DK36991D0 - Vaevsplasminoaktivator-(t-pa)-variant med zymogene eller fibrinspecifikke eller plasmakoagel-specifikke egenskaber, fremgangsmaade til fremstilling deraf, dna-sekvens, som koder for varianten, replicerbar udtrykkelsesvektor for denne og vaertsceller transformeret med vektoren - Google Patents

Vaevsplasminoaktivator-(t-pa)-variant med zymogene eller fibrinspecifikke eller plasmakoagel-specifikke egenskaber, fremgangsmaade til fremstilling deraf, dna-sekvens, som koder for varianten, replicerbar udtrykkelsesvektor for denne og vaertsceller transformeret med vektoren

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Publication number
DK36991D0
DK36991D0 DK91369A DK36991A DK36991D0 DK 36991 D0 DK36991 D0 DK 36991D0 DK 91369 A DK91369 A DK 91369A DK 36991 A DK36991 A DK 36991A DK 36991 D0 DK36991 D0 DK 36991D0
Authority
DK
Denmark
Prior art keywords
zymogens
variants
prepared
expression vectors
dna sequences
Prior art date
Application number
DK91369A
Other languages
English (en)
Other versions
DK175958B1 (da
DK36991A (da
Inventor
Stephen Anderson
William F Bennett
David Botstein
Deborah L Higgins
Nicholas A Paoni
Mark Zoller
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of DK36991D0 publication Critical patent/DK36991D0/da
Publication of DK36991A publication Critical patent/DK36991A/da
Application granted granted Critical
Publication of DK175958B1 publication Critical patent/DK175958B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK199100369A 1988-09-02 1991-03-01 Vævsplasminoaktivator-(t-PA)-variant med zymogene eller fibrinspecifikke eller plasmakoagel-specifikke egenskaber, fremgangsmåde til fremstilling deraf, DNA-sekvens, som koder for varianten, replicerbar udtrykkelsesvektor for denne og værtsceller tran DK175958B1 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US24085688A 1988-09-02 1988-09-02
US24085688 1988-09-02
US07/384,608 US5108901A (en) 1988-09-02 1989-07-24 Tissue plasminogen activator having zymogenic or fibrin specific properties
US38460889 1989-07-24
US8903755 1989-08-29
PCT/US1989/003755 WO1990002798A1 (en) 1988-09-02 1989-08-29 Tissue plasminogen activator having zymogenic or fibrin specific properties

Publications (3)

Publication Number Publication Date
DK36991D0 true DK36991D0 (da) 1991-03-01
DK36991A DK36991A (da) 1991-05-02
DK175958B1 DK175958B1 (da) 2005-08-29

Family

ID=26933781

Family Applications (1)

Application Number Title Priority Date Filing Date
DK199100369A DK175958B1 (da) 1988-09-02 1991-03-01 Vævsplasminoaktivator-(t-PA)-variant med zymogene eller fibrinspecifikke eller plasmakoagel-specifikke egenskaber, fremgangsmåde til fremstilling deraf, DNA-sekvens, som koder for varianten, replicerbar udtrykkelsesvektor for denne og værtsceller tran

Country Status (18)

Country Link
US (1) US5108901A (da)
EP (1) EP0457758B1 (da)
JP (1) JP2794028B2 (da)
KR (1) KR0148575B1 (da)
AT (1) ATE124452T1 (da)
AU (1) AU626323B2 (da)
CA (1) CA1341484C (da)
DE (1) DE68923298T2 (da)
DK (1) DK175958B1 (da)
ES (1) ES2018729A6 (da)
FI (1) FI109359B (da)
HK (1) HK1007334A1 (da)
HU (1) HU213922B (da)
IE (1) IE67508B1 (da)
IL (1) IL91306A (da)
NO (1) NO310778B1 (da)
NZ (1) NZ230509A (da)
WO (1) WO1990002798A1 (da)

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US5756093A (en) * 1985-04-22 1998-05-26 Genentech, Inc. Tissue plasminogen activator variants
US5736134A (en) * 1985-04-22 1998-04-07 Genentech, In.C Tissue plasminogen activator variants
GB8815135D0 (en) * 1988-06-24 1988-08-03 British Bio Technology Proteins & nucleic acids
DK395288D0 (da) * 1988-07-15 1988-07-15 Novo Industri As Proteiner
US5156969A (en) * 1988-09-02 1992-10-20 Genentech Inc. Tissue plasminogen activator variant with deletion of amino acids 466-470 having fibrin specific properties
US5262170A (en) * 1988-09-02 1993-11-16 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
US5304482A (en) * 1989-03-06 1994-04-19 The Board Of Regents Of The University Of Texas System Serine protease mutants of the chymotrypsin superfamily resistant to inhibition by their cognate inhibitors
US5550042A (en) * 1989-03-06 1996-08-27 The Board Of Regents Of The University Of Texas System Serine protease mutants of the chymotrypsin superfamily resistant to inhibition by their cognate inhibitors and genes encoding the same and serine protease inhibitor mutants and genes encoding the same
EP1029921B1 (en) * 1989-03-06 2002-10-23 The Board of Regents of The University of Texas System Serpin resistant t-PA; mutants; genes
US5866413A (en) * 1989-03-06 1999-02-02 Board Of Regents Of The University Of Texas System Pai-1 mutants
ATE155816T1 (de) * 1992-06-03 1997-08-15 Genentech Inc Varianten des gewebeplasminogenaktivators mit verbesserter therapeutischer wirkung
US5472692A (en) * 1993-07-02 1995-12-05 New England Deaconess Hospital Corporation Pro-urokinase mutants
US5877016A (en) 1994-03-18 1999-03-02 Genentech, Inc. Human trk receptors and neurotrophic factor inhibitors
US5656427A (en) * 1994-08-29 1997-08-12 Gen-Probe Incorporated Nucleic acid hybridization assay probes, helper probes and amplification oligonucleotides targeted to Mycoplasma pneumoniae nucleic acid
US5759775A (en) 1994-10-27 1998-06-02 Genetech, Inc. Methods for detecting nucleic acids encoding AL--1 neurotrophic factor
ZA966663B (en) 1995-08-17 1998-02-06 Genentech Inc Traf Inhibitors.
US6610296B2 (en) 1995-10-26 2003-08-26 Genentech, Inc. Methods of enhancing cognitive function using an AL-1 neurotrophic factor immunoadhesin
US6706504B1 (en) 1996-11-12 2004-03-16 The Scripps Research Institute Tissue type plasminogen activator (t-PA) variants: compositions and methods of use
WO1998021320A2 (en) * 1996-11-12 1998-05-22 The Scripps Research Institute TISSUE TYPE PLASMINOGEN ACTIVATOR (t-PA) VARIANTS: COMPOSITIONS AND METHODS OF USE
US20030113271A1 (en) * 1997-01-29 2003-06-19 University Technology Corporation Formulations for pulmonary delivery
JP3394540B2 (ja) 1997-01-31 2003-04-07 ジェネンテク・インコーポレイテッド Ｏ−フコシルトランスフェラーゼ
US20040241645A1 (en) * 1997-01-31 2004-12-02 Genentech, Inc. O-fucosyltransferase
WO1999009184A1 (de) * 1997-08-13 1999-02-25 Roche Diagnostics Gmbh Plasminogenaktivator mit verbesserter zymogenität und verminderter fibrinbindung
WO1999009185A1 (de) * 1997-08-13 1999-02-25 Roche Diagnostics Gmbh Plasminogenaktivator mit verbesserter zymogenität
KR100408844B1 (ko) * 2000-07-29 2003-12-06 한국산업기술평가원 동물세포 발현벡터
US20060104969A1 (en) * 2004-08-16 2006-05-18 Massachusetts Institute Of Technology Compositions and methods for enhancing structural and functional nervous system reorganization and recovery
JP2009533458A (ja) * 2006-04-14 2009-09-17 マサチューセッツ インスティテュート オブ テクノロジー 神経系の可塑性を媒介する分子経路の同定および変調
EP2056852A4 (en) * 2006-07-27 2010-01-13 Centocor Ortho Biotech Inc BMP-7 VARIANTS COMPOSITIONS, METHODS AND USES
WO2015023830A1 (en) 2013-08-14 2015-02-19 Stc.Unm Treatment and prevention of stroke and other neurological disorders
CA2966332C (en) 2014-11-03 2024-04-16 Thrombolytic Science, Llc Methods and compositions for safe and effective thrombolysis
WO2018232305A1 (en) 2017-06-16 2018-12-20 Thrombolytic Science, Llc Methods and compositions for thrombolysis

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EP0112122B1 (en) * 1982-12-14 1991-08-28 South African Inventions Development Corporation Plasminogen activator
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GB8528321D0 (en) * 1985-11-18 1985-12-24 Ciba Geigy Ag Modified fibrinolytic agents
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PT84589B (en) * 1986-04-02 1989-05-09 Beecham Group Plc Process for preparing a fibrinolytic enzyme
DK345087A (da) * 1986-07-11 1988-01-12 Novo Industri As Modificeret vaevsplasminogenaktivator
WO1988005081A2 (en) * 1986-12-30 1988-07-14 Cetus Corporation Novel plasminogen activator
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ZA883958B (en) * 1987-06-04 1989-07-26 Zymogenetics Inc Mutant t-pa with ringle replacement
FI101306B (fi) * 1987-06-04 1998-05-29 Zymogenetics Inc Menetelmä kudostyyppisen plasminogeeniaktivaattorin analogien, joissa on muokatut kasvutekijädomeenit, valmistamiseksi
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DK395288D0 (da) * 1988-07-15 1988-07-15 Novo Industri As Proteiner

Also Published As

Publication number Publication date
HU213922B (en) 1997-11-28
NZ230509A (en) 1991-06-25
WO1990002798A1 (en) 1990-03-22
HUT58812A (en) 1992-03-30
NO910811D0 (no) 1991-02-28
JPH04500157A (ja) 1992-01-16
DE68923298T2 (de) 1996-01-11
KR0148575B1 (ko) 1998-10-15
FI911049A0 (fi) 1991-03-01
AU626323B2 (en) 1992-07-30
HK1007334A1 (en) 1999-04-09
IE67508B1 (en) 1996-04-03
HU896005D0 (en) 1991-07-29
EP0457758B1 (en) 1995-06-28
DE68923298D1 (de) 1995-08-03
KR900702019A (ko) 1990-12-05
NO910811L (no) 1991-02-28
ES2018729A6 (es) 1991-05-01
JP2794028B2 (ja) 1998-09-03
FI109359B (fi) 2002-07-15
EP0457758A1 (en) 1991-11-27
US5108901A (en) 1992-04-28
AU4194689A (en) 1990-04-02
IL91306A (en) 1997-08-14
CA1341484C (en) 2005-05-24
ATE124452T1 (de) 1995-07-15
NO310778B1 (no) 2001-08-27
IE892650L (en) 1990-03-02
DK175958B1 (da) 2005-08-29
DK36991A (da) 1991-05-02
IL91306A0 (en) 1990-03-19

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