ES2174835T3 - Carboxilasa dependiente de la vitamina k. - Google Patents

Carboxilasa dependiente de la vitamina k.

Info

Publication number
ES2174835T3
ES2174835T3 ES92913019T ES92913019T ES2174835T3 ES 2174835 T3 ES2174835 T3 ES 2174835T3 ES 92913019 T ES92913019 T ES 92913019T ES 92913019 T ES92913019 T ES 92913019T ES 2174835 T3 ES2174835 T3 ES 2174835T3
Authority
ES
Spain
Prior art keywords
dna
vitamin
carboxylase
isolated
depending
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92913019T
Other languages
English (en)
Inventor
Darrell E Stafford
Sheue-Mei Wu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of North Carolina at Chapel Hill
Original Assignee
University of North Carolina at Chapel Hill
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of North Carolina at Chapel Hill filed Critical University of North Carolina at Chapel Hill
Application granted granted Critical
Publication of ES2174835T3 publication Critical patent/ES2174835T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

SE DESCRIBE UN DNA (CUALQUIERA DE LOS ACIDOS NUCLEICOS QUE CONTIENEN DEOXIRIBOSA) AISLADO CODIFICANDO UNA CARBOXILASA DEPENDIENTE DE LA VITAMINA K. EL CARBOXILATO SE SELECCIONA DEL GRUPO FORMADO POR: (A) DNA AISLADO, QUE CODIFICA CARBOXILASA DEPENDIENTE DE LA VITAMINA K EN GANADO BOVINO O EN LOS SERES HUMANOS; (B) DNA AISLADO, QUE PRODUCE HIBRIDOS PARA AISLAR EL DNA DE (A) ANTERIOR Y QUE CODIFICA UNA CARBOXILASA DEPENDIENTE DE LA VITAMINA K; Y (C) DNA AISLADO, QUE DIFIERE DE LOS DNAS AISLADOS DE (A) Y (B) ANTERIORES POR LA SECUENCIA NUCLEOTIDA DEBIDA A LA DEGRADACION DEL CODIGO GENETICO, Y QUE CODIFICA UNA CARBOXILASA DEPENDIENTE DE LA VITAMINA K. TAMBIEN SE DESCRIBEN VECTORES Y CELULAS HUESPEDES QUE CONTIENEN EL DNA CITADO ANTERIORMENTE, METODOS DE USO DEL MISMO Y PROTEINA DEPURADA PARA EL DNA CITADO ANTERIORMENTE.
ES92913019T 1991-05-08 1992-05-08 Carboxilasa dependiente de la vitamina k. Expired - Lifetime ES2174835T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69742791A 1991-05-08 1991-05-08
US07/756,250 US5268275A (en) 1991-05-08 1991-09-09 Vitamin K-dependent carboxylase

Publications (1)

Publication Number Publication Date
ES2174835T3 true ES2174835T3 (es) 2002-11-16

Family

ID=27106020

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92913019T Expired - Lifetime ES2174835T3 (es) 1991-05-08 1992-05-08 Carboxilasa dependiente de la vitamina k.

Country Status (9)

Country Link
US (1) US5268275A (es)
EP (1) EP0587742B1 (es)
AT (1) ATE215988T1 (es)
AU (1) AU665199B2 (es)
CA (1) CA2102702C (es)
DE (1) DE69232544T2 (es)
DK (1) DK0587742T3 (es)
ES (1) ES2174835T3 (es)
WO (1) WO1992019636A1 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19725796A1 (de) * 1997-06-18 1998-12-24 Basf Ag Herstellung optisch aktiver Phospholane, deren Metallkomplexe und Anwendung in der asymmetrischen Synthese
DE19824121A1 (de) 1998-05-29 1999-12-02 Basf Ag Herstellung optisch aktiver Phospholane, deren Metallkomplexe und Anwendung in der asymmetrischen Synthese
AU9165201A (en) 2000-10-02 2002-04-15 Novo Nordisk As Factor vii glycoforms
AU2002319786A1 (en) * 2001-08-08 2003-02-24 Cognetix, Inc. Conus gamma-carboxylase
EP2380985B1 (en) 2003-09-23 2014-01-01 University of North Carolina at Chapel Hill Cells expressing vitamin K epoxide reductase and use thereof
GB0324044D0 (en) 2003-10-14 2003-11-19 Astrazeneca Ab Protein
DE602004026897D1 (de) 2003-10-14 2010-06-10 Baxter Healthcare Sa Vkorc1 (vitamin k epoxide recycling polypeptide), ein therapeutisches ziel für coumarin und deren derivate
JP2008523837A (ja) * 2004-12-21 2008-07-10 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト ガンマ―カルボキシル化に欠陥のある宿主系におけるガンマ―カルボキシル化ポリペプチドの発現
PL1853700T3 (pl) 2005-02-28 2013-05-31 Baxalta Inc Koekspresja przez rekombinowanie podjednostki 1 reduktazy epoksydu witaminy K w celu poprawy ekspresji białka zależnego od witaminy K
US20090325226A1 (en) * 2005-03-15 2009-12-31 Stafford Darrel W Methods and Compositions for Producing Active Vitamin K-Dependent Proteins
EP1874928A1 (en) 2005-04-13 2008-01-09 AstraZeneca AB A host cell comprising a vector for production of proteins requiring gamma-carboxylation
PL1969127T5 (pl) * 2005-12-21 2018-02-28 Cnj Holdings, Inc Metoda wytwarzania biologicznie czynnych białek zależnych od witaminy K metodami rekombinacji
EP1993600B1 (en) * 2006-03-09 2019-04-24 Aethlon Medical, Inc. Extracorporeal removal of microvesicular particles
AU2008245524A1 (en) 2007-04-26 2008-11-06 Cnj Holdings, Inc. Recombinant vitamin K dependent proteins with high sialic acid content and methods of preparing same
US8206967B2 (en) 2007-07-06 2012-06-26 Medimmune Limited Method for production of recombinant human thrombin
US20110183906A1 (en) 2008-04-24 2011-07-28 Celtic Pharma Peg Ltd. Factor ix conjugates with extended half-lives
DK2451963T3 (da) 2009-07-10 2014-08-04 Csl Ltd Fremgangsmåde til forøgelse afvitamin-k-afhængige proteiners exprimerings-ydelse
US9631002B2 (en) 2010-12-21 2017-04-25 The University Of North Carolina At Chapel Hill Methods and compositions for producing active vitamin K-dependent proteins
EP3617316A4 (en) 2017-04-27 2020-12-23 Chugai Seiyaku Kabushiki Kaisha COAGULATION FACTOR IX WITH IMPROVED PHARMACOKINETICS
CN109207462B (zh) * 2018-08-01 2021-05-11 深圳市新产业生物医学工程股份有限公司 异常凝血酶原及其制备方法和包含其的检测剂、试剂盒及应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4912038A (en) * 1984-12-11 1990-03-27 California Biotechnology Inc. Recombinant DNA sequence encoding alveolar surfactant protein
SE447863B (sv) * 1985-07-09 1986-12-22 Per Ostemar Anordning for formning och pressning av ostmassa
NL8600206A (nl) * 1986-01-29 1987-08-17 Univ Limburg Werkwijze voor het winnen van een vitamine k afhankelijk carboxylase-complex, werkwijze voor het bereiden van antilichamen ten aanzien van het vitamine k afhankelijke carboxylase/niet-gecarboxyleerde bloedstollingsfactoren-complex, dragermaterialen met dergelijke antilichamen, waaraan een carboxylase-complex is gebonden, werkwijze voor het carboxyleren van glutaminezuur bevattende exogene produkten met deze dragermaterialen alsmede de op met deze laatstgenoemde werkwijze verkregen produkten gebaseerde farmaceutische preparaten.
JPH01502080A (ja) * 1986-11-17 1989-07-27 ニュー・イングランド・メディカル・センター 組み換えビタミンｋ依存性蛋白質のガンマカルボキシル化の増強
WO1991001372A1 (en) * 1989-07-17 1991-02-07 New England Medical Center Hospitals, Inc. VITAMIN K-DEPENDENT η-CARBOXYLASE
CA2087970A1 (en) * 1990-07-23 1992-01-24 Kathleen L. Berkner Gamma-carboxylase and methods of use

Also Published As

Publication number Publication date
DE69232544D1 (de) 2002-05-16
EP0587742A4 (en) 1995-05-24
WO1992019636A1 (en) 1992-11-12
US5268275A (en) 1993-12-07
DE69232544T2 (de) 2002-11-21
AU665199B2 (en) 1995-12-21
EP0587742A1 (en) 1994-03-23
DK0587742T3 (da) 2002-08-05
ATE215988T1 (de) 2002-04-15
AU2006292A (en) 1992-12-21
EP0587742B1 (en) 2002-04-10
CA2102702A1 (en) 1992-11-09
CA2102702C (en) 2000-09-26

Similar Documents

Publication Publication Date Title
ES2174835T3 (es) Carboxilasa dependiente de la vitamina k.
ES2038579T1 (es) Una celula de levadura del genero schwanniovices.
ES2164794T3 (es) Dna que codifica cd 19.
MX9203379A (es) Proteinas producidas por los linfocitos humanos, secuencia de adn que codifica para estas proteinas y composiciones farmaceuticas que las contienen.
MX9204685A (es) Secuencia de adn que codifica una proteina superficial externa (ospa) o derivado de la misma composicion de vacuna qe comprende tal proteina.
ES2193145T3 (es) Proteinas procoagulants quimericas.
DE68905633D1 (de) Markierer der t-zelle aktivierung.
ES2194010T3 (es) Mejoras en el diagnostico y profilaxis de la borrelia burgdorferi.
ES2153037T3 (es) Lacasas purificadas de scytalidium y acidos nucleicos que las codifican.
ES2070866T3 (es) Vacunas recombinantes contra la coccidiosis.
ES2056817T3 (es) Transformacion de trichoderma.
FI101720B1 (fi) Synteettisen DNA:n konstruointi ja sen käyttö suurten polypeptidien synteesissä
DE69433690D1 (de) Chimere proteine, welche borrelia polypeptide beinhalten, verwendungen dafür
FI945221A0 (fi) Yhdistelmä-DNA-molekyylejä, jotka koodittavat aminopeptidaasientsyymejä, ja niiden käyttö rokotteiden valmistamiseksi matotartuntoja vastaan
DK491487D0 (da) Dna-sekvens til ekspressionering af biologisk aktivt faktor xiii og anvendelse af samme
ES2087869T3 (es) Proteinas modificadas; interferones alfa y beta modificados, proteinas fosforiladas y analogos, secuencias de adn, y sus aplicaciones.
ES2146214T3 (es) Vacunas para actinobacillus pleuropneumoniae.
ATE110074T1 (de) Quinolyloxazol-2-one, nützlich als proteinkinase- c-inhibitoren.
DE3881023D1 (de) Proteine, expressionsvektoren, die fuer solche proteine kodierende dna enthalten und zellen, die solche expressionsvektoren enthalten.
IT8821619A0 (it) Meccanismo per il fissaggio di una tomaia o di una calotta di tomaia in scarponi da sci.
FI896261A0 (fi) Foerfarande foer framstaellning av ett protein eller en polypeptid, dna-sekvens som kodar foer polypeptiden, mikroorganism innehaollande dna-sekvensen samt polypeptiden och dess anvaendning som ett farmaceutiskt preparat.
EA200100395A1 (ru) Фармацевтическая композиция, содержащая фрагменты днк, кодирующей антигенный белок, обладающая противоопухолевым действием
AR011740A1 (es) Proteinas del virus que produce enrollamiento en las hojas de la vid del tipo 2, secuencias de codificacion y metodos
DE69008009D1 (de) Harte Gummizusammensetzung.
DE3866747D1 (de) Jod enthaltende pharmazeutische zubereitung.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 587742

Country of ref document: ES