IL96843A - Process for preparing (1r,5s,6s)-2-[(6,7-dihydro-5h-pyrazolo[1,2-a][1,2,4] triazolium-6-yl) thio-6-[(r)-1- hydroxyethyl]-1- emthyl-carbapenem-3-carboxylate and starting materials thereof - Google Patents

Process for preparing (1r,5s,6s)-2-[(6,7-dihydro-5h-pyrazolo[1,2-a][1,2,4] triazolium-6-yl) thio-6-[(r)-1- hydroxyethyl]-1- emthyl-carbapenem-3-carboxylate and starting materials thereof

Info

Publication number
IL96843A
IL96843A IL9684390A IL9684390A IL96843A IL 96843 A IL96843 A IL 96843A IL 9684390 A IL9684390 A IL 9684390A IL 9684390 A IL9684390 A IL 9684390A IL 96843 A IL96843 A IL 96843A
Authority
IL
Israel
Prior art keywords
formula
compound
dihydro
pyrazolo
triazolium
Prior art date
Application number
IL9684390A
Other languages
English (en)
Other versions
IL96843A0 (en
Original Assignee
Lederle Japan Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lederle Japan Ltd filed Critical Lederle Japan Ltd
Publication of IL96843A0 publication Critical patent/IL96843A0/xx
Publication of IL96843A publication Critical patent/IL96843A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/04—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IL9684390A 1990-10-12 1990-12-31 Process for preparing (1r,5s,6s)-2-[(6,7-dihydro-5h-pyrazolo[1,2-a][1,2,4] triazolium-6-yl) thio-6-[(r)-1- hydroxyethyl]-1- emthyl-carbapenem-3-carboxylate and starting materials thereof IL96843A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP27242890 1990-10-12
JP27242690 1990-10-12
JP27242790 1990-10-12

Publications (2)

Publication Number Publication Date
IL96843A0 IL96843A0 (en) 1991-09-16
IL96843A true IL96843A (en) 1995-07-31

Family

ID=27335996

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9684390A IL96843A (en) 1990-10-12 1990-12-31 Process for preparing (1r,5s,6s)-2-[(6,7-dihydro-5h-pyrazolo[1,2-a][1,2,4] triazolium-6-yl) thio-6-[(r)-1- hydroxyethyl]-1- emthyl-carbapenem-3-carboxylate and starting materials thereof

Country Status (13)

Country Link
EP (1) EP0480100B1 (cs)
KR (1) KR970011387B1 (cs)
AT (1) ATE144260T1 (cs)
AU (1) AU627970B2 (cs)
CA (1) CA2033479C (cs)
DE (1) DE69028920T2 (cs)
DK (1) DK0480100T3 (cs)
ES (1) ES2093010T3 (cs)
FI (1) FI906464L (cs)
GR (1) GR3021807T3 (cs)
IL (1) IL96843A (cs)
NO (1) NO176102C (cs)
TW (1) TW239142B (cs)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0776574A (ja) * 1993-09-06 1995-03-20 Wako Pure Chem Ind Ltd ジスルフィド化合物の製造法
CN101768174B (zh) * 2009-01-07 2012-08-08 四川科伦药业股份有限公司 一种比阿培南的制备方法
CN103497207B (zh) * 2011-01-29 2015-09-30 正大天晴药业集团股份有限公司 比阿培南b型结晶
CN102731534B (zh) * 2011-04-13 2016-02-03 石药集团中奇制药技术（石家庄）有限公司 一种比阿培南的制备方法
CN102268025A (zh) * 2011-07-15 2011-12-07 海南美兰史克制药有限公司 一种比阿培南化合物及其制法
CN103965220A (zh) * 2013-02-01 2014-08-06 上海医药工业研究院 一种制备高纯度比阿培南的方法
CN103570750A (zh) * 2013-11-15 2014-02-12 安徽悦康凯悦制药有限公司 一种比阿培南的制备工艺
CN105481883A (zh) * 2015-10-26 2016-04-13 山东鲁抗生物制造有限公司 一种高纯度比阿培南的合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE851586L (en) * 1984-07-02 1986-01-02 Interchem Internat S A I methylcarbapenems having a 2-quaternary¹heteroarylalkylthio substituent
JPS6425779A (en) * 1987-04-11 1989-01-27 Lederle Japan Ltd (1r,5s,6s)-2-substituted-thio-6-((r)-1-hydroxyethyl)-1-methyl -carbapenem-3-carboxylic acid derivative
US5102877A (en) * 1989-04-28 1992-04-07 Fujisawa Pharmaceutical Co., Ltd. 1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid compounds

Also Published As

Publication number Publication date
CA2033479A1 (en) 1992-04-13
NO176102C (no) 1995-02-01
TW239142B (cs) 1995-01-21
EP0480100A2 (en) 1992-04-15
DK0480100T3 (da) 1996-11-18
AU627970B2 (en) 1992-09-03
DE69028920T2 (de) 1997-02-13
NO905625L (no) 1992-04-13
CA2033479C (en) 2001-01-23
ATE144260T1 (de) 1996-11-15
NO176102B (no) 1994-10-24
DE69028920D1 (de) 1996-11-21
EP0480100A3 (en) 1992-10-21
KR920008039A (ko) 1992-05-27
NO905625D0 (no) 1990-12-28
ES2093010T3 (es) 1996-12-16
GR3021807T3 (en) 1997-02-28
IL96843A0 (en) 1991-09-16
KR970011387B1 (ko) 1997-07-10
AU6862891A (en) 1992-06-11
FI906464A7 (fi) 1992-04-13
FI906464L (fi) 1992-04-13
FI906464A0 (fi) 1990-12-31
EP0480100B1 (en) 1996-10-16

Similar Documents

Publication Publication Date Title
EP0337637B1 (en) 2-(Heterocyclylthio)carbapenem derivatives their preparation and their use as antibiotics
FI60867C (fi) Foerfarande foer framstaellning av en terapeutiskt anvaendbar 7-d-(-)-alfa-amino-alfa-(p-acyloxifenylacetamido)-cefalosporansyra
FI86729B (fi) Foerfarande foer framstaellning av antibiotiskt aktiva (1r,5s,6s)-2- -substituerade tio-6-/(r)-1-hydroxietyl/-1-metyl-karbapenem-3 -karboxylsyraderivat.
EP0480100B1 (en) Process for preparing (1R,5S,6S)-2-[(6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazolium-6-yl)thio]-6-[(R)-1-hydroxyethyl]-1-methyl-carbapenem-3-carboxylate and starting materials thereof
EP0557122B1 (en) A production method for sulfamide
FI120402B (fi) Menetelmä tioliyhdisteiden valmistamiseksi ja menetelmässä käytettävä välituote
US5241073A (en) Process for preparing (1R,5S,6S)-2-[(6,7-dihydro-5H-pyrazolo [1,2-a][1,2,4]triazolium-6-yl)]thio-6-[(R)-1-hydroxyethyl]-1-methyl-carbapenem-3-carboxylate and starting materials thereof
AU610063B2 (en) N-amino quaternized heteroarylium carbapenem antibacterial agents
KR20070104594A (ko) 카르바페넴 유도체 및 이에 대한 결정성 중간체의 제조방법
JP2531489B2 (ja) １−β−メチル−２−チオ―ル系カルバペネム誘導体およびその製造方法
JPS62265287A (ja) カルバペネム抗生物質
FI93962C (fi) 6,7-dihydro-6-merkapto-5H-pyratsolo/1,2-a//1,2,4/triatsolium-välituotteet ja menetelmä niiden valmistamiseksi
US5153188A (en) Piperidylthiocarbapenem derivatives
US4645769A (en) 1-oxa-1-dethia-cephalosporin compounds and antibacterial agent comprising the same
US20180353476A1 (en) C5-substituted carbapenem antibiotics, compositions containing such compounds, and methods of use in treatment of mycobacterium tuberculosis and non-tubercular mycobacteria
FI95382C (fi) 6,7-dihydro-5H-pyratsolo/1,2-a//1,2,4/triatsolium-6-yylidisulfidi, menetelmä sen valmistamiseksi käyttäen pyratsolidiini-4-yylidisulfidia ja pyratsoliini-4-yylidisulfidi
US6479478B1 (en) Carbapenem compounds
AU4608199A (en) Propenyl cephalosporin derivatives
JPH04230290A (ja) カルバペネム化合物の製造法
US4977256A (en) Method of eliminating protective groups
GB2146996A (en) 3-azidocephalosporins as intermediates and novel antibacterial agents
KR100309703B1 (ko) 이중고리 티올 유도체, 이를 치환기로 갖는 1-β-메틸-카바페넴 유도체, 및 그들의 제조방법
JPH08134075A (ja) 新規なカルバペネム誘導体
KR100535253B1 (ko) 에틸카바모일유도체를 포함하는 피롤리딘을 가지는1-베타메틸카바페넴 유도체 및 그 제조방법
KR101028689B1 (ko) 신규한 결정성 3-머캅토-1-(아세트이미도일)피롤리딘유도체 및 그의 제조방법

Legal Events

Date Code Title Description
KB Patent renewed
KB Patent renewed
KB Patent renewed
KB Patent renewed
EXP Patent expired