ATE114170T1 - Substitutionsvariante des gewebeplasminogenaktivators. - Google Patents
Substitutionsvariante des gewebeplasminogenaktivators.Info
- Publication number
- ATE114170T1 ATE114170T1 AT92903441T AT92903441T ATE114170T1 AT E114170 T1 ATE114170 T1 AT E114170T1 AT 92903441 T AT92903441 T AT 92903441T AT 92903441 T AT92903441 T AT 92903441T AT E114170 T1 ATE114170 T1 AT E114170T1
- Authority
- AT
- Austria
- Prior art keywords
- variants
- plasminogen activator
- tissue plasminogen
- prepared
- expression vectors
- Prior art date
Links
- 102000003978 Tissue Plasminogen Activator Human genes 0.000 title abstract 4
- 108090000373 Tissue Plasminogen Activator Proteins 0.000 title abstract 4
- 229960000187 tissue plasminogen activator Drugs 0.000 title abstract 4
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 2
- 239000013604 expression vector Substances 0.000 abstract 2
- 102000009123 Fibrin Human genes 0.000 abstract 1
- 108010073385 Fibrin Proteins 0.000 abstract 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 abstract 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N aspartic acid group Chemical group N[C@@H](CC(=O)O)C(=O)O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 230000009089 cytolysis Effects 0.000 abstract 1
- 230000008021 deposition Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229950003499 fibrin Drugs 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 208000019553 vascular disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62986390A | 1990-12-18 | 1990-12-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE114170T1 true ATE114170T1 (de) | 1994-12-15 |
Family
ID=24524805
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92903441T ATE114170T1 (de) | 1990-12-18 | 1991-12-16 | Substitutionsvariante des gewebeplasminogenaktivators. |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP0563280B1 (de) |
| JP (1) | JP2532193B2 (de) |
| AT (1) | ATE114170T1 (de) |
| AU (1) | AU649765B2 (de) |
| CA (1) | CA2096851C (de) |
| DE (1) | DE69105213T2 (de) |
| DK (1) | DK0563280T3 (de) |
| ES (1) | ES2067326T3 (de) |
| GR (1) | GR3015094T3 (de) |
| WO (1) | WO1992011377A1 (de) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0943332A1 (de) * | 1998-03-19 | 1999-09-22 | Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno | Vorbeugung und Behandlung von Adhesionen |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3537176C2 (de) * | 1984-10-18 | 1994-06-09 | Zymogenetics Inc | Gewebeplasminogenaktivator und Verfahren zu seiner Herstellung |
| JPH0811066B2 (ja) * | 1985-09-30 | 1996-02-07 | インテグレーテッド・ジエネティックス・インコーポレーテッド | 組換えｄｎａが生産するヒト子宮プラスミノ−ゲンアクチベ−タ− |
| DE69034013T2 (de) * | 1989-03-06 | 2003-07-31 | Board Of Regents, The University Of Texas System | Serpin-resistenter T-PA; Mutanten; Gene |
-
1991
- 1991-12-16 AU AU91714/91A patent/AU649765B2/en not_active Expired
- 1991-12-16 WO PCT/US1991/009455 patent/WO1992011377A1/en not_active Ceased
- 1991-12-16 EP EP92903441A patent/EP0563280B1/de not_active Expired - Lifetime
- 1991-12-16 DE DE69105213T patent/DE69105213T2/de not_active Expired - Lifetime
- 1991-12-16 DK DK92903441.1T patent/DK0563280T3/da active
- 1991-12-16 AT AT92903441T patent/ATE114170T1/de not_active IP Right Cessation
- 1991-12-16 CA CA002096851A patent/CA2096851C/en not_active Expired - Lifetime
- 1991-12-16 JP JP4503354A patent/JP2532193B2/ja not_active Expired - Lifetime
- 1991-12-16 ES ES92903441T patent/ES2067326T3/es not_active Expired - Lifetime
-
1995
- 1995-02-16 GR GR950400313T patent/GR3015094T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2096851A1 (en) | 1992-06-19 |
| EP0563280A1 (de) | 1993-10-06 |
| JP2532193B2 (ja) | 1996-09-11 |
| ES2067326T3 (es) | 1995-03-16 |
| WO1992011377A1 (en) | 1992-07-09 |
| AU9171491A (en) | 1992-07-22 |
| CA2096851C (en) | 1999-10-12 |
| EP0563280B1 (de) | 1994-11-17 |
| AU649765B2 (en) | 1994-06-02 |
| DE69105213T2 (de) | 1995-05-18 |
| DK0563280T3 (da) | 1995-04-18 |
| DE69105213D1 (de) | 1994-12-22 |
| GR3015094T3 (en) | 1995-05-31 |
| JPH06502544A (ja) | 1994-03-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EELA | Cancelled due to lapse of time |