IL91960A - Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides - Google Patents
Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamidesInfo
- Publication number
- IL91960A IL91960A IL9196089A IL9196089A IL91960A IL 91960 A IL91960 A IL 91960A IL 9196089 A IL9196089 A IL 9196089A IL 9196089 A IL9196089 A IL 9196089A IL 91960 A IL91960 A IL 91960A
- Authority
- IL
- Israel
- Prior art keywords
- oxindole
- carboxamides
- antiinflammatory
- prodrugs
- acyl
- Prior art date
Links
- 230000003110 anti-inflammatory effect Effects 0.000 title 1
- 229940002612 prodrug Drugs 0.000 title 1
- 239000000651 prodrug Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US1988/003658 WO1990004393A1 (en) | 1988-10-18 | 1988-10-18 | Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL91960A0 IL91960A0 (en) | 1990-07-12 |
| IL91960A true IL91960A (en) | 1994-04-12 |
Family
ID=22208957
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL9196089A IL91960A (en) | 1988-10-18 | 1989-10-12 | Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US5118703A (ja) |
| JP (1) | JPH07597B2 (ja) |
| KR (1) | KR910007237B1 (ja) |
| CN (1) | CN1022241C (ja) |
| AP (1) | AP118A (ja) |
| AR (1) | AR246519A1 (ja) |
| AT (1) | ATE125794T1 (ja) |
| AU (1) | AU606819B2 (ja) |
| BG (1) | BG50834A3 (ja) |
| CA (1) | CA1339558C (ja) |
| CZ (1) | CZ278983B6 (ja) |
| DD (1) | DD285604A5 (ja) |
| DK (1) | DK514989A (ja) |
| EG (1) | EG19887A (ja) |
| FI (1) | FI95253C (ja) |
| HU (1) | HU208421B (ja) |
| IE (1) | IE66586B1 (ja) |
| IL (1) | IL91960A (ja) |
| IS (1) | IS1598B (ja) |
| MA (1) | MA21657A1 (ja) |
| MX (1) | MX18021A (ja) |
| MY (1) | MY104238A (ja) |
| NO (1) | NO178027C (ja) |
| NZ (1) | NZ231044A (ja) |
| OA (1) | OA09140A (ja) |
| PH (1) | PH27554A (ja) |
| PL (2) | PL162316B1 (ja) |
| PT (1) | PT92000B (ja) |
| RO (1) | RO109195B1 (ja) |
| RU (1) | RU2036905C1 (ja) |
| SK (1) | SK278175B6 (ja) |
| WO (1) | WO1990004393A1 (ja) |
| YU (1) | YU48070B (ja) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5059693A (en) * | 1989-10-06 | 1991-10-22 | Pfizer Inc. | Process for making 3-aroyl-2-oxindole-1-carboxamides |
| RU2114854C1 (ru) * | 1992-11-23 | 1998-07-10 | Пфайзер Инк. | Производные 4-хлор-2-тиофенкарбоновой кислоты, способ получения 4-хлор-2-тиофенкарбоновой кислоты (варианты) и способ получения 5-фтор-6-хлор-3-(4-хлор-2-теноил)-2-оксиндол-1-карбоксамида (варианты) |
| US5270331A (en) * | 1993-01-26 | 1993-12-14 | Pfizer, Inc. | Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides |
| JP2709530B2 (ja) * | 1993-02-09 | 1998-02-04 | ファイザー・インク． | 抗炎症薬としてのオキシンドール１−［ｎ−（アルコキシカルボニル）］カルボキサミド類および１−（ｎ−カルボキサミド）カルボキサミド類 |
| US5449788A (en) * | 1994-01-28 | 1995-09-12 | Catalytica, Inc. | Process for preparing 2-oxindole-1-carboxamides |
| CN1094819C (zh) * | 1997-04-30 | 2002-11-27 | 大兴株式会社 | 环状坯料之制造装置 |
| EP0984012A3 (en) * | 1998-08-31 | 2001-01-10 | Pfizer Products Inc. | Nitric oxide releasing oxindole prodrugs with analgesic and anti-inflammatory properties |
| WO2001030151A1 (en) * | 1999-10-26 | 2001-05-03 | The University Of Texas Southwestern Medical Center | Methods of treating hair loss comprising administering indoline compound |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL96047C (ja) * | 1956-06-08 | |||
| US3564009A (en) * | 1966-01-13 | 1971-02-16 | Sumitomo Chemical Co | Process for producing 1-acylindole derivatives |
| BE756447A (fr) * | 1969-10-15 | 1971-03-22 | Pfizer | Oxindolecarboxamides |
| US3923996A (en) * | 1972-07-31 | 1975-12-02 | Sandoz Ag | 3-Substituted-oxindoles in compositions and methods of treating obesity |
| IE53102B1 (en) * | 1981-05-12 | 1988-06-22 | Ici Plc | Pharmaceutical spiro-succinimide derivatives |
| DE3268971D1 (en) * | 1981-10-06 | 1986-03-20 | Ici Plc | Biochemical process |
| US4556672A (en) * | 1984-03-19 | 1985-12-03 | Pfizer Inc. | 3-Substituted 2-oxindole-1-carboxamides as analgesic and anti-inflammatory agents |
| US4752609A (en) * | 1985-06-20 | 1988-06-21 | Pfizer Inc. | Analgesic and antiinflammatory 1,3-diacyl-2-oxindole compounds |
| RO105052B1 (en) * | 1987-02-02 | 1994-12-01 | Pfizer | Producing process for the crystalline sodium salt, anhydre, of 5-chlorine-3-(2-tenoil)-2-oxindol-1-carboxamide |
| EP0365194B1 (en) * | 1988-10-18 | 1995-08-02 | Pfizer Inc. | Prodrugs of antiinflammatory 3-acyl-2-oxindole-1-carboxamides |
| US5047554A (en) * | 1989-04-18 | 1991-09-10 | Pfizer Inc. | 3-substituted-2-oxindole derivatives |
| US5059693A (en) * | 1989-10-06 | 1991-10-22 | Pfizer Inc. | Process for making 3-aroyl-2-oxindole-1-carboxamides |
-
1988
- 1988-10-18 MX MX1802188A patent/MX18021A/es unknown
- 1988-10-18 RO RO147347A patent/RO109195B1/ro unknown
- 1988-10-18 SK SK5906-89A patent/SK278175B6/sk unknown
- 1988-10-18 WO PCT/US1988/003658 patent/WO1990004393A1/en not_active Ceased
- 1988-10-18 US US07/675,883 patent/US5118703A/en not_active Expired - Lifetime
- 1988-10-18 HU HU886740A patent/HU208421B/hu not_active IP Right Cessation
-
1989
- 1989-09-20 IS IS3509A patent/IS1598B/is unknown
- 1989-09-28 CA CA000614317A patent/CA1339558C/en not_active Expired - Fee Related
- 1989-10-04 PH PH39329A patent/PH27554A/en unknown
- 1989-10-09 AT AT89310319T patent/ATE125794T1/de active
- 1989-10-12 IL IL9196089A patent/IL91960A/xx not_active IP Right Cessation
- 1989-10-16 PT PT92000A patent/PT92000B/pt not_active IP Right Cessation
- 1989-10-16 BG BG090022A patent/BG50834A3/xx unknown
- 1989-10-16 YU YU200589A patent/YU48070B/sh unknown
- 1989-10-16 AP APAP/P/1989/000141A patent/AP118A/en active
- 1989-10-16 MY MYPI89001415A patent/MY104238A/en unknown
- 1989-10-17 PL PL89281871A patent/PL162316B1/pl unknown
- 1989-10-17 MA MA21909A patent/MA21657A1/fr unknown
- 1989-10-17 CN CN89107943A patent/CN1022241C/zh not_active Expired - Fee Related
- 1989-10-17 DK DK514989A patent/DK514989A/da not_active Application Discontinuation
- 1989-10-17 AU AU42956/89A patent/AU606819B2/en not_active Ceased
- 1989-10-17 KR KR1019890014914A patent/KR910007237B1/ko not_active Expired
- 1989-10-17 OA OA59665A patent/OA09140A/xx unknown
- 1989-10-17 NZ NZ231044A patent/NZ231044A/en unknown
- 1989-10-17 IE IE333289A patent/IE66586B1/en not_active IP Right Cessation
- 1989-10-17 JP JP1270174A patent/JPH07597B2/ja not_active Expired - Lifetime
- 1989-10-17 DD DD89333653A patent/DD285604A5/de not_active IP Right Cessation
- 1989-10-17 AR AR89315179A patent/AR246519A1/es active
- 1989-10-17 PL PL89296831A patent/PL163112B1/pl unknown
- 1989-10-18 EG EG49689A patent/EG19887A/xx active
- 1989-10-18 CZ CS895906A patent/CZ278983B6/cs not_active IP Right Cessation
-
1991
- 1991-04-17 RU SU914895525A patent/RU2036905C1/ru active
- 1991-04-17 NO NO911512A patent/NO178027C/no unknown
- 1991-04-17 FI FI911855A patent/FI95253C/fi not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RH | Patent void |