ATE215988T1 - Vitamin-k-abhängige carboxylase - Google Patents

Vitamin-k-abhängige carboxylase

Info

Publication number
ATE215988T1
ATE215988T1 AT92913019T AT92913019T ATE215988T1 AT E215988 T1 ATE215988 T1 AT E215988T1 AT 92913019 T AT92913019 T AT 92913019T AT 92913019 T AT92913019 T AT 92913019T AT E215988 T1 ATE215988 T1 AT E215988T1
Authority
AT
Austria
Prior art keywords
vitamin
dependent carboxylase
carboxylase
isolated dna
dna
Prior art date
Application number
AT92913019T
Other languages
English (en)
Inventor
Darrell E Stafford
Sheue-Mei Wu
Original Assignee
Univ North Carolina
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ North Carolina filed Critical Univ North Carolina
Application granted granted Critical
Publication of ATE215988T1 publication Critical patent/ATE215988T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
AT92913019T 1991-05-08 1992-05-08 Vitamin-k-abhängige carboxylase ATE215988T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US69742791A 1991-05-08 1991-05-08
US07/756,250 US5268275A (en) 1991-05-08 1991-09-09 Vitamin K-dependent carboxylase
PCT/US1992/003853 WO1992019636A1 (en) 1991-05-08 1992-05-08 Vitamin k-dependent carboxylase

Publications (1)

Publication Number Publication Date
ATE215988T1 true ATE215988T1 (de) 2002-04-15

Family

ID=27106020

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92913019T ATE215988T1 (de) 1991-05-08 1992-05-08 Vitamin-k-abhängige carboxylase

Country Status (9)

Country Link
US (1) US5268275A (de)
EP (1) EP0587742B1 (de)
AT (1) ATE215988T1 (de)
AU (1) AU665199B2 (de)
CA (1) CA2102702C (de)
DE (1) DE69232544T2 (de)
DK (1) DK0587742T3 (de)
ES (1) ES2174835T3 (de)
WO (1) WO1992019636A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19725796A1 (de) * 1997-06-18 1998-12-24 Basf Ag Herstellung optisch aktiver Phospholane, deren Metallkomplexe und Anwendung in der asymmetrischen Synthese
DE19824121A1 (de) 1998-05-29 1999-12-02 Basf Ag Herstellung optisch aktiver Phospholane, deren Metallkomplexe und Anwendung in der asymmetrischen Synthese
KR100880624B1 (ko) * 2000-10-02 2009-01-30 노보 노르디스크 헬스 케어 악티엔게젤샤프트 비타민 ｋ-의존 단백질의 생산 방법
WO2003014374A2 (en) * 2001-08-08 2003-02-20 University Of Utah Research Foundation CONUS η-CARBOXYLASE
DE602004025157D1 (de) 2003-09-23 2010-03-04 Univ North Carolina Zellen, die Vitamin-K-Reduktase und Vitamin-K-abhängiges Protein coexprimieren und deren Anwendung zur Verbesserung der Produktivität von diesem Vitamin-K-abhängigen Protein
ES2344413T3 (es) 2003-10-14 2010-08-26 Baxter International Inc. Polipeptido vkorc1 de reciclaje de la vitamina k-epoxido, una diana terapeutica de la cumarina y sus derivados.
GB0324044D0 (en) 2003-10-14 2003-11-19 Astrazeneca Ab Protein
WO2006067116A1 (en) * 2004-12-21 2006-06-29 Novo Nordisk Health Care Ag Expression of gamma-carboxylated polypeptides in gamma-carboxylation deficient host systems
EP2295547B1 (de) 2005-02-28 2017-09-20 Baxalta GmbH Rekombinante co-Expression der Vitamin-K-Epoxide-Reduktase-Untereinheit 1 zur Verbesserung der Expression Vitamin-K-abhängiger Proteine
US20090325226A1 (en) * 2005-03-15 2009-12-31 Stafford Darrel W Methods and Compositions for Producing Active Vitamin K-Dependent Proteins
MX2007012704A (es) 2005-04-13 2008-01-14 Astrazeneca Ab Celula huesped que comprende vector para la produccion de proteinas que requieren carboxilacion-gamma.
WO2007075976A2 (en) * 2005-12-21 2007-07-05 Inspiration Biopharmaceuticals, Inc. Method of producing biologically active vitamin k dependent proteins by recombinant methods
US8288172B2 (en) * 2006-03-09 2012-10-16 Aethlon Medical, Inc. Extracorporeal removal of microvesicular particles
AU2008245524A1 (en) 2007-04-26 2008-11-06 Cnj Holdings, Inc. Recombinant vitamin K dependent proteins with high sialic acid content and methods of preparing same
US8206967B2 (en) 2007-07-06 2012-06-26 Medimmune Limited Method for production of recombinant human thrombin
UA101497C2 (ru) 2008-04-24 2013-04-10 Селтик Фарма Пег Лтд. Конъюгаты фактора ix с увеличенным временем полужизни
WO2011003153A1 (en) 2009-07-10 2011-01-13 Csl Limited Method of increasing the expression yield of vitamin k-dependent proteins
EP2655607A4 (de) 2010-12-21 2014-05-14 Univ North Carolina Verfahren und zusammensetzungen zur herstellung aktiver vitamin-k-abhängiger proteine
WO2018199214A1 (ja) 2017-04-27 2018-11-01 中外製薬株式会社 薬物動態が改善された血液凝固第ｉｘ因子
CN109207462B (zh) * 2018-08-01 2021-05-11 深圳市新产业生物医学工程股份有限公司 异常凝血酶原及其制备方法和包含其的检测剂、试剂盒及应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4912038A (en) * 1984-12-11 1990-03-27 California Biotechnology Inc. Recombinant DNA sequence encoding alveolar surfactant protein
SE447863B (sv) * 1985-07-09 1986-12-22 Per Ostemar Anordning for formning och pressning av ostmassa
NL8600206A (nl) * 1986-01-29 1987-08-17 Univ Limburg Werkwijze voor het winnen van een vitamine k afhankelijk carboxylase-complex, werkwijze voor het bereiden van antilichamen ten aanzien van het vitamine k afhankelijke carboxylase/niet-gecarboxyleerde bloedstollingsfactoren-complex, dragermaterialen met dergelijke antilichamen, waaraan een carboxylase-complex is gebonden, werkwijze voor het carboxyleren van glutaminezuur bevattende exogene produkten met deze dragermaterialen alsmede de op met deze laatstgenoemde werkwijze verkregen produkten gebaseerde farmaceutische preparaten.
EP0289586A4 (de) * 1986-11-17 1990-04-10 New England Medical Ct Steigerung der gamma-carboxylation von rekombinanten, vitamin-k-abhängigen proteinen.
WO1991001372A1 (en) * 1989-07-17 1991-02-07 New England Medical Center Hospitals, Inc. VITAMIN K-DEPENDENT η-CARBOXYLASE
JPH05508551A (ja) * 1990-07-23 1993-12-02 ザイモジェネティクス，インコーポレイティド ガンマーカルボキシラーゼおよび使用の方法

Also Published As

Publication number Publication date
AU665199B2 (en) 1995-12-21
US5268275A (en) 1993-12-07
ES2174835T3 (es) 2002-11-16
WO1992019636A1 (en) 1992-11-12
DE69232544T2 (de) 2002-11-21
AU2006292A (en) 1992-12-21
CA2102702A1 (en) 1992-11-09
DE69232544D1 (de) 2002-05-16
EP0587742A1 (de) 1994-03-23
EP0587742B1 (de) 2002-04-10
CA2102702C (en) 2000-09-26
EP0587742A4 (de) 1995-05-24
DK0587742T3 (da) 2002-08-05

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