ES2013500A6 - Metodo para producir una variante de secuencioa de aminoacidos de un activador de plasmionogeno. - Google Patents
Metodo para producir una variante de secuencioa de aminoacidos de un activador de plasmionogeno.Info
- Publication number
- ES2013500A6 ES2013500A6 ES8901686A ES8901686A ES2013500A6 ES 2013500 A6 ES2013500 A6 ES 2013500A6 ES 8901686 A ES8901686 A ES 8901686A ES 8901686 A ES8901686 A ES 8901686A ES 2013500 A6 ES2013500 A6 ES 2013500A6
- Authority
- ES
- Spain
- Prior art keywords
- variants
- processes
- production
- plasminogen activators
- glycosylated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
METODO PARA PRODUCIR UNA VARIANTE DE SECUENCIA DE AMINOACIDOS DE UN ACTIVADOR DE PLASMINOGENO. SE PREPARA UNA VARIANTE DE SECUENCIA DE AMINOACIDOS FIBRINOLITICAMENTE ACTIVA DE UN ACTIVADOR DE PLASMINOGENO, QUE TIENE UNO O MAS SITIOS QUE NO ESTAN GLICOSILADOS EN LA MOLECULA NATURAL PERO QUE ESTAN GLICOSILADOS EN LA VARIANTE. SE PUEDEN PREPARAR SECUENCIAS DE ADN QUE CODIFICAN LAS VARIANTES, ASI COMO VECTORES DE EXPRESION QUE INCORPORAN LAS SECUENCIAS DE ADN Y CELULAS HOSPEDANTES TRANSFORMADAS CON LOS VECTORES DE EXPRESION. LAS VARIANTES SE PUEDEN UTILIZAR EN UN PREPARADO FARMACEUTICO PARA TRATAR UNA ENFERMEDAD O CONDICION VASCULAR EN PACIENTES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US19690988A | 1988-05-20 | 1988-05-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2013500A6 true ES2013500A6 (es) | 1990-05-01 |
Family
ID=22727245
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES8901686A Expired - Fee Related ES2013500A6 (es) | 1988-05-20 | 1989-05-19 | Metodo para producir una variante de secuencioa de aminoacidos de un activador de plasmionogeno. |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0424405B1 (es) |
JP (1) | JP2928798B2 (es) |
AT (1) | ATE111525T1 (es) |
AU (1) | AU624158B2 (es) |
CA (1) | CA1341432C (es) |
DE (1) | DE68918279T2 (es) |
DK (1) | DK175938B1 (es) |
ES (1) | ES2013500A6 (es) |
HK (1) | HK1007333A1 (es) |
IL (1) | IL90146A (es) |
NZ (1) | NZ229081A (es) |
WO (1) | WO1989011531A1 (es) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5098840A (en) * | 1986-07-03 | 1992-03-24 | The Green Cross Corporation | Human prourokinase mutants |
US5218092A (en) * | 1988-09-29 | 1993-06-08 | Kyowa Hakko Kogyo Co., Ltd. | Modified granulocyte-colony stimulating factor polypeptide with added carbohydrate chains |
NO894967L (no) * | 1988-12-12 | 1990-06-13 | Yamanouchi Pharma Co Ltd | Fremgangsmaate for fremstilling av nye thrombolytiske proteiner. |
JPH0387180A (ja) * | 1989-05-18 | 1991-04-11 | Green Cross Corp:The | 変異ヒトプロウロキナーゼ、その製法、dna配列、プラスミド、宿主 |
JP3126381B2 (ja) * | 1990-07-31 | 2001-01-22 | ジェネンテク,インコーポレイテッド | 減少されたクリアランスを有する組織プラスミノーゲンアクチベーター変異体 |
US5246850A (en) * | 1990-07-31 | 1993-09-21 | Genentech, Inc. | DNA molecules encoding human tissue plasminogen activator variants with decreased clearance, vectors, and host cells |
US5242688A (en) * | 1990-12-24 | 1993-09-07 | Eli Lilly And Company | Method of treating thromboembolic disorders by administration of diglycosylated t-pa variants |
US5595736A (en) * | 1991-04-22 | 1997-01-21 | Eli Lilly And Company | Compounds and methods for treatment of thromboembolic disorders |
US5223408A (en) * | 1991-07-11 | 1993-06-29 | Genentech, Inc. | Method for making variant secreted proteins with altered properties |
ATE155816T1 (de) * | 1992-06-03 | 1997-08-15 | Genentech Inc | Varianten des gewebeplasminogenaktivators mit verbesserter therapeutischer wirkung |
US5945432A (en) * | 1995-12-22 | 1999-08-31 | The University Of Vermont And State Agricultural College | Thrombolytic agents and thienopyridine derivatives in acute stroke |
US7553930B2 (en) | 2003-01-06 | 2009-06-30 | Xencor, Inc. | BAFF variants and methods thereof |
CA2553257A1 (en) * | 2004-01-14 | 2005-08-04 | Ohio University | Methods of producing peptides/proteins in plants and peptides/proteins produced thereby |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8528321D0 (en) * | 1985-11-18 | 1985-12-24 | Ciba Geigy Ag | Modified fibrinolytic agents |
ZA869626B (en) * | 1985-12-23 | 1987-10-28 | Chiron Corp | Peptide plasminogen activators |
DK43387A (da) * | 1986-01-29 | 1987-07-30 | Beecham Group Plc | Fibrinolytisk enzym |
AU7090787A (en) * | 1986-02-19 | 1987-10-08 | Beecham Group Plc | Tissue plasminogen activator |
IE81073B1 (en) * | 1986-03-18 | 2000-01-12 | Genentech Inc | Modified human tissue-type plasminogen activator and its preparation |
-
1989
- 1989-05-01 IL IL9014689A patent/IL90146A/en unknown
- 1989-05-04 AT AT89906612T patent/ATE111525T1/de not_active IP Right Cessation
- 1989-05-04 WO PCT/US1989/001947 patent/WO1989011531A1/en active IP Right Grant
- 1989-05-04 DE DE68918279T patent/DE68918279T2/de not_active Expired - Lifetime
- 1989-05-04 AU AU37448/89A patent/AU624158B2/en not_active Expired
- 1989-05-04 EP EP89906612A patent/EP0424405B1/en not_active Expired - Lifetime
- 1989-05-04 JP JP1506287A patent/JP2928798B2/ja not_active Expired - Lifetime
- 1989-05-11 NZ NZ229081A patent/NZ229081A/en unknown
- 1989-05-19 CA CA000600277A patent/CA1341432C/en not_active Expired - Lifetime
- 1989-05-19 ES ES8901686A patent/ES2013500A6/es not_active Expired - Fee Related
-
1990
- 1990-11-19 DK DK199002749A patent/DK175938B1/da not_active IP Right Cessation
-
1998
- 1998-06-25 HK HK98106555A patent/HK1007333A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO1989011531A1 (en) | 1989-11-30 |
DK274990A (da) | 1991-01-18 |
ATE111525T1 (de) | 1994-09-15 |
JPH03504327A (ja) | 1991-09-26 |
IL90146A0 (en) | 1989-12-15 |
CA1341432C (en) | 2003-06-17 |
JP2928798B2 (ja) | 1999-08-03 |
EP0424405A1 (en) | 1991-05-02 |
HK1007333A1 (en) | 1999-04-09 |
EP0424405B1 (en) | 1994-09-14 |
DK175938B1 (da) | 2005-07-25 |
NZ229081A (en) | 1991-03-26 |
AU624158B2 (en) | 1992-06-04 |
DE68918279T2 (de) | 1995-03-23 |
IL90146A (en) | 1994-10-07 |
AU3744889A (en) | 1989-12-12 |
DK274990D0 (da) | 1990-11-19 |
DE68918279D1 (de) | 1994-10-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20100315 |