells with histone deacetylase inhibitors
US6495719B2 (en) * 2001-03-27 2002-12-17 Circagen Pharmaceutical Histone deacetylase inhibitors
US7842727B2 (en) * 2001-03-27 2010-11-30 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
US7312247B2 (en) 2001-03-27 2007-12-25 Errant Gene Therapeutics, Llc Histone deacetylase inhibitors
EP1511477A4 (en) * 2002-05-22 2008-04-09 Errant Gene Therapeutics Llc HISTONE DEACETYLASE INHIBITORS BASED ON ALPHA-KETO-EPOXYDE COMPOUNDS
WO2003101177A2 (en) * 2002-06-04 2003-12-11 Sequenom, Inc. Diagnosing predisposition to fat deposition and therapeutic methods for reducing fat deposition and treatment of associated conditions
AU2003248794B2 (en) * 2002-06-27 2007-10-04 Harkness Pharmaceuticals, Inc. Therapeutic methods for reducing fat deposition and treating associated conditions
AU2003248793A1 (en) * 2002-06-27 2004-01-19 Sequenom, Inc Diagnosing predisposition to fat deposition and associated condition
WO2006052916A2 (en) * 2004-11-08 2006-05-18 Errant Gene Therapeutics, Inc. Histone deacetylase inhibitors
US7872023B2 (en) * 2005-02-17 2011-01-18 Research Triangle Institute Kappa opioid receptor ligands
US7399762B2 (en) * 2005-04-25 2008-07-15 Research Triangle Institute Opioid receptor agonist compounds and their use in treatment of pain
US7476679B2 (en) * 2005-07-26 2009-01-13 Research Triangle Institute Octahydroisoquinoline compounds as opioid receptor modulators
US20090170841A1 (en) * 2007-04-20 2009-07-02 Acucela Inc. Styrenyl Derivative Compounds for Treating Ophthalmic Diseases and Disorders
US8048895B2 (en) * 2008-04-18 2011-11-01 Research Triangle Institute Kappa opioid receptor ligands
JP6173693B2 (ja) 2010-02-24 2017-08-02 リサーチ・トライアングル・インスティチュート アリールピペラジンオピオイド受容体アンタゴニスト

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4194007A (en) * 1978-01-13 1980-03-18 Scott Eugene J Van α-Hydroxyretinoic acid, α-ketoretinoic acid and mixtures and their use in treating skin conditions
US4456618A (en) * 1982-10-15 1984-06-26 Sri International Naphthenic and heterocyclic retinoic acid analogues
US4568757A (en) * 1984-01-30 1986-02-04 Research Triangle Institute Configurationally locked retinoids

Also Published As

Publication number Publication date
PT99014B (pt) 1999-02-26
PT99014A (pt) 1992-08-31
FI914405A (fi) 1992-03-22
NZ239844A (en) 1993-04-28
EP0476682A1 (en) 1992-03-25
FI104168B1 (fi) 1999-11-30
IE913318A1 (en) 1992-02-25
FI104168B (fi) 1999-11-30
MX9101163A (es) 1992-05-04
OA09514A (en) 1992-11-15
AU637756B2 (en) 1993-06-03
EP0476682B1 (en) 1995-02-01
FI914405A0 (fi) 1991-09-19
AU8462691A (en) 1992-03-26
DE69107153D1 (de) 1995-03-16
DK0476682T3 (da) 1995-04-03
CA2051766A1 (en) 1992-03-22
ZA917531B (en) 1992-07-29
IE66745B1 (en) 1996-02-07
IL99536A0 (en) 1992-08-18
JPH04270261A (ja) 1992-09-25
DE69107153T2 (de) 1995-05-24
US5141959A (en) 1992-08-25
GR3014944T3 (en) 1995-05-31
IL99536A (en) 1995-10-31
JP2943089B2 (ja) 1999-08-30
ATE117979T1 (de) 1995-02-15

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