IL99213A - Diclofenac's codeine salt processes its preparation and its pharmaceutical preparations - Google Patents

Diclofenac's codeine salt processes its preparation and its pharmaceutical preparations

Info

Publication number
IL99213A
IL99213A IL9921391A IL9921391A IL99213A IL 99213 A IL99213 A IL 99213A IL 9921391 A IL9921391 A IL 9921391A IL 9921391 A IL9921391 A IL 9921391A IL 99213 A IL99213 A IL 99213A
Authority
IL
Israel
Prior art keywords
salt
codeine
formula
phenyl
amino
Prior art date
Application number
IL9921391A
Other languages
English (en)
Hebrew (he)
Other versions
IL99213A0 (en
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of IL99213A0 publication Critical patent/IL99213A0/xx
Publication of IL99213A publication Critical patent/IL99213A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C07D489/04—Salts; Organic complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Carbon And Carbon Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IL9921391A 1990-08-23 1991-08-16 Diclofenac's codeine salt processes its preparation and its pharmaceutical preparations IL99213A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH273590 1990-08-23

Publications (2)

Publication Number Publication Date
IL99213A0 IL99213A0 (en) 1992-07-15
IL99213A true IL99213A (en) 1995-07-31

Family

ID=4240432

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9921391A IL99213A (en) 1990-08-23 1991-08-16 Diclofenac's codeine salt processes its preparation and its pharmaceutical preparations

Country Status (20)

Country Link
US (1) US5190947A (ja)
EP (1) EP0472501B1 (ja)
JP (1) JPH04257587A (ja)
KR (1) KR920004391A (ja)
AT (1) ATE137753T1 (ja)
AU (1) AU652951B2 (ja)
CA (1) CA2049649A1 (ja)
DE (1) DE59107784D1 (ja)
DK (1) DK0472501T3 (ja)
ES (1) ES2086515T3 (ja)
FI (1) FI96421C (ja)
GR (1) GR3019872T3 (ja)
HU (1) HU209308B (ja)
IE (1) IE72479B1 (ja)
IL (1) IL99213A (ja)
NO (1) NO179175C (ja)
NZ (1) NZ239495A (ja)
PT (1) PT98731B (ja)
TW (1) TW225536B (ja)
ZA (1) ZA916642B (ja)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0498011T3 (da) * 1991-02-07 1995-07-03 Heumann Pharma Gmbh & Co Nye salte af 2-(2,6-dichloranilino)-phenyleddikesyre, fremgangsmåde til fremstilling af disse salte og saltenes anvendelse som topisk anvendelse farmaceutiske præparater
FR2708611B1 (fr) * 1993-07-29 1995-10-27 Meram Lab Sel de codéine de l'acide 2-(3-benzoylphényl)propionique, procédé d'obtention et compositions pharmaceutiques le contenant.
DE19607395C2 (de) * 1996-02-28 2002-11-21 Lohmann Therapie Syst Lts Salze aus einem kationischen narkotischen Analgetikum mit einem anionischen nichtnarkotischen Analgetikum, Verfahren zu deren Herstellung und die diese Salze enthaltenden pharmazeutischen Präparate
RS49982B (sr) 1997-09-17 2008-09-29 Euro-Celtique S.A., Sinergistička analgetička kombinacija analgetičkog opijata i inhibitora ciklooksigenaze-2
JP2001517669A (ja) * 1997-09-25 2001-10-09 エルティエス ローマン テラピー−ズュステーメ アーゲー モルヒネアルカロイド類の酸添加塩類およびその応用
EP1709957A3 (en) * 2001-06-05 2007-02-14 Control Delivery Systems Sustained-release analgesic compounds
WO2003043657A1 (en) * 2001-11-19 2003-05-30 Control Delivery Systems, Inc. Topical delivery of codrugs
US10004729B2 (en) 2002-07-05 2018-06-26 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
WO2004004693A1 (en) 2002-07-05 2004-01-15 Collgegium Pharmaceutical Abuse-deterrent pharmaceutical compositions of opiods and other drugs
US8557291B2 (en) * 2002-07-05 2013-10-15 Collegium Pharmaceutical, Inc. Abuse-deterrent pharmaceutical compositions of opioids and other drugs
US8840928B2 (en) 2002-07-05 2014-09-23 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
TW200500067A (en) * 2003-01-21 2005-01-01 Control Delivery Sys Inc Salts of codrugs and uses related thereto
LT1765292T (lt) * 2004-06-12 2018-01-10 Collegium Pharmaceutical, Inc. Nuo piktnaudžiavimo apsaugotos vaistų formos
US20090291121A1 (en) * 2008-05-23 2009-11-26 Symrise, Inc. Capsule and coated capsules as a delivery system for dietary supplements and therapeutic materials
KR101971412B1 (ko) 2009-03-12 2019-04-22 큠버랜드 파마슈티컬즈 인코포레이티드 정맥 내 투여용 이부프로펜의 투여
US10668060B2 (en) 2009-12-10 2020-06-02 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
WO2013112456A1 (en) 2012-01-24 2013-08-01 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Controlled release formulations for the induction and proliferation of blood cells
US9072710B2 (en) 2012-03-16 2015-07-07 Cumberland Pharmaceuticals Inc. Injectable ibuprofen formulation
WO2017222575A1 (en) 2016-06-23 2017-12-28 Collegium Pharmaceutical, Inc. Process of making more stable abuse-deterrent oral formulations

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA537946A (en) * 1957-03-12 J. Lewenstein Mozes Process for preparing improved compounds having narcotic effect
US936254A (en) * 1908-01-06 1909-10-05 Belden Mfg Co Attachment for telephones.
DE377588C (de) * 1922-08-29 1923-06-22 O Hinsberg Dr Verfahren zur Darstellung einer salzartigen Verbindung des Codeins
US2628185A (en) * 1949-04-01 1953-02-10 Lewenstein Mozes Juda Analgesic compounds and compositions
US3895063A (en) * 1965-04-08 1975-07-15 Ciba Geigy Corp Substituted Anilino Benzyl Alcohols
FR2051482B1 (ja) * 1969-04-04 1973-06-08 Rabot Ets David
CA964192A (en) * 1970-07-21 1975-03-11 Roy H. Reiner Long-acting narcotic antagonist formulations containing pamoate salts of dihydronormorphinone
FR2257606B1 (ja) * 1974-01-10 1978-02-24 Sumitomo Chemical Co
US4176186A (en) * 1978-07-28 1979-11-27 Boehringer Ingelheim Gmbh Quaternary derivatives of noroxymorphone which relieve intestinal immobility
DE2935776A1 (de) * 1979-09-05 1981-04-16 Theodor Prof. Dr. 4400 Münster Eckert Organische salze des indometacin, des naproxen und des diclofenac, ihre herstellung und sie enthaltende arzneimittel
AT370721B (de) * 1981-02-24 1983-04-25 Ciba Geigy Ag Verfahren zur herstellung von neuen salzen der 2- (2,6-dichloranilino)-phenylessigsaeure, der
CH664085A5 (de) * 1985-02-08 1988-02-15 Ciba Geigy Ag Pharmazeutische praeparate mit analgetischer wirksamkeit, sowie deren herstellung.

Also Published As

Publication number Publication date
HU912768D0 (en) 1992-01-28
EP0472501B1 (de) 1996-05-08
NO179175C (no) 1996-08-21
AU652951B2 (en) 1994-09-15
HUT60501A (en) 1992-09-28
IE72479B1 (en) 1997-04-23
PT98731B (pt) 1999-01-29
NO913295D0 (no) 1991-08-22
CA2049649A1 (en) 1992-02-24
DE59107784D1 (de) 1996-06-13
ES2086515T3 (es) 1996-07-01
PT98731A (pt) 1992-07-31
KR920004391A (ko) 1992-03-27
NO913295L (no) 1992-02-24
NO179175B (no) 1996-05-13
AU8268591A (en) 1992-02-27
ATE137753T1 (de) 1996-05-15
DK0472501T3 (da) 1996-05-28
ZA916642B (en) 1992-04-29
TW225536B (ja) 1994-06-21
FI913949A0 (fi) 1991-08-21
FI96421B (fi) 1996-03-15
IE912973A1 (en) 1992-02-26
HU209308B (en) 1994-04-28
JPH04257587A (ja) 1992-09-11
EP0472501A3 (en) 1993-02-24
US5190947A (en) 1993-03-02
NZ239495A (en) 1997-05-26
GR3019872T3 (en) 1996-08-31
EP0472501A2 (de) 1992-02-26
IL99213A0 (en) 1992-07-15
FI96421C (fi) 1996-06-25
FI913949A (fi) 1992-02-24

Similar Documents

Publication Publication Date Title
US5190947A (en) Codeine salt of a substituted carboxylic acid, its use and pharmaceutical compositions thereof
EP0415850B1 (fr) Sels de métaux bivalents de l'acide N, N-di(carboxyméthyl)amino-2 cyano-3 carboxyméthyl-4 carboxy-5 thiophène,leur procédé de préparation et les compositions pharmaceutiques les renfermant
EP2186792B1 (en) 2-(a-hydroxypentyl) benzoate and its preparation and use
IL30394A (en) Phenylacetic acid derivatives
SK216092A3 (en) Using of xantine derivatives for treating of secondary lesions of neurous cells and functional defects after injuring of cranium and cerebrum
US3953601A (en) Dibenzothiophene derivatives as serum lipid lowering agents
EP0133423B1 (en) Use of 4,5'-azo-bis-salicylic acid for the manufacture of a medicament for the treatment of inflammatory disorders in the intestine
US3870792A (en) Certain dihydrophthalizines for treating hemorrhage and thrombosis
EP0037187B1 (en) Salts and aqueous solutions of 6-methylamino-4-oxo-10-propyl-4h-pyrano(3,2-g)-quinoline-2,8-di-carboxylic acid and pharmaceutical compositions containing such salts and solutions
CH449652A (fr) Procédé de préparation de nouvelles hydroxydiamines
NL8003001A (nl) Nieuw derivaat van 1 alfa, 25-dihydroxy-cholecalciferol en werkwijzen voor het bereiden en toepassen van dit derivaat.
US3966960A (en) 3-(4-Biphenylcarbonyl)propionic acid as an inhibitor of platelet aggregation
US4094988A (en) Method of treating gastric ulcers using 5,6-dihydro-1,4-dithiinoxides
JP2804445B2 (ja) 胃潰瘍および十二指腸潰瘍の処置剤および抗炎症剤
JPS6056974A (ja) 環式ジチオジアセトアミドおよびその製造方法並びに薬剤
US4215143A (en) Anti-ulcer pharmaceutical composition containing inositol hexasulfate aluminum or sodium aluminum salt as active ingredient
CA1301776C (en) Compound of choline, a process for its preparation and therapeutic composition containing it
US3891699A (en) Biphenylenealkanoic acids
US3798322A (en) 6 or 7-substituted 4 or 8-(amino-1-methyl-butylamino)quinolines as hypolipidemic agents
US4181737A (en) 4-((3-Methoxyphenyl)amino)benzoic acid, a method for treating hyperlipidemia, and compositions thereof
CH648295A5 (fr) Acides 2-amino-3-(alkylthiobenzyl)-phenylacetiques et leurs derives.
GB1603651A (en) Normolipidemiant compositions
JPH0228113A (ja) 高尿酸血症改善・治療剤
NL8006341A (nl) Voor roentgenstralen amorfe, fysiologisch toelaatbare zuuradditiezouten van ergotalkaloiden en dihydroer- gotalkaloiden, werkwijze voor de bereiding en toepas- sing daarvan in de therapie.
JPS6322584A (ja) １−ハイドロキシ−５−オキソ−５Ｈ−ピリド〔３，２−ａ〕フエノキサジン−３−カルボン酸エステル類

Legal Events

Date Code Title Description
KB Patent renewed