IL85701A0 - Human manganese superoxide dismutase(hmn-sod),its preparation by genetic engineering,dna sequences coding therefor,vectors containing these dna sequences and host cells which can express them and pharmaceutical compositions containing said enzyme - Google Patents
Human manganese superoxide dismutase(hmn-sod),its preparation by genetic engineering,dna sequences coding therefor,vectors containing these dna sequences and host cells which can express them and pharmaceutical compositions containing said enzymeInfo
- Publication number
- IL85701A0 IL85701A0 IL85701A IL8570188A IL85701A0 IL 85701 A0 IL85701 A0 IL 85701A0 IL 85701 A IL85701 A IL 85701A IL 8570188 A IL8570188 A IL 8570188A IL 85701 A0 IL85701 A0 IL 85701A0
- Authority
- IL
- Israel
- Prior art keywords
- dna sequences
- enzyme
- hmn
- sod
- express
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0089—Oxidoreductases (1.) acting on superoxide as acceptor (1.15)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/07—Fusion polypeptide containing a localisation/targetting motif containing a mitochondrial localisation signal
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Peptides Or Proteins (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Bakery Products And Manufacturing Methods Therefor (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19873708306 DE3708306A1 (de) | 1987-03-14 | 1987-03-14 | Humane mangan-superoxiddismutase (hmn-sod) |
DE19873717695 DE3717695A1 (de) | 1987-05-26 | 1987-05-26 | Humane mangan-superoxiddismutase (hmn-sod) |
DE19873722884 DE3722884A1 (de) | 1987-07-10 | 1987-07-10 | Humane mangan-superoxiddismutase (hmn-sod) |
DE19873744038 DE3744038A1 (de) | 1987-12-24 | 1987-12-24 | Humane mangan-superoxiddismutase (hmn-sod) |
Publications (1)
Publication Number | Publication Date |
---|---|
IL85701A0 true IL85701A0 (en) | 1988-08-31 |
Family
ID=27433860
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL85701A IL85701A0 (en) | 1987-03-14 | 1988-03-11 | Human manganese superoxide dismutase(hmn-sod),its preparation by genetic engineering,dna sequences coding therefor,vectors containing these dna sequences and host cells which can express them and pharmaceutical compositions containing said enzyme |
Country Status (18)
Country | Link |
---|---|
US (3) | US5240847A (da) |
EP (2) | EP0676472A1 (da) |
JP (1) | JP2860100B2 (da) |
KR (1) | KR880011339A (da) |
AT (1) | ATE132902T1 (da) |
AU (1) | AU618526B2 (da) |
CA (1) | CA1341387C (da) |
DE (1) | DE3854872D1 (da) |
DK (1) | DK133388A (da) |
ES (1) | ES2083357T3 (da) |
FI (1) | FI881185A (da) |
GR (1) | GR3019091T3 (da) |
HU (1) | HU212920B (da) |
IE (2) | IE71940B1 (da) |
IL (1) | IL85701A0 (da) |
MX (1) | MX9203619A (da) |
NO (1) | NO176884C (da) |
PT (1) | PT86955B (da) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5714362A (en) * | 1983-04-29 | 1998-02-03 | Yeda Research And Development Co. Ltd. | Human superoxide dismutase cDNA |
US6610520B1 (en) * | 1985-11-22 | 2003-08-26 | Bio-Technology General Corp. | Gene encoding human manganese superoxide dismutase and recombinant polypeptide encoded thereby |
US6326003B1 (en) | 1986-10-14 | 2001-12-04 | Chiron Corporation | Manganese superoxide dismutase cloning and expression in microorganisms |
EP0676472A1 (de) * | 1987-03-14 | 1995-10-11 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Humane Mangan-Superoxiddismutase (hMn-SOD) |
DE3854678T2 (de) * | 1987-03-27 | 1996-06-13 | Bio Technology General Corp | Menschliches Mangansuperoxiddismutase und Behandlungsverfahren. |
JP2500543B2 (ja) * | 1991-05-24 | 1996-05-29 | 住友化学工業株式会社 | キメラp450産生菌株 |
EP0587055B1 (de) * | 1992-09-09 | 2001-12-05 | Bio-Technology General Corporation | Verwendung von Mangan-Superoxiddismutase (Mn-SOD) zur Herstellung von Arzneimitteln zur Behandlung von Erkrankungen in niedriger Dosierung |
US5843641A (en) * | 1993-02-26 | 1998-12-01 | Massachusetts Institute Of Technology | Methods for the daignosis, of familial amyotrophic lateral sclerosis |
WO1994021283A1 (en) * | 1993-03-24 | 1994-09-29 | Boehringer Ingelheim Pharmaceuticals, Inc. | Method for inhibiting pulmonary oxygen toxicity using manganese superoxide dismutase |
US6887856B1 (en) * | 1993-10-15 | 2005-05-03 | University Of Pittsburgh | Protection from ionizing irradiation or chemotherapeutic drug damage by in vivo gene therapy |
US6127356A (en) * | 1993-10-15 | 2000-10-03 | Duke University | Oxidant scavengers |
US5994339A (en) * | 1993-10-15 | 1999-11-30 | University Of Alabama At Birmingham Research Foundation | Oxidant scavengers |
US5747026A (en) * | 1993-10-15 | 1998-05-05 | University Of Alabama At Birmingham Research Foundation | Antioxidants |
US5506133A (en) * | 1994-04-11 | 1996-04-09 | Human Genome Sciences, Inc. | Superoxide dismutase-4 |
JP2517894B2 (ja) * | 1994-08-12 | 1996-07-24 | 住友化学工業株式会社 | フェレドキシン及びフェレドキシン還元酵素を同時に発現させるキメラp450産生菌株 |
AU3758695A (en) * | 1994-09-20 | 1996-04-09 | Duke University | Oxidoreductase activity of manganic porphyrins |
US5834248A (en) * | 1995-02-10 | 1998-11-10 | Millennium Pharmaceuticals Inc. | Compositions and methods using rchd534, a gene uregulated by shear stress |
US6359194B1 (en) | 1995-02-10 | 2002-03-19 | Millennium Pharmaceuticals, Inc. | Compositions and methods for the treatment and diagnosis of cardiovascular disease |
EP0904277A4 (en) * | 1996-02-16 | 2003-01-22 | Millennium Pharm Inc | COMPOSITIONS AND METHODS FOR TREATING AND DIAGNOSING CARDIOVASCULAR DISEASES |
US6099823A (en) * | 1996-02-16 | 2000-08-08 | Millennium Pharmaceuticals, Inc. | Compositions and methods for the treatment and diagnosis of cardiovascular disease |
US6171856B1 (en) | 1997-07-30 | 2001-01-09 | Board Of Regents, The University Of Texas System | Methods and compositions relating to no-mediated cytotoxicity |
WO1999006059A2 (en) * | 1997-07-30 | 1999-02-11 | Board Of Regents, The University Of Texas System | Methods and compositions relating to no-mediated cytotoxicity |
JP2001521939A (ja) | 1997-11-03 | 2001-11-13 | デューク・ユニバーシティー | 置換されたポルフィリン類 |
WO1999043697A1 (en) * | 1998-02-25 | 1999-09-02 | The Board Of Regents Of The University And Community College System Of Nevada On Behalf Of The University Of Nevada-Reno | Manganese superoxide dismutase exon 3-deleted isoforms and nucleic acid molecules encoding the isoforms |
US6737506B1 (en) * | 1998-02-25 | 2004-05-18 | Paul Anziano | Manganese superoxide dismutase exon 3-deleted isoforms and nucleic acid molecules encoding the isoforms |
JP4648542B2 (ja) | 1998-04-24 | 2011-03-09 | デューク ユニバーシティ | 置換ポルフィリン |
US6190658B1 (en) | 1998-05-08 | 2001-02-20 | Webb-Waring Institute For Biomedical Research | Genetically modified manganese superoxide dismutase for treating oxidative damage |
US6221848B1 (en) | 1998-05-11 | 2001-04-24 | University Of Pittsburgh | Protection of the esophagus from chemotherapeutic or irradiation damage by gene therapy |
GB9824282D0 (en) * | 1998-11-05 | 1998-12-30 | Microbiological Research Agenc | Delivery of superoxide dismutase to neuronal cells |
WO2000043395A1 (en) | 1999-01-25 | 2000-07-27 | National Jewish Medical And Research Center | Substituted porphyrins |
US6265172B1 (en) * | 1999-02-08 | 2001-07-24 | University Of Kentucky | Diagnostic test and therapy for manganese superoxide dismutate (mNsod) associated diseases |
FR2806911B1 (fr) * | 2000-03-28 | 2003-01-10 | Univ Rene Descartes | Utilisation de mimetiques de la sod dans le traitement d'insuffisances hepatocellulaires |
CN1322825A (zh) * | 2000-05-09 | 2001-11-21 | 上海博德基因开发有限公司 | 一种新的多肽——超氧化物歧化酶11和编码这种多肽的多核苷酸 |
ES2330728T3 (es) | 2001-01-19 | 2009-12-15 | National Jewish Health | Medicamento para proteccion en radioterapia. |
AU2002312194B8 (en) | 2001-06-01 | 2008-05-15 | Aeolus Sciences, Inc. | Oxidant scavengers for treatment of diabetes or use in transplantation or induction of immune tolerance |
WO2002100293A2 (en) * | 2001-06-13 | 2002-12-19 | Webb-Waring Institute For Biomedical Research | A diagnostic and prognostic method for evaluating ocular inflammation and oxidative stress and the treatment of the same |
JP2006501163A (ja) | 2002-06-07 | 2006-01-12 | デューク・ユニバーシティー | 置換ポルフィリン |
US8258105B2 (en) * | 2003-10-07 | 2012-09-04 | Isis Pharmaceuticals, Inc. | Antisense oligonucleotides optimized for kidney targeting |
US20050191653A1 (en) * | 2003-11-03 | 2005-09-01 | Freier Susan M. | Modulation of SGLT2 expression |
WO2006017559A1 (en) * | 2004-08-02 | 2006-02-16 | University Of Iowa Research Foundation | Methods of inhibiting manganese-containing superoxide dismutase 2 (mnsod) |
US9546312B2 (en) * | 2007-08-31 | 2017-01-17 | Hayes & Associates | Endotherm systems and methods utilizing carbohydrate in non-oxidizing environment |
RU2506083C2 (ru) | 2008-05-23 | 2014-02-10 | Нэшнл Джуиш Хелт | Способ лечения поражений, ассоциированных с воздействием алкилирующих веществ |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE813485A (fr) * | 1973-04-16 | 1974-10-09 | Superoxyde dismutases et leur application comme inhibiteurs d'oxydation | |
US4029819A (en) * | 1973-04-16 | 1977-06-14 | Etablissement Public Det: Agence Nationale De Valorisation De La Recherche Anver | Superoxide dismutase and its application as an oxidation inhibitor |
FR2225443B1 (da) * | 1973-04-16 | 1976-11-12 | Anvar | |
FR2240277B2 (da) * | 1973-08-10 | 1976-12-17 | Anvar | |
JPS5816685A (ja) * | 1981-07-22 | 1983-01-31 | Takeda Chem Ind Ltd | 固定化酵素,その製造法および製剤 |
US5196335A (en) * | 1983-04-29 | 1993-03-23 | Yeda Research And Development Co., Ltd. | Human superoxide dismutase cDNA |
EP0138111B1 (en) * | 1983-10-03 | 1991-11-21 | Chiron Corporation | Superoxide dismutase cloning and expression in microorganisms |
US5066591A (en) * | 1983-10-03 | 1991-11-19 | Chiron Corporation | Polypeptides of human copper/zinc superoxide dimutase |
US4751180A (en) * | 1985-03-28 | 1988-06-14 | Chiron Corporation | Expression using fused genes providing for protein product |
DK402785D0 (da) * | 1985-09-03 | 1985-09-03 | Syn Tek Ab | Fremgangsmaade til fremstilling af et enzym |
IE59498B1 (en) * | 1985-11-22 | 1994-03-09 | Bio Technology General Corp | Human manganese superoxide dismutase analog, plasmid for its expression and method of recovering it in enzymatically active form |
US5246847A (en) * | 1985-11-22 | 1993-09-21 | Bio-Technology General Corp. | Polypeptide analogs of human manganese superoxide dismutase and compositions and complexes thereof |
US5270195A (en) * | 1985-11-22 | 1993-12-14 | Bio-Technology General Corp. | Plasmids for expression and method of producing a human manganese superoxide dimutase analog |
EP0676472A1 (de) * | 1987-03-14 | 1995-10-11 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Humane Mangan-Superoxiddismutase (hMn-SOD) |
US5260204A (en) * | 1987-03-14 | 1993-11-09 | Boehringer Ingelheim International Gmbh | Human manganese superoxide dismutase (hMn-SOD) |
DE3854678T2 (de) * | 1987-03-27 | 1996-06-13 | Bio Technology General Corp | Menschliches Mangansuperoxiddismutase und Behandlungsverfahren. |
US5223538A (en) * | 1987-03-31 | 1993-06-29 | Duke University | Superoxide dismutase mimic |
NZ225760A (en) * | 1987-08-14 | 1991-02-26 | Bio Technology General Corp | Expression plasmids containing the deo promoter and bacterial hosts containing these plasmids |
JPH0283398A (ja) * | 1988-09-21 | 1990-03-23 | Ube Ind Ltd | 合成ペプチド、それを用いたヒトMn−スーパーオキシドジスムターゼの測定キットおよび測定法 |
EP0462836A3 (en) * | 1990-06-20 | 1992-08-26 | Mitsui Toatsu Chemicals, Inc. | Recombinant vector plasmid capable of expressing human manganese superoxide dismutase, and process of producing this enzyme |
-
1988
- 1988-03-10 EP EP95107460A patent/EP0676472A1/de not_active Withdrawn
- 1988-03-10 EP EP88103754A patent/EP0282899B1/de not_active Expired - Lifetime
- 1988-03-10 AT AT88103754T patent/ATE132902T1/de not_active IP Right Cessation
- 1988-03-10 ES ES88103754T patent/ES2083357T3/es not_active Expired - Lifetime
- 1988-03-10 DE DE3854872T patent/DE3854872D1/de not_active Expired - Fee Related
- 1988-03-11 IL IL85701A patent/IL85701A0/xx unknown
- 1988-03-11 US US07/167,261 patent/US5240847A/en not_active Expired - Fee Related
- 1988-03-11 PT PT86955A patent/PT86955B/pt not_active IP Right Cessation
- 1988-03-11 JP JP63058108A patent/JP2860100B2/ja not_active Expired - Lifetime
- 1988-03-11 CA CA000561228A patent/CA1341387C/en not_active Expired - Fee Related
- 1988-03-11 IE IE71788A patent/IE71940B1/en not_active IP Right Cessation
- 1988-03-11 DK DK133388A patent/DK133388A/da not_active Application Discontinuation
- 1988-03-11 IE IE960190A patent/IE960190L/xx not_active IP Right Cessation
- 1988-03-11 AU AU13027/88A patent/AU618526B2/en not_active Ceased
- 1988-03-11 NO NO881089A patent/NO176884C/no not_active IP Right Cessation
- 1988-03-14 FI FI881185A patent/FI881185A/fi not_active IP Right Cessation
- 1988-03-14 KR KR1019880002652A patent/KR880011339A/ko not_active Application Discontinuation
- 1988-03-14 HU HU881204A patent/HU212920B/hu not_active IP Right Cessation
-
1992
- 1992-06-26 MX MX9203619A patent/MX9203619A/es unknown
- 1992-09-15 US US07/945,240 patent/US5436162A/en not_active Expired - Fee Related
-
1995
- 1995-03-30 US US08/413,367 patent/US5589371A/en not_active Expired - Fee Related
-
1996
- 1996-02-23 GR GR960400511T patent/GR3019091T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
EP0282899A2 (de) | 1988-09-21 |
DE3854872D1 (de) | 1996-02-22 |
EP0282899B1 (de) | 1996-01-10 |
NO881089D0 (no) | 1988-03-11 |
US5589371A (en) | 1996-12-31 |
NO176884C (no) | 1995-06-14 |
PT86955B (pt) | 1992-06-30 |
DK133388A (da) | 1988-09-15 |
NO176884B (no) | 1995-03-06 |
ES2083357T3 (es) | 1996-04-16 |
CA1341387C (en) | 2002-09-03 |
FI881185A0 (fi) | 1988-03-14 |
EP0282899A3 (en) | 1989-11-15 |
IE71940B1 (en) | 1997-03-12 |
PT86955A (pt) | 1988-04-01 |
NO881089L (no) | 1988-09-15 |
HU212920B (en) | 1996-12-30 |
EP0676472A1 (de) | 1995-10-11 |
JP2860100B2 (ja) | 1999-02-24 |
MX9203619A (es) | 1992-09-01 |
KR880011339A (ko) | 1988-10-27 |
DK133388D0 (da) | 1988-03-11 |
US5240847A (en) | 1993-08-31 |
FI881185A (fi) | 1988-09-15 |
HUT46739A (en) | 1988-11-28 |
AU1302788A (en) | 1988-09-15 |
JPS6463383A (en) | 1989-03-09 |
IE960190L (en) | 1988-09-14 |
AU618526B2 (en) | 1992-01-02 |
ATE132902T1 (de) | 1996-01-15 |
GR3019091T3 (en) | 1996-05-31 |
IE880717L (en) | 1988-09-14 |
US5436162A (en) | 1995-07-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL85701A0 (en) | Human manganese superoxide dismutase(hmn-sod),its preparation by genetic engineering,dna sequences coding therefor,vectors containing these dna sequences and host cells which can express them and pharmaceutical compositions containing said enzyme | |
UA19765A (uk) | Фрагмеhт hуклеїhової кислоти, що кодує людський проаполіпопротеїн а-1 | |
AU568067B2 (en) | Oligonucleotide therapeutic agent and methods of making same | |
LTIP1656A (en) | Alpha-amidating enzyme compositions and process for their production | |
WO2002031134A3 (en) | Novel serine protease genes related to dppiv | |
NO172548C (no) | Saccharomyces cerevisiae hybride vektorer og anvendelse av disse ved fremstilling av polypeptider | |
DE69930955D1 (de) | Polypeptide mit lysophospholipaseaktivität und nukleinesäuren die sie kodieren | |
IL70414A (en) | Polypeptide having human h2-relaxin activity,double-stranded dna fragments coding therefor,vectors containing the dna fragments and methods for preparing the polypeptide,dna fragments and vectors | |
IL85878A (en) | Dna coding for anticoagulant proteins (vac), vac proteins encoded thereby, processes for preparing them, pharmaceutical compositions containing the proteins, monoclunal antibodies against such proteins and hybrid cell lines which secrete these antibodies | |
IL75963A0 (en) | Interferon derivatives,their preparation and pharmaceutical compositions containing them | |
ATE215988T1 (de) | Vitamin-k-abhängige carboxylase | |
EP1449849A3 (en) | Protease-resistant thrombomodulin analog | |
IL86058A (en) | Specifically glycosylates urokinase-type plasminogen activators, their preparation, hybrid vectors and transformed yeast containing them and pharmaceutical compositions containing such activators | |
AU5653294A (en) | Use of a dna sequence coding for an oxalic acid degrading protein as a selection gene | |
AU7949991A (en) | Cloned n-methylhydantoinase | |
EP0643719A4 (en) | NUCLEIC ACID SEQUENCES ENCODING NUCLEIC ACID SEQUENCES ENCODING THE INTERLEUKIN-9 RECEPTOR, OR COMPLEMENTARY TO THESE SEQUENCES. | |
WO2000071078A3 (fr) | Composition destinee a la mise en oeuvre d'un traitement antitumoral ou antiviral chez un mammifere | |
EP0422217A4 (en) | Human recombinant placental ribonuclease inhibitor and method of production | |
ATE87977T1 (de) | Herstellung menschlichen somatomedins c. | |
FR2603040A1 (fr) | Proteine, sequence d'adn, poxvirus, cellules et leur procede de culture, ainsi que les compositions pharmaceutiques les contenant, utiles dans la prevention de la schistosomose | |
IL121408A0 (en) | Human recombinant manganese superoxide dismutase (hMn-SOD) its preparation DNA sequences coding therefor vectors containing these DNA sequences and host cells which can express them and pharmaceutical compositions containing said enzyme | |
DK544789A (da) | Transkaryot implantering |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
HC | Change of name of proprietor(s) |