DK0587742T3 - Vitaminafhængig carboxylase - Google Patents

Vitaminafhængig carboxylase

Info

Publication number
DK0587742T3
DK0587742T3 DK92913019T DK92913019T DK0587742T3 DK 0587742 T3 DK0587742 T3 DK 0587742T3 DK 92913019 T DK92913019 T DK 92913019T DK 92913019 T DK92913019 T DK 92913019T DK 0587742 T3 DK0587742 T3 DK 0587742T3
Authority
DK
Denmark
Prior art keywords
vitamin
dependent carboxylase
carboxylase
isolated dna
dna
Prior art date
Application number
DK92913019T
Other languages
English (en)
Inventor
E Stafford Darrell
Sheue-Mei Wu
Original Assignee
Univ North Carolina
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ North Carolina filed Critical Univ North Carolina
Application granted granted Critical
Publication of DK0587742T3 publication Critical patent/DK0587742T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
DK92913019T 1991-05-08 1992-05-08 Vitaminafhængig carboxylase DK0587742T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US69742791A 1991-05-08 1991-05-08
US07/756,250 US5268275A (en) 1991-05-08 1991-09-09 Vitamin K-dependent carboxylase
PCT/US1992/003853 WO1992019636A1 (en) 1991-05-08 1992-05-08 Vitamin k-dependent carboxylase

Publications (1)

Publication Number Publication Date
DK0587742T3 true DK0587742T3 (da) 2002-08-05

Family

ID=27106020

Family Applications (1)

Application Number Title Priority Date Filing Date
DK92913019T DK0587742T3 (da) 1991-05-08 1992-05-08 Vitaminafhængig carboxylase

Country Status (9)

Country Link
US (1) US5268275A (da)
EP (1) EP0587742B1 (da)
AT (1) ATE215988T1 (da)
AU (1) AU665199B2 (da)
CA (1) CA2102702C (da)
DE (1) DE69232544T2 (da)
DK (1) DK0587742T3 (da)
ES (1) ES2174835T3 (da)
WO (1) WO1992019636A1 (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19725796A1 (de) * 1997-06-18 1998-12-24 Basf Ag Herstellung optisch aktiver Phospholane, deren Metallkomplexe und Anwendung in der asymmetrischen Synthese
DE19824121A1 (de) 1998-05-29 1999-12-02 Basf Ag Herstellung optisch aktiver Phospholane, deren Metallkomplexe und Anwendung in der asymmetrischen Synthese
DE60141908D1 (de) 2000-10-02 2010-06-02 Novo Nordisk Healthcare Ag Glykoformen von faktor vii
US20030096361A1 (en) * 2001-08-08 2003-05-22 Cognetix, Inc. Conus gamma-carboxylase
EP2380985B1 (en) 2003-09-23 2014-01-01 University of North Carolina at Chapel Hill Cells expressing vitamin K epoxide reductase and use thereof
DE602004026897D1 (de) 2003-10-14 2010-06-10 Baxter Healthcare Sa Vkorc1 (vitamin k epoxide recycling polypeptide), ein therapeutisches ziel für coumarin und deren derivate
GB0324044D0 (en) 2003-10-14 2003-11-19 Astrazeneca Ab Protein
EP1831363A1 (en) * 2004-12-21 2007-09-12 Novo Nordisk Health Care AG Expression of gamma-carboxylated polypeptides in gamma-carboxylation deficient host systems
CN103396998A (zh) 2005-02-28 2013-11-20 巴克斯特国际公司 重组共表达维生素k环氧化物还原酶亚基1以提高依赖维生素k的蛋白质表达
AU2005329450A1 (en) 2005-03-15 2006-09-28 University Of North Carolina At Chapel Hill Methods and compositions for producing active Vitamin K-dependent proteins
US7989193B2 (en) 2005-04-13 2011-08-02 Medimmune Limited Compositions and methods for producing gamma-carboxylated proteins
EP1969127B8 (en) * 2005-12-21 2017-12-13 Aptevo BioTherapeutics LLC Method of producing biologically active vitamin k dependent proteins by recombinant methods
ES2736726T3 (es) * 2006-03-09 2020-01-07 Aethlon Medical Inc Eliminación extracorpórea de partículas microvesiculares
US20100081187A1 (en) 2007-04-26 2010-04-01 Griffith Michael J Recombinant vitamin k dependent proteins with high sialic acid content and methods of preparing same
US8206967B2 (en) 2007-07-06 2012-06-26 Medimmune Limited Method for production of recombinant human thrombin
CN102046205A (zh) 2008-04-24 2011-05-04 凯尔特药物Peg有限公司 具有延长的半衰期的因子ix缀合物
ES2475718T3 (es) 2009-07-10 2014-07-11 Csl Limited Método para incrementar el rendimiento de la expresión de proteínas dependientes de vitamina K
EP2655607A4 (en) 2010-12-21 2014-05-14 Univ North Carolina METHOD AND COMPOSITIONS FOR PRODUCING ACTIVE VITAMIN K-DEPENDENT PROTEINS
WO2018199214A1 (ja) 2017-04-27 2018-11-01 中外製薬株式会社 薬物動態が改善された血液凝固第ｉｘ因子
CN109207462B (zh) * 2018-08-01 2021-05-11 深圳市新产业生物医学工程股份有限公司 异常凝血酶原及其制备方法和包含其的检测剂、试剂盒及应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4912038A (en) * 1984-12-11 1990-03-27 California Biotechnology Inc. Recombinant DNA sequence encoding alveolar surfactant protein
SE447863B (sv) * 1985-07-09 1986-12-22 Per Ostemar Anordning for formning och pressning av ostmassa
NL8600206A (nl) * 1986-01-29 1987-08-17 Univ Limburg Werkwijze voor het winnen van een vitamine k afhankelijk carboxylase-complex, werkwijze voor het bereiden van antilichamen ten aanzien van het vitamine k afhankelijke carboxylase/niet-gecarboxyleerde bloedstollingsfactoren-complex, dragermaterialen met dergelijke antilichamen, waaraan een carboxylase-complex is gebonden, werkwijze voor het carboxyleren van glutaminezuur bevattende exogene produkten met deze dragermaterialen alsmede de op met deze laatstgenoemde werkwijze verkregen produkten gebaseerde farmaceutische preparaten.
JPH01502080A (ja) * 1986-11-17 1989-07-27 ニュー・イングランド・メディカル・センター 組み換えビタミンｋ依存性蛋白質のガンマカルボキシル化の増強
WO1991001372A1 (en) * 1989-07-17 1991-02-07 New England Medical Center Hospitals, Inc. VITAMIN K-DEPENDENT η-CARBOXYLASE
WO1992001795A1 (en) * 1990-07-23 1992-02-06 Zymogenetics, Inc. Gamma-carboxylase and methods of use

Also Published As

Publication number Publication date
CA2102702A1 (en) 1992-11-09
AU665199B2 (en) 1995-12-21
CA2102702C (en) 2000-09-26
WO1992019636A1 (en) 1992-11-12
US5268275A (en) 1993-12-07
ES2174835T3 (es) 2002-11-16
ATE215988T1 (de) 2002-04-15
EP0587742A1 (en) 1994-03-23
AU2006292A (en) 1992-12-21
EP0587742A4 (en) 1995-05-24
EP0587742B1 (en) 2002-04-10
DE69232544T2 (de) 2002-11-21
DE69232544D1 (de) 2002-05-16

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