ATE540107T1 - Vkorc1 (vitamin k epoxide recycling polypeptide), ein therapeutisches ziel für coumarin und deren derivate - Google Patents
Vkorc1 (vitamin k epoxide recycling polypeptide), ein therapeutisches ziel für coumarin und deren derivateInfo
- Publication number
- ATE540107T1 ATE540107T1 AT10002316T AT10002316T ATE540107T1 AT E540107 T1 ATE540107 T1 AT E540107T1 AT 10002316 T AT10002316 T AT 10002316T AT 10002316 T AT10002316 T AT 10002316T AT E540107 T1 ATE540107 T1 AT E540107T1
- Authority
- AT
- Austria
- Prior art keywords
- vkorc1
- vitamin
- coumarin
- derivatives
- therapeutic target
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knockout animals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/04—Oxidoreductases acting on the CH-OH group of donors (1.1) with a disulfide as acceptor (1.1.4)
- C12Y101/04001—Vitamin-K-epoxide reductase (warfarin-sensitive) (1.1.4.1)
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/16—Aptamers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/531—Stem-loop; Hairpin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US51104103P | 2003-10-14 | 2003-10-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE540107T1 true ATE540107T1 (de) | 2012-01-15 |
Family
ID=34520024
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04790318T ATE466074T1 (de) | 2003-10-14 | 2004-10-12 | Vkorc1 (vitamin k epoxide recycling polypeptide), ein therapeutisches ziel für coumarin und deren derivate |
AT10002316T ATE540107T1 (de) | 2003-10-14 | 2004-10-12 | Vkorc1 (vitamin k epoxide recycling polypeptide), ein therapeutisches ziel für coumarin und deren derivate |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04790318T ATE466074T1 (de) | 2003-10-14 | 2004-10-12 | Vkorc1 (vitamin k epoxide recycling polypeptide), ein therapeutisches ziel für coumarin und deren derivate |
Country Status (13)
Country | Link |
---|---|
US (5) | US7939250B2 (de) |
EP (3) | EP1673450B1 (de) |
JP (2) | JP4777251B2 (de) |
AT (2) | ATE466074T1 (de) |
AU (2) | AU2004283246B2 (de) |
CA (1) | CA2542017A1 (de) |
DE (1) | DE602004026897D1 (de) |
DK (3) | DK2272951T3 (de) |
ES (3) | ES2515216T3 (de) |
HK (1) | HK1141834A1 (de) |
PL (2) | PL2189523T3 (de) |
PT (2) | PT1673450E (de) |
WO (1) | WO2005040367A1 (de) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1842920B2 (de) | 2003-09-23 | 2017-06-21 | University Of North Carolina At Chapel Hill | Zellen, die Vitamin-K-Reduktase und Vitamin-K-abhängiges Protein coexprimieren und deren Anwendung zur Verbesserung der Produktivität von diesem Vitamin-K-abhängigen Protein |
GB0324044D0 (en) | 2003-10-14 | 2003-11-19 | Astrazeneca Ab | Protein |
JP4777251B2 (ja) * | 2003-10-14 | 2011-09-21 | バクスター・インターナショナル・インコーポレイテッド | ビタミンkエポキシド還元酵素複合体サブユニット1vkorc1、クマリンおよびその誘導体の治療標的 |
EP1781779A2 (de) * | 2004-08-02 | 2007-05-09 | Novozymes A/S | Erzeugung von diversität in polypeptiden |
CA2583904C (en) * | 2004-10-18 | 2018-01-09 | University Of Washington | Methods and compositions for predicting drug responses |
US7445896B2 (en) | 2004-10-18 | 2008-11-04 | University Of Washington | Methods and compositions for detecting VKORC1 single nucleotide polymorphisms |
DK1853700T3 (da) * | 2005-02-28 | 2013-01-07 | Baxter Int | Rekombinant co-ekspression af vitamin-k-epoxid-reduktase-underenhed 1 til forbedring af vitamin-k-afhængig proteinekspression |
CA2601574C (en) | 2005-03-15 | 2014-12-02 | University Of North Carolina At Chapel Hill | Methods and compositions for producing active vitamin k-dependent proteins |
CN101198696B (zh) | 2005-04-13 | 2014-02-26 | 阿斯利康(瑞典)有限公司 | 包含产生需要γ-羧化的蛋白质用的载体的宿主细胞 |
WO2007110869A2 (en) * | 2006-03-28 | 2007-10-04 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Methods and kits for determining predisposition to warfarin resistance |
US8206967B2 (en) | 2007-07-06 | 2012-06-26 | Medimmune Limited | Method for production of recombinant human thrombin |
US20110183906A1 (en) | 2008-04-24 | 2011-07-28 | Celtic Pharma Peg Ltd. | Factor ix conjugates with extended half-lives |
US20110243958A1 (en) * | 2008-10-15 | 2011-10-06 | President And Fellows Of Harvard College | Antimicrobial agents that target bacterial vkor |
WO2011003153A1 (en) | 2009-07-10 | 2011-01-13 | Csl Limited | Method of increasing the expression yield of vitamin k-dependent proteins |
US9631002B2 (en) | 2010-12-21 | 2017-04-25 | The University Of North Carolina At Chapel Hill | Methods and compositions for producing active vitamin K-dependent proteins |
TWI600766B (zh) | 2012-08-09 | 2017-10-01 | 財團法人工業技術研究院 | 用於偵測一目標核苷酸序列中之一特定區域的一突變及/或多形性的套組 |
WO2015044292A1 (en) * | 2013-09-26 | 2015-04-02 | Universitat Autonoma De Barcelona | Gene therapy compositions for use in the prevention and/or treatment of non-alcoholic fatty liver disease |
US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
CN105177153B (zh) * | 2015-09-30 | 2018-04-24 | 南通市疾病预防控制中心 | 一种黄胸鼠pcr鉴定引物及鉴定方法 |
US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
CN109880889B (zh) * | 2019-04-08 | 2022-12-06 | 厦门市妇幼保健院(厦门市优生优育服务中心、厦门大学附属妇女儿童医院、厦门市林巧稚妇女儿童医院) | 华法林药物靶点基因特定位点甲基化水平定量检测的引物及其方法 |
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US2189523A (en) * | 1938-11-05 | 1940-02-06 | Alexander A Poch | Sprinkler head shut-off device |
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EP0127839B1 (de) | 1983-05-27 | 1992-07-15 | THE TEXAS A&M UNIVERSITY SYSTEM | Verfahren zur Herstellung eines rekombinanten Baculovirus-Expressionsvektors |
US4736866A (en) | 1984-06-22 | 1988-04-12 | President And Fellows Of Harvard College | Transgenic non-human mammals |
ATE87659T1 (de) | 1986-09-02 | 1993-04-15 | Enzon Lab Inc | Bindungsmolekuele mit einzelpolypeptidkette. |
GB8822584D0 (en) | 1988-09-27 | 1988-11-02 | Abco Technology Ltd | Steam boiler system |
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US5169784A (en) | 1990-09-17 | 1992-12-08 | The Texas A & M University System | Baculovirus dual promoter expression vector |
US5268275A (en) | 1991-05-08 | 1993-12-07 | The University Of North Carolina At Chapel Hill | Vitamin K-dependent carboxylase |
WO1993006213A1 (en) | 1991-09-23 | 1993-04-01 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
US5698765A (en) | 1991-12-02 | 1997-12-16 | The Ontario Cancer Institute | Mouse having a disrupted CD4 gene |
WO1993018144A1 (en) | 1992-03-05 | 1993-09-16 | The Trustees Of Columbia University Of The City Of New York | Recombination activating gene deficient animal |
US5625122A (en) | 1992-04-24 | 1997-04-29 | The Ontario Cancer Institute | Mouse having a disrupted lck gene |
JP3741447B2 (ja) | 1992-10-23 | 2006-02-01 | 中外製薬株式会社 | エンドセリン−1遺伝子の機能が欠損したマウス |
DE19625049A1 (de) | 1996-06-22 | 1998-01-02 | Inst Pflanzengenetik & Kultur | Transgenes, nicht-menschliches Säugetier, das ein zusätzliches DNA-Reparaturgen enthält |
AUPO864097A0 (en) | 1997-08-19 | 1997-09-11 | Peplin Pty Ltd | Anti-cancer compounds |
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EP1842920B2 (de) * | 2003-09-23 | 2017-06-21 | University Of North Carolina At Chapel Hill | Zellen, die Vitamin-K-Reduktase und Vitamin-K-abhängiges Protein coexprimieren und deren Anwendung zur Verbesserung der Produktivität von diesem Vitamin-K-abhängigen Protein |
JP4777251B2 (ja) * | 2003-10-14 | 2011-09-21 | バクスター・インターナショナル・インコーポレイテッド | ビタミンkエポキシド還元酵素複合体サブユニット1vkorc1、クマリンおよびその誘導体の治療標的 |
DK1853700T3 (da) | 2005-02-28 | 2013-01-07 | Baxter Int | Rekombinant co-ekspression af vitamin-k-epoxid-reduktase-underenhed 1 til forbedring af vitamin-k-afhængig proteinekspression |
CA2601574C (en) | 2005-03-15 | 2014-12-02 | University Of North Carolina At Chapel Hill | Methods and compositions for producing active vitamin k-dependent proteins |
US8647868B2 (en) | 2005-12-02 | 2014-02-11 | Wake Forest University Health Sciences | Compositions and methods for increasing production of recombinant gamma-carboxylated proteins |
WO2007075976A2 (en) | 2005-12-21 | 2007-07-05 | Inspiration Biopharmaceuticals, Inc. | Method of producing biologically active vitamin k dependent proteins by recombinant methods |
JP5829793B2 (ja) | 2007-03-14 | 2015-12-09 | エンドサイト・インコーポレイテッドEndocyte, Inc. | 結合性リガンドが結合したツブリシンの薬剤送達結合体 |
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2004
- 2004-10-12 JP JP2006534667A patent/JP4777251B2/ja not_active Expired - Fee Related
- 2004-10-12 DE DE602004026897T patent/DE602004026897D1/de active Active
- 2004-10-12 DK DK10011278.8T patent/DK2272951T3/da active
- 2004-10-12 PT PT04790318T patent/PT1673450E/pt unknown
- 2004-10-12 EP EP04790318A patent/EP1673450B1/de not_active Not-in-force
- 2004-10-12 PT PT10002316T patent/PT2189523E/pt unknown
- 2004-10-12 EP EP10011278.8A patent/EP2272951B1/de not_active Revoked
- 2004-10-12 DK DK10002316.7T patent/DK2189523T3/da active
- 2004-10-12 PL PL10002316T patent/PL2189523T3/pl unknown
- 2004-10-12 AT AT04790318T patent/ATE466074T1/de active
- 2004-10-12 AT AT10002316T patent/ATE540107T1/de active
- 2004-10-12 CA CA002542017A patent/CA2542017A1/en not_active Abandoned
- 2004-10-12 ES ES10011278.8T patent/ES2515216T3/es active Active
- 2004-10-12 AU AU2004283246A patent/AU2004283246B2/en not_active Ceased
- 2004-10-12 WO PCT/EP2004/011432 patent/WO2005040367A1/en active Application Filing
- 2004-10-12 EP EP10002316A patent/EP2189523B1/de not_active Not-in-force
- 2004-10-12 ES ES10002316T patent/ES2379764T3/es active Active
- 2004-10-12 DK DK04790318.2T patent/DK1673450T3/da active
- 2004-10-12 PL PL04790318T patent/PL1673450T3/pl unknown
- 2004-10-12 ES ES04790318T patent/ES2344413T3/es active Active
- 2004-10-14 US US10/965,694 patent/US7939250B2/en active Active
-
2008
- 2008-09-05 US US12/205,619 patent/US20090094708A1/en not_active Abandoned
-
2009
- 2009-08-26 AU AU2009212805A patent/AU2009212805A1/en not_active Abandoned
-
2010
- 2010-08-31 HK HK10108253.3A patent/HK1141834A1/xx not_active IP Right Cessation
- 2010-10-01 JP JP2010224376A patent/JP2011013231A/ja active Pending
- 2010-11-10 US US12/943,260 patent/US20110154520A1/en not_active Abandoned
-
2012
- 2012-12-10 US US13/710,064 patent/US20130318640A1/en not_active Abandoned
-
2015
- 2015-06-22 US US14/746,121 patent/US20170240867A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP2272951B1 (de) | 2014-07-23 |
ATE466074T1 (de) | 2010-05-15 |
US7939250B2 (en) | 2011-05-10 |
JP2007512002A (ja) | 2007-05-17 |
US20050271644A1 (en) | 2005-12-08 |
HK1141834A1 (en) | 2010-11-19 |
ES2515216T3 (es) | 2014-10-29 |
US20110154520A1 (en) | 2011-06-23 |
ES2344413T3 (es) | 2010-08-26 |
EP1673450B1 (de) | 2010-04-28 |
DK1673450T3 (da) | 2010-08-23 |
PL2189523T3 (pl) | 2012-05-31 |
AU2009212805A1 (en) | 2009-09-17 |
US20170240867A1 (en) | 2017-08-24 |
AU2004283246A1 (en) | 2005-05-06 |
EP2189523B1 (de) | 2012-01-04 |
DK2272951T3 (da) | 2014-10-13 |
DE602004026897D1 (de) | 2010-06-10 |
EP2272951A1 (de) | 2011-01-12 |
EP2189523A1 (de) | 2010-05-26 |
EP1673450A1 (de) | 2006-06-28 |
PT2189523E (pt) | 2012-01-24 |
PL1673450T3 (pl) | 2010-10-29 |
AU2004283246B2 (en) | 2009-07-23 |
US20090094708A1 (en) | 2009-04-09 |
PT1673450E (pt) | 2010-05-11 |
JP4777251B2 (ja) | 2011-09-21 |
CA2542017A1 (en) | 2005-05-06 |
DK2189523T3 (da) | 2012-03-12 |
US20130318640A1 (en) | 2013-11-28 |
WO2005040367A1 (en) | 2005-05-06 |
JP2011013231A (ja) | 2011-01-20 |
ES2379764T3 (es) | 2012-05-03 |
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