DK1853700T3 - Rekombinant co-ekspression af vitamin-k-epoxid-reduktase-underenhed 1 til forbedring af vitamin-k-afhængig proteinekspression - Google Patents

Rekombinant co-ekspression af vitamin-k-epoxid-reduktase-underenhed 1 til forbedring af vitamin-k-afhængig proteinekspression

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Publication number
DK1853700T3
DK1853700T3 DK06706455.0T DK06706455T DK1853700T3 DK 1853700 T3 DK1853700 T3 DK 1853700T3 DK 06706455 T DK06706455 T DK 06706455T DK 1853700 T3 DK1853700 T3 DK 1853700T3
Authority
DK
Denmark
Prior art keywords
vitamin
expression
epoxid
depended
reductase
Prior art date
Application number
DK06706455.0T
Other languages
English (en)
Inventor
Friedrich Scheiflinger
Ernst Boehm
Original Assignee
Baxter Int
Baxter Healthcare Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36130202&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1853700(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Baxter Int, Baxter Healthcare Sa filed Critical Baxter Int
Application granted granted Critical
Publication of DK1853700T3 publication Critical patent/DK1853700T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0093—Oxidoreductases (1.) acting on CH or CH2 groups (1.17)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/644—Coagulation factor IXa (3.4.21.22)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y117/00—Oxidoreductases acting on CH or CH2 groups (1.17)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21022—Coagulation factor IXa (3.4.21.22)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
DK06706455.0T 2005-02-28 2006-01-27 Rekombinant co-ekspression af vitamin-k-epoxid-reduktase-underenhed 1 til forbedring af vitamin-k-afhængig proteinekspression DK1853700T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65704105P 2005-02-28 2005-02-28
PCT/EP2006/000734 WO2006089613A1 (en) 2005-02-28 2006-01-27 Recombinant co-expression of vitamin k epoxide reductase subunit 1 to improve vitamin k dependent protein expression

Publications (1)

Publication Number Publication Date
DK1853700T3 true DK1853700T3 (da) 2013-01-07

Family

ID=36130202

Family Applications (1)

Application Number Title Priority Date Filing Date
DK06706455.0T DK1853700T3 (da) 2005-02-28 2006-01-27 Rekombinant co-ekspression af vitamin-k-epoxid-reduktase-underenhed 1 til forbedring af vitamin-k-afhængig proteinekspression

Country Status (18)

Country Link
US (2) US9617523B2 (da)
EP (2) EP1853700B1 (da)
JP (3) JP2008531026A (da)
KR (2) KR101310532B1 (da)
CN (2) CN101124320A (da)
AU (1) AU2006218216B2 (da)
BR (1) BRPI0607751A8 (da)
CA (1) CA2599284A1 (da)
DK (1) DK1853700T3 (da)
ES (1) ES2397530T3 (da)
HK (1) HK1113498A1 (da)
HR (1) HRP20130028T1 (da)
IL (1) IL184696A (da)
MX (2) MX349285B (da)
PL (1) PL1853700T3 (da)
PT (1) PT1853700E (da)
SI (1) SI1853700T1 (da)
WO (1) WO2006089613A1 (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006101474A1 (en) * 2005-03-15 2006-09-28 University Of North Carolina At Chapel Hill Methods and compositions for producing active vitamin k-dependent proteins
EP2336360A1 (en) * 2003-09-23 2011-06-22 University Of North Carolina At Chapel Hill Methods and compositions for the correlation of single nucleotide polymorphisms in the vitamin K epoxide reductase gene and warfarin dosage
ES2344413T3 (es) 2003-10-14 2010-08-26 Baxter International Inc. Polipeptido vkorc1 de reciclaje de la vitamina k-epoxido, una diana terapeutica de la cumarina y sus derivados.
KR101310532B1 (ko) 2005-02-28 2013-09-23 박스터 헬쓰케어 에스에이 비타민 ｋ 의존성 단백질 발현의 개선을 위한 비타민 ｋ에폭사이드 환원효소 소단위 １의 재조합 동시발현
EP1963506B1 (en) * 2005-12-02 2010-10-27 Wake Forest University Health Sciences Compositions and methods for increasing production of recombinant gamma-carboxylated proteins
DK1969127T4 (da) * 2005-12-21 2017-10-16 Cnj Holdings Inc Fremgangsmåde til fremstilling af biologisk aktivt vitamin K-afhængige proteiner med rekombinante fremgangsmåder
CN102046205A (zh) 2008-04-24 2011-05-04 凯尔特药物Peg有限公司 具有延长的半衰期的因子ix缀合物
WO2011003153A1 (en) * 2009-07-10 2011-01-13 Csl Limited Method of increasing the expression yield of vitamin k-dependent proteins
US9631002B2 (en) 2010-12-21 2017-04-25 The University Of North Carolina At Chapel Hill Methods and compositions for producing active vitamin K-dependent proteins
JP2012139232A (ja) * 2012-03-15 2012-07-26 Univ Of North Carolina At Chapel Hill 活性ビタミンｋ依存性タンパク質を生産するための方法及び組成物
RU2535871C1 (ru) * 2013-07-10 2014-12-20 Общество с ограниченной ответственностью "Лаборатория медицинской биотехнологии" (ООО "ЛМБТ") Плазмида для экспрессии в клетке китайского хомячка, клетка китайского хомячка - продуцент белка с Gla-доменом и способ получения белка с Gla-доменом
JP2014221048A (ja) * 2014-06-16 2014-11-27 ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル 活性ビタミンｋ依存性タンパク質を生産するための方法及び組成物
CN104293737B (zh) * 2014-09-16 2017-06-13 太原博奥特生物技术有限公司 一种包含表达功能性重组人凝血因子ⅶ载体的宿主细胞及其高水平表达方法
WO2017093482A1 (en) 2015-12-02 2017-06-08 Csl Behring Recombinant Facility Ag Improved media for the expression of recombinant vitamin k-dependent proteins

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8822584D0 (en) 1988-09-27 1988-11-02 Abco Technology Ltd Steam boiler system
WO1991001372A1 (en) 1989-07-17 1991-02-07 New England Medical Center Hospitals, Inc. VITAMIN K-DEPENDENT η-CARBOXYLASE
AU8427091A (en) 1990-07-23 1992-02-18 Zymogenetics Inc. Gamma-carboxylase and methods of use
US5268275A (en) 1991-05-08 1993-12-07 The University Of North Carolina At Chapel Hill Vitamin K-dependent carboxylase
WO2000003015A2 (en) 1998-07-10 2000-01-20 Incyte Pharmaceuticals, Inc. Human transport protein homologs
BR0114374A (pt) 2000-10-02 2003-12-30 Novo Nordisk As Preparação compreendendo uma pluralidade de polipeptìdeos de fator vii, métodos para a determinação do padrão de glicoforma de fator vii e de polipeptìdeos relacionados com fator vii, e para a produção da dita preparação, formulação farmacêutica, métodos para o tratamento de uma sìndrome responsiva a fator vii, para a prevenção de sangramento indesejado, para a prevenção de coagulação sanguìnea indesejada, e para prevenção de reações mediadas por fator de tecido, e, uso da preparação
CA2441832A1 (en) 2001-03-21 2002-12-27 Human Genome Sciences, Inc. Human secreted proteins
EP2336360A1 (en) 2003-09-23 2011-06-22 University Of North Carolina At Chapel Hill Methods and compositions for the correlation of single nucleotide polymorphisms in the vitamin K epoxide reductase gene and warfarin dosage
WO2006101474A1 (en) 2005-03-15 2006-09-28 University Of North Carolina At Chapel Hill Methods and compositions for producing active vitamin k-dependent proteins
ES2344413T3 (es) * 2003-10-14 2010-08-26 Baxter International Inc. Polipeptido vkorc1 de reciclaje de la vitamina k-epoxido, una diana terapeutica de la cumarina y sus derivados.
EP1831363A1 (en) 2004-12-21 2007-09-12 Novo Nordisk Health Care AG Expression of gamma-carboxylated polypeptides in gamma-carboxylation deficient host systems
KR101310532B1 (ko) 2005-02-28 2013-09-23 박스터 헬쓰케어 에스에이 비타민 ｋ 의존성 단백질 발현의 개선을 위한 비타민 ｋ에폭사이드 환원효소 소단위 １의 재조합 동시발현

Also Published As

Publication number Publication date
JP2008531026A (ja) 2008-08-14
EP1853700A1 (en) 2007-11-14
SI1853700T1 (sl) 2013-02-28
PL1853700T3 (pl) 2013-05-31
JP2013063089A (ja) 2013-04-11
CN101124320A (zh) 2008-02-13
CN103396998A (zh) 2013-11-20
IL184696A (en) 2013-09-30
PT1853700E (pt) 2013-01-14
BRPI0607751A8 (pt) 2015-10-27
EP2295547B1 (en) 2017-09-20
MX2007010489A (es) 2007-11-08
KR101310532B1 (ko) 2013-09-23
KR20130025952A (ko) 2013-03-12
US20170226487A1 (en) 2017-08-10
MX349285B (es) 2017-07-20
HK1113498A1 (en) 2008-10-03
IL184696A0 (en) 2007-12-03
BRPI0607751A2 (pt) 2010-03-16
JP5339391B2 (ja) 2013-11-13
ES2397530T3 (es) 2013-03-07
EP2295547A1 (en) 2011-03-16
US20060194284A1 (en) 2006-08-31
KR20070110106A (ko) 2007-11-15
AU2006218216B2 (en) 2011-01-20
EP1853700B1 (en) 2012-10-24
CA2599284A1 (en) 2006-08-31
WO2006089613A1 (en) 2006-08-31
US9617523B2 (en) 2017-04-11
JP2011142923A (ja) 2011-07-28
AU2006218216A1 (en) 2006-08-31
HRP20130028T1 (hr) 2013-02-28

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