KR920004391A - 치환된 카복실산의 코데인 염, 이의 제조방법, 이의 용도 및 약제학적 조성물 - Google Patents

치환된 카복실산의 코데인 염, 이의 제조방법, 이의 용도 및 약제학적 조성물 Download PDF

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Publication number
KR920004391A
KR920004391A KR1019910014490A KR910014490A KR920004391A KR 920004391 A KR920004391 A KR 920004391A KR 1019910014490 A KR1019910014490 A KR 1019910014490A KR 910014490 A KR910014490 A KR 910014490A KR 920004391 A KR920004391 A KR 920004391A
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KR
South Korea
Prior art keywords
salt
codeine
dichlorophenyl
phenyl
amino
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KR1019910014490A
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English (en)
Inventor
리에스 발터
살만 알프레드
Original Assignee
베르너 발데그
시바-가이기 에이지
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Application filed by 베르너 발데그, 시바-가이기 에이지 filed Critical 베르너 발데그
Publication of KR920004391A publication Critical patent/KR920004391A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C07D489/04—Salts; Organic complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains

Abstract

내용 없음

Description

치환된 카복실산의 코데인 염, 이의 제조방법, 이의 용도 및 약제학적 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 구조식(I)의 [2-[(2,6-디클로로페닐)-아미노]-페닐]-아세트산의 코데인염.
  2. [2-[(2,6-디클로로페닐)-아미노]-페닐]-아세트산 또는 구조식(I)의 염 이외의 이의 염기성 염을 코데인 또는 이의 염과 반응시킴을 특징으로 하는, 구조식(I)의 [2-[(2,6-디클로로페닐)-아미노]-페닐]-아세트산의 코데인 염의 제조방법.
  3. 제2항에 있어서, 적어도 동몰량의 코데인 또는 이의 염을 사용함을 특징으로 하는 방법.
  4. 제2항에 있어서, 실시예 1에 기술된 것과 같은 방법.
  5. [2-[(2,6-디클로로페닐)-아미노]-페닐]-아세트산의 코데인 염을 통상적인 약제학적 부형제와 함께 포함하는 약제학적 조성물.
  6. 실시예 2 또는 실시예 3 에 따른 약제학적 조성물.
  7. 인체 또는 동물체의 치료방법에 사용하기 위한 구조식(I)의 [2-[(2,6-디클로로페닐)-아미노]-페닐]-아세트산의 코데인염.
  8. 진통제로서 또는 진통제를 제조하기 위한 구조식(I)의 [2-[(2,6-디클로로페닐)-아미노]-페닐]-아세트산의 코데인 염의 용도.
  9. 제5항 또는 제6항에 따른 약제학적 조성물을 진통치료를 필요로 하는 온혈유지체에 투여함을 특징으로 하여, 통증을 치료하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910014490A 1990-08-23 1991-08-22 치환된 카복실산의 코데인 염, 이의 제조방법, 이의 용도 및 약제학적 조성물 KR920004391A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH2735/90-9 1990-08-23
CH273590 1990-08-23

Publications (1)

Publication Number Publication Date
KR920004391A true KR920004391A (ko) 1992-03-27

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910014490A KR920004391A (ko) 1990-08-23 1991-08-22 치환된 카복실산의 코데인 염, 이의 제조방법, 이의 용도 및 약제학적 조성물

Country Status (20)

Country Link
US (1) US5190947A (ko)
EP (1) EP0472501B1 (ko)
JP (1) JPH04257587A (ko)
KR (1) KR920004391A (ko)
AT (1) ATE137753T1 (ko)
AU (1) AU652951B2 (ko)
CA (1) CA2049649A1 (ko)
DE (1) DE59107784D1 (ko)
DK (1) DK0472501T3 (ko)
ES (1) ES2086515T3 (ko)
FI (1) FI96421C (ko)
GR (1) GR3019872T3 (ko)
HU (1) HU209308B (ko)
IE (1) IE72479B1 (ko)
IL (1) IL99213A (ko)
NO (1) NO179175C (ko)
NZ (1) NZ239495A (ko)
PT (1) PT98731B (ko)
TW (1) TW225536B (ko)
ZA (1) ZA916642B (ko)

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FR2708611B1 (fr) * 1993-07-29 1995-10-27 Meram Lab Sel de codéine de l'acide 2-(3-benzoylphényl)propionique, procédé d'obtention et compositions pharmaceutiques le contenant.
DE19607395C2 (de) * 1996-02-28 2002-11-21 Lohmann Therapie Syst Lts Salze aus einem kationischen narkotischen Analgetikum mit einem anionischen nichtnarkotischen Analgetikum, Verfahren zu deren Herstellung und die diese Salze enthaltenden pharmazeutischen Präparate
RS49982B (sr) * 1997-09-17 2008-09-29 Euro-Celtique S.A., Sinergistička analgetička kombinacija analgetičkog opijata i inhibitora ciklooksigenaze-2
CA2304722C (en) * 1997-09-25 2005-11-22 Lts Lohmann Therapie-Systeme Ag Acidic addition salts of morphine alkaloids and the application thereof
BR0210179A (pt) * 2001-06-05 2004-04-27 Control Delivery Sys Inc Compostos analgésicos de liberação sustentada
AU2002350207A1 (en) * 2001-11-19 2003-06-10 Control Delivery Systems, Inc. Topical delivery of codrugs
US8840928B2 (en) * 2002-07-05 2014-09-23 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
US8557291B2 (en) 2002-07-05 2013-10-15 Collegium Pharmaceutical, Inc. Abuse-deterrent pharmaceutical compositions of opioids and other drugs
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CA2491572C (en) * 2002-07-05 2010-03-23 Collegium Pharmaceutical, Inc. Abuse-deterrent pharmaceutical compositions of opiods and other drugs
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DK1765292T3 (en) 2004-06-12 2018-01-02 Collegium Pharmaceutical Inc ABUSE PREVENTIONAL PHARMACEUTICAL FORMULATIONS
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PT2405748T (pt) 2009-03-12 2018-11-23 Cumberland Pharmaceuticals Inc Administração de ibuprofeno intravenoso
US10668060B2 (en) 2009-12-10 2020-06-02 Collegium Pharmaceutical, Inc. Tamper-resistant pharmaceutical compositions of opioids and other drugs
WO2013112456A1 (en) 2012-01-24 2013-08-01 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Controlled release formulations for the induction and proliferation of blood cells
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Also Published As

Publication number Publication date
FI913949A (fi) 1992-02-24
PT98731B (pt) 1999-01-29
US5190947A (en) 1993-03-02
NO179175B (no) 1996-05-13
EP0472501B1 (de) 1996-05-08
NO179175C (no) 1996-08-21
HU912768D0 (en) 1992-01-28
CA2049649A1 (en) 1992-02-24
EP0472501A3 (en) 1993-02-24
FI96421B (fi) 1996-03-15
DK0472501T3 (da) 1996-05-28
PT98731A (pt) 1992-07-31
AU652951B2 (en) 1994-09-15
GR3019872T3 (en) 1996-08-31
IL99213A (en) 1995-07-31
DE59107784D1 (de) 1996-06-13
TW225536B (ko) 1994-06-21
EP0472501A2 (de) 1992-02-26
ES2086515T3 (es) 1996-07-01
JPH04257587A (ja) 1992-09-11
NO913295D0 (no) 1991-08-22
ATE137753T1 (de) 1996-05-15
FI913949A0 (fi) 1991-08-21
AU8268591A (en) 1992-02-27
IL99213A0 (en) 1992-07-15
HU209308B (en) 1994-04-28
IE912973A1 (en) 1992-02-26
NZ239495A (en) 1997-05-26
ZA916642B (en) 1992-04-29
FI96421C (fi) 1996-06-25
NO913295L (no) 1992-02-24
HUT60501A (en) 1992-09-28
IE72479B1 (en) 1997-04-23

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