IL91306A - Tissue plasminogen variant having amino acid substitution in the protease domain having improved zymogenic or fibrin specific properties - Google Patents

Tissue plasminogen variant having amino acid substitution in the protease domain having improved zymogenic or fibrin specific properties

Info

Publication number
IL91306A
IL91306A IL9130689A IL9130689A IL91306A IL 91306 A IL91306 A IL 91306A IL 9130689 A IL9130689 A IL 9130689A IL 9130689 A IL9130689 A IL 9130689A IL 91306 A IL91306 A IL 91306A
Authority
IL
Israel
Prior art keywords
amino acid
zymogenic
tissue plasminogen
protease domain
zymogens
Prior art date
Application number
IL9130689A
Other languages
English (en)
Other versions
IL91306A0 (en
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Priority to IL111767A priority Critical patent/IL111767A/xx
Priority to IL109735A priority patent/IL109735A/xx
Publication of IL91306A0 publication Critical patent/IL91306A0/xx
Publication of IL91306A publication Critical patent/IL91306A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Compounds Of Unknown Constitution (AREA)
IL9130689A 1988-09-02 1989-08-14 Tissue plasminogen variant having amino acid substitution in the protease domain having improved zymogenic or fibrin specific properties IL91306A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IL111767A IL111767A (en) 1988-09-02 1989-08-14 Method for identifying improved activity tissue plasminogen activator variants with substituted amino acid residue in the protease domain
IL109735A IL109735A (en) 1988-09-02 1989-08-14 Tissue plasminogen activator variants having zymogenic properties having amino acid insertions after position 304 or 305 or at least one residue deletion at positions 297 to 305

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24085688A 1988-09-02 1988-09-02
US07/384,608 US5108901A (en) 1988-09-02 1989-07-24 Tissue plasminogen activator having zymogenic or fibrin specific properties

Publications (2)

Publication Number Publication Date
IL91306A0 IL91306A0 (en) 1990-03-19
IL91306A true IL91306A (en) 1997-08-14

Family

ID=26933781

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9130689A IL91306A (en) 1988-09-02 1989-08-14 Tissue plasminogen variant having amino acid substitution in the protease domain having improved zymogenic or fibrin specific properties

Country Status (18)

Country Link
US (1) US5108901A (ja)
EP (1) EP0457758B1 (ja)
JP (1) JP2794028B2 (ja)
KR (1) KR0148575B1 (ja)
AT (1) ATE124452T1 (ja)
AU (1) AU626323B2 (ja)
CA (1) CA1341484C (ja)
DE (1) DE68923298T2 (ja)
DK (1) DK175958B1 (ja)
ES (1) ES2018729A6 (ja)
FI (1) FI109359B (ja)
HK (1) HK1007334A1 (ja)
HU (1) HU213922B (ja)
IE (1) IE67508B1 (ja)
IL (1) IL91306A (ja)
NO (1) NO310778B1 (ja)
NZ (1) NZ230509A (ja)
WO (1) WO1990002798A1 (ja)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5736134A (en) * 1985-04-22 1998-04-07 Genentech, In.C Tissue plasminogen activator variants
US5756093A (en) * 1985-04-22 1998-05-26 Genentech, Inc. Tissue plasminogen activator variants
GB8815135D0 (en) * 1988-06-24 1988-08-03 British Bio Technology Proteins & nucleic acids
DK395288D0 (da) * 1988-07-15 1988-07-15 Novo Industri As Proteiner
US5262170A (en) * 1988-09-02 1993-11-16 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
US5156969A (en) * 1988-09-02 1992-10-20 Genentech Inc. Tissue plasminogen activator variant with deletion of amino acids 466-470 having fibrin specific properties
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US5866413A (en) * 1989-03-06 1999-02-02 Board Of Regents Of The University Of Texas System Pai-1 mutants
CA2047702C (en) * 1989-03-06 2000-10-24 Joseph F. Sambrook Serpin resistant chymotrypsin superfamily proteases particularly pai-1 resistant t-pa, complementary inhibitor mutants; compositions; genes; expression
US5550042A (en) * 1989-03-06 1996-08-27 The Board Of Regents Of The University Of Texas System Serine protease mutants of the chymotrypsin superfamily resistant to inhibition by their cognate inhibitors and genes encoding the same and serine protease inhibitor mutants and genes encoding the same
US5304482A (en) * 1989-03-06 1994-04-19 The Board Of Regents Of The University Of Texas System Serine protease mutants of the chymotrypsin superfamily resistant to inhibition by their cognate inhibitors
AU664469B2 (en) * 1992-06-03 1995-11-16 Genentech Inc. Tissue plasminogen activator glycosylation variants with improved therapeutic properties
US5472692A (en) * 1993-07-02 1995-12-05 New England Deaconess Hospital Corporation Pro-urokinase mutants
US5877016A (en) 1994-03-18 1999-03-02 Genentech, Inc. Human trk receptors and neurotrophic factor inhibitors
US5656427A (en) * 1994-08-29 1997-08-12 Gen-Probe Incorporated Nucleic acid hybridization assay probes, helper probes and amplification oligonucleotides targeted to Mycoplasma pneumoniae nucleic acid
US5798448A (en) * 1994-10-27 1998-08-25 Genentech, Inc. AL-1 neurotrophic factor antibodies
ZA966663B (en) 1995-08-17 1998-02-06 Genentech Inc Traf Inhibitors.
US6610296B2 (en) 1995-10-26 2003-08-26 Genentech, Inc. Methods of enhancing cognitive function using an AL-1 neurotrophic factor immunoadhesin
AU735519B2 (en) * 1996-11-12 2001-07-12 Scripps Research Institute, The Tissue type plasminogen activator (t-PA) variants: compositions and methods of use
US6706504B1 (en) 1996-11-12 2004-03-16 The Scripps Research Institute Tissue type plasminogen activator (t-PA) variants: compositions and methods of use
US20030113271A1 (en) * 1997-01-29 2003-06-19 University Technology Corporation Formulations for pulmonary delivery
US20040241645A1 (en) * 1997-01-31 2004-12-02 Genentech, Inc. O-fucosyltransferase
DK0942992T3 (da) 1997-01-31 2007-07-02 Genentech Inc O-fucosyltransferase
WO1999009184A1 (de) * 1997-08-13 1999-02-25 Roche Diagnostics Gmbh Plasminogenaktivator mit verbesserter zymogenität und verminderter fibrinbindung
WO1999009185A1 (de) * 1997-08-13 1999-02-25 Roche Diagnostics Gmbh Plasminogenaktivator mit verbesserter zymogenität
KR100408844B1 (ko) * 2000-07-29 2003-12-06 한국산업기술평가원 동물세포 발현벡터
US20060104969A1 (en) * 2004-08-16 2006-05-18 Massachusetts Institute Of Technology Compositions and methods for enhancing structural and functional nervous system reorganization and recovery
EP2012815A4 (en) * 2006-04-14 2009-12-09 Massachusetts Inst Technology IDENTIFICATION AND MODULATION OF MOLECULAR PATHWAYS THAT INDUCE THE PLASTICITY OF THE NERVOUS SYSTEM
JP2009544325A (ja) * 2006-07-27 2009-12-17 セントカー・インコーポレーテツド Ｂｍｐ−７変異体組成物、方法および使用
US10220008B2 (en) 2013-08-14 2019-03-05 Stc.Unm Treatment and prevention of stroke and other neurological disorders
CA2966332C (en) 2014-11-03 2024-04-16 Thrombolytic Science, Llc Methods and compositions for safe and effective thrombolysis
WO2018232305A1 (en) 2017-06-16 2018-12-20 Thrombolytic Science, Llc Methods and compositions for thrombolysis

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0125269A1 (en) * 1982-11-11 1984-11-21 Beecham Group Plc Pharmaceutically active compounds
EP0112122B1 (en) * 1982-12-14 1991-08-28 South African Inventions Development Corporation Plasminogen activator
US4753879A (en) * 1984-08-27 1988-06-28 Biogen N.V. Modified tissue plasminogen activators
EP0201153A3 (en) * 1985-02-09 1987-10-07 Beecham Group Plc Modified enzyme and process for its preparation
DE3682104D1 (de) * 1985-04-22 1991-11-28 Genentech Inc Plasminogenaktivator-mutante des menschlichen gewebes, verfahren und zwischenprodukte dafuer und diese mutante verwendende zusammensetzungen.
GB8528321D0 (en) * 1985-11-18 1985-12-24 Ciba Geigy Ag Modified fibrinolytic agents
EP0227462B1 (en) * 1985-12-23 1992-04-01 Chiron Corporation Novel peptide plasminogen activators
DK43387A (da) * 1986-01-29 1987-07-30 Beecham Group Plc Fibrinolytisk enzym
DE3789664T3 (de) * 1986-01-31 2004-09-16 Genetics Institute, LLC, Cambridge Neue thrombolytische proteine.
IE81073B1 (en) * 1986-03-18 2000-01-12 Genentech Inc Modified human tissue-type plasminogen activator and its preparation
PT84589B (en) * 1986-04-02 1989-05-09 Beecham Group Plc Process for preparing a fibrinolytic enzyme
DK345087A (da) * 1986-07-11 1988-01-12 Novo Industri As Modificeret vaevsplasminogenaktivator
WO1988005081A2 (en) * 1986-12-30 1988-07-14 Cetus Corporation Novel plasminogen activator
GB8705377D0 (en) * 1987-03-07 1987-04-08 Beecham Group Plc Compounds
NO882226L (no) * 1987-05-22 1988-11-23 Zymogenetics Inc Fibrinolytiske proteiner.
DE3851259T2 (de) * 1987-06-04 1994-12-15 Eisai Co Ltd Mutierter t-PA mit Kringle-Ersatz.
DK302388A (da) * 1987-06-04 1989-02-03 Zymogenetics Inc T-pa analoger med dodificeret vaekstfaktordomaene
SE8702562L (sv) * 1987-06-18 1988-12-19 Kabigen Ab Nya fibrinolytiska enzymer
WO1988010119A1 (en) * 1987-06-22 1988-12-29 Genetics Institute, Inc. Novel thrombolytic proteins
EP0394261A4 (en) * 1987-07-06 1991-09-11 Genetics Institute, Inc. Novel thrombolytic proteins
AU1893988A (en) * 1987-07-13 1989-01-19 Collaborative Research Inc. Nonglycosylated plasminogen activator and method of preparation
DK395288D0 (da) * 1988-07-15 1988-07-15 Novo Industri As Proteiner

Also Published As

Publication number Publication date
US5108901A (en) 1992-04-28
DK175958B1 (da) 2005-08-29
FI109359B (fi) 2002-07-15
EP0457758A1 (en) 1991-11-27
KR0148575B1 (ko) 1998-10-15
IE67508B1 (en) 1996-04-03
DE68923298D1 (de) 1995-08-03
DK36991A (da) 1991-05-02
KR900702019A (ko) 1990-12-05
DK36991D0 (da) 1991-03-01
IL91306A0 (en) 1990-03-19
IE892650L (en) 1990-03-02
EP0457758B1 (en) 1995-06-28
NZ230509A (en) 1991-06-25
FI911049A0 (fi) 1991-03-01
HUT58812A (en) 1992-03-30
HU213922B (en) 1997-11-28
DE68923298T2 (de) 1996-01-11
JP2794028B2 (ja) 1998-09-03
ATE124452T1 (de) 1995-07-15
ES2018729A6 (es) 1991-05-01
NO310778B1 (no) 2001-08-27
NO910811L (no) 1991-02-28
JPH04500157A (ja) 1992-01-16
CA1341484C (en) 2005-05-24
NO910811D0 (no) 1991-02-28
AU626323B2 (en) 1992-07-30
HK1007334A1 (en) 1999-04-09
WO1990002798A1 (en) 1990-03-22
AU4194689A (en) 1990-04-02
HU896005D0 (en) 1991-07-29

Similar Documents

Publication Publication Date Title
IL91306A (en) Tissue plasminogen variant having amino acid substitution in the protease domain having improved zymogenic or fibrin specific properties
Kini Serine proteases affecting blood coagulation and fibrinolysis from snake venoms
Joseph et al. Amino acid sequence of trocarin, a prothrombin activator from Tropidechis carinatus venom: its structural similarity to coagulation factor Xa
EP0473689B1 (en) Thrombus-targeted complexes of plasminogen activator and fibrin fragments
Matsuda et al. A simple, large scale method for preparation of plasminogen-free fibrinogen
Etscheid et al. Activation of proPHBSP, the zymogen of a plasma hyaluronan binding serine protease, by an intermolecular autocatalytic mechanism
Paoni et al. Making tissue-type plasminogen activator more fibrin specific
Siigur et al. The direct actinc α-fibrin (ogen) olytic enzymes from snake venoms
DK0517756T3 (da) Vævs-plasminogenaktivator med fibrinspecifikke egenskaber
Gardell The search for the ideal thrombolytic agent: maximize the benefit and minimize the risk
Bachmann Fibrinolytic agents
Agnelli et al. Thrombolytic activity of two chimeric recombinant plasminogen activators (FK2tu-PA and K2tu-PA) in rabbits
Bode et al. New developments in thrombolytic therapy
Deguchi et al. Plasminogen activation by tissue plasminogen activator in the presence of platelets
DE69113049D1 (de) Varianten des gewebeplasminogenaktivators mit vermindertem abbau.
Credo et al. Fibrinolytic mechanism, biochemistry, and preclinical pharmacology of recombinant prourokinase
MXPA06002756A (es) Activadores de plasminogeno que tienen capacidad reducida para union a lisina.
ATE114170T1 (de) Substitutionsvariante des gewebeplasminogenaktivators.
Loscalzo Fibrinolytic therapy
ATE145669T1 (de) T-pa substitutionsvarianten mit verbesserter fibrinspezifität
Anderson et al. Tissue plasminogen activator having zymogenic or fibrin specific properties
Runge New horizons in the treatment of coronary artery thrombosis
Siigur et al. Polypeptides and proteins active in the coagulation process
Anderson et al. Method for identifying tissue plasminogen activator having zymogenic or fibrin specific properties
HUT65411A (en) Combined preparation with thrombolytic action

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
KB Patent renewed
KB Patent renewed