IL85767A - Benzoxazole derivatives, their preparation and pharmaceutical compositions containing them - Google Patents
Benzoxazole derivatives, their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL85767A IL85767A IL85767A IL8576788A IL85767A IL 85767 A IL85767 A IL 85767A IL 85767 A IL85767 A IL 85767A IL 8576788 A IL8576788 A IL 8576788A IL 85767 A IL85767 A IL 85767A
- Authority
- IL
- Israel
- Prior art keywords
- preparation
- pharmaceutical compositions
- compositions containing
- benzoxazole derivatives
- benzoxazole
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/34—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Thiazole And Isothizaole Compounds (AREA)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL102894A IL102894A (en) | 1987-03-18 | 1988-03-17 | 5-(substituted benzyl or benzylidene)-2,4- dioxothiazolidines |
IL102894A IL102894A0 (en) | 1987-03-18 | 1992-08-21 | 5-(substituted benzyl or benzylidene)-2,4-dioxothiazolidines |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6535987 | 1987-03-18 | ||
JP6707387 | 1987-03-20 |
Publications (2)
Publication Number | Publication Date |
---|---|
IL85767A0 IL85767A0 (en) | 1988-09-30 |
IL85767A true IL85767A (en) | 1993-08-18 |
Family
ID=26406503
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL85767A IL85767A (en) | 1987-03-18 | 1988-03-17 | Benzoxazole derivatives, their preparation and pharmaceutical compositions containing them |
Country Status (15)
Country | Link |
---|---|
US (2) | US4897393A (fi) |
EP (1) | EP0283035B1 (fi) |
KR (1) | KR930008450B1 (fi) |
CN (1) | CN1026322C (fi) |
AU (2) | AU600805B2 (fi) |
CA (1) | CA1304371C (fi) |
DE (1) | DE3865988D1 (fi) |
DK (1) | DK147488A (fi) |
ES (1) | ES2037752T3 (fi) |
FI (1) | FI91869C (fi) |
FR (1) | FR2612516B1 (fi) |
GR (1) | GR3003070T3 (fi) |
HU (2) | HU204525B (fi) |
IE (1) | IE59335B1 (fi) |
IL (1) | IL85767A (fi) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU210339B (en) * | 1985-05-21 | 1995-03-28 | Pfizer | Process for preparing thiazolidinediones and their pharmaceutical compositions haring hypoglycemic effect |
FI91869C (fi) * | 1987-03-18 | 1994-08-25 | Tanabe Seiyaku Co | Menetelmä antidiabeettisena aineena käytettävien bensoksatsolijohdannaisten valmistamiseksi |
JPS63230689A (ja) * | 1987-03-18 | 1988-09-27 | Tanabe Seiyaku Co Ltd | ベンゾオキサジン誘導体 |
JPH02167224A (ja) * | 1988-09-13 | 1990-06-27 | Tanabe Seiyaku Co Ltd | 抗脂血剤 |
JPH03173874A (ja) * | 1989-09-29 | 1991-07-29 | Mitsubishi Kasei Corp | 新規複素環化合物 |
WO1991007107A1 (en) * | 1989-11-13 | 1991-05-30 | Pfizer Inc. | Oxazolidinedione hypoglycemic agents |
US5037842A (en) * | 1990-06-05 | 1991-08-06 | Pfizer Inc. | Oxa- and thiazolidinedione hypoglycemic and hypocholesterolemic agents |
US5089514A (en) * | 1990-06-14 | 1992-02-18 | Pfizer Inc. | 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents |
JPH04210683A (ja) * | 1990-12-06 | 1992-07-31 | Terumo Corp | チアゾリジン−2,4−ジオン誘導体およびこれを含有する糖尿病合併症治療薬 |
US5158966A (en) * | 1991-02-22 | 1992-10-27 | The University Of Colorado Foundation, Inc. | Method of treating type i diabetes |
ATE142631T1 (de) * | 1991-06-25 | 1996-09-15 | Pfizer | Thiazolidindione als hypoglykämische wirkstoffe |
TW222626B (fi) * | 1991-07-22 | 1994-04-21 | Pfizer | |
EP0535269A1 (en) * | 1991-10-04 | 1993-04-07 | Tanabe Seiyaku Co., Ltd. | Pharmaceutical compositions containing thiazolidinedione derivatives |
US5498621A (en) * | 1992-05-01 | 1996-03-12 | Pfizer Inc. | Oxazolidinedione hypoglycemic agents |
CZ181493A3 (en) * | 1992-09-10 | 1994-03-16 | Lilly Co Eli | The use of rhodanine derivative for the preparation of a pharmaceutical composition reducing level of sugar in blood and for treating alzheimer's disease |
JP2845743B2 (ja) * | 1992-12-28 | 1999-01-13 | 三菱化学株式会社 | 新規なナフタレン誘導体 |
US5594016A (en) * | 1992-12-28 | 1997-01-14 | Mitsubishi Chemical Corporation | Naphthalene derivatives |
US5457109A (en) * | 1993-09-15 | 1995-10-10 | Warner-Lambert Company | Use of thiazolidinedione derivatives and related antihyperglycemic agents in the treatment of disease states at risk for progressing to noninsulin-dependent diabetes mellitus |
US6046222A (en) * | 1993-09-15 | 2000-04-04 | Warner-Lambert Company | Use of thiazolidinedione derivatives in the treatment of polycystic ovary syndrome, gestational diabetes and disease states at risk for progressing to noninsulin-dependent diabetes mellitus |
US5401761A (en) * | 1993-12-09 | 1995-03-28 | Pfizer, Inc. | Thiazolidinedione hypoglycemic agents |
US6251928B1 (en) | 1994-03-16 | 2001-06-26 | Eli Lilly And Company | Treatment of alzheimer's disease employing inhibitors of cathepsin D |
US5708012A (en) * | 1995-04-28 | 1998-01-13 | Sankyo Company, Limited | Use of thiazolidinedione derivatives and related antihyperglycemic agents in the treatment of insulin resistant subjects with normal glucose tolerance in order to prevent or delay the onset of noninsulin-dependent mellitus |
US5798375A (en) * | 1995-07-03 | 1998-08-25 | Sankyo Company, Limited | Treatment of arteriosclerosis and xanthoma |
US5860902A (en) * | 1996-02-09 | 1999-01-19 | Jang; Bor-Zeng Bohr | Paint roller frame with an adjustable handle |
CA2257284C (en) * | 1996-05-31 | 2005-10-04 | Sankyo Company Limited | Remedy for autoimmune diseases |
CA2323889A1 (en) * | 1997-03-12 | 1998-09-17 | Robert W. Esmond | A method for treating or preventing alzheimer's disease |
HUP9902721A2 (hu) | 1997-11-25 | 1999-12-28 | The Procter & Gamble Co. | Tömény textillágyító készítmény és ehhez alkalmazható magas telítetlenségű textillágyító vegyület |
US20040058873A1 (en) * | 1998-03-12 | 2004-03-25 | Esmond Robert W. | Method for treating or preventing Alzheimer's disease |
EP1143953A3 (en) * | 1998-11-20 | 2002-02-06 | Genentech, Inc. | Method of inhibiting angiogenesis |
US6191154B1 (en) | 1998-11-27 | 2001-02-20 | Case Western Reserve University | Compositions and methods for the treatment of Alzheimer's disease, central nervous system injury, and inflammatory diseases |
US6756360B1 (en) | 1998-12-24 | 2004-06-29 | Metabasis Therapeutics, Inc. | Combination of FBPase inhibitors and insulin sensitizers for the treatment of diabetes |
JP2001072592A (ja) | 1999-07-01 | 2001-03-21 | Kyowa Hakko Kogyo Co Ltd | テロメラーゼ阻害剤 |
JP2003508391A (ja) | 1999-08-31 | 2003-03-04 | マキシア・ファーマシューティカルズ・インコーポレイテッド | ベンジリデン−チアゾリジンジオン類およびアナログ類ならびに糖尿病の治療におけるその使用 |
CO5261573A1 (es) | 1999-11-19 | 2003-03-31 | Novartis Ag | Derivados de benzoxa y bezotiazol, compuesto y composicion farmaceutica que los contiene y proceso para la preparacion de la mencionada composicion |
US6680387B2 (en) * | 2000-04-24 | 2004-01-20 | Aryx Therapeutics | Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis |
US6958355B2 (en) * | 2000-04-24 | 2005-10-25 | Aryx Therapeutics, Inc. | Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis |
CY2010012I2 (el) * | 2000-05-25 | 2020-05-29 | Novartis Ag | Μιμητικα θρομβοποιητινης |
US20110212054A1 (en) * | 2000-05-25 | 2011-09-01 | Glaxosmithkline Llc. | Thrombopoietin mimetics |
US7563774B2 (en) | 2000-06-29 | 2009-07-21 | Metabasis Therapeutics, Inc. | Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes |
WO2002024689A1 (en) * | 2000-09-21 | 2002-03-28 | Aryx Therapeutics | Isoxazolidine compounds useful in the treatment of diabetes, hyperlipidemia, and atherosclerosis |
US6452014B1 (en) | 2000-12-22 | 2002-09-17 | Geron Corporation | Telomerase inhibitors and methods of their use |
WO2002051441A1 (fr) * | 2000-12-26 | 2002-07-04 | Sankyo Company, Limited | Compositions medicinales contenant un diuretique et un agent renforçant la resistance a l'insuline |
IL157740A0 (en) * | 2001-03-07 | 2004-03-28 | Incyte San Diego Inc | Heterocyclic derivatives and pharmaceutical compositions containing the same |
US7265139B2 (en) * | 2001-03-08 | 2007-09-04 | Incyte San Diego Inc. | RXR activating molecules |
US6660858B2 (en) | 2001-03-28 | 2003-12-09 | Lion Bioscience Ag | 2-aminobenzoxazole derivatives and combinatorial libraries thereof |
US20060047000A1 (en) * | 2001-04-24 | 2006-03-02 | Aryx Therapeutics, Inc. | Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis |
US7102000B2 (en) * | 2002-03-08 | 2006-09-05 | Incyte San Diego Inc. | Heterocyclic amide derivatives for the treatment of diabetes and other diseases |
US20050119314A1 (en) * | 2002-04-05 | 2005-06-02 | Sankyo Company, Limited | Pharmaceutical composition comprising an ACAT inhibitor and an insulin resistance reducing agent |
MY142390A (en) * | 2002-05-22 | 2010-11-30 | Glaxosmithkline Llc | 3' - [(2z)-[1-(3,4-dimethylphenyl)-1,5- dihydro-3- methyl-5-0xo-4h-pyrazol-4- ylidene]hydrazino]-2' -hydroxy -[1,1' -biphenyl]-3-carboxylic acid bis-(monoethanolamine) |
JP4562523B2 (ja) * | 2002-06-06 | 2010-10-13 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | トロンボポエチン疑似体 |
US7230016B2 (en) | 2003-05-13 | 2007-06-12 | Synthon Ip Inc. | Pioglitazone salts, such as pioglitazone sulfate, and pharmaceutical compositions and processes using the same |
DE10331675A1 (de) * | 2003-07-14 | 2005-02-10 | Bayer Cropscience Ag | Hetarylsubstituierte Pyrazolidindion-Derivate |
TW200526638A (en) * | 2003-10-22 | 2005-08-16 | Smithkline Beecham Corp | 2-(3,4-dimethylphenyl)-4-{[2-hydroxy-3'-(1H-tetrazol-5-yl)biphenyl-3-yl]-hydrazono}-5-methyl-2,4-dihydropyrazol-3-one choline |
WO2005080387A2 (en) | 2004-02-20 | 2005-09-01 | Synthon B.V. | Processes for making pioglitazone and compounds of the processes |
WO2005100331A2 (en) * | 2004-04-14 | 2005-10-27 | Ranbaxy Laboratories Limited | Antidiabetic agents |
WO2006022194A1 (en) * | 2004-08-23 | 2006-03-02 | Semiconductor Energy Laboratory Co., Ltd. | Electron injecting composition, and light emitting element and light emitting device using the electron injecting composition |
ECSP077628A (es) | 2007-05-03 | 2008-12-30 | Smithkline Beechman Corp | Nueva composición farmacéutica |
JP2012528184A (ja) | 2009-05-29 | 2012-11-12 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | トロンボポエチンアゴニスト化合物の投与の方法 |
US9623015B2 (en) | 2012-11-05 | 2017-04-18 | Commissariat À L'energie Atomique Et Aux Energies Alternatives (Cea) | Combination of an anti-cancer agent such as a tyrosinekinase inhibitor and a STAT5 antagonist, preferably a thiazolidinedione, for eliminating hematologic cancer stem cells in vivo and for preventing hematologic cancer relapse |
US9246108B2 (en) | 2012-12-28 | 2016-01-26 | Dow Global Technologies Llc | Quinoline-benzoxazole derived compounds for electronic films and devices |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58118577A (ja) * | 1982-01-07 | 1983-07-14 | Takeda Chem Ind Ltd | チアゾリジン誘導体 |
CN1003445B (zh) * | 1984-10-03 | 1989-03-01 | 武田药品工业株式会社 | 噻唑烷二酮衍生物,其制备方法和用途 |
AR240698A1 (es) * | 1985-01-19 | 1990-09-28 | Takeda Chemical Industries Ltd | Procedimiento para preparar compuestos de 5-(4-(2-(5-etil-2-piridil)-etoxi)benzil)-2,4-tiazolidindiona y sus sales |
HU210339B (en) * | 1985-05-21 | 1995-03-28 | Pfizer | Process for preparing thiazolidinediones and their pharmaceutical compositions haring hypoglycemic effect |
JPH06779B2 (ja) * | 1985-06-10 | 1994-01-05 | 武田薬品工業株式会社 | チアゾリジオン誘導体およびそれを含んでなる医薬組成物 |
JPS6212776A (ja) * | 1985-07-10 | 1987-01-21 | Taiho Yakuhin Kogyo Kk | ロ−ダニン誘導体 |
FI91869C (fi) * | 1987-03-18 | 1994-08-25 | Tanabe Seiyaku Co | Menetelmä antidiabeettisena aineena käytettävien bensoksatsolijohdannaisten valmistamiseksi |
GB8713861D0 (en) * | 1987-06-13 | 1987-07-15 | Beecham Group Plc | Compounds |
IE940525L (en) * | 1988-05-25 | 1989-11-25 | Warner Lambert Co | Known and selected novel arylmethylenyl derivatives of¹thiazolidinones, imidazolidinones and oxazolidinones useful¹as antiallergy agents and antiinflammatory agents |
CA2013599C (en) * | 1989-04-07 | 1999-11-16 | Jill A. Panetta | Aryl-substituted rhodanine derivatives |
-
1988
- 1988-03-09 FI FI881103A patent/FI91869C/fi not_active IP Right Cessation
- 1988-03-14 US US07/167,391 patent/US4897393A/en not_active Expired - Fee Related
- 1988-03-16 AU AU13177/88A patent/AU600805B2/en not_active Ceased
- 1988-03-16 CA CA000561556A patent/CA1304371C/en not_active Expired - Fee Related
- 1988-03-16 IE IE77188A patent/IE59335B1/en not_active IP Right Cessation
- 1988-03-17 CN CN88101542A patent/CN1026322C/zh not_active Expired - Fee Related
- 1988-03-17 IL IL85767A patent/IL85767A/xx not_active IP Right Cessation
- 1988-03-17 KR KR1019880002824A patent/KR930008450B1/ko not_active IP Right Cessation
- 1988-03-17 DK DK147488A patent/DK147488A/da not_active Application Discontinuation
- 1988-03-17 HU HU881317A patent/HU204525B/hu not_active IP Right Cessation
- 1988-03-18 FR FR8803570A patent/FR2612516B1/fr not_active Expired - Fee Related
- 1988-03-18 DE DE8888104361T patent/DE3865988D1/de not_active Expired - Fee Related
- 1988-03-18 ES ES198888104361T patent/ES2037752T3/es not_active Expired - Lifetime
- 1988-03-18 EP EP88104361A patent/EP0283035B1/en not_active Expired - Lifetime
-
1989
- 1989-11-13 US US07/435,807 patent/US4948900A/en not_active Expired - Fee Related
-
1990
- 1990-05-21 AU AU55783/90A patent/AU618483B2/en not_active Ceased
-
1991
- 1991-11-07 GR GR91401153T patent/GR3003070T3/el unknown
-
1995
- 1995-06-29 HU HU95P/P00601P patent/HU211959A9/hu unknown
Also Published As
Publication number | Publication date |
---|---|
CN1026322C (zh) | 1994-10-26 |
DK147488D0 (da) | 1988-03-17 |
IE59335B1 (en) | 1994-02-09 |
FI881103A (fi) | 1988-09-19 |
KR880011153A (ko) | 1988-10-26 |
HU211959A9 (en) | 1996-01-29 |
FI881103A0 (fi) | 1988-03-09 |
CN88101542A (zh) | 1988-10-05 |
HUT50339A (en) | 1990-01-29 |
GR3003070T3 (en) | 1993-02-17 |
DK147488A (da) | 1988-09-19 |
AU618483B2 (en) | 1991-12-19 |
FR2612516A1 (fr) | 1988-09-23 |
CA1304371C (en) | 1992-06-30 |
KR930008450B1 (ko) | 1993-09-04 |
ES2037752T3 (es) | 1993-07-01 |
US4897393A (en) | 1990-01-30 |
IL85767A0 (en) | 1988-09-30 |
EP0283035A1 (en) | 1988-09-21 |
AU5578390A (en) | 1990-10-11 |
HU204525B (en) | 1992-01-28 |
AU1317788A (en) | 1988-09-22 |
AU600805B2 (en) | 1990-08-23 |
IE880771L (en) | 1988-09-18 |
FI91869C (fi) | 1994-08-25 |
FI91869B (fi) | 1994-05-13 |
US4948900A (en) | 1990-08-14 |
DE3865988D1 (de) | 1991-12-12 |
EP0283035B1 (en) | 1991-11-06 |
FR2612516B1 (fr) | 1992-11-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
KB | Patent renewed | ||
MM9K | Patent not in force due to non-payment of renewal fees |