GR3015094T3 - Tissue plasminogen activator substitution variant. - Google Patents

Tissue plasminogen activator substitution variant.

Info

Publication number
GR3015094T3
GR3015094T3 GR950400313T GR950400313T GR3015094T3 GR 3015094 T3 GR3015094 T3 GR 3015094T3 GR 950400313 T GR950400313 T GR 950400313T GR 950400313 T GR950400313 T GR 950400313T GR 3015094 T3 GR3015094 T3 GR 3015094T3
Authority
GR
Greece
Prior art keywords
variants
plasminogen activator
tissue plasminogen
prepared
expression vectors
Prior art date
Application number
GR950400313T
Other languages
English (en)
Inventor
William F Bennett Iii
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of GR3015094T3 publication Critical patent/GR3015094T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
GR950400313T 1990-12-18 1995-02-16 Tissue plasminogen activator substitution variant. GR3015094T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62986390A 1990-12-18 1990-12-18
PCT/US1991/009455 WO1992011377A1 (en) 1990-12-18 1991-12-16 Tissue plasminogen activator substitution variant

Publications (1)

Publication Number Publication Date
GR3015094T3 true GR3015094T3 (en) 1995-05-31

Family

ID=24524805

Family Applications (1)

Application Number Title Priority Date Filing Date
GR950400313T GR3015094T3 (en) 1990-12-18 1995-02-16 Tissue plasminogen activator substitution variant.

Country Status (10)

Country Link
EP (1) EP0563280B1 (el)
JP (1) JP2532193B2 (el)
AT (1) ATE114170T1 (el)
AU (1) AU649765B2 (el)
CA (1) CA2096851C (el)
DE (1) DE69105213T2 (el)
DK (1) DK0563280T3 (el)
ES (1) ES2067326T3 (el)
GR (1) GR3015094T3 (el)
WO (1) WO1992011377A1 (el)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0943332A1 (en) * 1998-03-19 1999-09-22 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno Prevention and treatment of adhesions

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3537176C2 (de) * 1984-10-18 1994-06-09 Zymogenetics Inc Gewebeplasminogenaktivator und Verfahren zu seiner Herstellung
JPH0811066B2 (ja) * 1985-09-30 1996-02-07 インテグレーテッド・ジエネティックス・インコーポレーテッド 組換えｄｎａが生産するヒト子宮プラスミノ−ゲンアクチベ−タ−
ES2185529T3 (es) * 1989-03-06 2003-05-01 Univ Texas T-pa resistente a la serpina; mutante; genes.

Also Published As

Publication number Publication date
JP2532193B2 (ja) 1996-09-11
AU649765B2 (en) 1994-06-02
WO1992011377A1 (en) 1992-07-09
DK0563280T3 (da) 1995-04-18
ATE114170T1 (de) 1994-12-15
JPH06502544A (ja) 1994-03-24
EP0563280A1 (en) 1993-10-06
AU9171491A (en) 1992-07-22
EP0563280B1 (en) 1994-11-17
DE69105213D1 (de) 1994-12-22
ES2067326T3 (es) 1995-03-16
CA2096851C (en) 1999-10-12
DE69105213T2 (de) 1995-05-18
CA2096851A1 (en) 1992-06-19

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